AMINES, ALIPHATIC

 

 

Aliphatic amine compounds are formed when one or more hydrogen atoms in ammonia () are replaced by one, two or three alkyl or alkanol radicals. The lower aliphatic amines are gases like ammonia and freely soluble in water, but the higher homologues are insoluble in water. All the aliphatic amines are basic in solution and form salts. The salts are odourless, non-volatile solids freely soluble in water.

 

According to the number of hydrogens substituted, the amines may be primary (), secondary () or tertiary ().

 

Uses

Aliphatic amines are found in the chemical, pharmaceutical, rubber, plastics, dye-stuff, textile, cosmetics and metal industries. These chemicals are used as intermediates, solvents, rubber accelerators, catalysts, emulsifiers, synthetic cutting fluids, corrosion inhibitors and flotation agents. Several are used in the manufacture of herbicides, pesticides and dyes. In the photography industry, triethylamine and methylamine are used as accelerators for developers. Diethylamine is a corrosion inhibitor in the metal industries and a solvent in the petroleum industry. In the tanning and leather industries, hexamethylenetetramine is used as a tanning preservative; methylamine, ethanolamine and diisopropanolamine are softening agents for hides and leather.

 

2-Dimethylaminoethanol functions as a control agent for the acidity of boiler water treatment. Triethanolamine, isopropanolamime, cyclohexylamine and dicyclohexylamine are used in dry-cleaning soaps. Triethanolamine is used extensively in industry for the manufacture of surface-active agents, waxes, polishes, herbicides and cutting oils. It is also used to recover hydrogen sulphide from sour natural gas and sour crude petroleum. Ethanolamine extracts both carbon dioxide and hydrogen sulphide from natural gas.

 

Ethylamine acts as a stabilizer for rubber latex and as a dye intermediate, while butylamine is a pesticide and a strong alkaline liquid used in the rubber, pharmaceutical and dye-stuff industries. Ethylenediamine is another strongly alkaline liquid used in the preparation of dyes, rubber accelerators, fungicides, synthetic waxes, pharmaceuticals, resins, insecticides and asphalt wetting agents. Dimethylamine and isobutanolamine find use in the rubber industry as vulcanization accelerators. Dimethylamine is also used in the tanning industry and in the manufacture of detergent soaps.

 

Ethylenimine is an important compound found in the paper, textile, petroleum, lacquer and varnish, cosmetics and photography industries. Diethanolamine is a scrubbing agent for gases, a chemical intermediate, and an emulsifier in agricultural chemicals, cosmetics and pharmaceuticals. Other widely used emulsifying agents include isobutanolamine, isopropanolamine and cyclohexylamine.

 

Hazards

Since the amines are bases and may form strongly alkaline solutions, they can be damaging if splashed in the eye or if allowed to contaminate the skin. Otherwise they have no specific toxic properties, and the lower aliphatic amines are normal constituents of body tissues, so that they occur in a large number of foods, particularly fish, to which they impart a characteristic odour. One area of concern at present is the possibility that some aliphatic amines may react with nitrate or nitrite in vivo to form nitroso compounds, many of which are known to be potent carcinogens in animals, as is discussed more fully in the accompanying box.

 

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Formation of Nitrosamines

 

Nitrosamines are amines that contain a nitroso- functional group (-N-N=O). These chemicals are formed when a nitrogen (N) and an oxygen (O) from a “nitrosating” compound bind to the amino group nitrogen (N) of the amine compound. For example, the nitrate and nitrite salts used in the salt bath in rubber manufacturing serve as nitrosating agents and combine with amines in the rubber compound to form nitrosamines. Nitrosamines are also formed in vivo during the metabolism of nitrate- or nitrite-containing compounds. Rubber compounds that are nitrosamine precursors include sulphenamides, secondary sulphenamides, dithiocarbamates, thiurams and diethylhydroxylamines. Some rubber compounds actually contain a nitrosamine, such as nitrosodiphenylamine (NDPhA), a retarder, or dinitrosopentamethylenetetramine (DNPT), a blowing agent. These nitrosamines are weakly carcinogenic, but they can “transnitrosate”, or transfer their nitroso- groups to, other amines to form more carcinogenic nitrosamines. Nitrosamines that have been detected at salt bath operations include: nitrosodimethylamine (NDMA), nitrosopiperidine (NPIP), nitrosomorpholine (NMOR), nitrosodiethylamine (NDEA) and nitrosopyrrolidine (NPYR).

 

The formation of nitrosamines is a health concern because most nitrosamines are suspected to be human carcinogens, although a causal association between nitrosamine exposure and human cancer has not yet been firmly established. There is, however, circumstantial evidence that nitrosamines could cause cancer in humans. Nitrosamines are potent animal carcinogens; approximately 90% of the 300 tested nitrosamines have shown carcinogenic effects in laboratory animals. Approximately 40 animal species, including mammals, birds, fish and amphibia, have been studied, and none has been resistant. Nitrosamine effects have been demonstrated in multiple organs; the tumour sites depend on the specific nitrosamine, the species tested and the route of administration.

 

Biochemical, pathological and experimental nitrosamine research provide little evidence that humans might be resistant to the carcinogenic potential of nitrosamines. Human tissues have been shown to metabolize nitrosamines into compounds that bind to DNA, a process that is considered the first step in the development of many cancers, and human liver tissue appears to metabolize nitrosamines with a similar activity to rodent liver tissue. A few human DNA-adduct studies have revealed higher levels of nitrosamine-related DNA adducts in cancer cases than in controls, and studies in experimental animals have shown the formation of similar DNA-adducts to those detected in the human studies.

 

The International Agency for Research on Cancer (IARC) has classified both NDMA and NDEA as Group 2A carcinogens (probable human carcinogens), and NMOR, NPIP and NPYR as Group 2B carcinogens (possible human carcinogens). The US National Toxicology Program (NTP) has listed all five of these nitrosamines as substances that may be reasonably anticipated to be human carcinogens. In the United States, both the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH) consider nitrosodimethylamine (NDMA) to be an occupational carcinogen, but no exposure limit has as yet been established. In Germany, Der Ausschub fьr Gefahrstoffe (AGS) has strict regulations for occupational exposures to nitrosamines. In general industry, the total nitrosamine exposure may not exceed 1 . For certain processes, such as rubber vulcanization, total nitrosamine exposures may not exceed 2.5 .

