Allergies - 908 entries found

Your search criteria are

• Allergies

2005

CIS 06-1350 Elliott L., Heederick D., Marshall S., Peden D., Loomis D.
Incidence of allergy and allergy symptoms among workers exposed to laboratory animals
In this study on the relation between exposure to laboratory animals and laboratory animal allergy (LAA), data were obtained by questionnaires and serological tests from a cohort of workers exposed to laboratory animals at a pharmaceutical manufacturing company during a 12-year period. Poisson regression was used to model the incidence rate ratios of LAA at different levels of exposure. Higher incidence rate ratios were seen with increasing reported hours carrying out tasks involving working with animal cages or with many animals at one time. The most common symptoms were related to rhinitis rather than to asthma. This study suggests that the risk of LAA increases with duration of exposure to animals and work in animal related tasks. Incidence might be reduced by limiting hours per week of exposure to laboratory animals.
Occupational and Environmental Medicine, Nov. 2005, Vol.62, No.11, p.766-771. Illus. 19 ref.

CIS 06-902 Khader Y., Abu-Zaghlan M., Abu-Al Rish I., Burgan S., Amarin Z.
Self-reported allergy to latex gloves among health care workers in Jordan
The objective of this cross-sectional study was to determine the prevalence of natural rubber latex allergy and its associated factors among 500 health care workers using natural rubber gloves. Of the 420 subjects who responded to a self-administered questionnaire, 57 (13.6%) reported an allergy to latex gloves. The prevalence of allergy to natural rubber gloves was significantly higher for those who had allergy to certain foodstuffs (especially avocado, kiwifruits and chestnuts) or with history of eczema and hay fever. However, the prevalence of allergy to natural rubber gloves was independent of gender, age, job, family history, type of gloves, hours of use per day and number of years on the job.
Contact Dermatitis, Dec. 2005, Vol.53, No.6, p.339-343. Illus. 32 ref.

CIS 06-630 Latza U., Haamann F., Baur X.
Effectiveness of a nationwide interdisciplinary preventive programme for latex allergy
This study describes a nationwide awareness campaign aimed at reducing exposure to powdered high-protein latex gloves among health care workers in Germany and evaluates the effectiveness of the programme. Data on compensation claims for latex-related skin and airway diseases were compared before and after implementation of the programme. A survey on change in glove use was also conducted after implementing the programme. The number of compensation claims for latex-induced skin diseases increased from 664 at the start of the programme in 1996 to 884 in 1998, and then decreased to 567 in 1999 and 204 in 2002. Similar decreases were observed for respiratory diseases. This programme was found to be effective and can be regarded as a model for the reduction of other occupational diseases such as bakers' or isocyanate asthma.
International Archives of Occupational and Environmental Health, June 2005, Vol.78, No.5, p.394-402. Illus. 47 ref.
http://www.springerlink.com/media/lp3ef1rrqr5xxmylwa7w/contributions/j/3/3/1/j3314532m7844317.pdf [in English]

CIS 06-619 Cavallo D., Ursini C.L., Setini A., Chianese C., Cristaudo A., Iavicoli S.
DNA damage and TNFα cytokine production in hairdressers with contact dermatitis
This study examined the possible correlation between exposure of hairdressers to irritants and allergens and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. The evaluation involved 19 hairdressers with hand contact dermatitis, including 14 with allergic contact dermatitis (ACD) and five with irritant contact dermatitis (ICD), together with a control group of 19 persons working in administrative services. Determinations included TNFα serum levels and a direct-oxidative DNA damage test. Serum levels of TNFα in hairdressers with ACD were significantly higher than controls, with a correlation to exposure level. Significantly more DNA damage in ICD hairdressers with higher exposure was found as compared to controls. These findings suggest a relationship between exposure and direct-oxidative DNA damage, TNFα production and allergic inflammatory disease.
Contact Dermatitis, Sep. 2005, Vol.53, No.3, p.125-129. 17 ref.

CIS 06-444 Droste J., Vermeire P., Van Sprundel M., Bulat P., Braeckman L., Myny K., Vanhoorne M.
Occupational exposure among bakery workers: Impact on the occurrence of work-related symptoms as compared with allergy characteristics
This study examined the relationship between exposure to occupational allergens, sensitization, atopy and work-related symptoms among bakery workers. Data were collected by questionnaire, skin prick tests, lung function tests, and exposure measurements among 246 workers from 74 bakeries and analysed using logistic and linear regression analyses. It was found that exposure levels were associated with respiratory symptoms, with sensitization to baker's allergens and with decreased lung function. High exposure and sensitization to common and bakers' allergens were independent risk factors for work-related symptoms. However, allergy determinants performed best in predicting work-related symptoms.
Journal of Occupational and Environmental Medicine, May 2005, Vol.47, No.5, p.458-465. 32 ref.

CIS 06-381 Cahill J., Keegel T., Dharmage S., Nugriaty D., Nixon R.
Prognosis of contact dermatitis in epoxy resin workers
Among workers who attended an occupational dermatology clinic between 1993 and 2003, 40 were diagnosed with allergic contact dermatitis from epoxy resins. Twenty of these patients were followed up for at least two years post-diagnosis to establish prognosis. Patients completed a telephone questionnaire based on variables considered of importance for prognosis. All patients reported improvement in their skin condition since diagnosis. Twelve of the 20 patients had applied for workers' compensation and all claims were successful. Sixteen had ceased working with epoxy resins. Of these, nine reported complete healing and seven reported ongoing dermatitis. Factors that may be associated with a poor prognosis are age, atopy, duration of symptoms and severity at diagnosis. The prognosis of allergic contact dermatitis from epoxy resins is not always favourable, even if a worker ceases exposure.
Contact Dermatitis, Mar. 2005, Vol.52, No.3, p.147-153. 42 ref.

CIS 06-379 Aalto-Korte K., Mäkela E.A., Huttunen M., Suuronen K., Jolanki R.
Occupational contact allergy to glyoxal
Allergic contact dermatitis from glyoxal has been described in several occupations. In this study, data from patients in the dermatology department of the Finnish Institute of Occupational Health from 1998 to 2004 were analysed for allergic reactions to glyoxal. Twenty patients had allergic reactions to glyoxal on patch testing. Five of the patients worked in dentistry and four of these had present exposure to glyoxal. Nine patients were machinists without obvious exposure to glyoxal. The case of a grinder with work-related facial dermatitis is described in detail. The chemical analysis of air samples from his workplace revealed 9.4-21µg/m³ glyoxal. Glyoxal was found to be present in the metalworking fluid used. The remaining six patients worked in miscellaneous occupations and had no present exposure to glyoxal. It is recommended that glyoxal be added to the antimicrobial patch test series.
Contact Dermatitis, May 2005, Vol.52, No.5, p.276-281. 17 ref.

