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Phenols and phenolic compounds - 225 entradas encontradas

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  • Phenols and phenolic compounds


CIS 88-758 Phenol
Phénol [en francés]
Chemical safety information sheet. Exposure limits (France, 1983): TWA = 19mg/m3. Acute toxicity: is absorbed through skin; skin burns; irritation of respiratory tract; delayed pulmonary oedema; hepatic and renal damage; neurotoxic effects. Chronic toxicity: digestive, nervous and skin disorders. EEC identification number and labelling codes: No.604-001-00-2; T, R24/25, R34, S2, S28, S44.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1988. 4p. Bibl.


CIS 89-859 Triebig G., Csuzda I., Krekeler H.J., Schaller K.H.
Pentachlorophenol and the peripheral nervous system: a longitudinal study in exposed workers
A longitudinal study was performed to examine whether chronic occupational exposure to pentachlorophenol (PCP) or its compounds causes measurable alterations in the conduction velocity in peripheral nerves as an "adverse effect". The results of nerve conduction velocity (NCV) determinations in 1980 and 1984 in 10 subjects (7 men, 3 women) exposed for an average of 16yrs (range 4-24) were available. The concentrations of PCP in the workplace air varied between 0.3 and 180µg/m3 and were below the MAK value of 500µg/m3. Biological monitoring showed the following results: PCP in the serum: 38-1,270µg/L; PCP in the urine: 8-1,224µg/L. Compared with the upper normal limits (PCP in the serum 150µg/L, PCP in the urine 60µg/L), distinct internal exposure to PCP has resulted in some of the employees. It is concluded that occupational exposure to PCP over several years in the concentrations observed probably do not lead to any adverse effects on the peripheral nervous system.
British Journal of Industrial Medicine, Sep. 1987, Vol.44, No.9, p.638-641. Illus. 27 ref.

CIS 88-756 Pentachlorophenol and sodium salt
Pentachlorophénol et sel de sodium [en francés]
Chemical safety information sheet. Both compounds are absorbed through skin. Acute toxicity: irritates eyes, skin and upper respiratory tract. Chronic toxicity: dermatitis; chloracne. Exposure limit (France, 1986): TWA = 0.5mg/m3 (pentachlorophenol).
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1987. 5p. Bibl.

CIS 88-585 Pentachlorophenol
This evaluation of the toxicity data includes: identity, properties, and analysis; sources of human and environmental exposure; transport, distribution and transformation; environmental levels and human exposure; kinetics and metabolism; effect on organisms in the environment, on animals and on man; evaluation of human risks and effects on the environment; recommendations.
World Health Organization, Distribution and Sales Services, 1211 Genève 27, Switzerland, 1987. 236p. Bibl.


CIS 89-1480 Phenol
Chemical safety information sheet. Exposure limit: ACGIH TLV = 19mg/m3. Toxicity: skin absorption; conjunctivitis; cyanosis; pulmonary oedema.
Indian Chemical Manufacturing Association, India Exchange, India Exchange Place, Calcutta 700 001, India, 1986. 1p.

CIS 89-1324
Sovet Ėkonomičeskoj Vzaimopomo¿či
Occupational Safety and Health - Methods for determining chemical substances in workplace air
Gigiena truda i professional'nye zabolevanija - Metody opredelenija himičeskih veščestv v vozduhe rabočej zony [en ruso]
Methods for the determination of the following hazardous substances in workplace air: dimethyl sulfate, norbornene polychlorinated biphenyls, benzidine, p-chlorophenol, carbon monoxide, chloroacetophenone, water-soluble chromium compounds, tetraethyllead, oil aerosols, epichlorohydrin, volatile hydrocarbons from cutting fluids, solvent naphtha. The gas chromatographic and photometric methods have been adopted as official methods of the Council for Mutual Economic Assistance.
Izdatel'skij otdel, Upravlenija delami Sekretariata SĖV, prospekt Kalinina 56, 121205 Moskva, USSR, 1986. 49p.

CIS 87-1406 Medical monitoring of workers exposed to pentachlorophenol
This guideline for the prevention of adverse effects includes: background on pentachlorophenol; entry, metabolism and excretion; health effects; protective measures; health and biological monitoring; treatment of pentachlorophenol intoxication.
Alberta Community and Occupational Health, Medical Services Branch, 10709 Jasper Ave., Edmonton, Alberta T5J 3N3, Canada, Dec. 1986. 8p. 13 ref.

