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Aromatic amines - 303 entries found

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  • Aromatic amines

1989

CIS 89-1113 Aniline
Aniline [in French]
Chemical safety information sheet. Exposure limits (France, 1983): TWA = 10mg/m3. Acute toxicity: is absorbed through skin; methaemoglobinaemia; cyanosis; hepatic and renal disorders. Chronic toxicity: anaemia; dermatitis. EEC identification number and labelling codes: No.612-008-00-7; T; R23/24/25; R33, S28, S36/37; S44.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1989. 5p. Bibl.

1988

CIS 92-960
Commission of the European Communities
Biological indicators for the assessment of human exposure to industrial chemicals: Aromatic amines, aromatic nitro compounds, carbamate pesticides, nickel
The available data on the human health effects, metabolism and biological indicators of these substances are reviewed. Conclusions reached: for aromatic amines and aromatic nitro compounds, determination of methaemoglobin level is used for detecting recent exposure to those compounds capable of oxidising haemoglobin iron, along with measurement of the compounds or their metabolites in urine; the internal dose and level of exposure to carbamates can be assessed by determination of their urinary metabolites; for carbamate insecticides with anticholinesterase activity, blood cholinesterases can be used as bioindicators of absorption and effect; determination in plasma/serum and urine are the most useful methods for biological monitoring of nickel exposure.
Office for Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg, 1988. 80p. Illus. Bibl.ref.

CIS 90-1804 N,N-Diethylaniline
N,N-dwuetyloanilina [in Polish]
Chemical safety information sheet. No established exposure limit in Poland.
Centralny Instytut Ochrony Pracy, 1 Ul. Tamka, 00-349 Warszawa 30, Poland, 1988. 2p.

CIS 90-1271 Paustovskaja V.V., Torbin V.F., Ohota I.N., Onikienko F.A., Morgunova Ja.I.
Dimorpholinephenylmethane and benzilidenecyclohexylamine toxicity
Toksičnost' dimorfolinfenilmetana i benzilidenciklogeksilamina [in Russian]
Contents: formulae; physical and chemical properties; uses; toxicity; precautions; photometric method of determination of the substances in air (detection limit: 5µg) TSEL for dimorpholinephenylmethane (aerosol) is 10mg/m3 for workplace air, TSEL for benzilidenecyclohexylamine (aerosol+vapour) is 10mg/m3 for workplace air. The skin and the eyes should be protected during work with these compounds.
Gigiena truda i professional'nye zabolevanija, Sep. 1988, No.9, p.50-51.

CIS 90-407 Benzidine
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Toxicity: skin absorption; dermatitis; haematuria; bladder cancer (ACGIH A1 carcinogen).
U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati OH 45226-1988, USA, 1988. 6p. Bibl.

CIS 90-399 4-Aminodiphenyl, potential human carcinogen
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Toxicity: skin absorption; suspected carcinogen (ACGIH A2); methaemoglobinaemia; bladder cancer.
U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, 1988, 6p. Bibl.

CIS 90-50 beta-Naphthylamine, potential human carcinogen
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Exposure limits: none established. Toxicity: irritation of skin and eyes; blood in urine; possible cause of bladder cancer.
U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati OH 45226, USA, 1988. 6p. Bibl.

CIS 90-49 alpha-Naphthylamine, potential human carcinogen
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Exposure limits: none established. Toxicity: mild skin and eye irritation; methaemoglobinaemia; ataxia; suspected cause of bladder cancer.
US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati OH 45226, USA, 1988. 6p. Bibl.

CIS 89-1451 Aniline
Anilina [in Polish]
Chemical safety information sheet. Permissible exposure limit (Poland) = 5mg/m3.
Centralny Instytut Ochrony Pracy, 1 Ul. Tamka, 00-349 Warszawa 30, Poland, 1988. 2p.