CIS 06-375 Baur X.
Enzymes as occupational and environmental respiratory sensitisers
Airborne enzymes occurring in the general environment and in purified form in industrial production have a high allergenic potential to the airways and mucous membranes, causing rhinitis, conjunctivitis and asthma. It can be assumed that this also applies to the increasing number of enzymes manufactured by the cloning of genetically engineered microorganisms. Cross-sectional studies demonstrate exposure-response relations for IgE-mediated sensitization and airway disorders. Atopic individuals are more susceptible to enzyme allergy than non-atopic individuals. Skin prick testing and measurement of specific IgE antibodies have been shown to be useful diagnostic tools. Very high concentrations of proteases may lead to emphysema. There is also evidence of non-allergic airway inflammation by proteases. It is recommended that all enzymes be classified with the risk phrase R42 (may cause sensitization by inhalation) and that their inhalation uptake be totally avoided.
International Archives of Occupational and Environmental Health, May 2005, Vol.78, No.4, p.279-286. Illus. 41 ref.

CIS 06-369 Rasmussen K., Carstensen O., Pontén A., Gruvberger B., Isaksson M., Bruze M.
Risk of contact allergy and dermatitis at a wind turbine plant using epoxy resin-based plastics
A cross-sectional study was carried out among workers exposed to epoxy resin and other chemicals at a company producing plastic components. Risk factors for occupational contact allergy and dermatitis were investigated. Participants responded to a self-administered questionnaire, were interviewed by an occupational physician and were subjected to dermatological examinations including patch testing. Clinically-diagnosed dermatitis was found among 214 workers (35.8%) and contact allergy to materials used in the workplace was found in 66 workers (10.9% of the total population and 20.3% of those who underwent patch testing), among whom 40 (60.6%) were allergic to epoxy compounds, 25 (37.9%) to hardeners and ten (15.2%) to other workplace materials. Older age and longer duration of employment were individual risk factors for allergy to workplace materials, while work-related allergies and longer duration of employment at the workplace were significant risk factors for dermatitis.
International Archives of Occupational and Environmental Health, Apr. 2005, Vol.78, No.3, p.211-217. 20 ref.

CIS 06-135 Walusiak J., Wiszniewska M., Krawczyk-Adamus P., Nieścierenko E., Pałczyński C.
Allergy to α-amylase in apprentice bakers - prevalence, incidence, risk factors and clinical symptoms
Uczulenie na α-amylazę u uczniów szkół piekarskich - zapadalność, czynniki ryzyka i obraz kliniczny [in Polish]
The aim of the study was to evaluate the prevalence, incidence and risk factors of hypersensitivity to α-amylase and to identify allergy-related clinical symptoms in apprentice bakers. A group of 287 apprentice bakers was examined by questionnaire, skin prick tests to common and occupational allergens and evaluation of total serum IgE level, specific anti-flour and α-amylase IgE. Tests were carried out before the onset of vocational training and one and two years later. Respiratory disease was diagnosed by spirometry and inhalation challenge tests. 28 apprentices (9.8%) showed hypersensitivity to α-amylase after two years of exposure. Of those, 17 had allergic rhinitis and 15 had asthma. Results indicate that the incidence of allergy to α-amylase increases with increasing duration of exposure. Hypersensitivity to common allergens, especially moulds, is a risk factor for occupational allergy to α-amylase. It is recommended that skin prick tests to common allergens, particularly moulds, should be performed in bakers before starting occupational exposure to identify high-risk groups.
Medycyna pracy, 2005, Vol.56, No.2, p.121-130. 17 ref.

CIS 04-552 Rosenberg N.
Occupational respiratory allergies to acid anhydrides
Allergie respiratoire professionnelle aux anhydrides d'acide [in French]
Anhydrides of di- and tri-carboxylic acids are extremely reactive chemicals. They are widely used in the plastics industry. They are responsible for many allergic respiratory problems that result from their inhalation in the form of powder or smoke in occupational settings. Contents of this information sheet on occupational respiratory allergies to acid anhydrides: pathophysiology; prevalence among exposed occupations; diagnosis at the place of work; confirmation of diagnosis in a specialised medical institution; evolution; prevention; compensation of occupational diseases.
Documents pour le médecin du travail, 1st Quarter 2005, No.101, p.79-87. 63 ref.

2004

CIS 05-561 Lopata A.L., Baatjies R., Thrower S.J., Jeebhay M.F.
Occupational allergies in the seafood industry - A comparative study of Australian and South African workplaces
Although seafood allergy due to ingestion is commonly observed in clinical practice, the incidence of seafood allergies in occupational settings is largely unknown. In this study, the work practices, occupational health services and allergy problems in seafood processing enterprises in Australia were examined and compared to a those of a previous study conducted in South Africa. A cross-sectional survey design was used in both countries. In the South African study a response rate of 60% (n=41) was obtained, compared to a response rate of 18% (n = 140) in Australia. In both countries, skin rash accounted for highest of all reported health problems (78-81%) followed by asthmatic symptoms (7-10%) and other non-specific allergic symptoms (9-15%). Most enterprises reported the annual prevalence of work-related symptoms to be less than 5%. In Australia 7% of respondents in workplaces reported workers having left their workplace due to work-related allergy problems.
International Maritime Health, 2004, Vol.55, No.1/4, p.61-73. Illus. 18 ref.

CIS 05-463 Palmberg L., Larsson B.M., Sundblad B.M., Larsson K.
Partial protection by respirators on airways responses following exposure in a swine house
Exposure to swine dust leads to intense airway inflammation and increased bronchial responsiveness. This study evaluated the effect of respirator use during exposure in a swine confinement building. 22 subjects, of whom 11 wore respirators, were exposed. Before and seven hours after exposure, symptoms and body temperature were recorded, and a nasal lavage and a bronchial methacholine challenge were performed. For exposure assessment, a nasal sampler was evaluated. The subjects wearing respirators showed an attenuated inflammatory nasal response. An increase in bronchial responsiveness was observed in both groups, significantly greater in the unprotected group. The use of respirators reduced endotoxin exposure by more than 90% (assessed by nasal samplers).
American Journal of Industrial Medicine, Oct. 2004, Vol.46, No.4, p.363-370. Illus. 29 ref.

CIS 05-304 Radon K., Ehrenstein V., Praml G., Nowak D.
Childhood visits to animal buildings and atopic diseases in adulthood: An age-dependent relationship
Several studies have reported protective effects of farming environments against atopic diseases. A cross-sectional study was carried out in a rural town. 3112 inhabitants aged 18-44 responded to a postal questionnaire on atopic diseases, life-time exposure to farming environments, and potential confounders. Respondents with regular childhood exposure to animals had a significantly reduced risk of nasal allergies. The greatest reduction in risk was seen for respondents starting regular visits to animal stables during the first year of life or between the ages of three and five. Participants reporting start of exposure after age of five remained at a lower risk for nasal allergies. Findings indicate that the preventive effect of animal exposure against atopic respiratory diseases continues into adulthood.
American Journal of Industrial Medicine, Oct. 2004, Vol.46, No.4, p.349-356. Illus. 40 ref.