CIS 87-849 Phenol
Chemical safety information sheet. Toxicity: systemic poison; very corrosive to the skin and eyes. Phenol in solution is absorbed easily through the skin. Exposure limit recommended in Ontario: ACGIH (USA, 1985-86) TLV = 19mg/m3. Combustible liquid.
Industrial Accident Prevention Association, 2 Bloor St. West, Toronto, Ontario M4W 3N8, Canada, 1986. 2p.

CIS 87-608 Ogata M., Yamasaki Y., Kawai T.
Significance of urinary phenyl sulfate and phenyl glucuronide as indices of exposure to phenol
Urine samples from 20 workers who had been using phenol for treatment of chemical fibres were analysed for phenyl sulfate (PhS) and phenyl glucuronide (PhG) by high pressure liquid chromatography. The urinary concentration of phenol metabolites, as the total of PhS and PhG, levels of PhG and PhS had a correlation with the environmental concentration of phenol. The urinary concentration of phenol metabolites, as the total of PhS and PhG, corresponding to 5ppm of environmental phenol was 251mg phenol/g creatinine.
International Archives of Occupational and Environmental Health, 1986, Vol.58, No.3, p.197-202. Illus. 12 ref.

CIS 86-1356 Enarson D.A., Chan-Yeung M., Embree V., Wang R., Schulzer M.
Occupational exposure to chlorophenates - Renal, hepatic and other health effects
71 sawmill workers were identified as part of a group undergoing an extensive health and environmental evaluation in a pulp mill. This group was compared with a non-exposed control group. Exposure was highest for workers in direct contact with the wood. The peripheral blood leukocyte count was slightly lower in the exposed groups and their hematocrit was reduced, significantly so for heavily exposed workers. Urinalysis showed an increased prevalence of microscopic hematuria, especially with lower cell counts. No significant renal or hepatic effects were observed.
Scandinavian Journal of Work, Environment and Health, Apr. 1986, Vol.12, No.2, p.144-148. 14 ref.

CIS 86-1070 Kauppinen T.P., Partanen T.J., Nurminen M.M., Nickels J.I., Hernberg S.G., Hakulinen T.R., Pukkala E.I., Savonen E.T.
Respiratory cancers and chemical exposures in the wood industry: a nested case-control study
This case-control study involved 3805 men who had worked at least 1yr in the particleboard, plywood, sawmill or formaldehyde glue industries between 1944 and 1965, and who were then followed up until 1981. No relationship was found between exposure to wood dust and respiratory cancer, though significantly raised odds ratios were observed for exposures to pesticides and/or phenol present in wood dust. Exposure to terpenes and other products of the heating of coniferous woods was associated with a risk of respiratory cancer when the length of exposure exceeded 5yr.
British Journal of Industrial Medicine, Feb. 1986, Vol.43, No.2, p.84-90. 27 ref.

CIS 86-1069 Pearce N., Smith A.H., Howard J.K., Sheppard R.A., Giles H.J., Teague C.A.
Non-Hodgkin's lymphoma and exposure to phenoxyherbicides, chlorophenols, fencing work, and meat works employment: a case-control study
This case-control study, conducted in New Zealand, involved 83 men with non-Hodgkin's lymphoma, 168 controls with other kinds of cancer, and 228 controls from the general population. There were no significant differences between cases and controls regarding potential exposure to phenoxy herbicides or chlorophenols. There were significantly raised odds ratios for fencing work (odds ratio: 2.0), which involves exposure to several potential risk factors including arsenic and sodium pentachlorophenate, and for employment in meat-processing plants (odds ratio: 1.8), which entails exposure to 2,4,6-trichlorophenol and zoonotic viruses.
British Journal of Industrial Medicine, Feb. 1986, Vol.43, No.2, p.75-83. 41 ref.


CIS 87-83 Dinoterb
Chemical identity; exposure limits; physicochemical data; fire and explosion data; reactivity data; health hazards; uses (herbicide); precautions for safe handling and use.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 86-1932 Japukovič J.B.
Method for the determination of phenol in atmospheric air
Metod opredelenija fenola v atmosfernom vozduhe [en ruso]
Air to be sampled is drawn through a bed of Silochrom sorbent in a tube. The tube is placed in a heated chamber at the injector end of a gas chromatography column, where adsorbed phenol is thermally desorbed. The column is peaked with 15% polymethylphenylsiloxane on Chromaton NAW. A flame-ionisation detector is used. The method can detect 0.005mg/m3 in a 1L sample with a relative error of ±10%.
Gigiena i sanitarija, Sep. 1985, No.9, p.53-54. Illus. 5 ref.