CIS 89-1272 Gunderson E.C., Anderson C.C.
A sampling and analytical method for airborne m-phenylenediamine (MPDA) and 4,4'-methylenedianiline (MDA)
Aerosol and vapour MPDA and MDA are collected on an acid-coated, glass-fiber filter to stabilize them as their amine salts. The amines are extracted from the filter with a mixture of acetonitrile in aqueous base and then treated with acetic anhydride to form the diacetamide derivatives. The derivatives are analyzed by high performance liquid chromatography with UV detection. The method may be used with confidence to measure from 0.90 to 755µg of MPDA and/or 0.36 to 55µg of MDA in a total air volume of 200 to 630L, sampling at a rate of 1.5 to 2.0L/min. Collected samples remain stable on filters for at least 1 week before analysis. The method will not suffer from interference from high relative humidity or other process volatiles, including diglycidyl ether of bisphenyl [sic] A and bis(2,3-epoxycyclopentyl)ether. This method can be applied to most aromatic amines and is recommended for monitoring both ambient and workplace air.
American Industrial Hygiene Association Journal, Oct. 1988, Vol.49, No.10, p.531-538. Illus. 10 ref.

CIS 89-364 Dewan A., Jani J.P., Patel J.S., Gandhi D.N., Variya M.R., Ghodasara N.B.
Benzidine and its acetylated metabolites in the urine of workers exposed to Direct Black 38
Urine samples of workers in a small-scale unit manufacturing Direct Black 38 were analysed by high-pressure liquid chromatography for the presence of benzidine and mono and diacetyl benzidine. Acetylated metabolites were found in all the urine samples, and benzidine was found in all except two. Two workers excreted very high levels of benzidine and its metabolites in their urine. This study highlights the potential risk of bladder cancer in such units of developing countries where manufacture of benzidine-based dyes is yet to be regulated.
Archives of Environmental Health, July-Aug. 1988, Vol.43, No.4, p.269-272. 16 ref.

CIS 89-597 Schmidt P.
Zentralinstitut für Arbeitsmedizin der DDR
Biological monitoring methods in occupational medicine
Biologische Kontrollmethoden in der Arbeitsmedizin [in German]
Manual for occupational health care personnel and inspectors. Chapters cover: the value of laboratory diagnosis to the occupational physician; biological exposure tests as a component of medical surveillance of workers exposed to harmful substances; toxicological bases of exposure assessment; exposure to substances in the general environment as a part of total exposure; principles of genetics applicable to the evaluation of exposure tests; recognition and evaluation of carcinogens, mutagens, teratogens and embryotoxic substances; variations in the pollution of workplace air; sampling; the analytical laboratory; assessment of the reliability and validity of biological exposure tests; properties, analysis and monitoring of 21 substances or groups of substances.
VEB Volk und Gesundheit, Berlin, German Democratic Republic, 1988. 464p. Illus. Bibl.ref. Index.

CIS 88-1437 Aniline
Chemical safety information sheet. Exposure limit: ACGIH (1987-88) TLV = 10mg/m3. Toxicity: is absorbed through the skin; formation of methaemoglobin leading to cyanosis; eye irritation; skin burns. US DOT classification: Poisonous liquid, Class B.
National Safety Council, 444 North Michigan Ave., Chicago, IL 60611-3991, USA, 1988. 5p. Bibl.

1987

CIS 90-2002 Apricena M., Bavazzano P., Carnevale F., Constantini A.S.
Aromatic amines - Toxicity, use, control, monitoring
Ammine aromatiche - Tossicità, uso, controllo, vigilanza [in Italian]
Contents of this guidance note: industries using aromatic amines; statistics on workplaces and exposed workers in the Toscany region of Italy; toxic effects of aromatic amines; exposure evaluation (maintenance of regional data archives, environmental and biological monitoring, exposure standards). In annex: texts of relevant Italian legislation.
Giunta regionale, Regione Toscana, via di Novoli 26, Firenze 50127, Italy, 1987. 85p. 17 ref.