 

Eliminating the nitrosamine formation from operations such as those in the rubber industry can be done by either reformulating the rubber compounds or using alternate methods, such as hot air with glass beads or microwave curing. Both changes require research and development to ensure that the final product has all the same desirable properties as the former rubber product. Another option to reduce exposures is local exhaust ventilation (LEV). Not only does the salt bath need to be enclosed and properly ventilated, but also other areas along the line, such as places where the product is cut or drilled, need sufficient engineering controls to ensure that worker exposures are kept low.

 

Beth Donovan Reh

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Allylamine. The vapour is intensely irritating. In animals there is evidence of effects on the heart and circulatory system. Myocardial and vascular legions have been observed. Some of allylamine’s toxicity has been attributed to the formation of acrolein in vivo. There is also a definite risk of explosion over a wide range of concentrations in air.

 

Butylamine is the most important isomer commercially. Its vapour has been observed to have severe effects on the central nervous system (CNS) of animals exposed to it. It has intense effects on humans. It is extremely irritating to the eyes and respiratory tract. It also affects the CNS and can cause depression and even unconsciousness. Chest pains and severe coughing have also been reported. Butylamine is readily absorbed through the skin. Any absorbed butylamine is readily metabolized.

 

A main toxic effect of cyclohexylamine is to act as an irritant. It may damage and sensitize the skin. Cyclohexylamine is also a weak methaemoglobin inducer. This amine is also a principal metabolite of cyclamate.

 

Diethanolamine is irritating to the skin and mucous membranes. Exposure can lead to nausea and vomiting.

 

Dimethylamine vapours are both flammable and irritating. The solutions which it forms are strongly alkaline.

 

Ethanolamine may be weakly irritating but is not associated with major toxic effects on humans.

 

Ethylamine can cause eye irritation. Corneal damage may occur in those exposed to the vapour. The compound is excreted unchanged by humans.

 

Ethylenediamine damages the eyes, skin and respiratory tract. Sensitization may follow vapour exposure.

 

Methylamine a stronger base than ammonia, and the vapour is irritating to the eyes and respiratory tract. Cases of sensitization (bronchial) have been reported. The warning properties of this chemical are not good, since olfactory fatigue can set in.

 

Propylamine vapour may be injurious to the eyes and respiratory tract. Transitory visual disturbances have been reported.

 

Triethanolamine is of low human toxicity and is commonly added to many cosmetics and similar products.

 

Aliphatic amines tables

 

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Table 104.25.      Chemical identification

 

CHEMICAL

SYNONYMS

UN CODE

CAS-NUMBER

CHEMICAL FORMULA

ACETALDEHYDE-OXIME

Acetaldoxime;

Aldoxime;

Ethanal oxime;

Ethylidenehydroxylamine

UN2332

107-29-9

 

ALLYLAMINE

Allylamine;

3-Aminopropene;

3-Aminopropylene;

Monoallylamine;

2-Propenamine

UN2334

107-11-9

 

1,3-BIS(HYDROXYMETHYL)UREA

N,N’-Bis(hydroxymethyl)urea;

N,N’-Dihydroxymethylurea;

Dimethanol urea;

Dimethylolurea;

N,N’-Dimethylolurea;

1,3-Dimethylolurea;

Oxymethurea

140-95-4

 

1,3-BUTANEDIAMINE

1,3-Diaminobutane

590-88-5

 

BUTYLAMINE

1-Aminobutane;

1-Butanamine;

Monobutylamine

UN1125

109-73-9

 

sec-BUTYLAMINE

2-Aminobutane;

2-Butanamine;

1-Methylpropylamine,

13952-84-6

 

tert-BUTYLAMINE

2-Aminoisobutane;

2-Amino-2-methylpropane;

1,1-Dimethylethylamine;

Trimethylaminomethane

75-64-9

 

CYCLOHEXYLAMINE

Aminocyclohexane;

Aminohexahydrobenzene;

Cyclohexanamine;

Hexahydroaniline

UN2357

108-91-8

DIALLYLAMINE

Di-2-propenylamine ;

N-2-Propenyl 2-propen-1-amine

UN2359

124-02-7

3,3’-DIAMINODIPROPYLAMINE

Aminobis(propylamine);

Dipropylenetriamine;

Iminobis(propylamine);

3,3’-Iminobis(propylamine)

UN2269

56-18-8

 

DIBUTYLAMINE

Butyl-1-butanamine;

N-Dibutylamine

UN2248

111-92-2

2-DIBUTYLAMINOETHANOL

Dibutylaminoethanol;

N,N-Dibutylethanolamine;

N,N-Dibutyl-N-(2-hydroxyethyl)amine

UN2873

102-81-8

2,2’-DICHLORO-N-METHYLDIETHYLAMINE

Bis(2-chloroethyl)methylamine;

2-Chloro-n-(2-chloroethyl)-N-methylethanamine;

N,N-Di(chloroethyl)methylamine;

Methylbis(2-chloroethyl)amine

51-75-2

 

DICYCLOHEXYLAMINE

N-Cyclohexylcyclohexanamine;

N,N-Diclohexylamine;

Dodecahydrodiphenylamine

UN2565

101-83-7

 

DIETHYLAMINE

Diethamine;

N,N-Diethylamine;

N-Ethyl ethanamine

UN1154

109-89-7

2-DIETHYLAMINOETHANOL

Diethylaminoethanol;

Diethylethanolamine;

N,N-Diethylethanolamine

UN2686

100-37-8

 

DIETHYLENETRIAMINE

Aminoethylethandiamine;

Bis(2-aminoethyl)amine;

2,2’-Diaminodiethylamine;

Ethylamine, 2,2’-Iminobis-;

Ethylenediamine-N-(2-aminoethyl)-

UN2079

111-40-0

 

DIETHANOLAMINE

Bis(2-hydroxyethyl)amine;

Diethanolamine;

Diethylolamine;