CIS 86-1876 Sodium pentachlorophenate
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 4p.

CIS 86-1620 Phenol
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 86-1566 Pentachlorophenol
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 4p.

CIS 86-511 Palmer W.G., James R.H., Moorman W.J.
Analysis of emissions collected from four types of iron casting molds
The levels of polycyclic aromatic hydrocarbons (PAH) and related compounds, phenol and particulates were determined in emissions from 4 types of binders: furan, urethane, green sand with sea coal and phenol-formaldehyde resins in shell molds. The shell sample contained 50% particulates, green sand 25%, furan 10% and urethane 2%. The portion of particulate fraction soluble in cyclohexane varied from 16 to 36% between mold types. Emissions from urethane and furan molds contained the lowest quantities of cyclohexane-soluble components and of PAH and related compounds. Phenol which was fond in all 4 foundry samples, was present in the highest concentration in emissions from urethane molds. Shell mold emissions contained the highest levels of 2- and 4-nitrophenol.
American Industrial Hygiene Association Journal, Dec. 1985, Vol.46, No.12, p.724-730. Illus. 17 ref.

CIS 86-138 Pippard E.C., Acheson E.D.
The mortality of boot and shoe makers, with special reference to cancer
This study covers 5017 men known to have been employed in the boot and shoe manufacturing industry in 3 towns in the United Kingdom in 1939. At the end of 1982, 68.4% were known to be dead. The anticipated excess of nasal cancer was found. Excess mortality from leukaemia and rectal cancer was also found. Some supporting evidence for a risk of rectal cancer in this industry was found in the literature.
Scandinavian Journal of Work, Environment and Health, Aug. 1985, Vol.11, No.4, p.249-255. Illus. 28 ref.

CIS 85-1920 Gray R.E., Gilliland R.D., Smith E.E., Lockard V.G., Hume A.S.
Pentachlorophenol intoxication: Report of a fatal case, with comments on the clinical course and pathologic anatomy
Case study of a 33 year old man who died following exposure (3 weeks) to high levels of pentachlorophenol dust. His job involved breaking up large blocks of the compound with a jackhammer before it was ground into powder; this was done without any protective equipment. Postmortem examination revealed cerebral oedema and fatty degeneration of the viscera. The literature indicates that the clinical syndrome of poisoning with the compound results from mitochondrial toxicity with derangement of aerobic metabolism. Analysis of tissue and fluid samples revealed the following concentrations of pentachlorophenol: 162ppm in blood; 639ppm in the kidneys; 116ppm in the lung and 1130ppm in the bile.
Archives of Environmental Health, May-June 1985, Vol.40, No.3, p.161-164. Illus. 12 ref.

CIS 85-802 Kauppinen T., Lindroos L.
Chlorophenol exposure in sawmills
Personnel exposure to chlorophenol (CP) was measured in 10 Finnish sawmills where a chlorophenate salt formulation was used for the blue stain control of sawed wood. Average concentrations of CP in air were below the 0.5mg/m3 exposure limit. However, some workers had high CP levels in their urine, indicating a high skin adsorption rate from contact with the CP solutions. CP was also observed by breathing wood dust contaminated with the chemical. The risks associated with impurity contained in CP preparations (chlorinated dibenzodioxins and dibenzofurans) and the need for epidemiologic studies on possible cancer risks in sawmill work are discussed.
American Industrial Hygiene Association Journal, Jan. 1985, Vol.46, No.1, p.34-38. 17 ref.


CIS 89-1139
USSR Commission for UNEP
Chemical safety information sheet. Expsoure limit (USSR): MAC = 0.3mg/m3. Toxicity: skin absorption; irritation and necrosis of skin; irritation of eyes and respiratory tract; neurotoxic effects; hepatic and renal disorders.
Centre for International Projects, GKNT, Moskva, USSR, 1984. 36p. 138 ref.

