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TETRAHYDROFURANICSC: 0578
Tetramethylene oxide
Diethylene oxide
1,4-Epoxybutane
Oxacyclopentane
November 2019
CAS #: 109-99-9
UN #: 2056
EC Number: 203-726-8

  ACUTE HAZARDS PREVENTION FIRE FIGHTING
FIRE & EXPLOSION Highly flammable.  Vapour/air mixtures are explosive.  NO open flames, NO sparks and NO smoking.  Closed system, ventilation, explosion-proof electrical equipment and lighting. Do NOT use compressed air for filling, discharging, or handling.  Use alcohol-resistant foam, water spray, powder, carbon dioxide.  In case of fire: keep drums, etc., cool by spraying with water. 

 PREVENT GENERATION OF MISTS! STRICT HYGIENE!  
  SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Burning sensation in the throat and chest. Dizziness. Headache. Nausea. Unconsciousness.  Use ventilation, local exhaust or breathing protection.  Fresh air, rest. Refer immediately for medical attention. 
Skin Dry skin. Redness. Pain.  Protective gloves. Protective clothing.  First rinse with plenty of water for at least 15 minutes, then remove contaminated clothes and rinse again. Refer for medical attention . 
Eyes Redness. Pain.  Wear safety goggles or face shield.  Rinse with plenty of water for several minutes (remove contact lenses if easily possible). Refer for medical attention. 
Ingestion See Inhalation.  Do not eat, drink, or smoke during work.  Rinse mouth. Refer for medical attention . 

SPILLAGE DISPOSAL CLASSIFICATION & LABELLING
Evacuate danger area! Consult an expert! Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Remove all ignition sources. Ventilation. Do NOT wash away into sewer. Collect leaking liquid in sealable air tight containers. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. 

According to UN GHS Criteria

flam;flameexcl mark;warncancer;health haz
DANGER
Highly flammable liquid and vapour
Harmful if swallowed
Causes skin irritation
Causes serious eye irritation
May cause respiratory irritation
Suspected of causing cancer
May cause damage to kidneys and liver through prolonged or repeated exposure 

Transportation
UN Classification
UN Hazard Class: 3; UN Pack Group: II 

STORAGE
Fireproof. Well closed. Separated from : see Chemical Dangers. 
PACKAGING
Airtight. 
TETRAHYDROFURAN ICSC: 0578
PHYSICAL & CHEMICAL INFORMATION

Physical State; Appearance
COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. 

Physical dangers
The vapour is heavier than air and may travel along the ground; distant ignition possible. 

Chemical dangers
The substance can form explosive peroxides. Reacts violently with strong oxidants, strong bases and some metal halides. This generates fire and explosion hazard. Attacks some forms of plastic, rubber and coatings. 

Formula: C4H8O / (CH2)3CH2O
Molecular mass: 72.1
Boiling point: 66°C
Melting point: -108.5°C
Relative density (water = 1): 0.89
Solubility in water: freely soluble
Vapour pressure, kPa at 20°C: 19.3
Relative vapour density (air = 1): 2.5
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.28
Flash point: -14.5°C c.c.
Auto-ignition temperature: 321°C
Explosive limits, vol% in air: 2-11.8
Octanol/water partition coefficient as log Pow: 0.46 (estimated)
Viscosity: 0.5 mPa*s at 20°C 


EXPOSURE & HEALTH EFFECTS

Routes of exposure
The substance can be absorbed into the body by inhalation of its vapour, by ingestion and through the skin. 

Effects of short-term exposure
The substance and the vapour are irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system at high levels. This may result in narcosis. 

Inhalation risk
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. 

Effects of long-term or repeated exposure
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the liver and kidneys. This may result in impaired functions. This substance is possibly carcinogenic to humans. 


OCCUPATIONAL EXPOSURE LIMITS
TLV: 50 ppm as TWA; 100 ppm as STEL; (skin); A3 (confirmed animal carcinogen with unknown relevance to humans).
MAK: 150 mg/m3, 50 ppm; peak limitation category: I(2); skin absorption (H); carcinogen category: 4; pregnancy risk group: C.
EU-OEL: 150 mg/m3, 50 ppm as TWA; 300 mg/m3, 100 ppm as STEL; (skin) 

ENVIRONMENT
 

NOTES
The odour warning when the exposure limit value is exceeded is insufficient.
Check for peroxides prior to distillation; eliminate if found. 

ADDITIONAL INFORMATION
  EC Classification
 

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