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Gastrointestinal diseases - 143 entries found

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CIS 96-151 Burns P.B., Swanson G.M.
Stomach cancer risk among black and white men and women: The role of occupation and cigarette smoking
A telephone interview survey was carried out to determine occupational and tobacco-use histories for 739 stomach cancer cases and 3750 population controls. Cigarette smokers had a 50% increase in stomach cancer risk; risk increased with increasing levels of smoking. The majority of occupations with significant increases in stomach cancer risk were among white men and included agricultural workers, driver sales, assembly workers, mechanics and material movers. Black women assembly workers and white women food workers were also at increased risk. No association was found between dust exposure and stomach cancer.
Journal of Occupational and Environmental Medicine, Oct. 1995, Vol.37, No.10, p.1218-1223. 35 ref.

CIS 95-1411 Boulard J.C., Hanslik T., Mowlonguet Doleris L.M., Prinseau J., Baglin A.
Asbestos and idiopathic retroperitoneal fibrosis
This letter to the editor presents brief case studies of two men previously exposed to asbestos who had retroperitoneal fibrosis with evidence of pleural involvement. Since none of the usual causes of retroperitoneal fibrosis were present, it is suggested that exposure to asbestos may be a cause of this disease.
Lancet, 27 May 1995, Vol.345, No.8961, p.1379. 3 ref.

CIS 95-1009 Lagast H., Tomenson J., Stringer D.A.
Polypropylene production and colorectal cancer: A review of the epidemiological evidence
Early epidemiological studies of polypropylene production workers and carpet manufacturing employees who use polypropylene reported a significant excess of colorectal cancer. Recent updates of these two studies have found no continuation of this excess, thereby indicating that the earlier observations reflected the chance nature of a space-time cluster. Investigations of polypropylene workers in a number of countries found no association with colorectal cancer. Taken together, the epidemiological evidence and the absence of toxicological data do not support a causal association between polypropylene and colorectal cancer.
Occupational Medicine, Apr. 1995, Vol.45, No.2, p.69-74. 30 ref.


CIS 97-904 Kaleja R., Horbach L., Amsel J.
Polypropylene production workers and colorectal cancer in Germany: A brief report
A retrospective cohort study (from 1956 to 1990) of 640 male polypropylene production workers in Germany was performed to evaluate the reported association between colorectal cancer and polypropylene. The results do not support earlier reports of a link between polypropylene production and colorectal cancer, but are consistent with a number of recent investigations of polypropylene production workers that have reported no association with risk of colorectal cancer. Due to the small size of this and other similar studies, however, a small to moderate increase in risk cannot be ruled out.
Occupational and Environmental Medicine, Nov. 1994, Vol.51, No.11, p.784-785. 10 ref.

CIS 96-152 Chow W.H., McLaughlin J.K., Malker H.S.R., Weiner J.A., Ericsson J.L.E., Stone B.J., Blot W.J.
Occupation and stomach cancer in a cohort of Swedish men
Using the Swedish Cancer-Environment Registry, a population-based assessment of stomach cancer incidence by industry and occupation for men in Sweden was carried out for the years 1961 to 1979. Nearly 17,000 stomach cancer cases were diagnosed during this period. Incidence was elevated among miners and quarrymen, farmers and fishermen, and craftsmen and production workers. There was a reduced incidence among white collar workers. Examination of specific jobs revealed generally elevated rates of stomach cancer among men exposed to dusty work environments. Findings add to the evidence of a small but significant occupational role in stomach carcinogenesis.
American Journal of Industrial Medicine, 1994, Vol.26, No.4, p.511-520. 43 ref.

CIS 95-1331 Sorohan T., Faux A.M., Cooke M.A.
Mortality among a cohort of United Kingdom steel foundry workers with special reference to cancers of the stomach and lung, 1946-90
Occupational and Environmental Medicine, May 1994, Vol.51, No.5, p.316-322. 8 ref. ###

CIS 95-588 Maier H., Sennewald E.
Risk factors for developing epithelioma in parts of the head or neck
Risikofaktoren für Plattenepithelkarzinome im Kopf-Hals-Bereich [in German]
In three case-control studies conducted in the years 1988 to 1991 in Heidelberg, Germany, 369 patients with squamous-cell carcinoma of the mouth, the throat and the larynx were matched with a control group of 1,476 persons without epithelioma. For the patients and the control group the occupation, cigarette and alcohol consumption and leisure time activities were determined. Chronic tobacco and alcohol consumption were closely related with the occurrence of epithelioma in the upper digestive tract. Skilled and unskilled workers were more numerous in the patient group than in the control group. Machine operators, persons living in homes with fossil-fuel heated stoves as well as workers exposed to coal tar, pitch, dyes and paints, asbestos, coolants and sawdust were found to be at high risk. Summaries in English, French, German and Spanish.
Hauptverband der gewerblichen Berufsgenossenschaften, Abteilung Öffentlichkeitsarbeit, Alte Heerstrasse 111, 53754 Sankt Augustin, Germany, Jan.1994. 184p. Illus. 142 ref.

CIS 95-264 Polypropylene production and colorectal cancer
Polypropylene has been produced for over 35 years. It has many uses, including food packaging. Implantation of polypropylene produced sarcomas in experimental animals, apparently due to tissue trauma. The monomer, propylene, was not carcinogenic in a two-year inhalation study with mice and rats. Two early epidemiologic studies of polypropylene production workers and polypropylene carpet manufacturing workers showed an excess of colorectal cancer, but subsequent studies on these populations did not reproduce the observation, and studies on polypropylene production workers in several countries were also negative. Thus, specific medical surveillance programmes among these workers are not warranted.
European Centre for Ecotoxicology and Toxicology of Chemicals, 4 Ave. E. Van Nieuwen huyse, 1160 Bruxelles, Belgium, Feb. 1994. 40p. 108 ref.