CIS 87-1426 Kauppinen T.
Nordic Expert Group for Documentation of Occupational Exposure Limits - 54. Chlorophenols
Nordiska expertgruppen för gränsvärdesdokumentation - 54. Klorfenoler [en sueco]
The document contains a review and an evaluation of selected literature to be used for setting hygienic standards for the most widely used chlorophenols. Heavy exposure to chlorophenols, especially pentachlorophenol, can cause poisoning which is based on uncoupling of oxidative phosphorylation. Chlorophenols and their salts are irritants. High doses of chlorophenols have been associated with liver damage, aplastic anaemia, and immunosuppressive effects, usually after exposure to technical chlorophenols containing e.g. chlorinated dibenzodioxins and dibenzofurans as impurities. However, both pure and technical penta- or tetrachlorophenol are foetotoxic to rats at low doses. Human data on foetotoxicity are lacking. The most severe hazard reported is the possible carcinogenicity of certain chlorophenols. Four Swedish case-referent studies show an association between chlorophenol exposure and soft tissue sarcomas, malignant lymphomas and cancer of the nose and nasopharynx. Thus, technical chlorophenols should be held as suspected human carcinogens, although the possible risk may be due to the chlorinated dioxin and furan impurities. Hygienic and biological limit values ought to be based on the irritant effects, foetotoxic effects, and possible carcinogenicity of chlorophenols.
Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1984. 59p. Illus. 137 ref.

CIS 86-1541 Kristiansen E.
Nordic Expert Group for Documentation of Occupational Exposure Limits - 51. Phenol
Nordisk ekspertgruppe for grænseværdidokumentation - 51. Phenol [en danés]
A critical survey and evaluation of the relevant literature disclosed that data are insufficient for establishing a relationship between the air concentration and response. With few exceptions, human exposure to phenol in industry has been limited to accidental skin contact or inhalation of phenol vapour. The irritating effect of phenol should be taken into account in the establishment of a hygienic standard. Phenol vapour is readily absorbed via the lungs and skin and the quantity absorbed can be greatly increased through skin absorption from aqueous solutions of phenol. Phenol is suspected as being a promoter of tumour development in mice.
Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1984. 48p. 92 ref. Bibl.

CIS 86-118 Embree V., Enarson D.A., Chan-Yeung M., DyBuncio A., Dennis R., Leach J.
Occupational exposure to chlorophenates: Toxicology and respiratory effects
71 chlorophenate-exposed sawmill workers were identified as part of a group undergoing an extensive health and environmental evaluation in a pulp mill. This group was compared with a group (351) with no physical proximity to the area in which chlorophenates were used. A gradient of exposure was demonstrated from 230ppb in urine and 919ppb in serum for those directly handling the contaminated wood, to 139ppb in urine and 354ppb in serum for those working in the area but not in manual contact as compared with serum levels of 84ppb in the unexposed group. It was noted that the bulk chemical was primarily in the tetrachloro-form but the serum levels contained more pentachlorophenate. The urine proportions were intermediate, approximating the bulk chemical proportions at the lower levels of exposure. No excess prevalence of respiratory symptoms or spirometric abnormalities was found which could be explained by the chlorophenate exposure.
Journal of Toxicology - Clinical Toxicology, Oct. 1984, Vol.22, No.4, p.317-329. 14 ref.

CIS 85-1931 Skvortcova R.I., Merkulov A.M., Voroncova N.L.
Study of the prophylactic action of a complex of vitamins C, B1, B2, P and PP during chronic phenol exposure
Izučenie profilaktičeskogo dejstvija kompleksa vitaminov C, B1, B2, P i PP pri hroničeskom vozdejstvii fenola [en ruso]
Workers engaged in the production and processing of phenol-formaldehyde resins had elevated blood and urine levels of pyruvic acid. These elevated levels probably reflected metabolic disturbances resulting from phenol exposure. Administration of the title vitamins in daily doses of 0.2 (riboflavin) to 400 (P group) milligrams for 1 month restored pyruvate levels to normal.
Gigiena truda i professional'nye zabolevanija, Feb. 1984, No.2, p.34-37. 13 ref.

