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1987

CIS 88-501 Brandt-Rauf P.W., Fallon L.F.
Ampullary cancer in chemical workers
Although a relatively uncommon neoplasm, cancer of the ampulla of Vater accounts for over 300 deaths a year in the USA. Among biliary tract tumours, ampullary cancer has a relatively favourable prognosis. An examination of mortality statistics for chemical workers showed 11 cases of this cancer, instead of the < 5 expected, giving a statistically significant (p = 0.011) proportional mortality ratio (PMR) of 228.
British Journal of Industrial Medicine, Aug. 1987, Vol.44, No.8, p.569-570. 5 ref.

CIS 87-520 Koskela R.S., Klockars M., Järvinen E., Kolari P.J., Rossi A.
Cancer mortality of granite workers
This study included 1026 workers hired between 1940 and 1971 and followed until the end of 1981. Excess mortality from tumours was observed for workers followed 20 or more years; greatest excess was 25-29 years. Of the 46 tumours, 22 were lung and 15 gastrointestinal cancers. Granite exposure per se may be an aetiologic factor in the initiation or promotion of malignant neoplasms.
Scandinavian Journal of Work, Environment and Health, Feb. 1987, Vol.13, No.1, p.26-31. Illus. 35 ref.

1986

CIS 90-490 Gardner M.J., Winter P.D., Pannett B., Simpson M.J.C., Hamilton C., Acheson E.D.
Mortality study of workers in the man-made mineral fiber production industry in the United Kingdom
The workforces of 2 factories in the United Kingdom were followed up to the end of 1984 as part of the collaborative European study of the health of workers in the man-made mineral fibre industry. In the cohort from an English glass-wool plant there was no suggestion of any excess mortality compared to national or local rates, except for lung cancer among men in comparison to the national level. However, the data indicate that the workers were legally local persons by place of birth, occupation, and death, and they therefore suggest that the national comparison was inappropriate. Lung cancer mortality showed little relationship to length of employment, duration of time since first exposure, occupational classification, or level of exposure. In the cohort from a continuous-filament plant in Northern Ireland no excess mortality from cancer was found.
Scandinavian Journal of Work, Environment and Health, 1986, Vol.12, suppl.1, p.85-93. 21 ref.

CIS 90-489 Westerholm P., Bolander A.M.
Mortality and cancer incidence in the man-made mineral fiber industry in Sweden
This report gives an account of the Swedish contribution to the joint European epidemiologic study on production workers in the man-made mineral fibre (MMMF) industry. The exposed Swedish cohort consisted of 3,600 persons giving 61,690 person-years of observation. A total of 524 deaths was observed in the cohort, 230 cohort members had emigrated during the period of observation (147 of whom could be traced to other Nordic countries), and 62 other persons were lost to follow-up. It was observed that most of the persons contracting lung cancer in the Swedish cohort had been exposed during relatively short periods of time, i.e. during 1-4yrs of employment. This finding applied to both the rock-wool and glass-wool industry. It is pointed out that the observed excess risk in lung cancer deaths may also have other explanations than occupational exposure to MMMF.
Scandinavian Journal of Work, Environment and Health, 1986, Vol.12, suppl.1, p.78-84. Illus. 4 ref.

CIS 90-487 Bertazzi P.A., Zocchetti C., Riboldi L., Pesatori A., Radice L., Latocca R.
Cancer mortality of an Italian cohort of workers in man-made glass-fibre production
This study was undertaken in order to examine possible long-term effects, particularly cancer, associated with working in the man-made glass-fibre production industry in Italy (glass wool and continuous filament). All male production workers employed for a minimum of 1yr between 1944 and 1974 were admitted to the study (1,098 subjects), and their mortality was examined in the period 1944-1983 (21,325 person-years). The vital status ascertainment was successful for 98.9% of the cohort members. An increased risk of cancer of the larynx was noted based, however, on only 4 deaths. When contrasted with the values of the local population, the increase proved to be statistically significant after 25yrs since first exposure. The higher than expected larynx cancer mortality was confined to workers hired before the age of 25yrs, exposed for at least 15yrs, who started exposure before 1960 (main production: glass wool), and who belonged to the highest cumulative exposure categories.
Scandinavian Journal of Work, Environment and Health, 1986, Vol.12, suppl.1, p.65-71. 36 ref.