2,2’-Dihydroxydiethylamine ;

Di(2-hydroxyethyl)amine

111-42-2

 

DIISOPROPANOLAMINE

Bis(2-propanol)amine;

Bis(2-hydroxypropyl)amine;

DIPA;

1,1’-Iminobis-2-propanol;

1,1’-Iminodi-2-propanol

110-97-4

 

DIISOPROPYLAMINE

N-(1-Methylethyl)-2-propanamine

UN1158

108-18-9

3-DIMETHYLAMINOPROPYLAMINE

1-Amino-3-dimethylaminopropane;

N,N-Dimethyl-1,3-propanediamine;

N,N-Dimethyl-n-(3-aminopropyl)amine;

3-(Dimethylamino)propylamine;

N,N-Dimethyl-1,3-propylenediamine

109-55-7

 

DIMETHYLAMINE

DMA;

Methanamine, N-Methylmethanamine

UN1032

UN1160

124-40-3

 

DIMETHYLAMINE HYDROCHLORIDE

Dimethylammonium chloride;

Hydrochloric acid dimethylamine;

N-Methylmethanamine hydrochloride

506-59-2

2-DIMETHYLAMINOETHANOL

Dimethylaminoethanol;

Dimethylethanolamine;

N,N-Dimethyl-N-(2-hydroxyethyl)amine;

DMAE

UN2051

108-01-0

 

BIS(2-DIMETHYLAMINOETHYL)ETHER

Ethylamine, 2,2’-oxybis(N,N-Dimethyl;

NIAX Catalyst A1

3033-62-3

 

DIPENTYLAMINE

Diamyl amine;

Di-N-amylamine;

1-Pentanamine, N-Pentyl

UN2841

2050-92-2

 

ETHANOLAMINE

2-Aminoethanol;

Ethanolamine;

Glycinol;

2-Hydroxyethylamine;

Monoethanolamine

UN2491

141-43-5

 

 

ETHYLAMINE

Aminoethane;

1-Aminoethane;

Ethanamine;

Monoethylamine

UN1036

UN2270

75-04-7

 

 

ETHYLENEDIAMINE

1,2-Diaminoethane;

Dimethylenediamine;

1,2-Ethanediamine;

Ethylendiamine;

Ethylenediamine;

1,2-Ethylenediamine

UN1604

107-15-3

 

 

ETHYLENIMINE

Dihydroazirene;

Dihydro-1H-azirine;

Dimethyleneimine;

Dimethylenimine

UN1185

151-56-4

 

2-ETHYLHEXYLAMINE

2-Ethyl hexylamine

UN2276

104-75-6

 

ETHYLMETHYLKETONE OXIME

2-Butanone, oxime;

Ethyl methyl ketoxime;

MEK-oxime;

Methyl ethyl ketoxime

96-29-7

HEXAMETHYLENEDIAMINE

1,6-Diaminohexane;

Hexamethylenediamine;

1,6-Hexamethylenediamine

UN1783

UN2280

124-09-4

 

 

HEXAMETHYLENETETRAMINE

Formamine;

Hexaform;

1,6-Hexanediamine;

Hexamine;

Methamin;

Methenamine

UN1328

100-97-0

 

HYDROXYETHYLETHYLENEDIAMINE

N-Aminoethylethanolamine;

Ethanolethylene diamine;

N-Hydroxyethyl-1,2-ethanediamine Monoethanolethylenediamine;

2-((2-Aminoethyl)amino)ethanol

111-41-1

ISOBUTANOLAMINE

2-Aminodimethylethanol;

2-Amino-2-methylpropanol;

2-Amino-2-propanol;

Isobutanol-2-amine

124-68-5

ISOBUTYLAMINE

1-Amino-2-methylpropane;

Monoisobutylamine;

1-Propanamine, 2-methyl-

UN1214

78-81-9

ISOPROPANOLAMINE

a-Aminoisopropyl alcohol;

2-Hydroxypropylamine;

Isopropanolamine;

1-Methyl-2-aminoethanol;

Mono-iso-propanolamine

78-96-6

ISOPROPYLAMINE

1-Methylethylamine;

Monoisopropylamine;

2-Propanamine;

sec-Propylamine;

2-Propylamine

UN1221

75-31-0

 

METHYLAMINE

Aminomethane;

Carbinamine;

Mercurialin;

Monomethylamine

UN1061

UN1235

74-89-5

2-METHYLAMINOETHANOL

N-Methylaminoethanol;

Methylethanolamine;

Monomethylaminoethanol

109-83-1

 

1,5-PENTANEDIAMINE

Cadaverin;

1,5-Diaminopentane;

Pentamethylenediamine;

1,5-Pentamethylenediamine

462-94-2

 

 

1,3-PROPANEDIAMINE

1,3-Diaminopropane;

1,3-Propylenediamine;

Trimethylenediamine

109-76-2

 

PROPYLAMINE

1-Aminopropane;

Monopropylamine;

Propanamine;

1-Propylamine

UN1277

107-10-8

 

 

PROPYLENEDIAMINE1,2-PROPANEDIAMINE

1,2-Diaminopropane;

1,2-Propanediamine;

1,2-Propylenediamine;

Propylenediamine

UN2258

78-90-0

 

TETRAETHYLENEPENTAMINE

D.E.H. 26;

1,4,7,10,13-Pentaazatridecane;

1,2-Ethanediamine, N-(2-aminoethyl)-N’-(2-((2-aminoethyl)amino)ethyl

UN2320

112-57-2

 

TRIALLYLAMINE

N,N-Di-2-propenyl-2-propen-1-amine;

2-Propen-1-amine, N,N-Di-2-propenyl-

UN2610

102-70-5

 

TRIBUTYLAMINE

Tributylamine;

Tri-N-butylamine;

Tris-N-butylamine

UN2542

102-82-9

 

TRIETHYLAMINE

Diethylaminoethane;

N,N-Diethylethanamine;

Ethanamine, N,N-Diethyl

UN1296

121-44-8

TRIETHYLENETETRAMINE

N,N-Bis(2-aminoethyl)-1,2-Diaminoethane;