CIS 05-315 Jeebhay M.F., Rongo L.M.B, Lekei E.E., Mununa F.T., Uronu A.B., Afubwa S.O., Hanshi J.A., Ezeonu F.C., Musa A.O., Elhassan S.M., Hussein A.A., Ghebreyohannes T., Chithila A.
Allergies
Collection of articles on allergies and occupational safety and health of relevance to African countries. Main topics covered: occupational allergies; efficiency of information dissemination workshops in reducing allergy among small-scale industry workers in Dar es Salam; occupational allergy in the seafood processing industry in South Africa; pesticide labels and risk reduction in developing countries; occupational safety and health in the Kenyan health sector; occupational health hazards among cement industry workers in Nigeria; pollution problems from an open-air pesticide dump in Sudan.
African Newsletter on Occupational Health and Safety, Dec. 2004, Vol.14, No.3, p.51-71 (whole issue). Illus. Bibl.ref.
http://www.ttl.fi/NR/rdonlyres/19E9BF37-794D-4E0C-B647-428266ED0CE0/0/African.pdf [in English]

CIS 05-67 Meijer E., Grobbee D.E., Heederik D.
A strategy for health surveillance in laboratory animal workers exposed to high molecular weight allergens
The purpose of this study was to develop a model for the efficient detection and prediction of occupational allergic diseases. Data from 351 laboratory animal workers participating in an ongoing cohort study were used to develop diagnostic and prognostic models. The models were developed from questionnaire items and workplace concentration measurements to find factors for the estimation of the probability of sensitisation to allergens. The accuracy of the models was evaluated by statistical methods and by comparison of the predicted and observed prevalence. A diagnostic rule containing five questionnaire items allowed the identification of workers with a high risk of sensitisation. These workers showed high rates of work related asthma, allergic symptoms, doctor's visits and absenteeism. A prognostic rule based on four questionnaire items predicted workers at high risk of near future sensitisation.
Occupational and Environmental Medicine, Oct. 2004, Vol.61, No.10, p.831-837. Illus. 24 ref.

CIS 05-155 Rosenberg N.
Occupational respiratory allergy to dyestuffs
Allergie respiratoire professionnelle aux matières colorantes [in French]
Respiratory allergies to dyestuffs occur during occupational exposure to these substances in powder or aerosol form. Although these disorders have mainly been reported with reactive dyes and cochineal carmine, many other dyestuff molecules may also be responsible. Contents of this review article on respiratory allergies to dyestuffs: physiopathology and prevalence; diagnosis, based on the example of reactive dyes (in occupational settings and in specialised institutions); evolution and prevention of dyestuff asthma; compensation.
Documents pour le médecin du travail, 2nd Quarter 2004, No.98, p.255-264. Illus. 50 ref.
http://www.dmt-prevention.fr/inrs-pub/inrs01.nsf/IntranetObject-accesParReference/TR%2033/$File/TR33.pdf [in French]

CIS 04-554 Jost M., Rüegger M.
Reactive airways dysfunction syndrome (RADS)
Reactive airways dysfunction syndrome (RADS) [in German]
Reactive airway dysfunction syndrome (RADS) [in French]
The reactive airways dysfunction syndrome (RADS) is characterized by the incidence of persistent asthma among subjects previously without symptoms, following an exposure to respiratory irritants lasting several minutes to several hours. Respiratory disorders persist for at least three months, but generally last several years. Contents of this article on RADS: definition; physiopathology; frequencies of acute exposure that give rise to RADS; substances that may give rise to RADS; description of a clinical case; prognosis; occupational health and insurance aspects.
Informations médicales - Medizinische Mitteilungen, 2004, No.75, p.26-33 (French), p.25-32 (German). Illus. 16 ref.
http://wwwitsp1.suva.ch/sap/its/mimes/waswo/99/pdf/Med-Mitteilungen75-f.pdf [in French]
http://wwwitsp1.suva.ch/sap/its/mimes/waswo/99/pdf/Med-Mitteilungen-75-d.pdf [in German]

CIS 04-80 Gomez M.I., Hwang S.A., Lin S., Stark A.D., May J.J., Hallman E.M.
Prevalence and predictors of respiratory symptoms among New York farmers and farm residents
Data from telephone interviews with 1620 New York farmers and farm residents were used to study the prevalence and risk factors of symptoms that could be related to asthma and allergies. The prevalence of wheezing was 18.2%, that of rhinitis and lachrymation was 57.4%. Significant risk factors for wheeze were: cigarette smoking; a systemic reaction to allergy skin testing, immunotherapy or insect sting; reactivity to a pet; having goats; more acreage in corn for silage. Significant risk factors for rhinitis and lachrymation were younger age, having more than a high school education, being a worker on the farm and having done spraying. Wheeze may be indicative of existing or latent asthma, while rhinitis or lachrymation may indicate an increased sensitivity to respirable dusts and chemicals.
American Journal of Industrial Medicine, July 2004, Vol.46, No.1, p.42-54. Illus. 23 ref.

2003

CIS 06-200 Adverse human health effects associated with molds in the indoor environment
Review article on adverse effects associated with moulds in the indoor environment. Contents: allergy and hypersensitivity reactions (hypersensitivity pneumonitis, uncommon allergic syndromes); fungal infections; mycotoxins; recommendations on minimizing exposure to moulds among persons with allergic airway disease, on sampling and analysing, on cleaning indoor fabrics contaminated with moulds and on medical examinations.
Journal of Occupational and Environmental Medicine, May 2003, Vol.45, No.5, p.470-478. 83 ref.

CIS 05-100 Bonny J.S., Yéboué-Kouamé B.Y., Pillah M.A., Wognin S.B., Kouassi Y.M., Tchicaya A.F.
Intolerance to latex gloves among healthcare workers at teaching hospitals in Abidjan
L'intolérance aux gants de latex chez le personnel soignant des centres hospitaliers universitaires d'Abidjan [in French]
The objective of this cross-sectional study was to assess the degree of intolerance to latex gloves among healthcare workers at the three teaching hospitals in Côte d'Ivoire. Subjects included 609 healthcare workers. Data were collected by means of questionnaires, dermatological examinations and skin tests among workers reporting latex intolerance. Among the main findings: 9.8% of the workers reported signs of intolerance to latex gloves; clinical signs were found on 80% of the intolerant subjects, including eczema (39.5%), irritant contact dermatitis (33.3%) and urticaria (27.1%); the most frequent localization was the back of the hands (37.5%) and the most concerned services were paediatrics (16.2%), laboratory and radiology services (12.5%) and surgery (7.4%); concerned workers included nurses (15.8%), physicians (14%) and midwives (9.7%). Skin tests were carried out among 66.7% of workers with signs of latex intolerance, allowing an estimation of the rate of allergy as 2% of the healthcare workers.
Archives des maladies professionnelles et de médecine du travail, Sep. 2003, Vol.64, No.5, p.329-333. 16 ref.