CIS 95-177 Lewis R.J., Lerman S.E., Schnatter A.R., Hughes J.I., Vernon S.W.
Colorectal polyp incidence among polypropylene manufacturing workers
To follow up earlier findings of increased colorectal cancer and polyp risk among a group of Texas polypropylene manufacturing workers (CIS 89-1215), a second company-sponsored colorectal cancer screening program was conducted. Some 64% of the 147 male workers negative for polyps in the first screening were rescreened. Age- and examiner-adjusted incidence rate ratios (IRR) were modestly elevated for polypropylene manufacturing workers compared with patients screened in the same clinic for total and adenomatous polyps. However, risk of adenomas among the highest exposed group (IRR=1.77) was similar to risk in the least exposed group (IRR=2.02). The modest, nonsignificant excesses and the similarity in risk across job categories does not suggest an occupationally related risk, although small numbers and potential biases preclude making definitive conclusions.
Journal of Occupational Medicine, Feb. 1994, Vol.36, No.2, p.174-181. 25 ref.


CIS 94-1656 Paoletti L., Falchi M., Batisti D., Zappa M., Chellini E., Biancalani M.
Characterization of asbestos fibers in pleural tissue from 21 cases of mesothelioma
Pleural biopsies from patients with pleural mesothelioma and different kinds of asbestos exposure were analyzed by analytical electron microscopy. The aim was to investigate the presence, quantity, types, and sizes of asbestos fibres in pleural tissue. Concentration and size of fibres were poorly correlated to asbestos type and estimated exposure level. Fibre dimension is the most important characteristic determining their translocation to the pleural region. Summary in Italian.
Medicina del lavoro, Sep.-Oct. 1993, Vol.84, No.5, p.373-378. Illus. 21 ref.

CIS 94-223 Kusiak R.A., Ritchie A.C., Springer J., Muller J.
Mortality from stomach cancer in Ontario miners
A rather surprising excess mortality from stomach cancer was observed in gold miners in Ontario (Canada) in a retrospective cohort study of all miners in the province having attended compulsory chest clinics since 1928 (104 cases, SMR=152, 95% CI=125-185). Detailed exposure records and statistical analysis suggest that the probable causative agent is chromium-containing dust in gold mines, rather than, for example, arsenic or mineral fibres.
British Journal of Industrial Medicine, Feb. 1993, Vol.50, No.2, p.117-126. 28 ref.

CIS 94-308 Stayner L.T., Dannenberg A.L., Bloom T., Thun M.
Excess hepatobiliary cancer mortality among munitions workers exposed to dinitrotoluene
The association between dinitrotoluene (DNT) exposure and increased risk of cancers of the liver and biliary tract was studied through an analysis of the mortality experience of exposed workers (n=4,989) and unexposed workers (n=7,436) at a study facility between 1949 and 1980. An excess of hepatobiliary cancer was observed among workers exposed to DNT. The SMR for hepatobiliary cancer was 2.67 (six cases) based upon comparison with the US population, and 3.88 based upon comparison with controls. The study was limited by the small number of workers with long-term DNT exposure, and by the lack of quantitative information on exposure to DNT and other chemicals. Nonetheless, the excess in hepatobiliary cancer mortality observed among DNT-exposed workers in this study is similar to findings from animal studies.
Journal of Occupational Medicine, Mar. 1993, Vol.35, No.3, p.291-296. 16 ref.

CIS 93-1889 Mastrangelo G., Serena R., Marzia V.
Mortality from tumours in workers in an acrylic fibre factory
A retrospective epidemiological cohort study of mortality was undertaken in 671 workers with at least 12 months' exposure to acrylonitrile (AN) in an acrylic fibre factory at Porto Marghera, Venezia; 571 subjects had simultaneous exposure to dimethylacetamide (DMA). Observed mortality in the cohort was compared with expected mortality, calculated on the basis of the mortality rates of the general population in the Veneto region. A statistically significant excess was found in the mortality rate from intestinal and colon tumours (SMR=10.5, 4 observed). However, this finding was significant only in subgroups with 1 to 4 years exposure or 1 to 9 years latency. It is therefore concluded that there is no relationship between AN and/or DMA exposure and mortality from tumours of the colon and intestine.
Occupational Medicine, Aug. 1993, Vol.43, No.3. p.155-158. 15 ref.


CIS 94-944 Lehnert G., Raithel H.J., Valentin H.
Asbestos exposure, asbestosis, and lung cancer
Asbestfeinstaubexposition, Asbestose und Lungenkrebs [in German]
The connection between asbestos exposure, asbestosis and pleural or peritoneal mesothelioma has been well established by epidemiological studies. On the other hand, it is still unclear whether asbestos-exposed persons without asbestosis are also at a higher risk of developing mesothelioma. In order to answer this question, the international literature of the past ten years is reviewed. No evidence is found in support of an asbestos-related lung cancer without asbestosis or asbestos-induced lesions of the pleura. It is recommended that this kind of lung cancer not be included in the German list of occupational diseases.
Arbeitsmedizin - Sozialmedizin - Präventivmedizin, Mar. 1992, Vol.27, No.3, p.96-101. Illus. 28 ref.