CIS 85-1077 Baxter R.A.
Biochemical study of pentachlorophenol workers
Biological tests were performed on a group of workers employed in the manufacture of pentachlorophenol and sodium pentachlorophenate, on another group of workers with some contact with the process, and on a group of controls. The study extended over 3 years. Signs of chloracne appeared in 25 out of 40 in the first group and in 2 out of 25 in the second. Mean values for triglycerides were generally higher in the exposed group, with a more marked effect in those with chloracne, but in only 1 year was this significant. The high-density lipoprotein chlolesterol fraction showed significantly lower values for the exposed group in 1 year, while those with chloracne showed this consistently. Total cholesterol levels tended to be lower for the exposed group, and bilirubin levels were significantly lower. No other biochemical changes were found.
Annals of Occupational Hygiene, 1984, Vol.28, No.4, p.429-438. 6 ref.

CIS 85-724 Phenol
Contents of this data sheet on phenol: physical properties; fire hazard; uses; hazardous reactions; toxicity (acute and chronic exposure) and biological hazards; safety precautions; medical examination; leakage and spillage; handling and storage; first aid measures.
Safety Practitioner, Nov. 1984, Vol.2, No.11, p.6-7. 13 ref.

CIS 85-738 Andersen K.E., Hamann K.
How sensitizing is chlorocresol? Allergy tests in guinea pigs versus the clinical experience
The sensitising potential of the biocide chlorocresol, used widely in pharmaceutical products, was judged strong using the guinea pig maximisation test (GPMT) and doubtful in the less sensitive open epicutaneous test. An optimal sensitising concentration above which no further increase in the sensitisation rate occurred was found. Rechallenge after 2 weeks showed a marked decrease in sensitivity. Consecutive human patch tests with 2% chlorocresol showed 11 reactions among 1,462 patients tested, but none were explainable and reproducible during re-tests and provocative tests indicating that the GPMT overestimated the sensitisation potential.
Contact Dermatitis, July 1984, Vol.11, No.1, p.11-20. 29 ref.

CIS 85-166 Silkowski J.B., Horstman S.W., Morgan M.S.
Permeation through five commercially available glove materials by two pentachlorophenol formulations
5 glove materials (natural rubber, 2 PVC formulations, nitrile rubber, latex/neoprene) were tested for permeation by solutions of 4.3% pentachlorophenol (PCP) in diesel oil and 4.2% sodium pentachlorophenate (SPCP) in water. Nitrile rubber and one of the PVC materials resisted best to the diesel solution of PCP. The natural rubber material was the only one to perform poorly in contact with the SPCP solution. The breakthrough times and permeation rates are given for each brand of the gloves tested.
American Industrial Hygiene Association Journal, Aug. 1984, Vol.45, No.8, p.501-504. 10 ref.

CIS 84-1985 Olsen J.H., Jensen O.M., Gallagher R.P., Threlfall W.J.
Nasal cancer and chlorophenols (1). Cancer and occupational exposure to chlorophenols (2)
Article 1 is an analysis of the occupational histories of 839 cases of nasal cancer in Denmark. 2465 cases of other kinds of cancer served as controls. A slightly higher, but not significant, relative risk was found in persons with occupational exposure to chlorophenols, with the risk further reduced when adjustment was made for occupational wood-dust exposure. Article 2 is an analysis of proportional mortality ratios for workers in British Columbia (Canada). Among workers potentially exposed to chlorophenols (woodworkers, farmers, railway labourers), no significant increases were found in the incidence of nasopharyngeal tumours, lymphomas or soft tissue tumours, with Hodgkin's disease showing a significant increase (PMR of 250-290) among wood workers.
Lancet, 7 July 1984, Vol.2, No.8393, p.47-48. 9 ref.

CIS 84-408
(Institut national de recherche et de sécurité)
2,4,5-Trichlorophenol and 2,4,6-trichlorophenol
2,4,5-trichlorophénol et 2,4,6-trichlorophénol [en francés]
This data sheet contains the various names, uses, physical and chemical properties, methods of detection and determination in air, and fire hazards of these trichlorophenols. Pathology and toxicology: experimental toxicology (acute, subacute and chronic poisoning; research into teratogenic, embryotoxic, mutagenic and carcinogenic effects); toxicity in man (acute and chronic, epidemiology of carcinogenesis). Regulations: OSH (in France), transport (France and international). Technical and medical recommendations.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 1st quarter 1984, No.114, p.131-134. 22 ref.


CIS 86-437 Sodium pentachlorophenolate
Pentaclorofenato de sódio [en portugués]
Data sheet on sodium pentachlorophenolate, containing information on: chemical composition, properties, main hazards, emergency measures, first-aid measures, handling and storage, and treatment of residues. The TLV in Brazil is: (suggested) 0.5mg/m3 for a 40h week.
Fundacentro, C.P.11484, CEP 05499 São Paulo, SP, Brazil, 1983. 2p. Bibl.

