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Butadiene - 95 entries found

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CIS 90-1111 1,3-Butadiene
International chemical safety card. Danger symbols: highly flammable. Short-term exposure effects: irritation of eyes and respiratory tract; neurotoxic effects (central nervous system). Long-term exposure effects: bone marrow and liver disorders; probably carcinogenic to humans; may cause heritable genetic damage; suspected teratogen. EC identification number and labelling codes: 601-013-00-X; F; R13; S9-16-33. United Nations number and hazard class: UN 1010 (2.1; 3).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1990. 2p. Illus.


CIS 91-585 1,3-Butadiene in air: Laboratory method using molecular sieve diffusion samplers, thermal desorption and gas chromatography
Contents of this guidance note: properties, uses, toxicity and first aid following massive exposure to 1,3-butadiene; determination method (butadiene gas migrates down the tube of a diffusive sampler and is adsorbed on the Molecular Sieve; collected gas is desorbed by heat and transferred to a gas chromatograph equipped with a flame ionisation detector). Scope: suitable for sampling over periods in the range 30min to 8h for personal or fixed location monitoring; analytical range: 2-100mg/m3. Changing the polarity of the column stationary phase may remove interference due to the presence of compounds coeluting with the butadiene.
Health and Safety Executive Sales Point, St. Hugh's House, Stanley Precinct, Bootle, Merseyside L20 2QY, United Kingdom, June 1989. 7p. 7 ref. Price: GBP 2.50.


CIS 88-2009 Summary on the replies received concerning the information alert on 1,3-butadiene
Résumé des réponses reçues à la demande d'informations sur les risques du butadiène-1,3 [in French]
On the basis of information provided by OSHA, the Occupational Safety and Health Branch of the ILO addressed an information alert on 1,3-Butadiene (BD) to all national centres of the International Safety and Health Hazard Alert System. These centres were requested to provide information from their countries, in particular on: health effects from exposure to 1,3-Butadiene; control systems; substitution products; types of protective equipment and respirators; training programmes for workers; medical surveillance; costs of protective measures; information and data on possible environmental effects. Replies were received from 26 countries.
International Labour Office, International Occupational Safety and Health Hazard Alert System, 1211 Genève 22, Switzerland, Aug. 1987. 27p.

CIS 88-1992 Downs T.D., Crane M.M., Kim K.W.
Mortality among workers at a butadiene facility
Several studies of styrene-butadiene rubber (SBR) workers have reported excess cancers at various sites. The current study examined cause-specific mortality in a cohort of 2,586 male workers employed for at least 6 months between 1943-1979 in a butadiene manufacturing plant. Standardised mortality ratios were calculated using national (NSMR) and local (LSMR) comparison populations. The all-cause NSMR was 80 (p<0.05) and the all-cancer NSMR was 84; the corresponding LSMRs were 96 and 76 (p<0.05). No significant excesses were observed for any cause of death except lymphosarcoma and reticulum cell sarcoma (NSMR=235). When the cohort was subdivided into routine, non-routine, and low-exposure groups, the SMRs were consistently elevated for this cause of death in all 3 groups. This suggests that butadiene may not be responsible for the excess, but the association deserves close attention in future studies.
American Journal of Industrial Medicine, 1987, Vol.12, No.3, p.311-329. 12 ref. Appendices.

CIS 88-918 Ackley M.W.
Chemical cartridge respirator performance: 1,3-butadiene
1,3-Butadiene recently has been classified as a potential occupational carcinogen. The performance of Scott organic vapour (642-OV), organic vapour/acid gas (642-OA) and acid gas (642-AG) twin cartridges was determined for 1,3 butadiene. A cartridge test system was developed to generate challenge concentrations of 100ppm and 1000ppm; an infrared analyser was used to measure breakthrough at 10ppm. The twin cartridges tested demonstrated reasonable adsorption capacity for 1,3 butadiene. Cartridge service life was inversely proportional to airflow rate; it was reduced at elevated temperature and humidity conditions. Breakthrough times were approximately three times longer at 100ppm than at 1000ppm. When clean air was drawn through cartridges saturated with 1000ppm 1,3 butadiene, desorption occurred readily. The rate of desorption and the peak concentration were dependent upon the temperature, humidity and degree of saturation.
American Industrial Hygiene Association Journal, May 1987, Vol.48, No.5, p.447-453. Illus. 13 ref.