CIS 04-668 Skin sensitisers
Kožní senzibilizující materiály [in Czech]
Hudallergiframkallande ämnen [in Swedish]
Hautsensibilisierende Stoffe (Hautallergene) [in German]
Pēgés erethismoú (hupereuaisthēsías) tou dérmatos [in Greek]
Sensibilizadores cutáneos [in Spanish]
Nahka sensibiliseerivad ained [in Estonian]
Ihoa herkistävät aineet [in Finnish]
Sensibilisants cutanés [in French]
Bőr érzékenyitők [in Hungarian]
Sostanze sensibilizzanti della cute [in Italian]
Odą jautrinančios medžiagos [in Lithuanian]
Ādas jūtīguma paaugstinātāji [in Latvian]
Huidsensibilisatoren [in Dutch]
Czynniki uczulające skórę [in Polish]
Agentes sensibilizadores da pele [in Portuguese]
Senzibilátory pokožky [in Slovak]
Povzročitelji kožne preobčutljivosti [in Slovenian]
Hudallergifremkaldende stoffer [in Danish]
Occupational skin diseases are estimated to cost the European Union EUR 600 million every year, resulting in around three million lost working days. They affect virtually all industry and business sectors and force many workers to change jobs. The European Agency for Safety and Health at Work is producing a series of fact sheets on occupational safety and health information about dangerous substances for the European Week for Safety and Health at Work 2003. This fact sheet contains information on skin sensitizers as well as preventive measures for skin exposure. Contents: causes of occupational skin problems; allergic skin diseases; skin sensitizers; preventing exposure.
European Agency for Safety and Health at Work, http://osha.eu.int, 2003. 2p. Illus. 8 ref.
http://agency.osha.eu.int/publications/factsheets/40/sv/FACTS-40_SV.pdf [in Swedish]
http://agency.osha.eu.int/publications/factsheets/40/en/FACTSN40-EN.PDF [in English]
http://agency.osha.eu.int/publications/factsheets/40/es/FACTS-40_ES.pdf [in Spanish]
http://agency.osha.eu.int/publications/factsheets/40/fr/FACTS-40_FR.pdf [in French]
http://agency.osha.eu.int/publications/factsheets/40/cs/FACT40_CS.pdf [in Czech]
http://agency.osha.eu.int/publications/factsheets/40/da/FACTS-40_DA.pdf [in Danish]
http://agency.osha.eu.int/publications/factsheets/40/de/FACTS-40_DE.pdf [in German]
http://agency.osha.eu.int/publications/factsheets/40/et/FACT40_ET.pdf [in Estonian]
http://agency.osha.eu.int/publications/factsheets/40/el/FACTS-40_EL.pdf [in Greek]
http://agency.osha.eu.int/publications/factsheets/40/it/FACTS-40_IT.PDF [in Italian]
http://agency.osha.eu.int/publications/factsheets/40/lv/FACT40_LV.pdf [in Latvian]
http://osha.lv/ew2003/40.pdf [in Latvian]
http://agency.osha.eu.int/publications/factsheets/40/hu/FACT40_HU.pdf [in Hungarian]
http://agency.osha.eu.int/publications/factsheets/40/lt/FACT40_LT.pdf [in Lithuanian]
http://agency.osha.eu.int/publications/factsheets/40/nl/FACTS-40_NL.pdf [in Dutch]
http://agency.osha.eu.int/publications/factsheets/40/pl/FACT40_PL.pdf [in Polish]
http://agency.osha.eu.int/publications/factsheets/40/pt/FACTS-40_PT.pdf [in Portuguese]
http://agency.osha.eu.int/publications/factsheets/40/sk/FACT40_SK.pdf [in Slovak]
http://agency.osha.eu.int/publications/factsheets/40/sl/Fact40_SL.pdf [in Slovenian]
http://agency.osha.eu.int/publications/factsheets/40/fi/FACTS-40_FI.PDF [in Finnish]

CIS 04-667 Respiratory sensitizers
Respirační senzibilizující materiály [in Czech]
Ämnen som framkallar allergier i andningsorganen [in Swedish]
Atemwegssensibilisierende Stoffe (Inhallationsallergene) [in German]
Pēgés erethismoú (hupereuaisthēsías) tou anapneustikoú sustḗmatos [in Greek]
Sensibilizantes respiratorios [in Spanish]
Respiratoorset sensibilisatsiooni põhjustavad kemikaalid [in Estonian]
Hengityselinsairauksille herkistävät ainet [in Finnish]
Substances respiratoires allergisantes [in French]
Légzőrendszert érzékennyé tevő anyagok [in Hungarian]
Sostanze sensibilizzanti dell'apparato respiratorio [in Italian]
Kvėpavimo organus jautrinančios medžiagos [in Lithuanian]
Respiratorās sensitivitātes palielinātāji [in Latvian]
Inhalatie-allergenen [in Dutch]
Czynniki uczulające układ oddechowy [in Polish]
Alergéneos respiratórios [in Portuguese]
Respiračné senzibilátory [in Slovak]
Povzročitelji preobčutljivosti dihal [in Slovenian]
Indåndingsallergener [in Danish]
For the European Week for Safety and Health at Work 2003, the European Agency for Safety and Health at Work is producing a series of fact sheets focusing on the communication of occupational safety and health-related information on dangerous substances. Respiratory sensitizers are biological and chemical agents that can induce allergic respiratory diseases in humans. This fact sheet discusses important characteristics of the exposure to these agents and appropriate prevention measures. Contents: causes of occupational respiratory problems; allergic respiratory diseases; allergic sensitizers; managing respiratory sensitizers.
European Agency for Safety and Health at Work, http://osha.eu.int, 2003. 2p. Illus. 7 ref.
http://agency.osha.eu.int/publications/factsheets/39/en/FACTSN39-EN.PDF [in English]
http://agency.osha.eu.int/publications/factsheets/39/sv/FACTS-39_SV.pdf [in Swedish]
http://agency.osha.eu.int/publications/factsheets/39/fr/FACTS-39_FR.pdf [in French]
http://agency.osha.eu.int/publications/factsheets/39/cs/FACT39_CS.pdf [in Czech]
http://agency.osha.eu.int/publications/factsheets/39/da/FACTS-39_DA.pdf [in Danish]
http://agency.osha.eu.int/publications/factsheets/39/de/FACTS-39_DE.pdf [in German]
http://agency.osha.eu.int/publications/factsheets/39/et/FACT39_ET.pdf [in Estonian]
http://agency.osha.eu.int/publications/factsheets/39/el/FACTS-39_EL.pdf [in Greek]
http://agency.osha.eu.int/publications/factsheets/39/it/FACTS-39_IT.PDF [in Italian]
http://agency.osha.eu.int/publications/factsheets/39/lv/FACT39_LV.pdf [in Latvian]
http://osha.lv/ew2003/39.pdf [in Latvian]
http://agency.osha.eu.int/publications/factsheets/39/hu/FACT39_HU.pdf [in Hungarian]
http://agency.osha.eu.int/publications/factsheets/39/lt/FACT39_LT.pdf [in Lithuanian]
http://agency.osha.eu.int/publications/factsheets/39/nl/FACTS-39_NL.pdf [in Dutch]
http://agency.osha.eu.int/publications/factsheets/39/pl/FACT39_PL.pdf [in Polish]
http://agency.osha.eu.int/publications/factsheets/39/pt/FACTS-39_PT.pdf [in Portuguese]
http://agency.osha.eu.int/publications/factsheets/39/sk/FACT39_SK.pdf [in Slovak]
http://agency.osha.eu.int/publications/factsheets/39/sl/Fact39_SL.pdf [in Slovenian]
http://agency.osha.eu.int/publications/factsheets/39/fi/FACTS-39_FI.PDF [in Finnish]
http://agency.osha.eu.int/publications/factsheets/39/es/FACTS-39_ES.pdf [in Spanish]