N,N’-Bis(2-aminoethyl)ethylenediamine;

1,2-Ethanediamine, N,N’-bis(2-aminoethyl)-;

Ethylenediamine, N,N’-Bis(2-aminoethyl)-

UN2259

112-24-3

 

 

TRIETHANOLAMINE

Nitrilo-2,2’,2’’-triethanol;

Triethanolamine;

Tri(hydroxyethyl)amine;

Trihydroxytriethylamine

102-71-6

 

TRIISOPROPANOLAMINE

Triisopropanolamine;

Tris(2-hydroxypropyl)amine;

Tris(2-hydroxy-1-propyl)amine

122-20-3

 

TRIMETHYLAMINE

Methanamine, N,N-dimethyl-;

TMA

UN1083

UN1297

75-50-3

TRIPROPYLAMINE

N,N-Dipropyl-1-propanamine

UN2260

102-69-2

 

 

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Table 104.26.    Health hazards

 

CHEMICAL NAME

CAS-NUMBER

ICSC SHORT-TERM EXPOSURE

ICSC LONG-TERM EXPOSURE

ICSC ROUTES OF EXPOSURE AND SYMPTOMS

US NIOSH TARGET ORGANS & ROUTES OF ENTRY

US NIOSH SYMPTOMS

ALLYLAMINE

107-11-9

eyes; skin; resp tract; lungs; heart

skin

Inhalation: burning sensation, cough, chest pain, shortness of breath, sore throat

Skin: may be absorbed, redness, pain, blisters

Eyes: severe eye irritation, redness, pain, tear drawing, blurred vision, loss of vision

Ingestion: burning sensation, headache, nausea, weakness

 

 

1-AMINO-2-PROPANOL

78-96-6

eyes; skin; resp tract; lungs

 

Inhalation: burning sensation, cough, headache, laboured breathing, nausea, sore throat

 

 

BUTYLAMINE

109-73-9

eyes; skin; resp tract; lungs; CNS

skin

Inhalation: burning sensation, cough, dizziness, unconsciousness

Skin: may be absorbed, redness, roughness, skin burns, burning sensation, blisters

Eyes: pain, burns, loss of vision

Ingestion: cough, dizziness, nausea, unconsciousness, vomiting

Resp sys; eyes; skin

Inh, abs, ing, con

Irrit eyes, skin, nose, throat; head; skin flush, burns

sec-BUTYLAMINE

13952-84-6

eyes; skin; resp tract; lungs

skin

Inhalation: cough, laboured breathing, sore throat, symptoms may be delayed

Skin: redness, skin burns, pain

Eyes: redness, pain, blurred vision, severe deep burns

Ingestion: diarrhoea, sore throat, vomiting

 

 

CYCLOHEXYLAMINE

108-91-8

eyes; skin; resp tract; lungs; CNS

skin

 

Eyes; skin; resp sys; CNS

Inh, abs, ing, con

Irrit eyes, skin, muc memb, resp sys; eye, skin burns; skin sens; cough, pulm edema; drow, li-head, dizz; diarr, nau, vomit

DIALLYLAMINE

124-02-7

eyes; skin ; resp tract; lungs; heart

 

burning sensation, cough, sore throat, chest pain, shortness of breath

 

 

DIETHYLAMINE

109-89-7

eyes; skin; resp tract; lungs

skin

Inhalation: burning sensation, cough, chest pain

Skin: roughness, skin burns, pain

Eyes: pain, blurred vision, severe deep burns

Ingestion: abdominal cramps, abdominal pain, burning sensation, cough, sore throat

Eyes; skin; resp sys; CNS

Inh, abs, ing, con

Irrit eyes, skin, resp sys; in animals: myocardial degeneration

2-DIETHYLAMINOETHANOL

100-37-8

 

 

Inhalation: cough, laboured breathing, nausea, shortness of breath, sore throat, vomiting

Resp sys; skin; eyes

Inh, abs, ing, con

Irrit eyes, skin, resp sys; nau, vomit

DIETHYLENETRIAMINE

111-40-0

eyes; skin; resp tract; lungs

skin; resp tract

Inhalation: burning sensation, cough, headache, laboured breathing, nausea, sore throat, symptoms may be delayed

Skin: severe skin burns, pain

Eyes: pain, loss of vision, severe deep burns

Ingestion: abdominal pain, sore throat

Eyes; skin; resp sys

Inh, abs, ing, con

Irrit eyes, skin, muc memb, upper resp sys; derm, skin sens; eye, skin nec; cough, dysp, pulm sens

DIETHANOLAMINE

111-42-2

eyes; skin; resp tract

skin; resp tract

Inhalation: burning sensation, headache, nausea, sore throat, vomiting

Skin: redness, burning sensation

Eyes: redness, pain, severe deep burns

Ingestion: abdominal pain, burning sensation

Eyes; skin; resp sys

Ing, ing, con

irrit eyes, skin, nose, throat; eye burns, corn nec; skin burns; lac, cough, sneez

DIISOPROPANOLAMINE

110-97-4

eyes; skin

skin

Skin: redness, burning sensation

Eyes: redness, pain, blurred vision

 

 

DIISOPROPYLAMINE

108-18-9

eyes; resp tract; lungs

skin

Inhalation: cough, laboured breathing, nausea, sore throat

Skin: may be absorbed, dry skin, redness, burning sensation

Eyes: redness, pain, temporary or even permanent loss of vision

Ingestion: corrosive, abdominal cramps, cough, nausea, sore throat

Eyes; skin; resp sys

Inh, abs, ing, con

Irrit eyes, skin, resp sys; nau, vomit; head; vis dist

DIMETHYLAMINE

124-40-3

eyes; skin; resp tract; lungs

skin

Inhalation: abdominal pain, burning sensation, cough, diarrhoea, laboured breathing, shortness of breath, sore throat

Skin: redness, skin burns, pain

Eyes: redness, pain, blurred vision, severe deep burns

Resp sys; skin; eyes

Inh, con, (liq)