CIS 86-436 Pentachlorophenol
Pentachlorofenol [en portugués]
Data sheet on pentachlorophenol, containing information on: chemical composition, properties, main hazards, emergency measures, first-aid measures, handling and storage, and treatment of residues. The TLV in Brazil is: (suggested) 0.5mg/m3 for a 40h week.
Fundacentro, C.P.11484, CEP 05499 São Paulo, SP, Brazil, 1983. 2p. Bibl.

CIS 86-435 Phenol
Fenol [en portugués]
Data sheet on phenol, containing information on: chemical composition, properties, main hazards, emergency measures, first-aid measures, handling and storage, and treatment of residues. The TLV in Brazil is: 4ppm (15mg/m3).
Fundacentro, C.P.11484, CEP 05499 São Paulo, SP, Brazil, 1983. 2p. Bibl.

CIS 85-1647 Konasewich D.E., Henning F.A., Wile K.H., Gerencher E.
Chlorophenate wood protection - Recommendations for design and operation
Code of practice on the use of chlorophenols and chlorophenates for protecting lumber against fungi in specialised undertakings in British Columbia, Canada. Aspects covered: the need for wood protection; hazards of chlorophenols and chlorophenates; personnel protection; general practices at wood protection facilities; recommended design features and operating practices; transportation of treated materials; disposal of wastes; summary of legislation.
British Columbia Ministry of Environment, Environment Canada, British Columbia, Canada, Dec. 1983. 90p. Illus. 32 ref.

CIS 85-703 Dmitriev M.T., Miščihin V.A.
Gas-chromatographic determination of phenol in air
Gazohromatografičeskoe opredelenie fenola v vozduhe [en ruso]
Phenol in air is determined by passing the air to be analysed through a 15cm by 2.5mm tube filled with silica gel. The silica gel is washed with chloroform, the eluate is concentrated by evaporation, and an aliquot is applied to a 2m by 3mm column of 15% Reoplex 400 on Chromosorb AW-HMDS (granulation 0.16-0.25mm). At a carrier gas flow of 40mL/min, an injector temperature of 250°C and a column temperature of 150°C, phenol has a retention time of 4min 25s. With a 20-30L air sample, the method can detect as little as 0.002-0.005mg/m3 with a precision of 3-6%.
Gigiena i sanitarija, May 1983, No.5, p.42-44. Illus. 8 ref.

CIS 84-1992 Wilcosky T.C., Tyroler H.A.
Mortality from heart disease among workers exposed to solvents
A survivorship analysis was used to compare the cardiovascular disease mortality in a cohort of 1,282 white male workers exposed and non-exposed to solvents in a rubber and tyre manufacturing plant during a 15-year follow-up period. Detailed exposure estimates for 25 solvents were available. The known association between carbon disulfide exposure and ischaemic heart disease (IHD) was apparent among these workers, and 2 other solvents, ethanol and phenol, were also significant predictors of IHD. Solvents other than carbon disulfide may cause atherosclerotic disease.
Journal of Occupational Medicine, Dec. 1983, Vol.25, No.12, p.879-885. Illus. 20 ref.

CIS 84-1965 Kalman D.A., Horstman S.W.
Persistence of tetrachlorophenol and pentachlorophenol in exposed woodworkers
The decline in urinary concentrations of pentachlorophenol (PCP) and 2,3,4,6-tetrachlorophenol (TCP) was monitored in a group of 40 woodworkers during two successive annual 16-day vacation periods. Samples were taken on the last working day prior to shutdown and on the first day after the shutdown. Among workers with the highest pre-shutdown levels, uniform TCP reductions of 90±6% were observed, indicating elimination rates similar to those reported for PCP in a single-dose human exposure study. In 2 of 4 workers with significant pre-shutdown levels, sampled on alternate days during the shutdown, the declines in urine TCP were consistent with a simple one-compartment first order decay. The possible effect of environmental PCP exposure on observed biological decay rates, when occupational PCP exposures are low, was indicated by a wide variation in urinary PCP reduction and slight decreases or actual increases observed during the shutdown period.
Journal of Toxicology - Clinical Toxicology, 1983, Vol.20, No.4, p.343-352. Illus. 11 ref.