CIS 94-191 Fleming L.E.
Unusual occupational gastrointestinal and hepatic disorders
This review investigates associations between workplace exposures and the following noncancerous liver and gastrointestinal diseases: steatosis, increased liver microsomal activity, cholestatic liver injury, hepatoportal sclerosis and noncirrhotic portal hypertension, granulomatous liver disease, porphyria cutanea tarda, peptic ulcer disease, pancreatitis, gastroenteritis, coeliac disease and pneumatosis cystoides intestinalis.
Occupational Medicine: State of the Art Reviews, July-Sep. 1992. Vol.7, No.3, p.433-448. 162 ref.

CIS 93-1677 Garberg P., Högberg J.
Nordic Expert Group for the Documentation of Exposure Limits. 103. Selenium
Nordiska Expertgruppen för Gränsvärdesdokumentation. 103. Selen [in Swedish]
Review and evaluation of the relevant literature. Selenium is encountered in copper refining (where it is recovered as a by-product), in the electronics, glass and rubber industries and in medicine. Selenium acid is toxic, and may enter the body through the skin and respiratory tract. Exposure may occur incase of accidental spills. Hydrogen selenide is more likely to be encountered under normal conditions (metallurgy), and is toxic on inhalation. Short-term exposure via the diet affects primarily the gastrointestinal tract, while chronic exposure produces nail malformations. Some selenium compounds induce skin allergies. Selenium sulfide is a carcinogen at high doses in rats and mice.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1992. 26p. 104 ref.

CIS 93-829 Owen C.V., Acquavella J.A., Lynch J., Bird M.G.
An industrial hygiene methodology developed in support of a retrospective morbidity case-control study
This study investigated a potentially increased incidence of colorectal cancer among employees who manufactured polypropylene. The design of the case-control study provided an innovative industrial hygiene approach to circumvent the problems of estimating exposures, problems which are typical of retrospective epidemiological case-control studies. The industrial hygiene methodology included assessing historical exposures, developing an exposure estimating matrix, selecting candidate aetiological agents based on a joint toxicological and industrial hygiene review, administering a work activity questionnaire, calculating exposure scores, and conducting a statistical analysis. The study design also provided an additional exposure measurement independent of the toxicological and industrial hygiene review. This provided an opportunity to compare the likelihood of exposure misclassification and, as expected, showed that a more detailed exposure estimate resulted in less misclassification.
American Industrial Hygiene Association Journal, Sep. 1992, Vol.53, No.9, p.540-547. 29 ref.

CIS 93-865 Roscoe R.J., Steenland K., McCammon C.S., Schober S.E., Robinson C.F., Halperin W.E., Fingerhut M.A.
Colon and stomach cancer mortality among automotive wood model makers
To explore the excess risks for colon and other cancers among automotive wood model makers, a retrospective cohort mortality study was conducted, with follow-up from 1940 through 1984. White male wood model makers (n=2,294) employed at any time until 1980 by US automobile manufacturers were studied. Using US mortality rates for comparison, elevated standardised mortality ratios of 1.2 (95% confidence interval (CI), 0.8-1.9) for colon cancer and 1.6 (95% CI, 0.9-2.6) for stomach cancer were found. Nested case-control studies were also conducted for 20 colon and 17 stomach cancer cases and 543 age-matched controls. No trend was found of increased risk for colon or stomach cancer mortality with increased exposure to wood dust or to duration employed in wood model making. A two-page editorial on the same subject follows the article.
Journal of Occupational Medicine, Aug. 1992, Vol.34, No.8, p.759-768 (editorial: p.769-770). 38 + 4 ref.

CIS 93-498 Berger J., Manz A.
Cancer of the stomach and the colon-rectum among workers in a coke gas plant
4,908 male workers of the Hamburg (Germany) gas plant, employed for 10 or more years during the period 1 January 1900 to 31 December 1989, were traced for cancer mortality. Based on their jobs, they were grouped into three subcohorts: gas furnace workers, workers in other parts of the plant, and white-collar workers. Despite the general "healthy worker effect", gas furnace workers showed a significant incidence of cancer of all sites (standardised mortality ratio (SMR) = 186), particularly cancers of the lung (SMR=288), stomach (SMR=177), and the colon-rectum (SMR=184). In comparison with the death rates of white-collar workers, the manual workers in other parts of the plant also showed an excess of cancer mortality for cancer of these sites. The reason for this excess seems to be due to working conditions. The results contribute to the current evidence that exposure to coal carbonisation fumes causes not only lung cancer, but also cancers of the stomach and colon-rectum.
American Journal of Industrial Medicine, Dec. 1992, Vol.22, No.6, p.825-834. 26 ref.

CIS 93-490 Gerhardsson de Verdier M., Plato N., Steineck G., Peters J.M.
Occupational exposures and cancer of the colon and rectum
The association between occupational risks and colorectal cancer was examined in a Swedish population-based, case-referent study. The study was performed in Stockholm in 1986-1988 and included 569 cases and 512 referents. Relative risks (RRs) with 95% confidence intervals were calculated for different occupations/chemicals. Elevated risks of colon cancer were found among male petrol station/automobile repair workers (RR=2.3, 0.8-6.6) and among males exposed to asbestos (RR=1.8, 0.9-3.6), while elevated risks of rectal cancer were found among males exposed to soot (RR=2.2, 1.1-4.3), asbestos (RR=2.2, 1.0-4.7), cutting fluids/oils (RR=2.1, 1.1-4.0), and combustion gases from coal/coke/wood (RR=1.9, 1.0-3.7). However, due to a high correlation between the above-mentioned variables and the few exposed subjects, it is difficult to separate their effects properly. Further studies are recommended.
American Journal of Industrial Medicine, Sep. 1992, Vol.22, No.3, p.291-303. 40 ref.