CIS 03-1778 Rosenberg N.
Occupational respiratory allergies caused by wood dust
Allergies respiratoires professionnelles provoquées par les poussières de bois [in French]
Woodworking is a known cause of respiratory allergy risk. High-speed revolving machines produce large amounts of easily-inhalable fine dust, which when deposited at all levels in the respiratory tract may cause nose, bronchial and lung symptoms. Moulds, bacteria and bacterial endotoxins which grow on wood parts stored in the premises, together with substances used for wood treatment present additional respiratory hazards. Contents of this article on occupational respiratory allergies caused by wood dust: physiopathology; prevalence among exposed occupational groups; diagnosis in occupational settings; confirmation of diagnosis in specialized institutions; development; prevention; compensation.
Documents pour le médecin du travail, 4th Quarter 2003, No.96, p.501-510. 86 ref.

CIS 03-1183 Bunn W.B., Pikelny D.B., Paralkar S., Slavin T., Borden S., Allen H.M.
The burden of allergies - and the capacity of medications to reduce this burden - in a heavy manufacturing setting
This article presents the findings of a systematic study undertaken by a manufacturer to address the impact of allergies and use of allergy medications on health, safety and productivity. Data on 10,714 employees were obtained from employee surveys and administrative databases of the enterprise concerning absenteeism, workers compensation, short-term disability and group health measures. Results show that health and productivity decline, and absenteeism, workplace injuries and workers' compensation claims register consistent increases as allergy severity levels increase. This pattern is less pronounced for the short-term disability and group health measures. Among the 16 parameters registering a significant allergy burden, six posted significant advantages for the use of non-sedating antihistamines relative to other medication regimens that included sedative antihistamines. These results document the burden of allergies and the capacity of effective medication programmes to reduce this burden.
Journal of Occupational and Environmental Medicine, Sep. 2003, Vol.45, No.9, p.941-955. Illus. 12 ref.

CIS 03-1177 Crépy M.N.
Work-related eczema of the eyelids
Eczéma des paupières d'origine professionnelle [in French]
Work-related eczema of the eyelids caused by occupational factors is rare. Occupational factors are less likely to be involved than topical cosmetic or ophthalmologic creams. However, an investigation into possible occupational causes is still necessary in order to orient prevention and therapy efforts. Contents of this article on eczema of the eyelid: modes of sensitization; aetiology and exposed occupations; frequency of eyelid contact eczema; diagnosis in occupational settings; confirmation of diagnosis in specialized institutions; prognosis; prevention; compensation.
Documents pour le médecin du travail, 3rd Quarter 2003, No.95, p.365-371. Illus. 65 ref.

CIS 03-1316 Jones M., Cullinan P., Durham S., Newman Taylor A.
Health and Safety Executive
Cellular aspects of occupational asthma: Immunological studies in isocyanate exposed subjects
The cellular and molecular mechanisms that induce asthma due to expsoure to low molecular weight chemicals are not fully understood. The aim of this project was to gain a better understanding of the mechanisms of low molecular weight chemical haptens and in particular isocyanates. The study was carried out among occupational asthma patients in a university hospital, and involved bronchoscopy, specific IgE and T-cell studies. It was found that there was a lack of local IgE and IL-4 production in the lungs following challenge in patients allergic to isocyanates, which parallels the lack of detectable specific IgE in the serum of the majority of patients with isocyanate-induced asthma. There was, however, evidence of local tissue eosinophilia and IL-5 production. These findings suggest that isocyanate induced asthma in humans is a Th2 type response in which IgE does not have an obligatory role.
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, 2003. ix, 84p. Illus. 44 ref. Price: GBP 15.00.
http://www.hse.gov.uk/research/rrpdf/rr122.pdf [in English]

CIS 03-1230 Susitaival P., Kirk J.H., Schenker M.B.
Atopic symptoms among California veterinarians
To study the prevalence of allergic symptoms among veterinarians in California, a questionnaire was sent to 2,000 of them; the return rate was 71%. It was found that a history of either asthma, allergic rhinitis (AR) or atopic dermatitis (AD) was reported by 66% of respondents. AR was reported by 62%, asthma by 16% and AD by 11%. 40% of the veterinarians reported animal-related respiratory and/or skin symptoms. The most commonly-reported sources of symptoms were allergies to cats and dogs. In multivariate logistic analysis, the significant risk factors for having adult asthma were the history of AR with the history of AD (odds ratio (OR) 13.9), AR alone (OR 6.3) and asthma in childhood (OR 6.4).
American Journal of Industrial Medicine, Aug. 2003, Vol.44, No.2, p.166-171. Illus. 43 ref.

CIS 03-1305 Pałczyński C., Walusiak J., Krakowiak A., Szymczak W., Wittczak T., Ruta U., Górski P.
Nasal lavage fluid examination in diagnostics of occupational allergy to chloramine
Chloramine T is a known sensitizing agent in the occupational environment of health care workers. The aim of this study was to evaluate the usefulness of the nasal challenge test in diagnostics of respiratory allergy to chloramine T. The study was conducted in six subjects with chloramine T asthma and rhinitis. Two control groups comprised seven atopic subjects with asthma and rhinitis and six healthy persons. All controls had negative results of prick tests with chloramine T and none displayed any respiratory symptoms under exposure to the agent. A "nasal pool" technique was used to evaluate morphological and biochemical parameters in nasal washings before and 30min, 4h and 24h after the provocation with chloramine T and placebo. A significant increase was found in the total count and percentage of eosinophils and basophils, albumin, tryptase and eosinophil cationic proteins in the nasal lavage fluid from patients with chloramine T respiratory allergy when compared to both control groups. The results indicate the applicability of the "nasal pool" technique as a diagnostic procedure in chloramine T-induced airway allergy.
International Journal of Occupational Medicine and Environmental Health, 2003, Vol.16, No.3, p.231-240. Illus. 26 ref.