CIS 84-1633 Sodium pentachlorophenolate
Pentaclorofenato de sódio [en portugués]
This data sheet on sodium pentachlorophenolate (C6Cl5ONa) covers: properties of the substance; tolerance levels (suggested: 0.5mg/m3 of pentachlorophenol); symptoms of poisoning; effects of exposure; suggested warning sign; first-aid measures and follow-up; handling storage; treatment of residues; preventive measures.
Revista brasileira de saúde ocupacional, July-Sep. 1983, Vol.11, No.43, betw. pp.74-75. 8 ref.

CIS 84-1668 Miller T.L., Lorusso D.J., Walsh M.L., Deinzer M.L.
The acute toxicity of penta-, hexa-, and heptachlorohydroxydiphenyl ethers in mice
The acute intraperitoneal LD50 values determined for a series of polychlorohydroxydiphenyl ethers (Cl=5-7) were slightly less than those found for Irgasan DP-300 and substantially less than those observed for nonachlorohydroxydiphenyl ether and pentachlorophenol. A marked hypothermic effect was found, and symptomatology suggested a non-specific depressant effect on the central nervous system.
Journal of Toxicology and Environmental Health, Aug.-Sep. 1983, Vol.12, Nos. 2-3, p.245-253. Illus. 23 ref.

CIS 84-1362 Wood S., Rom W.N., White G.L., Logan D.C.
Pentachlorophenol poisoning
5 cases of pentachlorophenol (PCP) poisoning in workers at wood preservative manufacturing plants are described. 2 cases were fatal. All presented fever, severe in 2. An increased anion gap and renal insufficiency occurred in 2. PCP may uncouple oxidative phosphorylation. Hot weather appears to be a predisposing factor, and exposure to PCP should be kept to a minimum during hot periods. Treatment is briefly discussed.
Journal of Occupational Medicine, July 1983, Vol.25, No.7, p.527-530. 26 ref.

CIS 84-1336 Bond G.G., Ott M.G., Brenner F.E., Cook R.R.
Medical and morbidity surveillance findings among employees potentially exposed to TCDD
204 men potentially exposed to TCDD and 61 men who had been involved in a chloracne incident in the area of 2,4,5-trichlorophenol (TCP) production were compared with matched unexposed controls. There were few significant differences between exposed and unexposed subjects. Workers potentially exposed to TCDD during manufacture of 2,4,5-trichlorophenoxyacetic acid had a significantly higher incidence of ulcer and digestive diseases, but these were absent in TCP production workers.
British Journal of Industrial Medicine, Aug. 1983, Vol.40, No.3, p.318-324. 15 ref.

CIS 84-740 Oomens A.C., Schuurhuis F.G.
A method for the collection and determination of phenol and bisphenol A in air
The method is described. Air samples are concentrated on commercial silica by tube pump, and the trapped components are desorbed and analysed by high-pressure liquid chromatography. Using a 10l air sample, a concentration range of 0.5-50mg/m3 can be detected. Linearity of response, adsorption/desorption efficiency, and influence of humidity, temperature and storage are reported. The technique provides a selective and sensitive method for environmental monitoring and personal exposure measurement.
International Archives of Occupational and Environmental Health, 1983, Vol.52, No.1, p.43-48. Illus. 5 ref.

CIS 84-493 Golding J., Sladden T.
Congenital malformations and agricultural workers
Information collected for all births in Oxfordshire and West Berkshire (United Kingdom) since 1965 shows no evidence of excess congenital malformation in the children of agricultural, horticultural or forestry workers. There is no evidence to suggest that the herbicide 2,4,5-trichlorophenol has a teratogenic effect.
Lancet, 18 June 1983, Vol.1, No.8338, p.1393. 7 ref.


CIS 84-721 Psaltyra S.A., Tiščenkova I.A., Čeremuhin E.P.
Photometric determination of tetrabromodiphenylolpropane in workplace air
Fotometričeskoe opredelenie tetrabromdifenilolpropana v vozduhe rabočej zony [en ruso]
The title compound (TBDP) is a fire retardant used in the plastics industry. Airborne TBDP dust is measured by passing air to be sampled through a filter, eluting the filter with acetic acid, and reacting the TBDP in the eluate with diazotised sulfanilic acid. The absorbance of the resulting yellow solution is measured and compared with a standard curve. As little as 10µg of TBDP is detectable. Airborne hydrogen bromide, bromine and acetic acid do not interfere with the determination.
Gigiena truda i professional'nye zabolevanija, Oct. 1982, No.10, p.50-52. Illus. 2 ref.