CIS 93-1571 Beaumont J.J., Chu G.S.T., Jones J.R., Schenker M.B., Singleton J.A., Piantanida L.G., Reiterman M.
An epidemiologic study of cancer and other causes of mortality in San Francisco firefighters
To test the hypothesis that firefighter exposures may increase cancer risk, mortality rates were calculated for 3,066 San Francisco Fire Department firefighters employed between 1940 and 1970. Vital status was ascertained through 1982, and observed and expected rates, rate ratios (RR), and 95% confidence intervals (CI) were computed using United States death rates for comparison. The total number deceased (1,186) was less than expected and there were fewer cancer deaths than expected. However, there were significant excess numbers of deaths from oesophageal cancer (12 observed, 6 expected), cirrhosis and other liver diseases (59 observed, 26 expected), and accidental falls (21 observed, 11 expected). There were 24 line-of-duty deaths, which were primarily due to vehicular injury, falls, and asphyxiation. Heart disease and respiratory disease deaths occurred significantly less often than expected. It was concluded that the increased risks of death from oesophageal cancer and cirrhosis and other liver diseases may have been due to firefighter exposures, alcohol consumption, or interaction between alcohol and exposures. Because this was an older cohort and firefighter exposures have changed due to the increasing use of synthetic materials, it is recommended that the effects of modern-day exposures be further studied.
American Journal of Industrial Medicine, Mar. 1991, Vol.19, No.3, p.357-372. Illus. 61 ref.

CIS 93-484 Acquavella J.F., Owen C.V., Bird M.G., Yarborough C.M., Lynch J.
An adenomatous polyp case-control study to assess occupational risk factors following a workplace colorectal cancer cluster
To assess potential aetiological factors among a population of polypropylene workers previously found to have an excess of colorectal cancer, an adenomatous polyp case-control study was conducted. Cases (24) were workers found to have adenomatous polyps during a screening program, while controls (72) were workers found to be free of polyps. Exposure assessment utilised a thorough industrial hygiene and toxicologic review of operations in conjunction with work activity interviews of cases and controls to develop chemical-specific exposure scores weighted by time, exposure level, and frequency of exposure. Cases tended to have higher exposure to pre-extrusion polymer plus additives (odds ratio (OR)=2.6, 90% confidence interval (CI) 1.1-6.3) and higher exposure to certain finishing additives (OR=4.8, 90% CI 1.5-15.3). Analyses by job category or area of the plant did not indicate additional risk factors.
American Journal of Epidemiology, 15 Feb. 1991, Vol.133, No.4, p.357-367. 27 ref.

CIS 93-146 Robins T.G., Weinstein R.J., Demers R.Y.
Lymphocytopenia, T-lymphocyte subsets, and colorectal polyps in automotive pattern and model makers
The association of total lymphocyte, CD4 (T-helper cell), CD8 (T-suppressor cell), CD2 (total T-cell), and CD16 (natural killer cell) counts with biopsy-proved colorectal polyp status was investigated in 70 pattern makers. In logistic regression analyses after adjusting for age or trade years, pack-years smoked, and material worked with most frequently, a history of any type of polyp was significantly associated with total lymphocyte count (odds ratio of 2.01 for a 500 cell/cc decrease, p=0.03), and somewhat associated with decreased CD4 and CD2 counts (p values of 0.06 and 0.07, respectively). In linear regression models adjusted for age, pattern and model makers had (regardless of polyp status) significantly lower CD4, CD8, CD2, and CD16 counts than did laboratory reference controls (p value less than 0.01 for each comparison). The findings appear consistent with a sequence of carcinogenesis initiated by workplace exposure of pattern and model makers that depresses immune surveillance and therefore promotes the development of colorectal polyps as a precursor of carcinoma.
Journal of Occupational Medicine, Apr. 1991, Vol.33, No.4, p.510-515. 26 ref.

CIS 92-1974 Sherman J.D.
Polybrominated biphenyl exposure and human cancer - Report of a case and public health implications
This is a case report of a dairyman who was exposed to polybrominated biphenyls (PBBs) through contaminated animal feed. Signs and symptoms characteristic of PBB exposure lasted several years, culminating in stomach cancer. No epidemiological studies of PBB and cancer are available, but structure-activity relationships and animal studies are predictive of malignancy. The patient did not have the risk factors of alcoholism or cigarette smoking.
Toxicology and Industrial Health, 1991, Vol.7, No.3, p.197-205. 54 ref.

CIS 92-1556 González C.A., Sanz M., Marcos G., Pita S., Brullet E., Vida F., Agudo A., Hsieh C.C.
Occupation and gastric cancer in Spain
The association between occupational exposure and stomach cancer was investigated in a multicentre case-referent study conducted in Spain on 354 histologically confirmed cases and 354 hospital referents, matched by age, sex, and residence. An increased risk of gastric cancer was found for coal mining workers [odds ratio (OR) 11.8]. An increased risk was observed for wood and furniture workers (OR 1.76), construction workers (OR 1.68), and glass and ceramic workers (OR 2.18), but none of these risks was statistically significant. An increased risk was also found for occupations associated with exposure to silica and mineral dust (OR 1.80, 95% confidence interval 0.90-3.59). All of the OR estimates were adjusted for the confounding factors socioprofessional status and dietary habits. The possibility of a causal association between stomach cancer and coal and mineral dust is supported by the results.
Scandinavian Journal of Work, Environment and Health, Aug. 1991, Vol.17, No.4, p.240-247. 41 ref.