2002

CIS 03-1787 Hollund B.E., Moen B.E., Egeland G.M., Florvaag E., Omenaas E.
Occupational exposure to hairdressing chemicals and immunoglobulin E synthesis
The study was based on a questionnaire sent to 100 hairdressers and a reference group of 95 office workers. The questionnaire sought information on allergy, respiratory symptoms during the past year, work conditions (exposure) and smoking habits. The hairdressers were divided into high and low exposure groups. Total serum IgE and allergen-specific IgE towards the most prevalent airborne allergens were analysed. The serum levels of total IgE were significantly higher among the highly exposed hairdressers than among the office workers. The prevalence of asthma-like respiratory symptoms during the past year was significantly higher among the highly exposed hairdressers. The total serum IgE level was significantly higher among the hairdressers, but this difference disappeared after adjustment for age, atopy and smoking.
Scandinavian Journal of Work, Environment and Health, Aug. 2002, Vol.28, No.4, p.264-269. Illus. 29 ref.

CIS 03-638 Morfeld M., Schnabel P.E.
What is the value of self-diagnosis? Postvalidation of a screening form that allows the evaluation of occupational allergies in craft industries
"Was ist Selbstdiagnose wert?" Postvalidierung eines Screeningbogens zur Erfassung berufsbedingter Allergien im Handwerk [in German]
In the context of a multicentric study aimed at preventing occupational allergies among craftsmen, 1000 workers in the wood and plastic converting industries were asked to evaluate the possible allergies from which they suffered, their safety at work and their job satisfaction by means of a questionnaire. A total of 278 responses was collected. For validating the self-diagnosis responses and evaluating the effective prevalence of allergies, 100 workers were subjected to further allergy and lung function tests and had to respond to the questionnaire a second time. Examinations enabled to identify 96 cases of allergy. 32 subjects showed a significant allergy from the clinical point of view, among whom 72% had diagnosed it in the questionnaire. 22 subjects exhibited non-specific toxic symptoms and eight had noticeable lung-function problems. The comparison of questionnaire data and medical diagnoses showed a relationship between safety shortcomings within the enterprise and allergies.
Ergo-Med, Sep.-Oct. 2002, Vol.26, No.5, p.142-150. Illus. 27 ref.

CIS 03-757 De Schryver L., Van Cauwenberge P.
Occupational allergies
Allergies professionnelles [in French]
Contents of this general overview of occupational allergies: description of the reactions of the human immune system; allergens at the workplace; occupations at risk; risk factors; definitions of allergy and atopy; rhinitis and asthma; diagnosis; prevention.
Travail et bien-être, Sep.-Oct. 2002, Vol.5, No.4, p.25-30. Illus. 7 ref.

CIS 03-102 Technical advisory on hazardous material and health - No.1 - Workplace chemicals and Stevens-Johnson Syndrome
The Stevens-Johnson syndrome (SJS) is an extreme allergic reaction to a variety of substances, including certain chemicals and pharmaceuticals. The objective of this booklet is to offer advice to employers and workers on preventing risks of SJS and other illnesses caused by exposure to chemicals. Contents: introduction and description of SJS; causes of SJS; workplace hazards and SJS; symptoms; persons at risk; hazard evaluation; preventive measures, including limitation of exposure; legal aspects; points to remember about types of chemicals found in the workplace.
Department of Labor and Employment, Occupational Safety and Health Center, OSHC Building, North Avenue corner Agham Road, Diliman, Quezon City, Philippines, Aug. 2002. 11p. Illus.

CIS 03-443
Health and Safety Executive
Control of laboratory animal allergy
Aimed at employers, managers, employees and safety and health professionals, this guidance note describes possible health risks that could result from exposure to laboratory animal allergens. It includes advice to employers and managers of animal facilities on the precautions needed to prevent or control exposure as required by the Control of Substances Hazardous to Health Regulations (COSHH, see CIS 00-620). It also addresses duties under Management of Health and Safety at Work Regulations (MHSW, see CIS 00-403), including the need to co-operate and coordinate where different employers share a workplace. Contents: description of laboratory animal allergy; management of health and safety in animal facilities; assessment of hazards to health; prevention and control of exposure (ventilation, systems of work, personal protective equipment); maintenance, examination and testing of control measures; information and training of employees.
HSE Books, P.O. Box 1999, Sudbury, Suffolk CO10 2WA, United Kingdom, Aug. 2002. 8p. 13 ref. Price: GBP 7.50.

CIS 03-299 Giusti F., Mantovani L., Martella A., Seidenari S.
Hand dermatitis as an unsuspected presentation of textile dye contact sensitivity
From 1996 to 2000, 130 patients with hand dermatitis reacting to one of the seven dyes included in the standard series were identified. In 82 subjects, dermatitis was localized in the hands alone, whereas the other 48 patients had lesions both on the hands and on other skin sites. Disperse Blue and Disperse Orange were the most common sensitizers. Among the 13 subjects allergic to disperse dyes alone, there were three cases of occupational allergic contact dermatitis, one child with atopic dermatitis worsening after the use of synthetic fibre garments, four subjects affected by clothing dermatitis, and five individuals occupationally exposed to irritants with a dermatitis involving the hands alone. In the latter, the hands may represent a locus minoris resistentiae, and both induction and elicitation of contact sensitization could be caused by impaired barrier function at a skin site repeatedly exposed to sensitizing garments.
Contact Dermatitis, Aug. 2002, Vol.47, No.2, p.91-95. Illus. 16 ref.

CIS 03-318 Bauer A., Geier J., Elsner P.
Type IV allergy in the food processing industry: Sensitization profiles in bakers, cooks and butchers
To identify the most frequent allergens and sensitization profiles in employees of the food processing industry, patch testing was performed in 873 bakers, cooks and butchers suspected of having occupational allergic contact dermatitis between 1992 and 1999. A final diagnosis of allergic contact dermatitis was made in 213 patients (24.4%). Qualitative and quantitative differences in allergen profiles could be identified. Significantly higher sensitization rates were found in employees in the food processing industry, compared to the total test population, for nickel sulfate (22.4% versus 17.2%), thiuram mix (4.9% versus 2.6%), formaldehyde (3.5% versus 2.1%), and Compositae mix (6.2%, versus 2.4%). Significantly lower sensitization rates were found for thimerosal (4.5% versus 6.9%). For patch testing in food industry workers, the standard, the rubber and the Compositae series are recommended, as well as the specific products to which patients are exposed.
Contact Dermatitis, Apr. 2002, Vol.46, No.4, p.228-235. 50 ref.