CIS 90-485 Claude J., Frentzel-Beyme R.
Mortality of workers in a German rock-wool factory - A second look with extended follow-up
A cohort of 2,092 workers employed in a German rock-wool factory was followed until the end of 1982, and the mortality experience was compared with the national mortality rates and the rates of an internal reference cohort. This mortality analysis revealed a standardised mortality ratio (SMR) of 110 for overall mortality. Significantly more malignant neoplasms occurred than were expected (SMR 127). The increase in risk for lung cancer (SMR 121), which was not statistically significant, was also not related to time since first exposure or length of employment. The occurrence of an unusually high SMR of 336 for benign and unspecified neoplasms could not be clarified. Most of the excess from other specific causes of death, such as stomach cancer, pancreatic cancer, and alcoholism, appear to be unrelated to the rock-wool production since they occurred either among workers employed for very short periods (less than 1yr) or as frequently among workers in the reference cohort.
Scandinavian Journal of Work, Environment and Health, 1986, Vol.12, suppl.1., p.53-60. 16 ref.

CIS 86-1370 Malker H.S.R., McLaughlin J.K., Malker B.K., Stone B.J., Weiner J.A., Ericsson J.L.E., Blot W.J.
Biliary tract cancer and occupation in Sweden
An investigation of 2,068 cases of biliary-tract cancer in Sweden revealed statistically significant increased risks for cancer of the gall bladder in men employed in petroleum refining, papermills, chemical processing, shoemaking and repairing, and for both sexes in the textile industry. A significant increase in the incidence of other cancers of the biliary tract was found in shipbuilding, the construction-materials industry and among insulation workers. The possible implication in the last 3 industries of asbestos is discussed.
British Journal of Industrial Medicine, Apr. 1986, Vol.43, No.4, p.257-262. 17 ref.

CIS 86-1066 Hogstedt C., Aringer L., Gustavsson A.
Epidemiologic support for ethylene oxide as a cancer-causing agent
The mortality and incidence of cancer in 3 groups of Swedish workers (733 in all) with occupational exposure to ethylene oxide (EO) was assessed, and compared with national average values in Sweden. Cases of leukaemia (8 observed; 0.83 expected) and stomach cancer (6 observed; 0.65 expected) were more common than expected among the exposed workers. These results provide evidence for an increased risk of malignancy in workers with extended and intermittent exposure to low concentrations of EO.
Journal of the American Medical Association, 28 Mar. 1986, Vol.255, No.12, p.1575-1578. 21 ref.

CIS 86-763 Matanoski G.M., Stockwell H.G., Diamond E.L., Sweeney M.H., Joffe R.D., Mele L.M., Johnson M.L.
A cohort mortality study of painters and allied tradesmen
The mortality experience of 57.175 workers in 4 states in the USA, from 1975 to 1979 was examined. No excess mortality was observed for the total union membership when compared to that of all US white males. When the study population was subdivided by the trade affiliation, members of locals comprised primarily of painters exhibited a significant elevation in mortality from all malignant neoplasms, lung and stomac cancer, compared to all US white males. This observation still remained after the data was treated to reduce the effect of non occupational activities. In addition, there was a statistically significant difference in mortality from leukemia and cancer of the bladder observed between the groups.
Scandinavian Journal of Work, Environment and Health, Feb. 1986, Vol.12, No.1, p.16-21. 21 ref.

1985

CIS 86-1062 Araki S.
Peptic ulcer in factory workers: incidence, prevalence and risk factors (preliminary report)
The prevalence rate of active and inactive peptic ulcer was 23% in male workers aged 31-60 at a plastics processing factory in Tokyo. Similarly, the incidence of active and inactive peptic ulcer during one year was 5% or more. The findings from a case-control study suggested that smoking and family history were the major aetiological factors. The incidence and prevalence of peptic ulcer in male factory workers in Japan appear to be higher than elsewhere.
Igaku no Ayumi, Feb. 1985, Vol.132, No.7, p.526-527. 8 ref.