CIS 89-1580 Šmidt P., Ivanov N.G.
Methodological approaches to the assessment of short-term exposure to industrial chemicals with hepatotoxic properties
Metodočeskie podhody k ocenke gepatotropnogo dejstvija promyšlennyh veščestv pri kratkosročnom vozdejstvii [in Russian]
Animal experiments carried out to investigate changes in liver function as a result of short-term exposure to known hepatotoxic chemicals (carbon tetrachloride, allyl alcohol, styrene) and to new industrial chemical compounds (diallyl phthalate, diaminodiphenylmethane etc.) showed the need for standardisation of experimental conditions for determination of the threshold of acute action of toxic chemicals on liver function for the purposes of hygienic standardisation. A set of compulsory and additional tests for detecting hepatotoxic effects of occupational poisons under conditions of short-term exposure is recommended.
Gigiena truda i professional'nye zabolevanija, Dec. 1987, No.12, p.33-36. Illus. 8 ref.

CIS 89-759 2-Naphthylamine
2-Naftylamin; β-naftylamin [in Swedish]
Chemical safety information sheet taken from the Kemiska Ämnen Register (see CIS 89-214). Toxicity: carcinogen; skin absorption.
Arbetarskyddsnämnden, Box 3208, 103 64 Stockholm, Sweden, 1987. 3p.

CIS 89-404 Benzidine
Bensidin, 4,4'-diaminobifenyl [in Swedish]
Chemical safety information sheet taken from the Kemiska Ämnen Register (CIS 89-214). Toxicity: carcinogen; skin absorption; liver and kidney damage; blood disorders.
Arbetarskyddsnämnden, Box 3208, 103 64. Stockholm, Sweden, 1987. 2p.

CIS 89-393 4-Aminobiphenyl
4-aminobifenyl; 4-aminodifenyl [in Swedish]
Chemical safety information sheet taken from the Kemiska Ämnen Register (see CIS 89-214). Toxicity: carcinogen; skin absorption; toxic effects are similar to those of benzidine; affects blood; liver and kidney damage.
Arbetarskyddsnämnden, Box 3208, 103 64 Stockholm, Sweden, 1987. 2p.

CIS 88-1784 Aniline
Aniline [in French]
Chemical safety information sheet. Exposure limit (France, 1983): TWA = 10mg/m3. Toxicity: cyanosis, dermatitis, anaemia.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1987. 4p. 24 ref.

CIS 88-1308 Diaminotoluenes
This evaluation of the toxicity data includes: summary and conclusions; identity, properties, analytical methods; sources in the environment, environmental transport and distribution; environmental levels and human exposure; kinetics and metabolism; effects on organisms in the environment; effects on animals and in vitro test systems; effects on man; evaluation of human health risks and effects on the environment; recommendations; previous evaluations by international bodies.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1987. 67p. Bibl. Price: CHF 9.00.

CIS 88-238 Fowler J.F.
Occupational dermatitis from stamp pad ink
Report of a case of eczema in a bank employee who spent long periods marking cheques and documents with rubber stamps. Patch testing showed her to be allergic to the red stamp pad ink, which contained p-phenylazoaniline. As she also reacted to p-phenylenediamine, which is an intermediate in the production of p-phenylazoaniline that might have been present in the ink, the precise chemical identity of the causative agent remains unclear. Careful avoidance of contact with the ink prevented recurrence of the problem.
Contact Dermatitis, Jan. 1987, Vol.16, No.1, p.38. 2 ref.

CIS 87-781
Institution of Occupational Safety and Health
Aniline
Chemical safety information sheet. Moderately flammable. Is rapidly absorbed through the skin. Acute toxicity: asphyxiant (inhibits blood oxygen uptake). Chronic toxicity: anaemia, headaches, digestive disorders. Exposure limits (United Kingdom): 8h TWA = 10mg/m3; 10min TWA = 20mg/m3.
Safety Practitioner, June 1987, Vol.4, No.6, p.44-45. 17 ref.