CIS 87-792
Institution of Occupational Safety and Health
Chemical safety information sheet. Exposure limits (HSE Control Limits as of Jan. 1988): 8h TWA = 10ppm. Highly flammable and explosive gas. Toxicity: irritation of the eyes and upper respiratory tract; narcotic effects at high concentrations. Contact with the liquefied gas can cause skin or eye burns. Suspected carcinogen and teratogen; may affect reproductive functions.
Safety Practitioner, Aug. 1987, Vol.4, No.3, p.34-35. 11 ref.


CIS 89-410 Butadiene
1,3-butadieeni [in Finnish]
Chemical safety information sheet. Flammable gas. Exposure limit: TLV = 2200mg/m3. Toxicity: asphyxiant; irritates skin, eyes and mucous membranes; narcotic at high concentrations. Mandatory European labelling: F, R13, S9, S16, S33.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 536, 33101 Tampere, Finland, Aug. 1986. 2p. Original on microfiche.

CIS 89-616
International Agency for Research on Cancer
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans - Some chemicals used in plastics and elastomers
This review covers: chemical and physical properties; production, use, occurrence and analysis; biological data relevant to the evaluation of carcinogenicity; evaluation of 20 compounds. Substances covered: acrylamide, n-butyl acrylate, ethyl and methyl acrylates, vinyl acetate, vinyl bromide, vinyl fluoride, 1,3-butadiene, 4-vinylcyclohexene, vinylidene chloride and fluoride, 11-aminoundecanoic acid, caprolactam, 3,3'-dimethoxybenzidine-4,4'-diisocyanate, toluene diisocyanate, 2,6-dichloro-p-phenylenediamine, melamine, 4,4'-methylenedianiline and its dihydrochloride, dichloroacetylene.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, Vol.39, 1986. 412p. Bibl. Price: CHF 60.00.

CIS 88-1613 Lundberg P.
Scientific basis for Swedish Occupational Standards VII
A collection of consensus reports for establishing exposure limits for chlorophenols, butadiene, nitrogen oxides, selenium and its compounds, cotton dust, chloroprene, and propylene oxide.
Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1986. 90p. Illus. Bibl.

CIS 88-961 1,3-Butadiene in air
Guidance note on a laboratory method using pumped molecular sieve adsorbent tubes, thermal desorption and gas chromatography. Scope: suitable for sampling over periods of 10min-8h. Although recommended for the determination of personal exposure, the method may be used for fixed location monitoring by suitable modification. Suitable for the measurement of airborne butadiene gas in the concentration range 0.2-100mg/m3 for samples of 5L of air. The overall precision of the method is expected to be better than 10% (assuming a pump error of 5%). The bias is expected to be better than 5%. Any compound that co-elutes with the butadiene under the operating conditions chosen is a potential interferent. Additional information on 1,3-butadiene: properties, uses, toxicity, first aid.
Health and Safety Executive Sales Point, St Hugh's House, Stanley Precinct, Bootle, Merseyside L20 2QY, United Kingdom, Jan. 1986. 5p. 10 ref. Price: GBP 1.00.

CIS 88-787 1,3-Butadiene
Chemical safety information sheet. Exposure limit: ACGIH TLV = 2200mg/m3. Toxicity: irritates eyes and respiratory tract; liquid causes frostbite.
Indian Chemical Manufacturers Association, India Exchange, India Exchange Place, Calcutta 700 001, India, 1986. 1p.

CIS 87-1006 Rohatgi A.K.
Safe handling of hazardous chemicals
This detailed manual provides information on physical and chemical properties (including lists of safety reminders presented in a point-by-point format), toxicity, symptoms of poisoning and first aid connected with 21 common industrial chemicals: chlorine, ammonia, sulfur dioxide, phosgene, hydrogen cyanide, hydrogen sulfide, bromine, carbon monoxide, hydrogen fluorine, ethylene oxide, butadiene, benzene, methyl bromide, vinyl chloride, ethyl alcohol, acetylene, caustic soda, sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid. There are also chapters devoted to: personal respiratory protection; cylinders used for hazardous chemicals; recommendations for the safe handling of such cylinders; hazardous chemicals in bulk storage tanks (handling and storage); leak detection, neutralisation and disposal; emergencies and their management; transportation of hazardous chemicals; release calculations; prevention of emergencies and disasters; emergency control and disaster planning. Relevant Indian laws and regulations are cited throughout. Labelling requirements.
J.K. Enterprises, 13, New Nandu Industrial Estate, Mahakali Caves Road, Andheri (East), Bombay 400 093, India, 1986. 372p. Illus. 83 ref. Price: Rp.185.00.