Irrit nose, throat; sneez, cough, dysp; pulm edema; conj; derm; liq: frostbite

2-DIMETHYLAMINOETHANOL

108-01-0

eyes; skin; resp tract; lungs

skin

Inhalation: cough, laboured breathing, symptoms may be delayed

Skin: may be absorbed, redness, pain

Eyes: pain, severe deep burns

Ingestion: abdominal pain, nausea, vomiting

 

 

DIPENTYLAMINE

2050-92-2

eyes; skin; resp tract

 

cough

 

 

1,2-ETHANEDIAMINE

107-15-3

eyes; skin; resp tract; lungs; liver; kideys

skin; resp tract

Inhalation: burning sensation, cough, laboured breathing, shortness of breath, sore throat

Skin: may be absorbed, redness, skin burns, pain

Eyes: redness, pain, blurred vision

Ingestion: abdominal pain, diarrhoea, sore throat, vomiting

Resp sys; liver; kidneys; skin

Inh, abs, ing, con

Irrit nose, resp sys; sens derm; asthma; liver, kidney damage

ETHANOLAMINE

141-43-5

 

 

 

Resp sys; skin; eyes; CNS

Inh, ing, con

Irrit eyes, skin, resp sys; leth

ETHYLAMINE

75-04-7

eyes; skin; resp tract

kidneys; lungs

Inhalation: cough, laboured breathing, sore throat

Skin: may be absorbed, redness, burning sensation

Eyes: redness, pain

Ingestion: abdominal pain, burning sensation

Resp sys; eyes; skin

Inh, abs (liq), ing (liq), con (liq)

Irrit eyes, skin, resp sys; skin burns; derm

ETHYLENIMINE

151-56-4

eyes; skin; resp tract; lungs; CNS; kidneys; liver

skin

Inhalation: cough, dizziness, headache, laboured breathing, nausea, vomiting, symptoms may be delayed

Skin: may be absorbed, redness, skin burns, blisters

Eyes: redness, pain, severe deep burns

Ingestion: Vomiting

Eyes; lungs; skin; liver; kidneys; resp sys; In animals: lung & liver tumors

Ing, abs, ing, con

Irrit eyes, skin, nose, throat; nau, vomit; head, dizz; pulm edema; liver, kidney damage; eye burns; skin sens; (carc)

HEXAMETHYLENEDIAMINE

124-09-4

eyes; skin; resp tract

skin

Inhalation: cough, laboured breathing, shortness of breath

Skin: redness, pain

Eyes: redness, pain

Ingestion: abdominal cramps, abdominal pain

 

 

ISOBUTANOLAMINE

124-68-5

eyes; skin; resp tract; lungs

 

 

 

 

ISOPHORONE DIAMINE

2855-13-2

eyes; skin; resp tract; lungs

skin; lungs

Inhalation: burning sensation, cough, headache, cardiac dysrhythmia, symptoms may be delayed

Skin: may be absorbed, redness, skin burns, burning sensation, pain

Eyes: redness, pain, blurred vision, loss of vision, severe deep burns

Ingestion: abdominal pain, burning sensation, sore throat

 

 

ISOPROPYLAMINE

75-31-0

 

 

 

Resp sys; skin; eyes

Inh, abs, ing, con

Irrit eyes, skin, nose, throat; pulm edema; vis dist; eye, skin burns; derm

METHYLAMINE

74-89-5

eyes; skin; resp tract; lungs

skin

Inhalation: abdominal cramps, cough, diarrhoea, laboured breathing, shortness of breath, sore throat, vomiting

Skin: redness, pain

Eyes: redness, pain

Ingestion: abdominal cramps

Resp sys; eyes; skin

Inh, abs (soln), ing (soln), con (liq

soln)

irrit eyes, skin, resp sys; cough; skin, muc memb burns; derm; conj; liq: frostbite

PROPYLAMINE

107-10-8

eyes; skin; resp tract; lungs

 

Inhalation: burning sensation, cough, sore throat, shortness of breath

 

 

TRIETHYLAMINE

121-44-8

 

 

 

Resp sys; eyes; skin; CVS; liver; kidneys

Ing, abs, ing, con

Irrit eyes, skin, resp sys; in animals: myocardial, kidney, liver damage

TRIETHYLENETETRAMINE

112-24-3

eyes; skin; resp tract; lungs

skin

Inhalation: burning sensation, cough, laboured breathing

Skin: redness, pain, blisters

Eyes: redness, pain, severe deep burns

Ingestion: abdominal pain, burning sensation, weakness

 

 

TRIISOPROPANOLAMINE

122-20-3

eyes; skin; resp tract; lungs

 

Inhalation: burning sensation, cough, laboured breathing, sore throat

 

 

TRIMETHYLAMINE

75-50-3

 

 

Inhalation: abdominal pain, burning sensation, cough, diarrhoea, laboured breathing, shortness of breath, sore throat

Skin: redness, skin burns, pain

Eyes: redness, pain, blurred vision, severe deep burns

Eyes; skin; resp sys

Inh, ing (soln), con

Irrit eyes, skin, nose, throat, resp sys; cough, dysp, delayed pulm edema; blurred vision, corn nec; skin burns; liq: frostbite

 

___________________________________________________________________________

 

Table 104.27.    Physical & chemical hazards

 

For UN Class: 1.5 = very insensitive substances which have a mass explosion hazard; 2.1 = flammable gas; 2.3 = toxic gas; 3 = flammable liquid; 4.1 = flammable solid; 4.2 = substance liable to spontaneous combustion; 4.3 = substance which in contact with water emits flammable gases; 5.1 = oxidizing substance; 6.1 = toxic; 7 = radioactive; 8 = corrosive substance

 

CHEMICAL NAME

CAS-NUMBER

PHYSICAL

CHEMICAL

UN CLASS OR DIVISION /  SUBSIDIARY RISKS

ACETALDEHYDE-OXIME

107-29-9

 

 

3

ALLYLAMINE

107-11-9

The vapour is heavier than air and may travel along the ground; distant ignition possible

The substance decomposes on heating and on burning producing toxic fumes (nitrogen oxides)  Reacts violently with oxidants causing explosion hazard  Reacts violently with acids and acid anhydrides Corrosive to copper (alloys), aluminium, zinc (alloys) and steel