CIS 92-1251 Walker A.M., Cohen A.J., Loughlin J.E., Rothman K.J., DeFonso L.R.
Mortality from cancer of the colon or rectum among workers exposed to ethyl acrylate and methyl methacrylate
Mortality from colon and rectum cancer was reviewed in three cohorts working in 1933-1982 in two plants manufacturing and polymerising acrylate monomers. The two cohorts with more recent dates of employment showed no excess mortality. In the earliest cohort, excess colon cancer seemed restricted to men employed extensively in the early 1940s in jobs entailing the highest exposures to vapour-phase ethyl acrylate (EA) and methyl methacrylate (MMA) monomer and volatile by-products of the EA/MMA polymerisation process. The excess mortality appeared only some two decades after the equivalent of three years' employment in jobs with the most intense exposures. A smaller elevation in colon cancer mortality also appeared in a low-exposure group in the early cohort. Rectal cancer mortality was elevated in the same categories that showed excess rates of colon cancer death. Because of the lower rates, the rectal cancer results are more imprecise.
Scandinavian Journal of Work, Environment and Health, Feb. 1991, Vol.17, No.1, p.7-19. 2 ref.

CIS 92-1028 Seuri M.
Risk of appendicectomy in occupations entailing contact with pigs
A questionnaire survey among pig farmers, abattoir workers, and farmers not exposed to pigs was conducted to determine the prevalence of appendicitis in these occupations. The author concludes the biological basis of an increased risk of appendicitis in occupations entailing close contact with pigs might be explained by Yersinia bacteria whose presence is common in pigs.
British Medical Journal, 10 Aug.1991, Vol.303, No.6798, p.345-346. 5 ref.

CIS 92-484 James M., Green R.
Airline pilot incapacitation survey
A worldwide questionnaire survey was carried out to investigate the aetiology of inflight incapacitation on commercial flight decks. Results indicated that 29% of the 4345 respondents had been incapacitated at least once. Gastro-intestinal symptoms accounted for the majority of the incidents, other main causes being symptoms of nasal and sinus congestion, headaches and faintness or general weakness. Of those who had experienced an incident of incapacitation, 48% claimed that safety was actually or potentially affected. However, when all respondents were asked about safety in the event of incapacitation, only 25% expressed concern.
Aviation, Space, and Environmental Medicine, Nov. 1991, Vol.62, No.11, p.1068-1072. 2 ref.

CIS 92-459 Ehrlich A., Gordon R.E., Dikman S.H.
Carcinoma of the colon in asbestos-exposed workers - Analysis of asbestos content in colon tissue
The present study evaluates the colon tissue asbestos burden, by light and electron microscopic analytical techniques, in patients with a history of occupational asbestos exposure and colon cancer. Asbestos fibres and/or asbestos bodies were present in colon tissue from 14 of 44 (31.8%) asbestos workers with colon carcinoma (range 0.14-15.2 million fibres/g/wet weight, mean 2.5 million). Chrysotile was identified in 9 patients and amosite in 3 patients. Other forms of asbestos (e.g., crocidolite, tremolite, or anthophyllite) were not found. Asbestos fibres and asbestos bodies were not found in colon tissue from 20 control patients (colon carcinoma and no asbestos exposure). Asbestos fibres frequently enter and reside in the wall of the colon and are often intimately associated with tumour tissue at the site of colon carcinoma in workers with asbestos exposure and colon carcinoma.
American Journal of Industrial Medicine, May 1991, Vol.19, No.5, p.629-636. Illus. 19 ref.

CIS 92-120 Suzuki Y., Kohyama N.
Translocation of inhaled asbestos fibers from the lung to other tissues
To investigate the translocation of asbestos fibres, tissue samples from 13 North American insulation workers were examined, using electron microscopy. Of the 2 major types of asbestos, chrysotile and amosite, chrysotile was much more active in the translocation than amosite, being the fibre mainly detected in mesotheliomas and hyaline plaques.
American Journal of Industrial Medicine, June 1991, Vol.19, No.6, p.701-704. 5 ref.

CIS 91-1534 Ribak J., Lilis R., Suzuki Y., Penner L., Selikoff I.J.
Death certificate categorisation of malignant pleural and peritoneal mesothelioma in a cohort of asbestos insulation workers
Accuracy of diagnosis of malignant mesothelioma (pleural and peritoneal) was studied in a cohort of asbestos insulation workers in the United States and Canada. Initial clinical diagnosis, clinical diagnosis at death and death certificate diagnosis were compared with the diagnosis of malignant mesothelioma ascertained by full data review at the Division of Environmental and Occupational Medicine, Mount Sinai Medical Center, New York. In both groups the death certificate diagnosis was somewhat less frequently accurate than clinical diagnosis at death. Knowledge of the patients' occupational history by the attending physician and its relation to accuracy of diagnosis of malignant mesothelioma is considered.
Journal of the Society of Occupational Medicine, Autumn 1991, Vol.41, No.3, p.137-139. 12 ref.


CIS 92-1930 Rafnsson V., Gunnarsdóttir H.
Mortality study of fertiliser manufacturers in Iceland
A retrospective cohort study was carried out on workers in a fertiliser plant to assess the risk of stomach and lung cancer. The cohort comprised 603 subjects and their death rates were compared with those of the general male population in Iceland. The study period was 1954 to 1985. The results do not provide evidence of an excess of deaths from stomach or lung cancer. Total mortality was lower than expected and even lower when the analysis was restricted to those who had worked at the plant for more than one year. Shiftwork operators had the highest SMRs for all cancers, however, with a reverse dose response according to duration of employment, indicating that this might be due to factors unrelated to manufacture of fertilisers. As examples of these factors life style and social class may be implicated, as well as possible selection of weaker subjects to do this assumed easy work.
British Journal of Industrial Medicine, Nov. 1990, Vol.47, No.11, p.721-725. 33 ref.