CIS 86-480 Ehrlich A., Rohl A.N., Holstein E.C.
Asbestos bodies in carcinoma of colon in an insulation worker with asbestosis
This case study involved a worker with over 30 years of exposure to asbestos insulation. He developed advanced asbestosis, as well as adenocarcinoma of the colon. Examination of the removed tumour revealed a high concentration of amosite fibres (1.06 x 10⁶ fibres dry tissue) in the section of mesentery analysed. A possible pathway is suggested for the asbestos bodies to reach the colon.
Journal of the American Medical Association, 22-29 Nov. 1985, Vol.254, No.20, p.2932-2933. Illus. 10 ref.

CIS 85-1892 McCammon C., Robinson C., Waxweiler R.J., Roscoe R.
Industrial hygiene characterization of automotive wood model shops
A proportionate mortality study and an industrial hygiene survey were conducted by NIOSH in the shops of several car manufacturers in the USA. A significant excess of deaths due to colon cancer and leukaemia was observed. Total dust concentrations measured in the worker's breathing zone ranged from 0.03 to 25mg/m³. The percentage of respirable dust ranged from 19 to 38%. Solvent exposure levels ranged from non-detectable to about 10% of the OSHA permissible exposure levels. Relevant recommendations for the improvement of contamination control are made (ventilation, materials, work practices, etc.).
American Industrial Hygiene Association Journal, July 1985, Vol.46, No.7, p.343-349. 15 ref.

1984

CIS 87-189 Yamazaki K., Shirai T., Ueno K., Shimakura K., Nozawa K., Akamatsu T., Nakama H., Nakamura Y., Matsuda Y., Endo R., Kohno K., Sakato M., Shigeno T., Furuta S., Sato A., Nakajima T.
Two cases of pneumatosis cystoides coli in persons occupationally exposed to trichloroethylene
Primary pneumatosis cystoides coli (PCC) is a relatively rare disease of unknown origin in which gas-filled cysts form in the large intestine. Two cases of primary PCC, each of which was associated with occupational exposure to trichloroethylene (TCE), are reported. In each case spontaneous healing of PCC was observed after discontinuation of exposure to TCE. In one case, TCE was detected in the gas endoscopically collected from the cystic spaces and from venous blood, and its metabolites were detected in the patients' urine. The disappearance of TCE from the cystic spaces and venous blood was followed by the endoscopic healing of the lesion. These cases suggest that occupational exposure to TCE could be one of the aetiological factors of PCC.
Shinshu Medical Journal, Dec. 1984, Vol.32, No.6, p.579-587. Illus. 27 ref.

CIS 86-1101 Itoh Y., Ohtani M., Niiya Y., Shima S.
Relationship between blood vanadium level and serum bile acid concentration in lead-exposed workers
Blood lead and vanadium levels in healthy lead-exposed steel-industry workers were measured and compared with serum concentrations of bile acids and several enzymes. Vanadium levels were significantly correlated only with bile acid concentration. This suggests that vanadium inhibits the secretory function of the gall bladder.
Medicine and Biology, Aug. 1984, Vol.109, No.2, p.113-115. Illus. 9 ref.

CIS 85-1412 Magni C., Rizzardo R., De Leo D., Salmi A.
Adverse environmental factors, peptic ulcer and chronic gastritis in a metalworking industry
This study included 917 men doing bluecollar jobs in an Italian metalworking plant in 1981. 60 of the workers had peptic ulcer and 26 had chronic gastritis. There was a correlation between the presence of these diseases and certain environmental factors (noise, temperature, vibration, shiftwork, workload and work departments).
Medicina del lavoro, May-June 1984, Vol.75, No.3, p.215-220. 22 ref.

CIS 85-498 Suskind R.R., Hertzberg V.S.
Human health effects of 2,4,5-T and its toxic contaminants
A clinical epidemiological study was conducted on a population consisting of 204 white males exposed to the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T) and contaminants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, as a result of employment in the production of 2,4,5-T between 1948 and 1969, and 163 white males currently or formerly employed at the same plant but never associated with production or maintenance functions. In the exposed group clinical evidence of chloracne persisted in 55.7%, but none was found among unexposed workers. Persistence of chloracne was also associated with the presence and severity of actinic elastosis of the skin. An association was found between exposure and the history of gastrointestinal tract ulcer. Among smokers, pulmonary function values were lower among exposed workers than among unexposed workers. An evidence was found of increased risk for cardiovascular disease, hepatic disease, renal damage or central or peripheral nervous system problems.
Journal of the American Medical Association, 11 May 1984, Vol.251, No.18, p.2372-2380. 42 ref.