CIS 86-1016
(Bundesministerium für Arbeit und Sozialordnung)
Technical rules for the application of the Ordinance on dangerous industrial substances
Technische Regeln zur Verordnung über gefährliche Arbeitsstoffe [in German]
Notifications of new technical rules (edition of April 1986) concerning carcinogenic industrial substances. TRgA 120 defines terms and gives bibliographic references for action levels for carcinogenic industrial substances. Action levels are workplace levels at which employers must take secondary preventive measures (e.g., special medical examinations). Rules TRgA 121-TRgA 135 concern action levels for: acrylonitrile, aromatic nitro or amino compounds, arsenic compounds, asbestos, benzene, benzo(a)pyrene, beryllium and its compounds, 1,3-butadiene, hexavalent chromium compounds, cobalt and its compounds, dimethyl sulfate, epichlorohydrin, hydrazine, nickel and its compounds, vinyl chloride. The rules give the physical and chemical properties of the substances, health hazards, appropriate preventive medical examinations, short- and long-term action levels, jobs that typically lead to exposure above the action level and safe working methods.
Bundesarbeitsblatt, Apr. 1986, No.4, p.52-81.


CIS 86-1584 Butadiene
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 4p.

CIS 86-1745
Chemical Manufacturers Association
Risk analysis in the chemical industry
Papers presented at a symposium sponsored by the Chemical Manufacturers Association (Washington, DC, USA, 23-24 Sep. 1985). Titles: risk assessment for chemicals, an overview; risk assessment: introduction and overview; hazard assessment: considerations in the design and interpretation of studies; exposure assessment in risk analysis; occupational exposure assessment; some capabilities, limitations, and pitfalls in the quantitative risk assessment of formaldehyde; EPA assessment of formaldehyde under the Toxic Substances Control Act; improving quantitative risk estimates with mechanistic data: the case of formaldehyde; environmental risk assessment (evaluating environmental exposure to chemicals; the toxicological data base and decision making); risk assessment issues presented by 1,3-butadiene; risk analysis for physical hazards: a toxic chemical case study; prioritising health risk assessments; some issues in the quantitative modeling portion of cancer risk assessment; risk analysis and its role in managing risk.
2501 M Street, NW, Washington DC 20037, USA, 1985. 269p. Illus. Bibl. Price: US$39.00.

CIS 86-1293 Illing H.P.A., Shillaker R.O.
Health and Safety Executive
1,3-butadiene and related compounds
This toxicity review deals with butadiene, its dimer 4-vinyl-1-cyclohexene and its metabolites. It covers: identity; disposition and metabolism of butadiene and its dimer in animals and man; toxicity in animals (acute toxicity (very low); skin and eye irritation; subacute and subchronic toxicity; mutagenicity; carcinogenicity; effects on the reproductive system); toxicity to man (acute and irritant effects; long-term health effects; results from mortality studies). Extensive tables present the results of animal tests.
H.M. Stationery Office, 49 High Holborn, London WC1V 6HB, United Kingdom, 1985. 34p. Illus. 160 ref. Price: £3.60.

CIS 85-1298
(Bundesministerium für Arbeit und Sozialordnung)
Technical rules for application of the Ordinance on Hazardous Industrial Substances
Technische Regeln zur Verordnung über gefährliche Arbeitsstoffe [in German]
Notification of new and modified technical rules (Mar. 1985 edition): TRgA 102 - Indicative technical concentrations (reduction of limits for benzene to 16mg/m3 and for 1,2-dibromomethane to 0.8mg/m3, toxicology, results of determination in air); TRgA 400 - Conditions to be met by services that measure dangerous substances in workplace air; TRgA 910 - Bases for the classification of carcinogenic industrial substances in conformity with the annex to the Ordinance (4-nitrobiphenyl, benzo(a)pyrene, ethylene oxide, 1,3-butadiene, 1,2-epoxypropane)
Bundesarbeitsblatt, Mar. 1985, No.3, p.120-125.