CIS 02-1806 Daftarian H.S., Lushniak B.D., Reh C.M., Lewis D.M.
Evaluation of self-reported skin problems among workers exposed to toluene diisocyanate (TDI) at a foam manufacturing facility
To investigate the dermal effects of toluene diisocyanate (TDI), a cross-sectional study was carried out at a polyurethane foam manufacturing plant. A totla of 114 workers completed a medical questionnaire and provided blood for antibody testing to TDI and other allergens. A subset of participants reporting skin symptoms underwent skin patch testing to a standard diisocyanate panel. Production line workers were more likely to report skin problems than those working in non-production areas (OR 2.66). Age, sex and duration of employment at the plant were comparable among participants working in production and non-production areas. Specific IgG antibody to TDI was detected in two individuals, while none of the samples demonstrated specific IgE antibody to TDI. Of the 26 workers who underwent skin patch testing, none developed reactions to the diisocyanate allergens. These results suggest that skin symptoms represent an irritant rather than an immunological reaction to TDI, or to an unidentified allergen present in the foam.
Journal of Occupational and Environmental Medicine, Dec. 2002, Vol.44, No.12, p.1197-1202. 30 ref.

CIS 02-1932 Goodno L.E., Stave G.M.
Primary and secondary allergies to laboratory animals
Although laboratory animal allergy (LAA) is a significant occupational hazard among workers exposed to laboratory animals, few studies have evaluated long-term risks to workers. In this study, surveillance data from a ten-year LAA prevention programme were analysed to estimate incidence rates of primary and secondary LAA and to evaluate the effectiveness of the prevention programme in reducing the development of primary LAA. The ten-year incidence rates of primary and secondary LAA were 1.34 and 11 cases per 100 person-years, respectively. The annual incidence of primary LAA was reduced from 3.6% to 0% in the first five years and did not rise above 1.2% over the remaining years, whereas the incidence of secondary LAA was greater than 8% in most years. These findings suggest that programmes effective at preventing primary LAA may need to be evaluated for their effectiveness at protecting against further risk.
Journal of Occupational and Environmental Medicine, Dec. 2002, Vol.44, No.12, p.1143-1152. Illus. 30 ref.

CIS 02-1737 Rosenberg N.
Respiratory allergies in bakers
Allergie respiratoire du boulanger [in French]
Wheat flour contains numerous allergens, and bakers' asthma remains the most common occupational asthma in France. In this occupation, one also encounters cases of allergic rhinitis and rhinoconjunctivitis. Contents of this article on bakers' allergic respiratory diseases: physiopathology; incidence and frequency; diagnosis in occupational settings; confirmation of diagnosis in specialized establishments; evolution; prevention; compensation.
Documents pour le médecin du travail, 2nd Quarter 2002, No.90, p.189-196. 71 ref.

CIS 02-1688 Breton C.
Prevention of occupational respiratory allergies in bakeries and confectionaries
Prévention des allergies respiratoires professionnelles en boulangerie-pâtisserie [in French]
Flour is the prime source of respiratory allergies in France. The average incidence rate of occupational asthma in bakery workers in approximately 25 times that of all workers. Contents of this review article on the prevention of occupational of allergic respiratory diseases in bakery workers: epidemiological data; recognition of baker's asthma as an occupational disease; collaboration between government, employers' and employees' representatives in defining a prevention approach; role of medical centres and physicians; risk factors for diseases due to exposure to flour; pluridisciplinary approach to prevention; preventive measures (choice of flour, choice of additives, length of the filling hose, use of a protective lid during kneading); role of the occupational physician.
Documents pour le médecin du travail, 2nd Quarter 2002, No.90, p.111-129. Illus. 47 ref.

CIS 02-1687 Baur X., Gahnz G.
Allergy to pumpkin seeds in the form of food intolerance and occupational contact urticaria
Kürbiskernallergie in Form einer Nahrungsmittelunverträglichkeit und einer berufsbedingten Kontakturtikaria [in German]
Case study of a 21-year-old baker regularly suffering from skin urticaria when handling pumpkin seeds. Three years earlier, this patient developed an allergy that caused the swelling of the pharynx and swallowing difficulties after he had eaten bread containing pumpkin seeds. Prick tests revealed an immediate sensitization to raw and roasted pumpkin seeds. There are no literature reports of similar cases of allergy to pumpkin seed in the form of food intolerance and occupational allergic contact urticaria.
Dermatologie in Beruf und Umwelt, Sep.-Oct. 2002, Vol.50, No.5, p.178-179. 7 ref.

CIS 02-1686 Zanoni G., Martini S., Zedde A., Pagani M., Guarnieri A., Tridente G., Romeo L.
Specific immune response to occupational antigens in asymptomatic egg processing workers
Hen's egg proteins are known sensitizers and may cause occupational respiratory diseases in exposed workers. This study was conducted in order to determine the prevalence of sensitization to work-related antigens in asymptomatic egg processing factory workers. Clinical history, respiratory function, atopy and the presence of specific antibodies to environmental and occupational antigens were evaluated in 77 workers. A total of 116 unexposed controls were also studied. The antigen concentration of the factory environment was measured. Specific IgE and precipitin positivity to egg components was more frequently present in workers than among controls. The egg white protein concentration was higher in the egg breaking area. The avian proteins inhaled induced immune responses to occupational antigens in asymptomatic, professionally exposed subjects. Measures to decrease environmental antigen concentrations and thorough monitoring of sensitized workers are advocated.
American Journal of Industrial Medicine, June 2002, Vol.41, No.6, p.490-497. 24 ref.

CIS 02-667 Akasya-Hillenbrand E., Özkaya-Bayazit E.
Patch test results in 542 patients with suspected contact dermatitis in Turkey
In this retrospective study, patch test results of 542 patients (303 female and 239 male), referred to a dermatology clinic between June 1996 and July 1999, were evaluated. All patients were patch tested with 32 allergens of an extended European standard series, 140 patients were tested with supplemental series, and 246 patients with their own substances. 280 (51.7%) patients had one or more positive results but allergic contact dermatitis, according to clinical relevance, was diagnosed in only 190 (67.9%) of these. Nickel sulfate was the most frequent sensitizer (19.1%), followed by potassium dichromate (11.8%), palladium chloride (9.4%), cobalt chloride (8.5%), and thiuram mix (7.7%). Occupational contact dermatitis was diagnosed in 77 of the patients with positive reactions (27.5%), most of these being construction workers and house painters who showed relevant sensitizations to potassium dichromate, cobalt chloride, thiuram mix and carba mix.
Contact Dermatitis, Jan. 2002, Vol.46, No.1, p.17-23. 22 ref.