6.1/ 3

BUTYLAMINE

109-73-9

The vapour is heavier than air and may travel along the ground; distant ignition possible

On combustion, forms carbon monoxide and oxides of nitrogen  Reacts with strong oxidants, acids

3/ 8

sec-BUTYLAMINE

13952-84-6

The vapour is heavier than air and may travel along the ground; distant ignition possible

The substance decomposes on burning producing toxic fumes and gases (ammonia, oxides of nitrogen)  The substance is a weak base, forming water-soluble salts with acids  Reacts with strong oxidants and strong acids  Corrosive to tin, aluminum, and some steels

 

CYCLOHEXYLAMINE

108-91-8

The vapour is heavier than air

The substance decomposes on heating producing toxic gases (nitrogen oxides)  The substance is a strong base, it reacts violently with acid and is corrosive  Reacts violently with strong oxidants causing fire hazard

8/ 3

DIALLYLAMINE

124-02-7

The vapour mixes well with air, explosive mixtures are easily formed

May explode on heating  On contact with hot surfaces or flames this substance decomposes forming toxic and corrosive fumes (nitrogen oxides)  The substance is a medium strong base  Reacts violently with oxidants and acids  Attacks copper, tin, aluminium and zinc  Solutions of diallylamine in water may attack glass

6.1/ 3

DIBUTYLAMINE

111-92-2

 

 

8/ 3

DICYCLOHEXYLAMINE

101-83-7

 

 

8

DIETHANOLAMINE

111-42-2

The vapour is heavier than air

The substance decomposes on burning producing toxic fumes  The solution in water is a medium strong base  Reacts violently with oxidants  Reacts violently with strong acids and anhydrides  Attacks copper

 

DIETHYLAMINE

109-89-7

The vapour is heavier than air and may travel along the ground; distant ignition possible

On combustion, forms carbon monoxide and oxides of nitrogen  Upon heating, toxic fumes are formed  The solution in water is a medium strong base  Reacts with oxidants causing fire and explosion hazard

3/ 8

2-DIETHYLAMINOETHANOL

100-37-8

 

On combustion, forms toxic gases (nitrogen oxides)  Reacts violently with oxidants, acids, acid chlorides, and isocyanates  Attacks light metals and copper

3

DIETHYLENETRIAMINE

111-40-0

The vapour is heavier than air

The substance decomposes on burning producing toxic fumes  The solution in water is a strong base, it reacts violently with acid and is corrosive  Reacts violently with strong oxidants, nitric acid, and organic nitro compounds  Attacks many metals in presence of water

8

DIISOPROPYLAMINE

108-18-9

The vapour is heavier than air and may travel along the ground; distant ignition possible

The substance decomposes on heating and on burning producing toxic and corrosive fumes (eg  NOx)  The substance is a medium strong base and reacts violently with strong acids  Reacts violently with strong oxidants  Reacts with a lot of compounds like organic chlorides, nitriles, oxides, etc  Attacks many metals forming combustible gas (Hydrogen): aluminium, zinc, copper and tin

3/ 8

DIMETHYLAMINE

124-40-3

The gas is heavier than air and may travel along the ground; distant ignition possible

The substance decomposes on burning producing toxic fumes (nitrogen oxides)  The substance is a medium strong base  Reacts violently with strong oxidants, such as chlorine  Reacts violently with mercury causing fire and explosion hazard  Attacks plastics, rubber, and coatings

2.1

DIMETHYLETHANOLAMINE

108-01-0

The vapour is heavier than air

Reacts with strong oxidants and many other substances, causing fire and explosion hazard  Attacks copper

8/ 3

3,3’-DIAMINODIPROPYLAMINE

56-18-8

 

 

6.1

DIISOPROPANOLAMINE

110-97-4

Dust explosion possible if in powder or granular form, mixed with air

The substance decomposes on heating andon burning producing toxic gases (nitrogen oxides)  The substance is a strong oxidant and reacts with combustible and reducing materials  The solution in water is a medium strong base and reacts with strong acids  Reacts violently with strong oxidants causing fire and explosion hazard

 

ETHANOLAMINE

141-43-5

 

 

8

ETHYLAMINE

75-04-7

The gas is heavier than air and may travel along the ground; distant ignition possible  Do not use compressed air when filling, emptying, or processing

The substance decomposes on heating producing toxic gases including nitrogen oxides  The solution in water is a strong base  It reacts violently with acid, strong oxidants and organic compounds causing fire and explosion hazard  Attacks many non-ferrous metals and plastics

3/ 8

ETHYLENEDIAMINE

107-15-3

 

The substance decomposes on heating producing toxic fumes (nitrogen oxides)  The substance is a medium strong base  Reacts violently with chlorinated organic compounds strong oxidants

8/ 3

ETHYLENIMINE

151-56-4

The vapour is heavier than air Compilerand may travel along the ground; distant ignition possible  The vapour mixes well with air, explosive mixtures are easily formed

The substance may polymerize under the influence of aqueous acidic conditions, acids, oxidising materials  On combustion, forms toxic and irritating fumes including nitrogen oxides  The substance is a medium strong base

6.1/ 3

HEXAMETHYLENEDIAMINE

124-09-4

 

Upon heating, toxic fumes are formed  The solution in water is a strong base, it reacts violently with acid and is corrosive  Reacts with oxidants  Attacks many metals in presence of water

8

ISOBUTYLAMINE

78-81-9

 

 

3/ 8

ISOPHORONE DIAMINE

2855-13-2

 

May explode on heating  Reacts with brass, copper, zinc and tin  Reacts violently with acids  Attacks many metals

8

ISOPROPANOLAMINE

78-96-6

 

On combustion, forms nitrous oxide  Reacts with strong oxidants

 

ISOPROPYLAMINE

75-31-0

 

 

3

METHYLAMINE

74-89-5

The gas is heavier than air and may travel along the ground; distant ignition possible

The substance decomposes on burning producing toxic fumes (nitrogen oxides)  The substance is a medium strong base  Reacts violently with mercury causing fire and explosion hazard  Reacts violently with strong oxidants, such as chlorine

2.1

DIPENTYLAMINE

2050-92-2

 