CIS 85-1309 Henschler D.
Harmful industrial substances - Toxicological and medical basis for the establishment of maximum permissible concentrations
Gesundheitsschädliche Arbeitsstoffe - Toxikologisch-arbeitsmedizinische Begründung von MAK-Werten [in German]
This loose-leaf collection was published under the auspices of the Toxic Substance Control Committee of the German Research Association. It has basic information on 215 industrial substances (gases, fumes), as well as on silica, asbestos, cotton and wood dust, on artificial mineral fibres and on cutting fluids. Supplement 10 contains a study on the formation of nitroso amines in the workplace, and information on iron oxide dust and on 24 other harmful substances: 1,3-butadiene, ethoxybutyl acetate, bis(2-chloroethyl) ether, diethylamine, diisocyanates, dinitronaphthalene, 1,2-epoxypropane, 2-ethoxyethylacetate, ethylamine, ethylene oxide, 2-methoxyethyl acetate, 1-methoxy-2-propanol, methylamine, chloromethane, methyl methylacrylate, phosgene, phosphoryl chloride, polycyclic aromatic hydrocarbons, trimethyl phosphite, vanadium pentoxide, iron oxide. Each monograph contains toxicologic information, results of observations in man and in animals, and the reasons behind the adopted TLVs.
Verlag Chemie GmbH, Postfach 1260/1280, 6940 Weinheim, Federal Republic of Germany, 10th supplement, 1984. 262p. Price: DM.109.00. Full work: 4 Vols. 1870p. Bibl. Price: DM.818.00.

CIS 85-1064 Haseman J.K., Crawford D.D., Huff J.E., Boorman G.A., McConnell E.E.
Results from 86 two-year carcinogenicity studies conducted by the National Toxicology Program
Of these studies on rats and mice 50% were regarded as showing carcinogenic effects, 42% gave no evidence of carcinogenicity and 8% gave unclear results. The liver was the most frequent site of cancer in male and female rats and mice. Each chemical tested is listed with information on the animal strain, route and exposure dose, site and type of tumour, and positivity or negativity of the tests.
Journal of Toxicology and Environmental Health, 1984, Vol.14, No.5-6, p.621-639. 15 ref.

CIS 85-414 Isoprene
Isoprène [in French]
Contents of this data sheet: chemical and physical properties; manufacture; synonyms and formula; toxicity; fire and explosion hazards; preventive measures (elimination of the danger of spills and of the release of fumes into open air, elimination of ignition sources, separation and minimisation of risks); fire-fighting agents; regulations in France; labelling; protection of workers and of the general population; transportation; insurance.
Face au risque, Aug.-Sep. 1984, No.205, p.85-88. Illus. 5 ref.

CIS 84-1001 1,3-Butadiene
Inhalation exposure of rats and mice to 1,3-butadiene (BD) at 625-8000ppm induced a carcinogenic response at multiple sites. Offspring of pregnant rats exposed to BD at 8000ppm had major skeletal defects, and foetal toxicity was observed after exposure at 200-8000ppm. Workers employed in facilities producing styrene-butadiene rubber showed an increased, but not statistically significant, risk of mortality from neoplasms of the lymphatic and haematopoietic tissues and from leukaemia. BD should be regarded as a potential occupational carcinogen and teratogen and a possible reproductive hazard.
U.S. Department of Health and Human Services, NIOSH, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA, 9 Feb. 1984. 18p. 32 ref.


CIS 85-1022 Mańkowska W., Kijeńska D.
Determination of butadiene concentration in air by gas chromatography
Oznaczanie stężenia butadienu w powietrzu metodą chromatografii gazowej [in Polish]
Two methods of gas chromatographic analysis were developed to determine butadiene in air. The 1st involves the use of a 3m column of dimethylsulphonal on Chromosorb P and a thermoconductimetric detector, and the other, a 3m column of Reoplex 400 on alumina and a flame ionisation detector. Butadiene can be determined directly from the gas sample within 7h after sample collection, later on from a solvent-enriched sample. It was possible to determine butadiene at 0.3 times the TLV.
Prace Centralnego instytutu ochrony pracy, 1983, Vol.33, No.118, p.151-158. Illus. 6 ref.

CIS 85-767 Danilin V.A., Koroljuk I.P., Špigel' A.S.
Time course of secretion of immunoreactive insulin and somatotropin in response to hazardous chemicals in the workplace
Dinamika sekrecii immunoreaktivnogo insulina i somatotropina pri vozdejstvii professional'nyh vrednostej himičeskoj prirody [in Russian]
Healthy workers from the isoprene rubber industry, rubber workers with signs of chemical poisoning, healthy workers exposed to aromatic hydrocarbons, and healthy controls were compared. Insulin and somatotropin were measured by radioimmunoassay in the blood of the workers before and after administration of a glucose load. Although the coefficients of variation of the data were high (up to 149.3%), there were discernable differences between the groups studied in the level and time course of hormone secretion.
Gigiena truda i professional'nye zabolevanija, Dec. 1983, No.12, p.29-32. 8 ref.