CIS 91-1552 Ebihara I., Shinokawa E., Kawami M., Kurosawa T.
Cohort mortality study of stone masons
Ishiku no "cohort" kenkyū [in Japanese]
A study of mortality experience was conducted among stone masons in the Tokyo area and cause-specific comparisons were made with the general Japanese male population. A higher total mortality was observed among stone masons. The increase in mortality was due firstly to malignant neoplasms, especially of the respiratory system and stomach, secondly to pneumoconiosis and its complications and to tuberculosis. The observed 2.7-fold increase in lung cancer was not attributed to the effects of age, smoking, radioactivity (such as radon daughters) or polycyclic aromatic hydrocarbons. Dust exposure per se probably contributes to the development of lung cancer, and smoking is a contributory factor towards the disease.
Journal of Science of Labour - Rōdō Kagaku, 10 Oct. 1990, Vol.66, No.10, p.451-458. 57 ref.

CIS 90-1577 Tilley B.C., Johnson C.C., Schultz L.R., Buffler P.A., Joseph C.L.M.
Risk of colorectal cancer among automotive pattern and model makers
This paper reports the investigation of a cohort of 7545 General Motors pattern and model makers originally defined for the purpose of cancer screening. All-cause mortality for this cohort was lower than that of the US population. There were 22 colon cancer deaths v 10.9 expected, consistent with previous studies.
Journal of Occupational Medicine, June 1990, Vol.32, No.6, p.541-546. 12 ref.

CIS 90-1293 Acquavella J.F., Owen C.V.
Assessment of colorectal cancer incidence among polypropylene pilot plant employees
The purpose of this investigation was to determine whether colorectal cancer incidence was elevated among pilot plant workers who may have had exposures similar to those experienced on a commercial production unit. The study population included 183 employees who worked at least 6 months on either of 2 pilot plants. Overall, there were 3 observed colorectal cases versus 3.3 expected. Analysis for the process, mechanic, and laboratory subgroup showed rates consistent with expected values (3 observed, 2.8 expected). Analysis by duration of employment and latency did not show patterns consistent with the colorectal cancer excess previously reported. The likelihood of lower or different exposures on the pilot plant than would be found on commercial production units is discussed along with the need for studies of workers in other polypropylene manufacturing environments.
Journal of Occupational Medicine, Feb. 1990, Vol.32, No.2, p.127-130. 5 ref.


CIS 90-1903 De Klerk N.H., Armstrong B.K., Musk A.W., Hobbs M.S.T.
Predictions of future cases of asbestos-related disease among former miners and millers of crocidolite in Western Australia
In a cohort of 6,502 male and 410 female former workers from the crocidolite (blue asbestos) mining and milling works at Wittenoom, Western Australia, there were 94 cases of malignant mesothelioma, 141 cases of lung cancer and 356 successful compensation claims for asbestosis to the end of 1986. Using various statistical techniques, predictions were made on the future incidence of these diseases to the year 2020. The number of new cases of mesothelioma is expected to rise to a peak of around 25 cases per year in 2010, with an expected total number of 692 cases of mesothelioma (95% confidence interval (CI), 394-990 cases) between 1987 and 2020. A total of 2,898 deaths (95% CI, 2,284-3,511 deaths) of any cause is expected in the same period. New cases of lung cancer and asbestosis are expected to continue at roughly the current rates of 8 and 17 cases per year, respectively, before declining after the year 2000, leading to totals of 183 cases (95% CI, 34-335 cases) and 482 cases (95% CI, 236-728 cases), respectively, being expected by the year 2020.
Medical Journal of Australia, 4/18 Dec. 1989, Vol.151, No.11/12, p.616-620. Illus. 25 ref.

CIS 90-1283 Sasagawa M.
Agricultural chemicals in cholesterol gallstones - with special reference to an epidemiological study on cancer of the biliary tract
Tanno koresterōru kessekichū no zanryū nōyaku bunseki - tokuni tandōgan no ekigakuteki shiten kara [in Japanese]
Niigata prefecture (Japan) has a very high mortality rate from biliary tract cancer. There is a correlation between the standardised mortality ratio (SMR) for biliary tract cancer and the amount of certain agricultural chemicals consumed. Agricultural chemicals were detected in cholesterol gallstones of 99 patients, including 11 patients with gallbladder cancer. DLD, pp'-DDT, β-BHC and PCB were detected in the gallstones, even though the epidemiological study showed no positive correlation between them and the SMR for biliary tract cancer. MCPA, MCPB, CNP and simetryn, which did show significant correlations with the SMR, were not detected. Further investigation of the biliary excretion of the metabolites of these chemicals is indicated.
Niigata Medical Journal, Feb. 1989, Vol.103, No. 2, p.104-111. Illus. 22 ref.

CIS 90-1021 Ho M.S., Glass R.I., Monroe S.S., Madore H.P., Stine S., Pinsky P.F., Cubitt D., Ashley C., Caul E.O.
Viral gastroenteritis aboard a cruise ship
237 passengers (22%) and 28 crew members (3%) on a cruise ship were infected with viral gastroenteritis (vomiting and/or diarrhoea, abdominal cramps, headache, myalgia, fever) on a transatlantic crossing. Epidemiological findings indicate that vomitus was an important factor in the transmission of the disease, and therefore strategies for prevention of the disease should include protection against environmental contamination by viruses in airborne droplets or vomitus.
Lancet, 21 Oct. 1989, Vol.2, No.8669, p.961-965. Illus. 33 ref.

