Amides - 479 entries found

Your search criteria are

• Amides

1994

CIS 95-1016 Kanerva L., Estlander T., Jolanki R.
Occupational allergic contact dermatitis caused by thiourea compounds
Case reports are presented of five patients with allergic patch test reactions caused by thiourea compounds. Sources of thiourea included diphenylthiourea in neoprene gloves and pesticides, and diethylthiourea in a knee brace. Since allergic contact dermatitis by thiourea compounds can be verified only by patch testing, patients with contact dermatitis who have been exposed to thiourea compounds (such as rubber, PVC plastic or adhesive, diazo paper, paints or glue remover, anticorrosive agents, fungicides or pesticides) should be patch tested with a series of thiourea compounds.
Contact Dermatitis, Oct. 1994, Vol.31, No.4, p.242-248. 48 ref.

CIS 95-988 Nagatoshi H., Itoh I., Takeda S.
Determination of urinary metabolites of organic solvents among chemical industry workers
Sōgō kagaku kōgyō ni okeru yūkiyōzai no nyōchū taishabutsu sokutei seiseki [in Japanese]
The Japanese Regulation on the Prevention of Organic Solvent Poisoning was revised on 30 June 1989. It requires employers, as part of workers' health examinations, to measure urinary metabolites of 8 additional organic solvents: xylene, N,N-dimethylformamide, styrene, 1,1,1-trichloroethane, tetrachloroethylene, trichloroethylene, toluene and n-hexane. Eight establishments of five chemical companies (the members of an industry association) conducted such examinations on 1073 workers in 1990. Workers exposed to imperceptible amounts of organic solvents or those whose urine was collected at an unknown time after exposure numbered 615 (57.3%). Workers whose urine was collected within 5h after exposure numbered 458 (42.7%). These workers' urinary metabolite concentrations were significantly lower than the official Biological Exposure Index values. Thus, at establishments of chemical companies where good health-protection measures are in place, worker exposure levels seem to be low.
Japanese Journal of Industrial Health - Sangyō-Igaku, Mar. 1994, Vol.36, No.2, p. 106-113. Illus. 3 ref.

CIS 95-674
Gesellschaft Deutscher Chemiker (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
N,N-Dimethylformamide
Dimethylformamide (DMF) is readily absorbed orally, dermally and by inhalation. The main effects are hepatotoxic effects following both acute and chronic exposure. Other effects include irritation of the skin and mucous membranes, skin sensitization, eczema, neurotoxic effects, cardiovascular and gastrointestinal complaints and damage to the kidneys and other organs. DMF also leads to synergistic effects with alcohol or to alcohol intolerance reactions. Embryotoxic and teratogenic effects have been observed in experimental animals and there are reports of increased chromosome aberrations in humans. Reports of a possible relationship between cancer and DMF exposure have not been confirmed.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1994. xiii, 84p. 188 ref. Price: DEM 48.00.

CIS 94-2030 Davies C.
Health and Safety Executive
Dimethylcarbamoyl chloride
Very little information is available on the human health effects of dimethylcarbamoyl chloride and no conclusions can be drawn from the few studies reported. Animal studies indicate that the substance may be absorbed through the skin and causes irritation of the skin, eyes and respiratory tract. Findings of carcinogenicity and mutagenicity in animals are predicted to be relevant to human health.
HSE Books, P.O. Box 1999, Sudbury CO10 6FS, Suffolk, United Kingdom, 1994. iii, 11p. 26 ref. Price: GBP 7.50.

CIS 94-2018 Gregg N., Rajan B., Wright A., White J.
Health and Safety Executive
Paracetamol. Criteria document for an occupational exposure limit
Most of the information on the effects of acute exposure to paracetamol (acetaminophen) are from cases of intentional oral overdosing; death is usually attributed to liver failure. There is no information on inhalation or dermal exposure. Paracetamol is not expected to produce skin or eye irritation and does not have any significant sensitization potential. No firm conclusions can be drawn regarding genotoxic or developmental effects. Occupational exposure standard: 10mg/m³ total inhalable paracetamol (8h TWA). List of abbreviations.
HSE Books, PO Box 1999, Sudbury, Suffolk CO10 6FS, United Kingdom, 1994. v, 50p. 118 ref. Price: GBP 10.00.

CIS 94-1156 Ferbam
Ferbam [in Spanish]
Chemical safety sheet published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: skin absorption; irritation of the eyes and respiratory tract; gastrointestinal disorders on ingestion; skin eruption and dermatitis.
Noticias de seguridad, Mar. 1994, Vol.56, No.3. 4p. Insert.