CIS 84-1999 Rom W.N., Renzetti A.D., Lee J.S., Archer V.E.
Environmental and occupational medicine
This textbook in 3 parts provides a clinical approach to occupational medicine. Part I covers environmental and occupational diseases by organ systems and includes discussions on the discipline of environmental and occupational disease; occupations that can be hazardous; tests used in the recognition, evaluation and treatment of occupational health problems. Part II covers various potentially hazardous environmental and occupational exposures including toxic metals, organic chemicals, radiation; aspects of the physical environment that can be harmful, e.g. noise, temperature and lighting. Part III covers legal aspects of the regulation and control of environmental and occupational diseases and exposures including information on the labour unions' perspective, workers' compensation, ethics in occupational medicine and the passage of legislation designed to maintain standards of occupational health and safety. New frontiers in occupational medicine are also discussed.
Little, Brown and Co., Medical Division, 34 Beacon Street, Boston, MA 02106, USA, 1983. 1015p. Illus. Over 4,000 ref. Index. Price: US$82.50.


CIS 85-109
Clayton Environmental Consultants Inc.
Medical management of chemical exposures in the petroleum industry
An introduction and description of the petroleum industry is followed by general recommendations for employee health evaluation and medical surveillance, industrial record-keeping and reporting, and data sheets for more than 90 substances which cover: physical data and properties; synonyms; degree of health hazard; exposure limits; toxicity; medical treatment and follow-up; additional comments; biological monitoring.
Publications and Distribution Dept., American Petroleum Institute, 2101 "L" Street Northwest, Washington, DC 20037, USA, 1982. 211p. Bibl. Price: US$14.75.

CIS 84-453 Meinhardt T.J., Lemen R.A., Crandall M.S., Young R.J.
Environmental epidemiologic investigation of the styrene-butadiene rubber industry - Mortality patterns with discussion of the hematopoietic and lymphatic malignancies
After 2 men had died of leukaemia at 2 styrene-butadiene rubber production plants, their cases were studied by NIOSH on the basis of records from 1943 and 1950, respectively, until 1976. There was no statistically significant excess in total or cause-specific mortality in the overall worker population of either plant. One plant showed a non-significant excess of leukaemia and aleukaemia (standardised mortality ratio (SMR) 203). A subgroup of white males with at least 6 months' employment had an SMR of 278 for these categories, also not statistically significant. Production or manufacture of styrene-butadiene rubber may be associated with an excess of lymphatic and haematopoietic neoplasms.
Scandinavian Journal of Work, Environment and Health, Dec. 1982, Vol.8, No.4, p.250-259. 13 ref.

CIS 83-17
Fire Protection Association (UK)
Uses, hazards (highly flammable liquid; fire and explosion risk; moderately toxic; breathing the vapour can cause unconsciousness); precautions (storage, marking; removal of spills; no smoking; prohibition of naked flames, use of explosion-proof electrical equipment, with reference to pertinent British Standards); fire fighting; U.K. regulations; physical and chemical properties.
Fire Prevention, May 1982, No.149, p.47-48. 6 ref.

CIS 83-184 Checkoway H., Williams T.M.
A hematology survey of workers at a styrene-butadiene synthetic rubber manufacturing plant
Personal air samples and blood specimens were obtained from 157 production workers in order to determine exposure levels for styrene, butadiene, benzene and toluene and any haematologic variations, in a population at a facility in which a previous excess of leukemia and lymphoma mortality had been found. Exposure levels for all 4 chemicals were below recommended standards. The highest mean styrene and butadiene concentrations, 13.67 and 20.03ppm respectively, were found in the tank farmer area. In all other departments the mean levels for the 4 chemicals were < 2ppm. The tank farm workers had slightly lower levels of circulating erythrocytes, haemoglobin, platelets and neutrophils, and slightly higher mean corpuscular red cell volumes and neutrophil band counts than the other workers. No pronounced evidence of haematologic abnormality was found in this group.
American Industrial Hygiene Association Journal, Mar. 1982, Vol.43, No.3, p.164-169. Illus. 40 ref.


CIS 86-1057 Basic safety rules for handling butadiene
Reglas básicas de seguridad para el manejo de butadieno en la industria [in Spanish]
This illustrated data sheet covers all the safety and health aspects related to the industrial production of butadiene. A summary in comic strip format is included.
Petróleos Mexicanos, Av. Marina Nacional No.329, Edif. A. Colonia Huasteca, México D.F., C.P.11311, Mexico, 1981. 31p. Illus. suppl.