CIS 85-134 Osborne S.F.
Medical diagnosis aboard submarines: use of a computer-based Bayesian method of analysis in an abdominal pain diagnostic program
A Bayesian method of analysis using an onboard microcomputer has been used to diagnose causes of abdominal pain in crewmen aboard submarines. Early results from sea trials showed an appropriate diagnosis in 8 of 10 cases of abdominal pain. The programme, which is still in a test phase, may replace or enhance current methods which involve the use of a medical history and physical examination, clinical acumen and limited laboratory testing by the submarine medical department representative.
Journal of Occupational Medicine, Feb. 1984, Vol.26, No.2, p.110-114. Illus. 12 ref.

CIS 84-1688 McDowall M.E.
A mortality study of cement workers
A mortality study of 607 men who were cement workers in 1939 and were still alive in 1948. 419 of them died by 31 Dec. 1981, showing a death rate slightly below the expected. Significant excess deaths were found for stomach cancer (22 cases). This excess mortality is significant even if social class is taken into consideration. Mortality from respiratory diseases was not increased, while mortality from ischaemic heart disease was significantly lower than expected.
British Journal of Industrial Medicine, May 1984, Vol.41, No.2, p.179-182. 10 ref.

1983

CIS 85-763 Medvedeva V.N.
Structure and function of the mucosa of the stomach and duodenum in aluminium smelter workers
Struktura i funkcija slizistoj oboločki želudka i dvenadcatiperstnoj kiški u rabočih aljuminievogo proizvodstva [en ruso]
A study of 157 workers, including potroom workers and workers engaged in dust collection and fluoride salt production. Gastrointestinal pathology was found in 96.8% of the workers. Chronic gastritis was the most frequent symptom, with both the presence and absence of fluorosis. Gastritis developed like ulcers, with erosion of the gastric mucosa in 15.7% of the workers without fluorosis and 34.4% of the fluorotic workers. Workers exposed to fluorine compounds often had duodenal ulcers. Preventive measures must be reinforced, and efforts should be made toward the early detection of chronic gastritis and ulcers.
Gigiena truda i professional'nye zabolevanija, Nov. 1983, No.11, p.25-28. 6 ref.

CIS 84-1676 Ames R.G., Gamble J.F.
Lung cancer, stomach cancer, and smoking status among coal miners - A preliminary test of a hypothesis
A case-referent study which compared 46 white male coal miners who died from stomach cancer with 46 age-matched miners who died from lung cancer, and with reference miners who died from other cancers or from non-cancer, non-accident causes failed to confirm the Meyer hypothesis that inhaled carcinogens are a risk for both stomach and lung cancer, with stomach cancer occurring in persons with non-impaired lungs and lung cancer in persons with impaired lungs. The data suggest that airway obstruction may be a precondition for stomach cancer and normal pulmonary function a precondition for lung cancer, which is a reverse relationship than that postulated. For coal miners with airway obstruction, more years of coal mine dust exposure posed a slightly elevated stomach cancer risk while for miners with normal ventilatory function, cigarette smoking posed a disproportionately elevated lung cancer risk.
Scandinavian Journal of Work, Environment and Health, Oct. 1983, Vol.9, No.5, p.443-448. 11 ref.

CIS 83-1981 Norell S., Ahlbom A., Lipping H., Österblom L.
Oesophageal cancer and vulcanisation work
A 13-year follow-up of 2345 Swedish vulcanisation workers showed a tenfold increased risk for oesophageal cancer. The risk for laryngeal cancer was also significantly raised. The study was based on the 1960 census and the cancer registry in Sweden. Records of the 8 cases of oesophageal cancer showed 3 of them to be localised in the upper third, 4 in the middle third, and 1 in the middle and lower third of the oesophagus. 2 cases showed poorly differentiated and the rest moderalety differentiated squamous carcinoma.
Lancet, 26 Feb. 1983, Vol.1, No.8322, p.462-463. 2 ref.

