Glycols - 55 entries found
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Wills J.H., Coulston F., Harris E.S., McChesney E.W., Russell J.C., Serrone D.M.
Inhalation of aerosolized ethylene glycol by man.
After a brief review of the literature and a description of the signs and symptoms observed after experimental ethylene glycol ingestion, the authors present their own experiments in humans, in which 19 male volunteers were exposed to aerosolized ethylene glycol in mean daily concentrations of 3-67mg/m3 almost continually for 4 weeks. Blood and urine examinations gave no evidence of the absorption of important quantities of ethylene glycol. There were no serious signs of toxicity but some complaints of irritation of the upper respiratory tract. Irritation became common with an ethylene glycol concentration of 140mg/m3, and more than 200mg/m3 was intolerable. It was concluded that an individual with normal sensory apparatus could not absorb a harmful quantity of ethylene glycol through the respiratory tract. Detailed results of laboratory and psychometric tests are given in tables.
Clinical Toxicology, Oct. 1974, Vol.7, No.5, p.463-476. Illus. 27 ref.
Mundy R.L., Hall L.M., Teague R.S.
Pyrazole as an antidote for ethylene glycol poisoning.
Pyrazole, a potent alcohol dehydrogenase inhibitor, given intraperitoneally to mice in a single dose of 300mg/kg, increased significantly the LD50 of orally-administered ethylene glycol. It appears to act like ethanol in preventing conversion of glycol to more toxic metabolites. Although pyrazole is a toxic chemical and may cause damage in several organs in experimental animals, the compound has been used in experimental studies in man; its use on a one-time basis in life-threatening poisoning might be an acceptable risk.
Toxicology and Applied Pharmacology, May 1974, Vol.28, No.2, p.320-322. 12 ref.
A simple chemical method for determining ethylene glycol in air
Jednoduchá chemická metoda na stanovení etylénglykolu v ovzduší [in Czech]
The method described is based upon the oxidation of ethylene glycol by periodic acid in a dilute sulfuric acid medium. The formaldehyde produced by the oxidation is determined by polarography in a medium of excess lithium hydroxide, which simultaneously removes any remaining periodic acid. The method may be used to determine concentrations of ethylene glycol between 0 and 200µg/10ml of solution. Air samples are obtained by using frit absorbers. The absorbent solution used is distilled water.
Pracovní lékařství, Sep. 1973, Vol.25, No.8, p.330-332. 11 ref.
Dubejkovskaja L.S., Asanova T.P., Rozina G.Ju., Budanova L.F., Zenkevič E.S., Revnova N.V., Gorn L.Ė.
Hygienic assessment of ethylene glycol during the manufacture of certain electronic components
Gigieničeskoe značenie ėtilenglikolja v proizvodstve nekotoryh radiodetalej [in Russian]
Determinations carried out in the atmosphere of 2 electronic components manufacturing workshops showed that the mean concentration of ethylene glycol at critical points was 49mg/m3. No cases of occupational ethylene glycol poisoning were found, but the subjective symptoms noted (headaches, general asthenia, fatigue, etc.) and the functional disorders of the nervous system observed in almost half of the exposed workers point to the neurotoxic effect of this substance. A TLV of 5mg/m3 is recommended.
Gigiena truda i professional'nye zabolevanija, Oct. 1973, No.10, p.1-4. 3 ref.
Determination of ethylene glycol in air by polarography
Stanovení étylénglykolu v ovzduší polarografickou metodou [in Czech]
Description of a method developed to determine ethylene glycol in the air of a factory producing Nitrosan 50. The method is based on splitting vicinal glycols by means of periodic acid. The reaction gives rise to formaldehyde and iodic acid which is freed from any periodic-acid excess by means of lithium hydroxide and determined by polarography. The presence of dinitro-o-cresol affects the determination by a deviation of about 3%, which is within the limits of reproducibility. The TLV which has been proposed for ethylene glycol in Czechoslovakia is 40µg/L; the method described in this article enables concentrations down to 1µg/L to be detected in air samples of 5L.
Chemický průmysl, Dec. 1972, Vol.22, No.12, p.628-630. Illus. 13 ref.
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