The COVID-19 pandemic has had an unprecedented, disastrous impact on the ability of people to balance work and care for their children and families. This policy brief is an outcome of a collaboration between Women in Informal Employment: Globalizing and Organizing (WIEGO), UNICEF and the International Labour Organization (ILO) in advocating for family-friendly policies to protect and ensure social protection and care systems that are good for children, good for women and good for the economy. The policy brief features an increased focus on the well-being and working conditions of caregivers in the informal economy and their children’s development in low- and middle-income countries. The brief highlights the need to consider sustainable policy and protection responses instead of quick, short-term measures for more gender-transformative and equitable solutions. This represents a critical gap which, if not addressed, will make our goals to tackle child poverty, hunger and gender inequality – and fulfil the SDGs – impossible to achieve.