CIS 83-1761
German Federal Ministry of Labour and Social Affairs (Bundesministerium für Arbeit und Sozialordnung)
Data sheets on medical examinations for occupational diseases numbered 41 03, 41 04, 41 05 and 41 07 in Annex 1 of the Ordinance on occupational diseases
Merkblätter für die ärztliche Untersuchung zu den Nrn. 41 03, 41 04, 41 05 und 41 07 der Anlage 1 zur Berufskrankheitenverordnung (BeKV) [en alemán]
Data sheets on the detection and diagnosis of scheduled occupational diseases: 41 03 - asbestosis; 41 04 - asbestosis and lung cancer; 41 05 - pleural and peritoneal mesotheliomas due to asbestos; 41 07 - pulmonary fibrosis due to hard metals. The sheets give the harmful agents and the corresponding dangerous occupations, the physiology and pathology, clinical pictures and diagnosis of the diseases, and requirements for histories and evaluations.
Bundesarbeitsblatt, 1983, No.7-9, p.51-55.

1982

CIS 83-1962 Lazdin O.A.
State of the biliary tract in workers in hot shops
Sostojanie želčevyvodjaščih putej u rabočih gorjačih cehov [en ruso]
Duodenal probing and x-ray studies were applied to 145 workers (95 men and 50 women) from hot workplaces (for example, in metallurgical plants) and to 35 controls from other places in the same enterprises. 57 (39.3%) of the heat-exposed group showed neither functional nor organic disorders of the biliary tract, although the motor activity of their gall bladders was lower than that of the controls. 45 (31.1%) of the heat-exposed group showed some functional disorder of the biliary tract, most commonly hypomotor-hypotonic dyskinesia. 43 (29.6%) of the heat-exposed group showed organic disorders, most frequently latent chronic cholecystitis.
Gigiena truda i professional'nye zabolevanija, Feb. 1982, No.2, p.24-27. 11 ref.

CIS 83-1961 Polonskaja V.V., Drozdova G.A., Misautova A.A., Odinokova V.A., Ljubčenko P.N.
Functional and morphological features of the mucosa of the small intestine in victims of chronic lead poisoning
Funkcional'no-morfologičeskie osobennosti slizistoj oboločki tonkoj kiški u bol'nyh s hroničeskoj svincovoj intoksikaciej [en ruso]
The morphology and γ-amylase and alkaline phosphatase activities of the mucosa of the proximal small intestine were examined in 40 workers who had had prolonged contact with lead; 26 showed symptoms of chronic lead poisoning while 14 were asymptomatic. Both asymptomatic and symptomatic groups showed reduced levels of both enzymes in comparison with unexposed controls. Alkaline phosphatase activity in intestinal juice was also reduced. Both lead-exposed groups also showed dystrophic changes in the enterocytes and villi of the mucosa and a reduced number of caliciform cells. Morphological alterations in the blood vessels suggested altered microcirculation in both groups. There was no quantitative difference between symptomatic and asymptomatic groups. The observed physiological effects of lead may contribute to the "abdominal syndrome" observed in lead poisoning, and should be taken into account in the diet of lead poisoning victims.
Sovetskaja medicina, 1982, No.1, p.24-29. 31 ref.

CIS 83-1407 Ross R., Nichols P., Wright W., Lukes R., Dworsky R., Paganini-Hill A., Koss M., Henderson B.
Asbestos exposure and lymphomas of the gastrointestinal tract and oral cavity
An epidemiological case-control study of non-Hodgkin's lymphomas revealed an excess of male patients with large-cell lymphomas primary to the gastrointestinal tract and oral cavity who had evidence of substantial exposure to asbestos. Histopathological slides from 26 of 28 cases of men interviewed between 1977 and 1981 about environmental exposure, showed evidence of non-Hodgkin's lymphoma of the large-cell type. When neighbourhood controls were matched to patients for age, race and sex, 13 matched pairs were discordant for asbestos exposure, and in 12 of these the exposed individual was a lymphoma patient. 10 patients and 1 control also reported a history of malaria.
Lancet, 20 Nov. 1982, Vol.2, No.8308, p.1118-1119. 16 ref.

CIS 83-1380 Yoshida K., Sakurai H., Toyama T.
Gastrointestinal symptoms in lead workers
Prevalence of GI symptoms was studied in 109 battery manufacturing workers in relation to lead absorption and other factors. The mean blood lead and urinary δ-ALA concentrations in subjects complaining of loss of appetite were significantly higher than in those who did not. 49 workers (45%) complained of at least one symptom associated with peptic ulcer.
Japanese Journal of Industrial Health - Sangyō-Igaku, 1982, Vol.24, p.229-235. 20 ref.