CIS 84-420 Miller T.L., Lorusso D.J., Deinzer M.L.
The acute toxicity of nonachloropredioxin and 3- and 4-hydroxynonachlorodiphenyl ether in mice
The acute intraperitoneal LD50 values of hydroxynonachlorodiphenyl ethers (HNDPE), contaminants of technical pentachlorophenol (PCP) wood preservative, were determined in mice and compared with those of PCP and Triclosan, a commonly used bactericide. The acute toxicity decreased in the order 2-hydroxynonachlorodiphenyl ether, PCP, 3-hydroxynonachlorodiphenyl ether, 4-hydroxynonachlorodiphenyl ether, Triclosan. Symptomatology following exposure to HNDPE was similar to that observed for PCP. Technical PCP contains 1-5% of HNDPE which do not contribute significantly to its acute toxicity.
Journal of Toxicology and Environmental Health, Oct.-Nov. 1982, Vol.10, Nos.4-5, p.699-707. Illus. 24 ref.

CIS 84-141
Canada Safety Council
Contents of this data sheet: identification and physical properties; industrial use; hazards (chloracne, foetotoxicity); emergency action information in case of fire or spill; first aid; occupational exposure limits (ACGIH TLV-TWA : 0.5mg/m3-skin); preventive measures (personal protective equipment, process control, disposal); transportation; storage and handling; training and supervision; glossary; 2-page summary for poster displays.
1765 St. Laurent Blvd., Ottawa, Ontario K1G 3V4, Canada, 1982. 8p. 10 ref.

CIS 84-200 Drummond I., Van Roosmalen P.B., Kornicki M.
Determination of total pentachlorophenol in the urine of workers
Free pentachlorophenol (PCP) represents a small and variable fraction of total PCP in the urine of exposed workers. In the method of determination described, 3,5-dichloro-2,4,6-tribromophenol (DTP) is added as internal standard. PCP is measured using high-pressure liquid chromatography. Detection is by fixed wavelength detector at 313nm. The biological threshold value used in Alberta, Canada, to trigger action to reduce exposure is 7mg/l.
International Archives of Occupational and Environmental Health, 1982, Vol.50, No.4, p.321-327. Illus. 23 ref.

CIS 84-117 Larsen K.O., Hardt F., Sørup P., Kristiansen E., Larsen J.C., Lynge E., Hansen T.
Chlorophenols - Phenoxycarboxylic acids
Klorfenoler - Fenoxykarbonsyrer [en danés]
Literature surveys and the conclusions of a research group were used to produce this report. The group's work included animal and human experiments, dealing with absorption, excretion, acute and subacute toxicity, genetic and carcinogenic effects. Discussed were: chemical data; the toxicology of chlorophenols and of their impurities; the toxicity of phenoxycarboxylic acids and of their impurities; the production of these compounds; epidemiology of the cancers associated with phenoxycarboxylic acids (sarcomas, lymphomas, etc.); toxicologic and technical data on chlorophenols and chlorocresols; toxicologic data on phenoxycarboxylic acids and their impurities.
Arbejdstilsynet, Arbejdsmiljøinstituttet, Rosenvængets Allé 16-18, 2100 København Ø, Denmark, Oct. 1982. 127p. Illus. 250 ref. Price:

CIS 83-1313 Williams P.L.
Pentachlorophenol, an assessment of the occupational hazard
Pentachlorophenol (PCP), a wood preservative, is absorbed into the body by all the routes of occupational exposure. It causes local irritation to the eyes and nose and systemic effects that result from its ability to uncouple mitochondrial oxidative phosphorylation. PCP is foetotoxic and teratogenic during early gestation. Commercial PCP is contaminated with chlorinated dioxins and dibenzofurans, tetrachlorophenols, and hydroxychlorodiphenyl ethers, which can cause chloracne and liver damage. Direct contact with PCP should be avoided during occupational exposure, and air levels should be kept below the TLV of 0.5mg/m3.
American Industrial Hygiene Association Journal, Nov. 1982, Vol.43, No.11, p.799-810. Illus. 55 ref.

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