2001

CIS 03-788 Pillière F., Galey J.F., Maison A.
Reactive dyes in textile dyeing and finishing: Allergic diseases resulting from their use
Colorants réactifs dans le secteur de l'ennoblissement textile: pathologies allergiques liées à leur utilisation [in French]
Workers in the dyeing and finishing sector of the textile industry are exposed to dyestuffs. Among these, reactive dyes which are characterized by the presence of one or several reactive groups on the molecule have experienced rapid growth. Despite the large number of reactive dyestuffs that are labelled as being potential skin sensitizers, there are few recent publications on the potential for allergic diseases resulting from occupational exposure to these products. Furthermore, only few cases of occupational allergy caused by these substances been reported in France. Carried out by occupational physicians responsible for the medical supervision of employees in the dyeing and finishing sector, this questionnaire survey was carried out with a view to better understand the frequency of these allergies.
Documents pour le médecin du travail, 1st Quarter 2001, No.85, p.33-47. Illus. 22 ref.
http://www.inrs.fr/htm/colorants_reactifs_dans_secteur_ennoblissement.html [in French]

CIS 02-1681 Farruggia E., Bellia M.
Occupational allergic asthma in greenhouse cultivation: Description of a clinical case
Asma occupazionale allergica in colture protette. Descrizione di un caso clinico [in Italian]
Case of occupational allergic asthma observed in a greenhouse worker. Colonies of Aspergillus niger were identified on the plants cultivated in the greenhouse, and the mould proved to be the aetiologic agent responsible of the asthma. Allergy tests were conducted for the diagnostic procedure.
Medicina del lavoro, May-June 2001, Vol.92, No.3, p.203-205. 11 ref.

CIS 02-1931 Belisario A., Cipolla C., Nucci C., Auletti G., Nobile M., Raffi G.B.
Four-year follow-up of a group of workers with allergic sensitization employed in breeding of insects for biological pest control
Follow-up di 4 anni in un gruppo di lavoratori con sensibilizzazione allergica addetti alla produzione di insetti per la lotta biologica [in Italian]
As a follow-up to preventive measures (semi-closed cycles, gloves, masks, overalls and sunglasses) implemented after previous reports of sensitization, workers employed in insect breeding were monitored through allergy and respiratory function tests. A decrease in skin sensitization for insects and a decrease in allergic conditions (rhinoconjunctivitis and asthma) were found. The application of preventive measures is vindicated.
Medicina del lavoro, Mar.-Apr. 2001, Vol.92, No.2, p.125-129. Illus. 20 ref.

CIS 02-1792 Previdi M., Marraccini P.
Latex protein allergy and preventive measures
Allergia alle proteine del lattice e percorsi di prevenzione [in Italian]
A clinical and epidemiological outline of latex allergy and its management is presented. A feasibility analysis and a literature survey were made in a hospital of a latex-free stream. There is equipment available now, in particular non-powdered gloves with low levels of protein residue, which can minimize the occurrence of latex sensitization, especially in operating theatres.
Medicina del lavoro, Mar.-Apr. 2001, Vol.92, No.2, p.108-119. 60 ref.

CIS 02-1367 Vanhanen M., Tuomi T., Tiikkainen U., Tupasela O., Tuomainen A., Luukkonen R., Nordman H.
Sensitization to enzymes in the animal feed industry
To assess the prevalence of enzyme sensitization in the animal feed industry in Finland, a cross-sectional study was conducted in four animal feed factories, where several enzymes had been used in powder form for 7-9 years. 218 workers were tested, including 140 employed in various manufacturing tasks where exposure to various organic dusts and to enzymes was possible, together with 78 non-exposed office workers. The workers were interviewed for work-related respiratory and skin symptoms. Enzyme concentrations in the air varied from less than 0.8ng/m³ up to 16ng/m³ for xylanase, from less than 20ng/m³ up to 200 ng/m³ for α-amylase, and from less than 0.4ng/m³ up to 2900ng/m³ for protease. Ten workers were sensitized to enzymes in the exposed group of 140, whereas none were sensitized in the non-exposed group. Six of the sensitized workers had respiratory symptoms at work, of which two especially in connection with exposure to enzymes.
Occupational and Environmental Medicine, Feb. 2001, Vol.58, No.2, p.119-123. 16 ref.

CIS 02-660 Saad A., Besher S., Ammar N., Emam H.
Therapeutic effects of Nigella sativa on occupational contact dermatitis
Nigella seeds have known anti-allergic effects in traditional medicine. The therapeutic effects of Nigella sativa powdered in the form of capsules, lipoidal matter extract and the aqueous alcoholic extract of nigella seeds in the form of two ointments were studied in 50 male volunteers aged between 25 and 55 years suffering from chronic occupational contact dermatitis. Blood picture, IgE and natural killer (NK) cells were recorded before and after two weeks of therapy. Treatment with lipoidal extract ointment, alcoholic extract ointment and powdered seed capsules led to complete recovery of the eczematous lesions in 89%, 46%, and 63%, respectively. Clinical improvement by these three treatments was statistically significant, while placebos achieved no significant improvement. NK cell fraction was significantly augmented in treated groups. No harmful effects on the liver and the kidney functions were found.
Central European Journal of Occupational and Environmental Medicine, 2001, Vol.7, No.1, p.26-38. Illus. 42 ref.

CIS 02-814 Uter W., Schnuch A., Geier J., Pfahlberg A., Gefeller O.
Association between occupation and contact allergy to the fragrance mix: A multifactorial analysis of national surveillance data
To assess the role of occupational risk factors for fragrance contact allergy (FCA), data from all 57,779 patch-tested patients in the centres of the Information Network of Departments of Dermatology between January 1992 and December 1998 were analysed. It was found that the proportion of patients with FCA varied greatly between different occupational groups from 2.5% to 17.4%, the highest occupational risk of FCA beeing associated with work as a masseur or physiotherapist, foundry operator, potter or glass worker, or geriatric nurse. Non-occupational factors that influenced risk of FCA included atopy, female sex, several sites, in particular the axillae, and age. Occupations with a high risk of FCA were identified as targets of preventive action, namely the substitution of scented products with fragrance-free substances such as skin disinfectants, cleaning solutions or personal care products.
Occupational and Environmental Medicine, June 2001, Vol.58, No.6, p.392-398. 23 ref.

CIS 02-300 Allmers H.
Wearing test with two different types of latex gloves with and without the use of a skin protection cream
Among 72 subjects reporting symptoms indicating Type I hypersensitivity reactions to natural rubber latex (NRL) gloves, 44 (60%) had a positive prick test to NRL. They underwent wearing tests using 2 types of NRL gloves with high and low allergen contents. Gloves with a high allergen content caused positive skin reactions in 47% of SPT-positive subjects. After application of a skin protection cream, the frequency of positive skin responses in wearing tests decreased to 30% in prick-test-positive subjects. The gloves with low allergen caused hypersensitivity with and without skin protection cream in 2 cases (5%) of the prick-test-positive. No prick-test-negative subjects showed any urticaria during the glove-wearing test. The study demonstrates that high allergen contents in latex gloves frequently elicit skin responses in NRL-sensitized subjects. Hand skin cream may hamper the uptake of allergens from gloves, thus decreasing allergic reactions.
Contact Dermatitis, Jan. 2001, Vol.44, No.1, p.30-33. Illus. 16 ref.

< previous | 1, 2, 3, 4, 5, 6, 7 ...19 | next >