CIS 83-1058 Kurppa K., Koskela R.S., Gudbergsson H.
Gastrointestinal cancer in workers exposed to quartz
In dusty work most inhaled particles larger than 5-10µm run into the walls of the nasopharynx and may be subsequently swallowed, exposing the gastrointestinal (GI) tract to quartz. 1087 men working in the granite industry for at least 3 months were studied. Mean exposure was 12 years. Mean follow-up was 12.5 (4-35) years. Average concentration was >40mg/m³ in drilling, the dustiest operation. 15 deaths caused by GI cancer were detected, against an expected value of 7.4 (relative risk 2). Their sites were: stomach 10, oesophagus 2, liver 1, unspecified 2.
Lancet, 17 July 1982, Vol.2, No.8290, p.150. 3 ref.

CIS 82-1935 Argouarch L.P., Borel B., Justum A.M., Davy A., Verwaerde J.C., Valla A.
Six cases of primary peritoneal mesothelioma following exposure to asbestos
Mésothéliome primitif du péritoine et exposition à l'amiante. A propos de 6 cas [en francés]
Description of the 6 cases (in one case there were 2 tumours: one pleural, one peritoneal); clinical picture of peritoneal mesothelioma. Diagnostic aspects of para-clinical tests (cytological analysis of fluid drained from ascites, and of peritoneal cells obtained by biopsy following laparascopy); problems of histological interpretation; experimental and epidemiological considerations emphasising the role of asbestos. Preventive measures are imperative, since no adequate therapy is as yet available.
Médecine et chirurgie digestives, 1982, Vol.10, p.583-586. 29 ref.

CIS 82-1992 Ames R.G.
Gastric cancer in coal miners: Some hypotheses for investigation
A series of hypothesis are proposed to explain the evidence of an elevated risk of gastric cancer in US coal miners. These hypotheses range from direct occupational links including, coal mine and other dust exposure to darkness, soil and moisture, to causes related to social class, and lifestyle including exposure to raw tobacco juice and nitroso amines, a lower than normal ingestion of antioxidants, and a lag effect compared to national trends. These hypotheses and others can form the basis of epidemiologic studies to determine the most probable reason for excess risk.
Journal of the Society of Occupational Medicine, Apr. 1982, Vol.32, No.2, p.73-81. 56 ref.

1980

CIS 81-546 Balestra V., Bogetto B., De Luca F.
Gastroduodenopathy in sailors - Pathogenic aspects I
Le gastroduodenopatie nei marittimi - Aspetti patogenetici I [en italiano]
150 sailors under medical care and 150 healthy sailors were studied. Apscts considered and analysed statistically include eating, drinking, and smoking habits, physiological and psychological factors. An important occupational factor involved is shift work.
Medicina del lavoro, May-June 1980, Vol.71, No.3, p.259-269. Illus. 10 ref.

CIS 81-465 Hillerdal G.
Gastrointestinal carcinoma and occurrence of pleural plaques on pulmonary x-ray.
386 men and 420 women, each with 3 controls of the same age and sex with a roentgenogram taken in the same year, were studied. 3.4% of the male tumour patients, compared with 1.7% of controls (significant at the 2% level) had pleural plaques on their x-ray film. The results in women were inconclusive.
Journal of Occupational Medicine, Dec. 1980, Vol.22, No.12, p.806-809. 50 ref.

CIS 81-168 Esping B., Axelson O.
A pilot study on respiratory and digestive tract cancer among woodworkers
95 cases (25 of respiratory cancer and 70 of digestive tract cancer) and 370 controls were studied. There was a 4-fold excess of respiratory cancer, other than nasal cancer, particularly in furniture workers. There was no definite excess of digestive tract cancer.
Scandinavian Journal of Work, Environment and Health, Sep. 1980, Vol.6, No.3, p.201-205. 19 ref.