1986

CIS 89-1324
Sovet Ėkonomičeskoj Vzaimopomo¿či
Occupational Safety and Health - Methods for determining chemical substances in workplace air
Gigiena truda i professional'nye zabolevanija - Metody opredelenija himičeskih veščestv v vozduhe rabočej zony [in Russian]
Methods for the determination of the following hazardous substances in workplace air: dimethyl sulfate, norbornene polychlorinated biphenyls, benzidine, p-chlorophenol, carbon monoxide, chloroacetophenone, water-soluble chromium compounds, tetraethyllead, oil aerosols, epichlorohydrin, volatile hydrocarbons from cutting fluids, solvent naphtha. The gas chromatographic and photometric methods have been adopted as official methods of the Council for Mutual Economic Assistance.
Izdatel'skij otdel, Upravlenija delami Sekretariata SĖV, prospekt Kalinina 56, 121205 Moskva, USSR, 1986. 49p.

CIS 89-558 Jarym-Agaeva N.T., Putilina O.N.
Photometric method of aniline and phenyl isocyanate determination in workplace air
Fotometričeskij metod opredelenija anilina i fenilizocianata v vozduhe rabočej zony [in Russian]
Aniline and phenyl isocyanate are determined by rection with p-dimethylaminobenzaldehyde to give diphenylmethanediamine and diphenylmethane diisocyanate. Air samples are passed through absorber solutions containing the reagent. In 40% acetic acid, both aniline and phenyl isocyanate react; in 1% ammonia, only aniline reacts. The absorbance of the solutions at 430-450nm is measured and compared with the absorbance of standard solutions. Phenyl isocyanate concentration is calculated from the difference in absorbance between the acetic-acid and ammonia reaction media.
Gigiena truda i professional'nye zabolevanija, Oct. 1986, No.10, p.56-57. 2 ref.

CIS 89-610 The health effects of aromatic amines - A review
This review covers anilines, benzidines, diaminodiphenylmethanes, naphthylamines and aminoazobenzenes. Topics: commercial production, uses, environmental sources and fate, environmental and occupational levels and exposure, comparative metabolism and structure-toxicity relationships, and clinical studies and short-term tests of toxicity. The International Agency for Research on Cancer classifies 6 products as known human carcinogens: analgesic mixtures containing phenacetin, benzidine, 2-naphthylamine, chlornaphazine, 4-aminobiphenyl and compounds involved in auramine manufacture. Probably carcinogenic are o-toluidine, phenacetin, compounds involved in magenta manufacture ("higher degree of evidence"), 3,3'-dimethoxybenzidine, 3,3'-dichlorobenzidine, auramine, Direct Black 38, Direct Blue 6 and Direct Brown 95 ("lower degree of evidence").
King's College London, Monitoring and Assessment Research Centre, MARC, The Octagon Building, 459A Fulham Road, London SW10 OQX, United Kingdom, 1986. 127p. Bibl. Price: GBP 15.00.

CIS 88-782 Aniline
Chemical safety information sheet. Exposure limit: ACGIH TLV = 10mg/m3 (skin). Toxicity: skin absorption; methaemoglobinaemia; liver and kidney damage.
Indian Chemical Manufacturers Association, India Exchange, India Exchange Place, Calcutta 700 001, India, 1986. 1p.

CIS 88-274 Gudéhn A., Kolmodin-Hedman B.
Sampling and determination of airborne fenitrothion, dimethoate, mevinphos, linuron, metoxuron and trifluralin
Luftprovtagning av bekämpningsmedel inom trädgårdsnäringen [in Swedish]
Methods for personal sampling in the breathing zone of market gardeners working with pesticides were developed and/or evaluated in laboratory experiments. Fenitrothion, dimethoate, linuron, metoxuron and trifluralin were trapped on fibreglass filters and mevinphos was trapped in an XAD-4 adsorption tube. Recoveries ranged from 83-106%. No impairment in recovery was found after samples were stored for 3 weeks in the dark at -20°C.
Arbetarskyddsstyrelsen, Publikationsservice, 171 84 Solna, Sweden, 1986. 31p. Illus. 33 ref.