The substance decomposes on heating producing toxic and irritating gases (nitrogen oxides)  Reacts with oxidants

 

PROPYLAMINE

107-10-8

The vapour is heavier than air and may travel along the ground; distant ignition possible

The substance decomposes on heating or on burning producing toxic gases (nitrogen oxides)  The substance is a medium strong base  Reacts violently with oxidants and mercury causing fire and explosion hazard, Reacts violently with concentrated acids, nitroparrafins, halogenated hydrocarbons, alcohols and many other compounds

 Attacks many metals and alloys, especially copper  Is corrosive to copper (alloys), aluminium, zinc (alloys) and galvanised surfaces  Solutions of propylamine in water may attack glass

3/ 8

TETRAETHYLENEPENTAMINE

112-57-2

 

 

8

TRIALLYLAMINE

102-70-5

 

 

3/ 8

TRIBUTYLAMINE

102-82-9

 

 

8

TRIETHYLAMINE

121-44-8

 

 

3/ 8

TRIETHYLENETETRAMINE

112-24-3

 

On combustion, forms toxic fumes of carbon monoxide and nitrogen oxides  The substance is a medium strong base  Reacts violently with oxidants causing fire and explosion hazard  Reacts with acid chlorides, acid anhydrides, aldehydes, ketones, halogenated organic compounds and acrylates  Attacks metals such as aluminium, zinc, copper and its alloys

 

TRIISOPROPANOLAMINE

122-20-3

 

On combustion, forms toxic gases of carbon and nitrogen oxides  Reacts with strong oxidants and acids

 

TRIMETHYLAMINE

75-50-3

The gas is heavier than air and may travel along the ground; distant ignition possible

The substance decomposes on burning producing toxic gases (nitrous oxides)  The substance is a medium strong base  Reacts violently with mercury causing fire and explosion hazard  Reacts violently with strong oxidants, such as chlorine

2.1

TRIPROPYLAMINE

102-69-2

 

 

3/ 8

 

___________________________________________________________________________

 

Table 104.28.     Physical & chemical properties

 

CHEMICAL NAME

CAS-NUMBER

COLOUR/FORM

BOILING POINT  

MELTING POINT  

MOLECULAR WEIGHT

SOLUBILITY IN WATER

RELATIVE DENSITY (WATER=1)

RELATIVE VAPOUR DENSITY (AIR=1)

VAPOUR PRESSURE/ (KPA)

INFLAM.

LIMITS

FLASH POINT  

AUTO IGNITION POINT  

ACETALDEHYDE-OXIME

107-29-9

needles; two crystalline modifications

115

47

59.07

sol

0.9656

 

10 mm Hg

@ 25.8 °C

 

<22

 

ALLYLAMINE

107-11-9

colourless to light yellow liquid

55-58

-88

57.09

misc

0.76

2.0

26.4

2.2 ll

22 ul

-29 cc

370

BUTYLAMINE

109-73-9

clear, colourless liquid

77.8

-50

73.1

misc

0.7414

2.5

10.9

1.7 ll

9.80 ul

-1 oc

312

sec-BUTYLAMINE

13952-84-6

colourless liquid

63

-104

73.14

misc

0.724

2.52

18

1.7 ll

9.8 ul

- 9

378

tert-BUTYLAMINE

75-64-9

colourless liquid

44

-72.65

73.1

misc

0.6951

2.5

362 mm Hg

@ 25°C .

1.7 ll

8.9 ul

10

380

CYCLOHEXYLAMINE

108-91-8

colourless to yellow liquid

134

-17.7

99.17

sol

0.8191

3.42

1.2

1.5 ll

9.4 ul

31 cc

293

DIALLYLAMINE

124-02-7

liquid

111

-88.4

97.2

8.6 g/ 100 ml

0.7627

@ 10°C/4°C

3.35

2.4

 

21

 

1,3-BUTANEDIAMINE

590-88-5

water white liquid

143-150

 

 

 

0.858

 

 

 

516

 

1,5-PENTANEDIAMINE

462-94-2

 

179

9

102.17

sol

0.873 25°C

 

 

 

 

 

1,3-PROPANEDIAMINE

109-76-2

 

140

 

74.12

sol

0.884

 

 

 

 

 

DIBUTYLAMINE

111-92-2

liquid; colourless

160

-60-59

129.24

sol

0.7670

4.46

1.9 mm Hg

1.1

57 oc

 

2,2’-DICHLORO-N-METHYLDIETHYLAMINE

51-75-2

mobile liquid

87

@ 18 mm Hg

-60

156.07

sl sol

1.118

@ 25°C/4°C

 

 

 

 

 

DICYCLOHEXYLAMINE

101-83-7

colourless liquid

256

-0.1

181.31

sl sol

0.9123

6.25

 

 

110

 

DIETHANOLAMINE

111-42-2

prisms; usually offered as a viscous liquid; crystalline solid

268.8

28

105.1

v sol

1.0966

3.65

< 0.001

 

134 oc

660

DIETHYLAMINE

109-89-7

colourless liquid

55.5

-49.8

73.1

v sol

0.71

2.53

25.9

1.8 ll

10.1. ul

-26 cc

312

2-DIETHYLAMINOETHANOL

100-37-8

colourless liquid

163

-70

117.19

misc

0.8921

4.03

0.19

6.7 ll

11.7 ul

52 cc

250

DIETHYLENETRIAMINE

111-40-0

yellow liquid

207

-39

103.2

misc

0.96

3.56

0.037

1 ll

10 ul

97-102 oc

390-395

DIISOPROPYLAMINE

108-18-9

colourless liquid

84

-61

101.19

sl sol

0.7169

3.5

8.0

0.8 ll

7.1 ul

-1 oc

316

DIMETHYLAMINE

124-40-3

gas at ordinary temperature; colourless gas

7

-92

45.08

v sol

0.680

1.6

206

2.8 ll

14.4 ul

 

402

DIMETHYLAMINE HYDROCHLORIDE

506-59-2

 

 

171

81.54

v sol

 

 

 

 

 

 

