ICSC 0678 - THEOPHYLLINE

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THEOPHYLLINE	ICSC: 0678 (April 2007)
3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione 1,3-Dimethylxanthine

CAS #: 58-55-9

UN #: 1544

EC Number: 200-385-7

	ACUTE HAZARDS	PREVENTION	FIRE FIGHTING
FIRE & EXPLOSION	Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.		In case of fire in the surroundings, use appropriate extinguishing media.


	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	See Ingestion.	Avoid inhalation of dust and mist.	Fresh air, rest.
Skin		Protective gloves.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
Eyes		Wear safety spectacles.	Rinse with plenty of water for several minutes (remove contact lenses if easily possible).
Ingestion	Headache. Nausea. Vomiting. Irritability. Palpitations. Convulsions.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Give a slurry of activated charcoal in water to drink. Refer for medical attention .

SPILLAGE DISPOSAL	CLASSIFICATION & LABELLING
Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into sealable containers. If appropriate, moisten first to prevent dusting. Then store and dispose of according to local regulations.	According to UN GHS Criteria DANGER Toxic if swallowed May be harmful if inhaled May cause harm to breast-fed children Causes damage to vascular system and kidneys Causes damage to the kidneys through prolonged or repeated exposure Transportation UN Classification UN Hazard Class: 6.1; UN Pack Group: III
STORAGE
Separated from food and feedstuffs.
PACKAGING
Do not transport with food and feedstuffs.

THEOPHYLLINE

ICSC: 0678

PHYSICAL & CHEMICAL INFORMATION
Physical State; Appearance WHITE CRYSTALLINE POWDER. Physical dangers Chemical dangers Decomposes on heating. This produces toxic fumes including nitrogen oxides.	Formula: C₇H₈N₄O₂ Molecular mass: 180.2 Melting point: 270-274°C Density: g/cm³ Solubility in water: moderate Vapour pressure: negligible Octanol/water partition coefficient as log Pow: -0.02 (estimated)

PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
WHITE CRYSTALLINE POWDER.

Physical dangers

Chemical dangers
Decomposes on heating. This produces toxic fumes including nitrogen oxides.

Formula: C₇H₈N₄O₂
Molecular mass: 180.2
Melting point: 270-274°C
Density: g/cm³
Solubility in water: moderate
Vapour pressure: negligible
Octanol/water partition coefficient as log Pow: -0.02 (estimated)

EXPOSURE & HEALTH EFFECTS
Routes of exposure The substance can be absorbed into the body in hazardous amounts by ingestion. Effects of short-term exposure The substance may cause effects on the heart and central nervous system. This may result in cardiac dysrhythmia and convulsions. The effects may be delayed.	Inhalation risk A nuisance-causing concentration of airborne particles can be reached quickly when dispersed. Effects of long-term or repeated exposure

EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body in hazardous amounts by ingestion.

Effects of short-term exposure
The substance may cause effects on the heart and central nervous system. This may result in cardiac dysrhythmia and convulsions. The effects may be delayed.

Inhalation risk
A nuisance-causing concentration of airborne particles can be reached quickly when dispersed.

Effects of long-term or repeated exposure

OCCUPATIONAL EXPOSURE LIMITS

ENVIRONMENT

NOTES

ADDITIONAL INFORMATION

EC Classification

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