CIS 90-233 Acquavella J.F., Douglass T.S., Vernon S., Hughes J.I., Thar W.E.
Assessment of colorectal cancer screening outcomes among workers involved in polypropylene manufacture
Evaluation of polyp prevalence rates for POU (Polyolefin unit) workers of Exxon Corporation versus rates for non-Exxon employees screened at the same clinic showed a general pattern of elevated rates for POU employees, especially for mechanical and process workers. This pattern was mot marked for polyps at least 0.5cm in diameter, but findings were less clear for adenomatous polyps. The effect of factors that might bias evaluation of colorectal polyp prevalence rates is discussed, but none of these factors seemed a likely explanation for the findings observed in this study.
Journal of Occupational Medicine, Sep. 1989, Vol.31, No.9, p.785-791. 16 ref.


CIS 91-544 Park R.M., Wegman D.H., Silverstein M.A., Maizlish N.A., Mirer F.E.
Causes of death among workers in a bearing manufacturing plant
Recent studies identify digestive cancer excesses among workers exposed to cutting fluids, abrasive dusts, and oil smoke. Standardised proportional mortality and mortality odds ratio studies were carried out for a ball bearing plant. Cause of death and work histories were obtained for 702 of 768 hourly employees with 10 or more years' service who died between 1969-82. The major findings were significant excesses in proportional mortality ratios (PMR) from stomach cancer (PMR = 2.0) and rectal cancer (PMR = 3.1) among white men. There was a significant association between stomach cancer and precision grinding exposures, consisting primarily of direct contact with water-based cutting fluids and their aerosols. The pattern of stomach cancer is consistent with previous findings and suggests an association with the soluble oil cutting fluids.
American Journal of Industrial Medicine, May 1988, Vol.13, No.5, p.569-580. Bibl.ref.

CIS 91-199 Teichman R.F., Fallon L.F., Brandt-Rauf P.W.
Health effects on workers in the pharmaceutical industry: a review
Until now little has been published about the known or suspected health risks of people employed in the manufacture and formulation of pharmaceutical products. Physicians are the only segment of the health care industry that have been studied extensively. Although pharmaceutical workers experience a potential risk from carcinogenic agents, the evidence for or against a real threat to their health remains both meagre and speculative. This paper reviews the available literature concerning occupational exposure to pharmaceutical agents.
Journal of the Society of Occupational Medicine, Autumn 1988, Vol.38, No.3, p.55-57. 19 ref.

CIS 89-1877 Gustavsson P., Gustavsson A., Hogstedt C.
Excess of cancer in Swedish chimney sweeps
The incidence of cancer was investigated among 5,266 Swedish chimney sweeps employed between 1918-80. An analysis of the mortality showed an increased number of deaths from coronary heart disease, respiratory diseases, liver cancer, and excessed risks for cancer of the lung and oesophagus. In addition, a more than doubled risk for bladder cancer and an increase of malignancies of the haematopoietic system was found. There were, however, no cases of scrotal cancer, the classic occupational hazard among chimney sweeps. Chimney sweeps are exposed to polycyclic aromatic hydrocarbons generated by the combustion of organic material (coal, wood, coke, and oil). They are also exposed to cancerogenic metals (arsenic, nickel, and chromium). These results support the need for improved working conditions.
British Journal of Industrial Medicine, Nov. 1988, Vol.45, No.11, p.777-781. 21 ref.

CIS 89-1215 Acquavella J.F., Douglass T.S., Phillips S.C.
Evaluation of excess colorectal cancer incidence among workers involved in the manufacture of polypropylene
In response to reports of an unusually high number of colorectal cancers among employees on a unit devoted to the manufacture of polypropylene, colorectal cancer incidence rates were examined for 335 workers with at least 6 months employment on this unit from 1960 to 1985. Assuming a 10-year latent period, a significant 5 to 6-fold colorectal cancer excess (7 observed/1.26 expected), concentrated among mechanical (5 observed/0.47 expected) and process workers (2 observed/0.40 expected) was found. No colorectal cancer was found among administrative/office personnel on the study roster. All of the cancers occurred in employees who initially worked on the unit during its first 6yrs of operation, and the minimum interval from start of employment to cancer development was 20yrs. Since this study was descriptive in nature, it was not possible to evaluate whether the cancer excess was related to occupational exposures, other environmental factors, or "chance".
Journal of Occupational Medicine, May 1988, Vol.30, No.5, p.438-442. 17 ref.

CIS 89-1022 Reid J.A., White D.G., Caul E.O., Palmer S.R.
Role of infected foold handler in hotel outbreak of Norwalk-like viral gastroenteritis: Implications for control
Investigation of an outbreak of viral (Norwalk-like) gastroenteritis amongst staff (40 cases), resident guests (over 70 cases), and persons attending functions (54 cases) at one hotel over 8 days suggested that the main vehicle of infection was cold foods prepared by a food handler during and after a mild gastrointestinal illness. He was excreting Norwalk-like virus particles 48 hours after the illness. In addition, ill kitchen staff vomited in the kitchen area and may have contaminated surfaces and stored foods. It is recommended that food handlers should be regarded as potentially infectious until at least 48 hours after clinical recovery from viral gastroenteritis. Stored foods that may have been contaminated should be immediately discarded and areas of the work place which may have been affected should be identified and decontaminated.
Lancet, 6 Aug. 1988, Vol.2, No.8606, p.321-323. 17 ref.