3-DIMETHYLAMINOPROPYLAMINE

109-55-7

colourless liquid

123

-70

102.2

sol

0.8100

@ 30°C

3.5

 

 

 

 

DIMETHYLETHANOLAMINE

108-01-0

colourless liquid

135

-59

89.1

misc

0.8866

3.03

560

 

41oc

220

3,3’-DIAMINODIPROPYLAMINE

56-18-8

 

15

@ 50°C

-14

131.22

 

0.938

@ 25°C

 

 

 

 

 

ETHANOLAMINE

141-43-5

viscous, clear, hydroscopic fluid; viscous liquid

171

10.5

61.08

misc

1.0180

2.1

0.26 mm Hg

@ 25°C

 

85 cc

410

ETHYLAMINE

75-04-7

colourless liquid or gas

17

-81

45.08

misc

0.689

@ 15°C/15°C

1.55

121

3.5 ll

14 ul

-17 cc

725

ETHYLENEDIAMINE

107-15-3

colourless liquid; water-white liquid

117

8.5

60.10

v sol

0.8979

2.07

1.2

4.2 ll

14.4 ul

34 cc

385

ETHYLENIMINE

151-56-4

colourless, mobile fluid; oil

56-57

-71.5

43.08

sol

0.8321

@ 24°C/4°C

1.48

21.3

3.6 ll

46 ul

11 cc

322

2-ETHYLHEXYLAMINE

104-75-6

colourless liquid

 

 

129.24

sol

 

 

1.2

 

60 oc

 

HEXAMETHYLENEDIAMINE

124-09-4

colourless leaflets; rhombic bipyramidal plates

205

42

116.20

v sol

0.93

4.01

200 Pa

@ 50°C

0.7 ll

6.3 ul

71

310

HYDROXYETHYL ETHYLENEDIAMINE

111-41-1

colourless liquid

238-40

 

104.15

misc

1.0286

3.59

8.19x mm Hg

@ 25°C

 

135 cc

 

ISOBUTANOLAMINE

124-68-5

crystalline mass

165

31

89.1

misc

0.934

3.0

 

 

67 cc

 

ISOBUTYLAMINE

78-81-9

colourless liquid

68

-85

73.1

v sol

0.724

@ 25°C/4°C

2.5

100 mm Hg

@ 18.8°C

3.4 ll

9 ul

 

378

ISOPHORONE DIAMINE

2855-13-2

colourless liquid

247

10

170.30

v sol

0.92

 

2 Pa

 

110

 

ISOPROPANOLAMINE

78-96-6

liquid

159.46

1.74

75.11

sol

0.9611

2.6

< 0.2

 

77

374

ISOPROPYLAMINE

75-31-0

colourless liquid

33-34

-101

59.1

misc

0.694

@ 15 °C/4°C

2.04

579.6 mm Hg

@ 25°C

2.3 ll

12 ul

-37 oc

402

HEXAMETHYLENETETRAMINE

100-97-0

rhombic crystals from alcohol; crystals or granules or powder; colourless, lustrous crystals or white crystalline powder

 

 

140.19

1 g /1.5 ml

1.331

@ -5°C

 

 

 

 

 

ETHYL METHYL KETONE OXIME

96-29-7

 

152.5

-29.5

87.12

sol

0.9232

 

 

 

 

 

METHYLAMINE

74-89-5

colourless gas or liquid

-6.3

-94

31.1

v sol

0.6628

1.07

290

4.9 ll

20.7 ul

 

430

2-METHYLAMINOETHANOL

109-83-1

viscous liquid

155-156

-4.5

75.11

misc

0.937

2.6

0.7 mm Hg

 

74 oc

 

2-DIBUTYLAMINOETHANOL

102-81-8

colourless liquid

224-232

 

173.29

 

0.859

 

 

 

933

 

DIISOPROPANOLAMINE

110-97-4

crystals

249-250

@ 745 mm Hg

44.5

133.2

sol

0.989

4.6

0.003

@ 42°C

1.1 ll

5.4 ul

127

374

DIPENTYLAMINE

2050-92-2

colourless to light-yellow liquid

202

-44

157.3

sl sol

0.7771

5.4

 

 

52

 

PROPYLAMINE

107-10-8

colourless liquid

48-49

-83

59.11

sol

0.72

2.0

33.1

2.0 ll

10.4 ul

<-37 oc

317

PROPYLENEDIAMINE

78-90-0

 

119.5

 

74.12

v sol

0.878

@ 15°C

 

 

 

 

 

TETRAETHYLENEPENTAMINE

112-57-2

viscous, hygroscopic liquid; yellow liquid

340

-30

189.3

sol

0.9980

6.53

8.0x  

mm Hg

@ 25°C

 

163 oc 

 321 

TRIALLYLAMINE

102-70-5

liquid

155.5

-70

137.2

0.25 g/100 ml

0.809

4.73

 

 

39 oc

 

TRIBUTYLAMINE

102-82-9

colourless liquid; pale yellow liquid

216.5

-70

185.34

sl sol

0.78

6.39

0.29 mm Hg

@ 25°C

 

86 oc

 

TRIETHANOLAMINE

102-71-6

viscous liquid; colourless to pale yellow

335

20.5

149.2

misc

1.1242

5.1

< 0.01 mm Hg

 

 

 

TRIETHYLAMINE

121-44-8

colourless liquid

89

-115

101.19

sol

0.7275

3.49

400 mm Hg

@ 31.5°C

1.2 ll

8.0 ul

-667 oc

 

TRIETHYLENETETRAMINE

112-24-3

moderately viscous, yellowish liquid

266.5

12

146.2

v sol

0.9818

5.04

1.3 Pa

1.1 ll

>6.4 ul

118-143 cc

338

TRIISOPROPANOLAMINE

122-20-3

crystals

305

45

191.3

sol

1.0

 

<0.001

 

160

320

TRIMETHYLAMINE

75-50-3

colourless gas

3

-117

59.11

v sol

0.6356

2.0

220

2.0 ll

11.6 ul

12 cc

190

TRIPROPYLAMINE

102-69-2

water white liquid

150-156

-94

143.28

 

0.7558

 

 

 

405

 

 

_____________________________________________________________________________________