CIS 88-59 Anisidine (o, p-isomers)
Anisidiini [in Finnish]
The substance o-anisidine is a sensitising toxic liquid (TLV = 0.5mg/m3). The vapour is toxic if inhaled. The liquid is readily absorbed through the skin; toxic if ingested; irritates the skin; can cause eczema and damage to the eyes. Causes anaemia and a lowered ability of the blood to take up oxygen. Long term exposure can cause damage to the central nervous system, the liver and the kidneys. Mandatory European labelling: T, R26, R27, R28, R33, S28, S36, S37, S45.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 536, 33101 Tampere, Finland, Aug. 1986. 2p. Original on microfiche.

CIS 88-58 Aniline
Aniliini [in Finnish]
Aniline is a carcinogen (LD50 = 440mg/kg; TLV = 2ppm). The vapour is toxic if inhaled. The liquid is absorbed through the skin, is toxic if in contact with the skin and is harmful if ingested. It irritates the skin and the mucous membranes and is a sensitiser. It causes lowered ability of the blood to take up oxygen, leading to anaemia and haematuria. Long term exposure can cause damage to the central nervous system, the liver and the kidneys. Mandatory European labelling: T, R23, R24, R25, R33, R103, S28, S36, S37, S44, S103.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 538, 33101 Tampere, Finland, Feb. 1986. 2p. Original on microfiche.

CIS 87-629 4,4'-Methylenedianiline (MDA)
Increased incidences of cancer in workers exposed to MDA have been reported. Described are: background (properties, production and uses, exposure limits); toxicity (acute, mutagenic and carcinogenic effects and effects on human health); recommendations. Guidelines are given to reduce worker exposure to the feasible limit: exposure monitoring; controlling exposure (product substitution, closed systems and ventilation, worker isolation, personal protective clothing, respiratory protection, decontamination procedure); medical surveillance.
U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control (NIOSH), Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, 25 July 1986. (Revised edition). 21p. 57 ref.

CIS 87-108 Methylenedianiline
4,4'-Diaminodiphénylméthane [in French]
Uses; physicochemical properties; storage; measurement in air; fire hazards; toxicology (animal, human); health effects (hepatotoxic); regulations; recommendations (medical, technical).
Cahiers de notes documentaires - Sécurité et hygiène du travail, 3rd Quarter 1986, No.124, p.405-408. Bibl.

CIS 86-1862 Skipper P.L., Bryant M.S., Tannenbaum S.R., Groopman J.D.
Analytical methods for assessing exposure to 4-aminobiphenyl based on protein adduct formation
Past studies with animals have demonstrated that 4-aminobiphenyl (ABP) administration results in the formation of appreciable amounts of adducts between the carcinogen and both serum albumin and haemoglobin. The haemoglobin adduct is relatively stable in vivo, but may be readily hydrolysed in vitro to regenerate ABP. The formation of this adduct reflects a mixed-function-oxidase-mediated metabolic pathway operating directly on the amine. The predominant albumin adduct, 3-(tryptophan-N1-yl)-4-acetylaminobiphenyl, reflects the contribution of N-acetyltransferase activity as well as mixed-function-oxidase activity to the overall metabolism. The simultaneous measurement of these 2 different adducts thus offers an opportunity to investigate the role of both ABP and acetylator phenotype in bladder carcinogenesis. An analytical method, using gas chromatography coupled with electron capture detection, was developed to quantitate ABP adducted to haemoglobin.
Journal of Occupational Medicine, Aug. 1986, Vol.28, No.8, p.643-646. Illus. 8 ref.