CIS 89-561 Edelman D.A.
Exposure to asbestos and the risk of gastrointestinal cancer: A reassessment
The notion that asbestos workers have a higher risk of gastrointestinal cancer has persisted since 1964 despite several studies that have found no increased risk. The risks of gastrointestinal cancer to workers exposed to asbestos were reassessed, based on the results of published studies on 32 independent cohorts of asbestos workers. No consistent evidence was found to indicate that exposure to asbestos increases the risk of gastrointestinal cancer. Generally, the higher SMRs came from studies conducted in the United States or Canada and might reflect factors not related to exposure to asbestos. In studies in which asbestos exposed and non-asbestos exposed workers were evaluated the SMRs were not consistently higher for the group exposed to asbestos. There was no apparent dose response relation between accumulated asbestos dose and the risk of gastrointestinal cancer.
British Journal of Industrial Medicine, Feb. 1988, Vol.45, No.2, p.75-82. Illus. 44 ref.


CIS 89-817 Finkelstein M., Liss G.M., Krammer F., Kusiak R.A.
Mortality among workers receiving compensation awards for silicosis in Ontario 1940-85
The mortality experience of 1,190 miners and 289 surface industry workers receiving workers' compensation awards for silicosis in Ontario since 1940 was studied up to mid-1985. Both groups were found to have a significantly increased mortality from lung cancer (miners' SMR: 230; surface workers' SMR: 302) and stomach cancer (miners' SMR: 188; surface workers' SMR: 366). Adjustment for smoking and country of origin did not explain the excesses observed. The lung cancer findings are consistent with observations from silicosis registries in Europe. Possible explanatory factors are discussed.
British Journal of Industrial Medicine, Sep. 1987, Vol.44, No.9, p.588-594. 25 ref.

CIS 88-1890 Yamada Y., Kido T., Ishizaki M., Yamaya H., Honda R., Tsuritani I., Nogawa K.
Evaluation of an x-ray mass screening programme for gastric cancer in an occupational population: Effects and problems
Shokuba ni okeru i shūdan kenshin no hyōka - sono kōka to mondai ten [in Japanese]
X-ray screening of workers above 35 years of age for gastric cancer has been conducted annually in a metal-products factory in Toyama Prefecture, Japan, since 1980. The standardised mortality ratio (SMR) for gastric cancer of male workers during the period from 1980 to 1984 was 35 in comparison with the prefectural population, whereas the SMR of the workers had been 147 during the period from 1975 to 1979. Nine cases of gastric cancer were found in x-ray examinations from April 1980 to December 1986, but 4 cases of gastric cancer were missed during the same period. Endoscopic examination was done in 85% of the workers who visited large hospitals for closer examination, but it was done only in 18% of the workers who visited small clinics.
Hokuriku Journal of Public Health - Hokuriku Koshu Eisei Gakkaishi, Aug. 1987, Vol.14, No.1, p.47-53. Illus. 19 ref.

CIS 88-1910 Swaen G.M.H., Aerdts C.W.H.M., Slangen J.J.M.
Gastric cancer in coalminers: Final report
A matched case-control study was conducted to investigate the risk of gastric cancer in coalminers in the southern part of Limburg (Netherlands). All 683 histologically confirmed cases of gastric cancer in males were identified at the 5 pathology departments in the area. For each case a control patient, free of gastric cancer, was selected matched by date of birth. Of the 1,366 patients enrolled in the study, an occupational history was collected regarding previous employment in a Dutch coal mine. Of the patients with gastric cancer, 28% had been employed as underground workers in a coalmine compared with 25% of the control group. The odds ratio for underground coalmining and gastric cancer was 1.15 (95% confidence limits: 0.89-1.47). The study did not provide support for the hypothesis that underground coalmining increases the risk of gastric cancer.
British Journal of Industrial Medicine, Nov. 1987, Vol.44, No.11, p.777-779. 21 ref.

CIS 88-1205 Jeyaratnam J., Lee J., Lee H.P., Phoon W.O.
Stomach cancer incidence in a cohort of fishermen in Singapore
A retrospective cohort study of 279 Chinese fishermen in Singapore was undertaken to examine the possibiity of an elevated incidence of stomach cancer. The fishermen as a group had a greater than twofold excess in stomach cancer relative to controls but the difference was not statistically significant. Four stomach cancer cases were observed among the subgroup of divers. The standardised incidence ratio for the divers was 4.3. There was no evidence of an increased risk for cancer of any other site (lung, nasopharynx and liver) in this cohort. Dietary factors are suggested as a possible explanation for the increased risk for stomach cancer among fishermen, but larger studies are required to test this hypothesis.
Scandinavian Journal of Work, Environment and Health, Dec. 1987, Vol.13, No.6, p.524-526. 25 ref.

CIS 88-867 Sánchez Añon A.
Gastroduodenal diseases in hospital workers
Las enfermedades gastroduodenales en los trabajadores del hospital/Las enfermedades gastroduodenales en los trabajadores del hospital [in Spanish]
In this article, the incidence of work-related gastroduodenal diseases in workers at a hospital in Valenica, Spain, is examined. The causes of the diseases are analysed (toxic factors, working periods, responsibility etc.) and the presence of gastroduodenal ulcer, gastritis and hiatus hernia is quantified. The cases are compared according to age, sex, professional category, blood group and working hours.
Medicina y seguridad del trabajo, Jan.-Mar. 1987, Vol.34, No.134, p.42-54. 13 ref.

CIS 88-501 Brandt-Rauf P.W., Fallon L.F.
Ampullary cancer in chemical workers
Although a relatively uncommon neoplasm, cancer of the ampulla of Vater accounts for over 300 deaths a year in the USA. Among biliary tract tumours, ampullary cancer has a relatively favourable prognosis. An examination of mortality statistics for chemical workers showed 11 cases of this cancer, instead of the < 5 expected, giving a statistically significant (p = 0.011) proportional mortality ratio (PMR) of 228.
British Journal of Industrial Medicine, Aug. 1987, Vol.44, No.8, p.569-570. 5 ref.

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