1979

CIS 81-484 Bulatova F.D., Sof'ina L.I.
Pancreatic disorders in workers in the petrochemical industry
Funkcional'noe sostojanie podželudočnoj železy u rabočih, zanjatyh na neftehimičeskih proizvodstvah [en ruso]
Pancreatic internal and external secretion tests in 346 workers exposed to saturated, unsaturated and aromatic hydrocarbons (concentrations approximating their TLVs) showed a predominance of pancreatic disorders in subjects with chronic cholecystitis and biliary dyskinesia without symptoms of inflammation. Conclusions to be drawn regarding medical supervision of workers.
Gigiena truda i professional'nye zabolevanija, Dec. 1979, No.12, p.28-30. 13 ref.

CIS 80-1055 Bulatova F.D.
Incidence and clinical picture of biliary tract diseases in petrochemical industry workers
Rasprostranennost' i kliničeskoe tečenie zabolevanij želčnyh putej u rabočih neftehimičeskih proizvodstv [en ruso]
346 workers with different levels of exposure to synthetic products and 79 controls were studied: the incidence of biliary tract diseases was greater in the exposed group and was related to length of service. Cholecystitis was the chief cause of unfitness for work. The clinical picture was dominated by dyskinesia due to autonomic instability, frequently giving rise to hepatic and pancreatic disorders.
Gigiena truda i professional'nye zabolevanija, Aug. 1979, No.8, p.8-11. 13 ref.

1978

CIS 79-1094 Chronic gastritis and its occupational causes
Die chronische Gastritis und ihre berufliche Verursachung [en alemán]
This issue, which is mainly devoted to specialist studies of medical (occupational and social) aspects of chronic gastritis, contains the following articles: pathological aspects of gastritis (Elster K.); clinical aspects of chronic gastritis (Heinkel K., von Gaisberg U.); aetiology of gastritis (Antonin K.H., Heinkel K.); problems of giving expert opinion on chronic gastritis cases (Heinkel K., Maier K., Rehmann I.).
Arbeitsmedizin - Sozialmedizin - Präventivmedizin, Sep. 1978, Vol.13, No.9, p.181-196. Illus. 88 ref.

1977

CIS 95-801 Reglamento sobre el cáncer gastro-intestinal promulgado por la Comisión de accidentes de trabajo, del 3 de marzo de 1977 [Canadá - Columbia Británica]
Regulation Promulgated by the Board on March 3, 1977, re cancer of the gastro-intestinal tract [Canada - British Columbia] [en inglés]
Este Reglamento, promulgado el 16 de marzo de 1977, modifica las disposiciones de la Ley provincial de Indemnización de enfermedades profesionales y accidentes de trabajo y añade el cáncer gastro-intestinal inducido por fibras de amianto al cuadro B de enfermedades profesionales. Al menos deben transcurrir veinte años entre la primera exposición al amianto y el diagnóstico de la patología y la exposición debe ser ininterrumpida y haber constituido una parte importante de las actividades profesionales del trabajador.
Canadian OSH Legislation CD-ROM, CCOHS, 250 Main Street East, Hamilton, Ontario L8N 1H6, Canadá, 1977. 3p.

CIS 78-480 Strašimirova R., Ivanova S., Petkova V., Matakieva M., Dičeva C., Čepilov I.
Gastrointestinal disorders in lead-exposed workers
Kăm uvreždanijata na stomašno-črevnija trakt u raboteštite v kontakt s olovo [en búlgaro]
286 workers were divided into 5 groups according to degree of symptoms of poisoning. Gastrointestinal disturbances increased in proportion to their severity: they occurred in 28% without such symptoms; in 45% of those in the initial stage of poisoning; in 80% with moderate or severe poisoning. Detailed study of clinical findings showed the cause to be gastrointestinal dysfunction in 21.7% and organic gastrointestinal disorders in 42.8%. 35.2% presented no objective signs.
Higiena i zdraveopazvane, May 1977, Vol.20, No.3, p.224-229. Illus. 9 ref.

CIS 78-147 Tereščenko Ju.A., Tarlov E.L., Medvedev V.N., Udinceva A.N.
Structure of the gastric mucosae and secretion function in chronic carbon disulfide poisoning
Struktura slizistoj oboločki i sekretornaja funkcija želudka pri hroničeskoj intoksikacii serouglerodom [en ruso]
Results of tests by submaximal histamine stimulation (modified Lambling's method) and gastric biopsy in 41 female workers with carbon disulfide poisoning. In 34 cases damage to the gastric mucosae suggesting gastritis was observed (gastritis without atrophy or with moderately marked or pronounced atrophy of the mucosae). Atrophic gastritis was accompanied by varying degrees of inhibition of the secretory function depending on the severity of the atrophic changes.
Gigiena truda i professional'nye zabolevanija, Feb. 1977, No.2, p.21-24. 10 ref.