CIS 86-1645 Cocker J., Gristwood W., Wilson H.K.
Assessment of occupational exposure to 4,4'-diaminodiphenylmethane (methylene dianiline) by gas chromatography-mass spectrometry analysis of urine
Description of a new specific and sensitive analytical method used for the monitoring of workers exposed to 4,4'-diaminodiphenylmethane (DDM). The method involves the isolation and identification of a major urinary metabolite of DDM, i.e. one of its N-acetyl conjugates. This determination method is judged to be particularly useful where the main exposure pathway is not inhalation.
British Journal of Industrial Medicine, Sep. 1986, Vol.43, No.9, p.620-625. Illus. 21 ref.

1985

CIS 99-1992 Castegnaro M., Barek J., Dennis J., Ellen G., Klibanov M., Lafontaine M., Mitchum R., Van Roosmalen P., Sansone E.B., Sternson L.A., Vahl M.
Laboratory decontamination and destruction of carcinogens in laboratory wastes: Some aromatic amines and 4-nitrobiphenyl
Topics: 4-nitrobiphenyl; aromatic amines; carcinogens; methylenebis(2-chloroaniline); dimethoxybenzidine; dimethylbenzidine; 1-naphthylamine; 2-naphthylamine; 3,3'-dichlorobenzidine; 4-aminobiphenyl; benzidine; 2,4-diaminotoluene; description of technique; disposal of harmful waste; IARC; laboratory work; manuals; pollution control.
International Agency for Research on Cancer (IARC), 150 cours Albert Thomas, 69372 Lyon Cedex 08, France, 1985. 85p. Illus. 88 ref.

CIS 87-1201 Benzidine dihydrochloride
Bentsidiinidihydrokloridi [in Finnish]
Benzidine dihydrochloride is a highly toxic carcinogenic agent (LDLO = 200mg/kg). The dust and the vapour are toxic if inhaled. The substance is toxic if ingested and if in contact with the skin. It is absorbed through the skin. Causes methaemoglobinaemia, headache and nausea. Long term exposure can cause renal and hepatic damage. Mandatory European labelling: T, R26, R27, R28, R38, R39, R102, S22, S27, S36, S45, S23, S38, S46, S102.
Register of Safety Information of Chemical Products, National Board of Labour Protection, Box 536, 33101 Tampere, Finland, May 1985. 2p. Original on microfiche.

CIS 87-804 C.I. Basic Green 1
Chemical safety information sheet. Very toxic; probable human lethal dose is 50-500mg/kg. Irritates the skin. No established exposure limit.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 4p.

CIS 86-1618 Dimethyl-p-phenylenediamine
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 86-1603 Diethyl-p-phenylenediamine
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 86-1600 Benzenamine, 3-(trifluoromethyl)-
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 4p.

CIS 86-1683 Lewalter J., Korallus U.
Blood protein conjugates and acetylation of aromatic amines - New findings on biological monitoring
Internal stress by aromatic amines has so far been evaluated by their determination in blood or urine and by the degree of methaemoglobin formation. These materials can form adducts and conjugates with proteins and nucleic acids. The formation of protein conjugates depends on the individual's ability to acetylate foreign substances, as only free non-acetylated aminoaromates can form conjugates with haemoglobin. These aminoaromates or their metabolites can then be detected quantitatively in intact erythrocytes. The degree of this protein conjugate formation correlates inversely with the magnitude of the acetylation potential. If these facts are kept in mind, a clearer assessment of past or recent stress can be obtained by a single determination of such haemaglobin adducts rather than by the traditional quantitative determination of aminoaromates or their metabolites or methaemoglobin in blood and/or urine.
International Archives of Occupational and Environmental Health, 1985, Vol.56, No.3, p.179-196. Illus. 46 ref.

CIS 86-1564 Aniline, 2,4,6-trimethyl-
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 3p.