CIS 83-2003 Al'berton N.I., Zimin S.A., Džangozina D.M., D'jačenko N.V., Poznjakova V.M., Vil'gel'm L.A., Fomenko V.P., Jakšin V.A.
Parameters of the kallikrein-kinin system in synthetic rubber workers suffering from neurocirculatory dystonia
Pokazateli kallikrein-kininovoj sistemy u bol'nyh nejrocirkuljatornoj distoniej, rabotajuščih na proizvodstve sintetičeskogo kaučuka [in Russian]
Blood levels of kallikrein were elevated and levels of kallikreinogen, kininogen and kininase were reduced (in comparison with control levels) in synthetic rubber workers who suffered from neurocirculatory dystonia as a result of exposure to alpha-methylstyrene and divinyl (butadiene); patients with neurocirculatory dystonia of psychogenic origin showed only an elevation in kallikrein and depression in kininogen. The alterations in enzyme and zymogen levels seen in the rubber workers indicate a disturbance in their liver function. A programme of therapy for these patients should include treatment with inhibitors of the kallikrein-kinin system.
Gigiena truda i professional'nye zabolevanija, Dec. 1981, No.12, p.23-26. 9 ref.

CIS 82-721 Hazardous materials section
This section provides nomenclature, physical and chemical data, computerised structural formulas and new toxicity and hazard information about abietic acid, acetic anhydride, adiponitrile, aflatoxin G1, americium, ammonium ferrocyanide, ammonium sulfate, arsenic, barium carbonate, barium chloride, barium cyanide, barium hydroxide, barium nitrate, beryllium chloride, butyl mercaptan, cadmium, chloramine-T, chlorosulfonic acid, m-cresol, 2,2'-dichloroethyl ether, 2,4-dichlorophenoxyacetic acid, diisobutyl ketone, ethylene glycol, ehtyl ether, ferbam, heptane, hexane, hydrocyanic acid, hydrofluoric acid, hydrogen peroxide, hydrogen sulfide, isodecanol, indole, iron, isoprene, isopropyl acetone, lactic acid, lead fluoborate, lithium chloride, magnesium, magnesium sulfate, malathion, maltose, m-nitrophenol, phenyl methyl ketone, beta-propiolactone, crystalline and amorphous silica.
Dangerous Properties of Industrial Materials Report, July-Aug. 1981, Vol.1, No.6, p.15-96. Illus. Bibl.


CIS 79-1967 Pullinger D.H., Crouch C.N., Dare P.R., Gaunt I.F.
Inhalation toxicity studies with 1,3-butadiene - 1. Atmosphere generation and control - 2. Three-month toxicity studies in rats.
The first article describes the preparation of methods for monitoring exposure chamber concentrations of butadiene, 4-vinyl-1-cyclohexene, t-butyl catechol and other impurities, and the development of analytical methods. The second article reports on studies in which rats were exposed to 1,3-butadiene gas at concentrations of 0, 1,000, 2,000, 4,000, and 8,000ppm for 13 weeks. There were no untoward effects except moderately increased salivation, nor were changes found on macroscopic and histopathological examination. A 2-year study with concentrations of 1,000 and 8,000ppm is in progress.
American Industrial Hygiene Association Journal, Sep. 1979, Vol.40, No.9, p.789-795; 796-802. Illus. 23 ref.

CIS 79-1392 Leleu J.
Hazardous chemical reactions - 63. Hydrocarbons
Réactions chimiques dangereuses - 63. Hydrocarbures. [in French]
Enumeration and description of possible explosive reactions of 48 hydrocarbons (saturated aliphatic, ethylenic, acetylenic, aromatic, cycloaliphatic, unsaturated cyclic and terpenic hydrocarbons) in contact with various organic and mineral substances and/or due to the effect of heat or pressure. The references used are listed for each reaction.
Cahiers de notes documentaires - Sécurité et hygiène du travail, 2nd quarter 1979, No.95, Note No.1185-95-79, p.293-305.


CIS 79-621 Lathrop J.K., Best R.
Training makes the difference.
This article describes 3 recent train derailments in the USA, all of them involving hazardous materials, and how the firefighting and safety teams dealt with the situation. The first (Lewisville, Arkansas, 28 Mar. 1978) involved a train transporting butadiene, vinyl chloride, tetrahydrofuran and propylene oxide, the second (Brownson, Nebraska, 2 Apr. 1978) involved the derailment of a tank car containing phosphorus, and the third (Nacodoches, Texas, 14 May 1978) resulted in a train (of tank cars containing acetic acid, propylene oxide, butadiene, and ethyl acrylate, and 5 cars containing synthetic rubber) overturning and igniting. Description of firefighting methods, and discussion.
Fire Command, Nov. 1978, Vol.45, No.11, p.30-34. Illus.