1976

CIS 77-1394 Bulatova F.D., Muhametova G.M., Sof'ina L.I.
Biliary secretion in petrochemical industry workers with chronic biliary tract diseases
Ėkskretorno-biliarnaja funkcija pečeni u rabočih neftehimičeskih proizvodstv s hroničeskimi zabolevanijami želčnyh putej [en ruso]
Study of the clinical course of liver and biliary tract disease in workers exposed to small concentrations of hydrocarbons and aromatic compounds in the air of petrochemical plants. Study of hepato-biliary functions in 346 workers showed that chronic cholecystitis has a very painful evolution because of biliary system dyskinesia and biliary secretion dysfunction. The authors frequently observed hepatic insufficiency, with severity related to length of service. They recommend that the very specific clinically observable course taken by cholecystitis in persons employed in petrochemical plants should be borne in mind when prescribing therapeutic and preventive measures and in assessing aptitude for this kind of work.
Gigiena truda i professional'nye zabolevanija, July 1976, No.7, p. 23-27. 6 ref.

CIS 76-1239 Robinson T.J.
Coeliac disease with farmers' lung.
The case-histories of 2 patients with extrinsic allergic alveolitis due to mouldy hay exhibiting malabsorption due to coeliac disease are given. As similar associations have been found with other alveolar diseases, the findings are probably not due to chance.
British Medical Journal, 27 Mar. 1976, Vol.1, No.6012, p.745-746. 19 ref.

1975

CIS 76-490 Berrill W.T., Eade O.E., Fitzpatrick P.F., Hyde I., Macleod W.M., Wright R.
Bird-fancier's lung and jejunal villous atrophy.
16 patients with bird-fancier's lung were screened for evidence of coeliac disease (clinical features, erythrocyte or serum folate levels, serum tests for reticulin antibodies). 5 of the 9 patients selected for jejunal biopsy showed villous atrophy, which appeared to be a true gluten-sensitive enteropathy in some. The 5 case histories are given. The findings represent a strong case for routine jejunal biopsy in patients with bird-fancier's lung, since villous atrophy may be observed in the absence of gastrointestinal symptoms and when screening tests are negative. 4 possible explanations for the association between villous atrophy and bird-fancier's lung are proposed.
Lancet, 22 Nov. 1975, Vol.2, No.7943, p.1006-1008. 9 ref.

1973

CIS 74-233 Cobb S., Rose R.M.
Hypertension, peptic ulcer, and diabetes in air traffic controllers.
The hypothesis that certain diseases are unduly frequent in air traffic controllers was tested by comparing the aeromedical certification examinations on 4,325 traffic controllers with those on 8,435 second class airmen. There is compelling evidence to support the hypothesis with regard to hypertension; for peptic ulcer, the evidence is strong; for diabetes it is slight but sufficiently suggestive for the matter to be examined in subsequent studies.
Journal of the American Medical Association, 23 Apr. 1973, Vol.224, No.4, p.489-492. 9 ref.

1972

CIS 74-742 Mas S.
Chromium-related gastro-intestinal disorders
Les entéropathies liées au chrome. [en francés]
MD thesis. The author's intention is to draw attention to the risk of gastro-intestinal impairment resulting from chromium and its derivatives, hazards which are not recognised by French legislation. A review of the uses of chromium and its compounds is followed by a description of the chromium cycle in the body, and monitoring techniques. The section on toxicology gives the results of experiments and cites cases referred to in the literature which suggest that there is very probably a relationship between exposure to chromium and gastro-intestinal disorders. The case of a 24 year old worker in a tannery is analysed in detail. The possible carcinogenous effect of chromium is considered, not only at the level of the upper airways, but also as affecting the entire digestive tract. The importance of detailed questioning of the patient as regards digestive disorders is stressed, and practical preventive measures are suggested.
Université de Paris V, Faculté de médecine Paris-Ouest, Paris, France, 1972. 49p. 40 ref.

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