CIS 86-1321 Aniline
Aspects covered in this data sheet: chemical identity; exposure limits; physicochemical properties; fire and explosion hazards; reactivity; health hazards; uses; handling of spills or releases.
In: EPA Chemical Profiles, United States Environmental Protection Agency, Washington D.C. 20460, USA, Dec. 1985. 4p.

CIS 86-1025 Poddubnaja L.P.
Products of the thermal destruction of aromatic polyamide materials in an air stream
Produkty termodestrukcii v toke vozduha materialov na osnove aromatičeskih poliamidov [in Russian]
Materials based on aromatic polyamides form during their pyrolysis in air (600-850°C) a complex of volatile substances - carbon oxides, saturated, unsaturated and aromatic hydrocarbons, and a number of nitrogen-containing compounds including hydrogen cyanide. Polyamides based on meta-phenylenediamine and isophthalic acid form the largest amount of volatile substances such as hydrogen cyanide, aromatic amines, ammonia, and nitrogen oxides.
Gigiena i sanitarija, Jan. 1985, No.1, p.25-28. Illus. 7 ref.

CIS 86-174 Mathur N.K., Mathur A., Banerjee K.
Contact dermatitis in tie and dye industry workers
A survey of the 'tie and dye' industry of Jodhpur City in India was made to investigate occupational dermatoses. 49 (16.6%) of 250 workers had incapacitating dermatitis. Skin lesions were seen mostly over the dorsa of the hands and fingers. 26 patients were patch tested with various dyes and chemicals; 14 were positive. Fast Red RC salt was the most potent sensitiser. Other dyes showing positive reactions were Orange GC salt, Bordeaux GP salt, Blue B salt, Red B base and naphthol.
Contact Dermatitis, Jan. 1985, Vol.12, No.1, p.38-41. Illus. 5 ref.

CIS 85-1913 Upadhyay S., Gupta V.K.
A new reagent system for spectrophotometric determination of benzidine
This method is based on the diazotisation of benzidine and its subsequent coupling with 8-hydroxyquinoline. The red coloured dye thus formed is extracted into 3-methyl-1-butanol. The Beer's law is obeyed in the range of 0.03 to 0.30µg/mL. The molar absorptivity and Sandell's sensitivity are 6.4 x 104L/mol/cm and 0.0026µg/cm2 respectively. Analysis of urine samples showed a 95% benzidine recovery level. Metal ions forming hydroxides in alkaline medias were expected to interfere but were masked with EDTA. The standard deviation and relative standard deviation for the method were 0.01 and 0.15%, respectively.
American Industrial Hygiene Association Journal, Sep. 1985, Vol.46, No.9, p.524-525. 9 ref.

CIS 85-1948 Totolo R.
Medical surveillance of workers at risk of developing bladder cancer due to exposure to aromatic amines
Surveillance médicale des travailleurs soumis à un risque de tumeur vésicale due aux amines aromatiques [in French]
Medical thesis covering early detection methods for bladder tumours due to exposure to aromatic amines in industry. Epidemiology, aetiopathology, histology and evolution of bladder cancer. Clinical investigation techniques in occupational medicine. Strategies for medical surveillance during pre-employment examinations and for exposed workers. Legislative aspects, particularly in Italy. The need for new regulations (clinical and complementary examinations, medical files, periodic examinations, follow-up after the cessation of exposure) and for the standardisation of surveillance criteria are emphasised.
Université de Paris Val-de-Marne, Faculté de médecine de Créteil, Paris, France. 1985. 139p. 172 ref.

CIS 85-1028 Castegnaro M., Malaveille C., Brouet I., Michelon J., Barek J.
Destruction of aromatic amines in laboratory wastes through oxidation with potassium permanganate/sulfuric acid into non-mutagenic derivatives
Description of the experimental conditions for the complete degradation of 9 aromatic amines (benzidine; o-tolidine; o-dianisidine; 3,3'-dichlorobenzidine; 4-aminobiphenyl; 1- and 2-naphthylamine; 4,4' - methylene bis(2-chloroaniline); m-toluenediamine). The corresponding degradation products were found to be non-mutagenic to Salmonella typhimurium strains.
American Industrial Hygiene Association Journal, Apr. 1985, Vol.46, No.4, p.187-191. Illus. 23 ref.