CIS 79-232 Engineering control technology assessment for the plastics and resins industry.
In-depth and well-indexed surveys of 15 polymerisation and compounding processes and their case summaries are reported for: major toxic chemicals and harmful physical agents; engineering controls and work practices; workplace monitoring systems and air sampling programmes; personal protective equipment; exposure data and conclusions; and planned or ongoing improvements. Flow sheets and process discussions and diagrams are given for systems dealing with polyvinyl chloride, acrylonitrile-butadiene-styrene, polystyrene, phenolic and epoxy resins, tolylene diisocyanate, and polyester resins. Problem areas are identified.
DHEW (NIOSH) Publication No.78-159, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA, Mar. 1978. 234p. Illus. 60 ref.


CIS 78-2049 Martynova A.P.
Occupational hygiene in production and processing of synthetic fibres
Gigiena truda v proizvodstve i pererabotke sintetičeskih volokon [in Russian]
Contents of this monograph: classification of synthetic fibres and manufacturing procedures (polymerisation, polycondensation); exposure of workers engaged in polymer and polycondensate production to harmful substances, and recommendations for improving working conditions (enclosure and exhaust, mechanical handling of dusty products, etc.); health engineering in fibre spinning (rim exhausts around the spinning baths, ventilation, personal protection, etc.); occupational hygiene on processing of filaments (harmful substances contained in batching oils, etc.); hazards of pyrolysis products formed during heat treatment; effect of technical processes on workers' health (toxicology of pollutants, etc.); occupational hygiene in processing of synthetic yarns and fabrics.
Izdatel'stvo "Medicina", Petroverigskij per. 6/8, Moskva, USSR, 1977. 167p. Illus. 149 ref. Price: Rbl.1.40.

CIS 78-470 L'Epée P., Lazarini H.J., Doignon J.
Acyclic and cyclic hydrocarbons
Hydrocarbures acycliques et cycliques. [in French]
Chemical classification of the acyclic and cyclic hydrocarbons; study of the health hazards of exposure to these substances, based on the above classification and on the physical state in which they are usually encountered. The following are studied: petrochemicals; saturated and unsaturated gaseous acyclic hydrocarbons; saturated gaseous cyclic hydrocarbons; liquid and solid hydrocarbons; coal and coal tar hydrocarbons (for each substances: origin, properties, uses, hazards, occupational safety and health aspects, treatment in case of poisoning).
Encyclopédie médico-chirurgicale. Intoxications - Pathologie professionnelle. Fascicule 16045 A10, 9-1977. 18 rue Séguier, 75006 Paris, France, 1977. 28p.

CIS 78-25
H63, Information sheets on hazardous materials, Fire Protection Association, London.
Details are given of uses of butadiene, hazards (flammability, toxicity, frost burns), fire fighting, precautions (storage, ambient heat, ventilation, explosion venting, enclosed systems, British standards for flameproof enclosures of electrical apparatus and light fittings, electrical apparatus for explosive atmospheres, etc.), source of further information, relevant British regulations, physical and chemical properties.
Fire Prevention, Dec. 1977, No.122, p.45-46.

CIS 77-1738 Rappaport S.M., Fraser D.A.
Air sampling and analysis in a rubber vulcanization area.
Samples were taken at the centre and the periphery of the tyre curing area. Substances identified included styrene, toluene, ethylbenzene and several oligomers of 1,3-butadiene, in concentrations of 0.007-1.1ppm. At these levels, acute and chronic health effects appear unlikely, but little information is available on the carcinogenic potential of the compounds identified.
American Industrial Hygiene Association Journal, May 1977, Vol.38, No.5, p.205-210. 41 ref.


CIS 78-1389 Soldatov I.B., Danilin V.A., Mitin Ju.V.
Occupational pathology of the upper airways in the chemical industry
Professional'naja patologija verhnih dyhatel'nyh putej v himičeskoj promyšlennosti [in Russian]
Monograph with chapters devoted to: role of changes in the upper airways in human pathology; influence, on the status of the upper airways, of harmful substances to which workers are exposed in the chemical industry; medical data concerning upper respiratory disease in chemical industry workers; methods of functional exploration of the mucosae and results of histological examinations; relations between occupational pathology of the upper airways and disease affecting other organs; morphological features of the upper airways of laboratory animals exposed to some toxic substances; health engineering, prophylaxis and therapy of occupational disease of the upper airways in the chemical industry.
Izdatel'stvo "Medicina", Petroverigskij per. 6/8, Moskva, USSR, 1976. 187p. Illus. 269 ref. Price: Rbl.1.22.