CIS 85-1042 Schulte P.A., Ringen K., Hemstreet G.P., Altekruse E.B., Gullen W.H., Patton M.G., Allsbrook W.C., Crosby J.H., West S.S., Witherington R., Koss L., Bales C.E., Tillet S., Rooks S.C.F., Stern F., Stringer W., Schmidt V.A., Brubaker M.M.
Risk assessment of a cohort exposed to aromatic amines - Initial results
A cohort of 1,385 U.S. workers potentially exposed to carcinogenic amines was evaluated to determine the extent of their risk of contracting bladder cancer. Initial results revealed 13 confirmed cases of bladder cancer. The latency period was found to be much shorter in black workers than in the general U.S. population.
Journal of Occupational Medicine, Feb. 1985, Vol.27, No.2, p.115-121. Illus. 19 ref.

1984

CIS 85-1330 Belegaud J.
Oxygenated and halogenated derivatives. Amino and nitro derivatives. Organic nitriles. Sulfur derivatives of hydrocarbons
Dérivés oxygénés et halogénés. Dérivés aminés et nitrés. Nitriles organiques. Dérivés soufrés des hydrocarbures [in French]
General review of the principal derivatives of hydrocarbons: physical and chemical properties, uses, toxicity, clinical aspects of exposure, preventive measures; exposure limits and occupational disease criteria for certain compounds. Classes and representative compounds dealt with are: halogenated alcohols (epichlorohydrin and chloroethanol); ethers (bis-chloromethyl ether and chloromethyl methyl ether); phenols (pentachlorophenol and hexachlorophene); polycyclic oxygen-containing compounds (dioxins); aliphatic and alicyclic amines (alkylamines, polyamines and alkanolamines); derivatives of benzene, naphthalene, biphenyl and benzyl compounds; aliphatic, and aromatic nitro, nitroso, azo and quaternary ammonium compounds; organic nitriles (cyanohydrins, acetonitrile, acrylonitrile and methacrylonitrile); sulfur-containing derivatives (thiols, thioethers, dimethylsulfoxide, alkyl sulfates).
Encyclopédie médico-chirurgicale, Intoxications, 1984, 16p. 18 ref.

CIS 85-1065 Bastian P.G.
Occupational hepatitis caused by methylenedianiline
4 of 6 workmen engaged in laying an epoxy-resin based floor developed an acute hepatic illness. They worked in a confined space, under hot and humid conditions. Gauze masks or half-face respirators were worn. In 2 of the men the illness recurred on re-exposure a few months later, and their convalescence was prolonged. Methylenedianiline, used as a curing agent for the epoxy resin, was the most likely hepatotoxin (conclusion based on the similarity of symptoms to other reports of toxic exposure to this substance). No evidence of lasting liver damage was found.
Medical Journal of Australia, 13 Oct. 1984, Vol.141, No.8, p.533-535. 13 ref.

CIS 85-762 Candura F., Moscato G.
Do amines induce occupational asthma in workers manufacturing polyurethane foams?
12 workers occupationally exposed to polyurethane foams and with symptoms of wheezing and breathlessness were subjected to a bronchial provocation test with methacholine (to establish a dose-response curve), toluenediisocyanate (TDI) at 0.01ppm, and toluenediamine (TDA) at 1.31mg/m3 and at 3.21mg/m3. High sensitivity to methacholine (positive response below 1000g administered) was shown in 10 subjects. All the subjects had positive reactions to TDI, and none of them responded to TDA at either concentration. These data suggest that TDI is the agent for the respiratory symptoms, and that TDA does not produce asthma.
British Journal of Industrial Medicine, Nov. 1984, Vol.41, No.4, p.552-553. Illus. 10 ref.

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