CIS 77-1623 Proceedings of NIOSH styrene-butadiene briefing.
The National Institute for Occupational Safety and Health held a briefing (Covington, Kentucky, 30 Apr. 1976) to explore with concerned persons from government, labour, management, and academic areas the implications of data on the possible linkage between exposure to styrene-butadiene and leukaemia deaths, the potential problems to be anticipated, and alternatives for action. Chemicals and working conditions in 2 Port Neches, Texas, styrene-butadiene plants were described. Reports of disease among workers included 8 leukaemia deaths in these 2 plants; a 6-fold excess of leukaemia and lymphoma deaths in an Akron, Ohio, plant; 1 death from leukaemia and 2 from Hodgkin's disease in a Louisville, Kentucky, plant; and 2 leukaemia deaths and 1 lymphoma death among 563 styrene workers in a plant in Pennsylvania. Speakers presented suggestions for epidemiologic studies, both industry-wide and in specific plants, and discussed sampling and analytical methods, engineering controls, work practices, and standards development as they relate to controlling exposures in styrene-butadiene plants.
HEW Publication No.(NIOSH)77-129, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, Ohio 45226, USA, Dec. 1976. 169p. Illus. 64 ref.


CIS 75-2041 Kryńska A., Grabowski Z.
Study of the composition of volatile products given off during moulding of polymers and copolymers of styrene
Badanie składu produktów lotnych emitowanych przy przetwórstwie polimerów i kopolimerów styrenu [in Polish]
Description of a technique for identification and determination of the products given off during injection or extrusion moulding of plastics. Based on gas chromatography, it requires a pyrolysis cell of special design. Substances identified and determined in laboratory experiments with the commonest styrene polymers and copolymers (200-300°C; heating time 0.5-5min.): styrene, ethylbenzene, benzene and toluene, acrylonitrile and hydrogen cyanide. Analysis of factory samples confirmed the emission of the substances detected by the laboratory technique, which can also be easily modified for other groups of plastics. Graphs and tables complete the description and interpretation of results.
Prace Centralnego instytutu ochrony pracy, 1974, Vol.24, No.83, p.347-362. Illus. 31 ref.

CIS 75-1399 Bokov A.N., Gus'kova S.I., Gus'kov E.P., Mas'ko V.I.
Use of anaphase studies for estimating bone-marrow chromosome aberrations in the hygienic assessment of the mutagenic effect of polymer building materials
Ispol'zovanie anafaznogo metoda učeta hromosomnyh perestroek v kostnom mozge pri gigieničeskoj ocenke mutagennogo ėffekta polimernyh stroitel'nyh materialov [in Russian]
Literature review and results of animal experiments concerning the chromosome aberrations induced by exposure to polymer-containing concretes and putties. It was found that polymer concretes which produced no chronic toxic action in animals had no cytogenic effect. Polymer putties containing unsaturated hydrocarbons, petrol, divinyl and xylene caused changes characteristic of certain toxic effects and an increase (by a factor of almost 2) in the number of chromosome aberrations as compared with a control group.
Gigiena i sanitarija, Aug. 1974, No.8, p.17-20. 6 ref.

CIS 75-450 Properties and essential information for safe handling and use of butadiene.
Physical and chemical properties and information on health hazards, fire and explosion hazards and polymerisation hazards are followed by recommendations on engineering control measures in manufacturing areas, employee education and training, personal protective equipment, fire fighting, shipping containers, labelling, handling and storage, tank and equipment cleaning and repairs, waste disposal, medical management and first aid.
Chemical Safety Data Sheet SD-55, Manfacturing Chemists' Association, 1825 Connecticut Avenue, N.W., Washington, D.C. 20009, USA, 1974. 19p.


CIS 72-2253 Širokov Ju.G.
Working conditions and health status of automobile tyre vulcanizers
K harakteristike uslovij truda i sostojanija zdorov'ja vulkanizatorščikov avtopokryšek [in Russian]
Industrial hygiene surveys in tyre-vulcanisation plants revealed, in particular, the following hazards: arduous physical work, hot micro-climate; noise; atmospheric pollution with styrene, butadiene, carbon monoxide, nitrogen oxides, etc. (a total of 50 organic compounds). Medical examination of 180 exposed workers revealed muscle, bone and joint lesions of the upper extremities (including the scapulohumeral joint), relatively frequent nervous system functional disorders, smell and balance disorders, and dystrophic disorders of the respiratory tract mucosae. The authors recommend complete mechanisation of mould insertion and extraction procedures and effective thermal insulation of vulcanisation vessels.
Gigiena truda i professional'nye zabolevanija, Jan. 1972, Vol.16, No.1, p.16-19.

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