1993

CIS 07-1407
International Programme on Chemical Safety (IPCS)
Benomyl - Health and safety guide
This document provides practical guidance on the application of exposure limitation guidelines contained in Environmental Health Criteria 148 (see CIS 93-1974). Contents: identity and uses of benomyl; human health hazards; health surveillance and first aid; safety in storage and use; environmental hazards; summary of chemical safety information for use in the workplace; current regulations and guidelines. Benomyl has a low toxicity in humans; the primary toxic effects are dermal sensitization and contact dermatitis.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1993. 23p. Illus. 8 ref.
http://www.inchem.org/documents/hsg/hsg/hsg81_e.htm [in English]

CIS 07-1405
International Programme on Chemical Safety (IPCS)
Carbaryl - Health and safety guide
This document provides practical guidance on the application of exposure limitation guidelines contained in Environmental Health Criteria 153 (see CIS 98-1401). Contents: identity and uses of carbaryl; human health hazards; health surveillance and first aid; safety in storage and use; environmental hazards; current regulations and guidelines. Carbaryl may be absorbed via inhalation, ingestion and through the skin; ingestion may lead to severe poisoning. The principal mechanism of action is cholinesterase inhibition. It is irritating to the eyes, skin and respiratory tract.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1993. 39p. Illus. 32 ref.
http://www.inchem.org/documents/hsg/hsg/hsg78_e.htm [in English]

CIS 97-963 Savolainen K.
Nordic Expert Group for Documentation of Occupational Exposure Limits. 108. Ethylenebisdithiocarbamates and ethylenethiourea
Nordiska Expertgruppen för Gränsvärdesdokumentation. 108. Etylenbisditiokarbamater och etylentiourinämne [in Swedish]
A critical survey of the literature relevant to the discussion of an occupational exposure limit for ethylenebisdithiocarbamate (EBDC) fungicides (maneb, mancozeb and zineb) and ethylenethiourea (ETU) is given. The critical effects of exposure to EBDCs are toxic effects on the thyroid gland, and their sensitizing, cross sensitizing and cross-reactivity properties. Mancozeb is also a possible carcinogen. The critical effects of ETU are directed towards the thyroid gland, where ETU induces thyroid hyperplasia and follicular carcinomas at low doses. The occupational exposure limits for EBDCs are based on their sensitizing properties, on their effects on the thyroid gland and their possible carcinogenic effects in rodents. The main emphasis in the occupational exposure limit for ETU is on its goitrogenic and thyroid carcinogenic properties. There is a need to emphasize the significance of biological monitoring, and to reduce exposure to EBDCs and ETU rather than develop more detailed occupational exposure limits. It is important, therefore, to delineate dermal absorption, and the metabolic pathways of EBDC fungicides and ETU for the development of biological monitoring methods. Moreover, an understanding of the effects of these fungicides on the thyroid is crucial for adequate risk assessment.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1993. 44p. 165 ref.

CIS 97-962 Beije B, Lundberg P.
Criteria Documents from the Nordic Expert Group, 1993
This volume consists of English translations of the criteria documents which were published in a Scandinavian language during 1993. The documents concern: crystalline silica, diesel exhaust (see CIS 97-961), ethylenebisdithiocarbamates and ethylenethiourea (see CIS 97-963) and limonene.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1993. 249p. 1016 ref.

CIS 96-1581 Formamide
International Chemical Safety Card. Short-term exposure effects: skin absorption; affects the central nervous system; swallowing the liquid may cause aspiration into the lungs with the risk of chemical pneumonitis. Long-term exposure effects: affects the liver; genetic effects. Occupational exposure limit: 10ppm, 18mg/m³ (skin) (ACGIH 1990-1991).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 96-1249 Chlorthiamid
International Chemical Safety Card. Short-term exposure effects: no specific effects.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 96-1222 Ferbam
International Chemical Safety Card. Short-term exposure effects: Irritates the eyes, the skin and the respiratory tract; effects on the central nervous system. Long-term exposure effects: dermatitis, skin sensitization; may in high doses cause toxicity in the nervous system and the thyroid gland. Occupational exposure limit: TLV: 10mg/m³ (ACGIH 1990-1991).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 95-1204 Thiocarbamide
International chemical safety card. Synonym: thiourea. Short-term exposure effects: skin absorption; irritation of mucosa, eyes and respiratory tract. Long-term exposure effects: skin sensitization; may affect the bone marrow (anaemia or goitre); possible human carcinogen.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Geneva 27, Switzerland, 1993. 2p.

CIS 95-820 2-Chloroacetamide
International chemical safety card. Acute hazards: cough, headache, nausea, shortness of breath, vomiting if inhaled; chemical burns on contact.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 95-397 Hardening plastics [Sweden]
Härdplaster [in Swedish]
This directive, which came into force 1 January 1994, applies to all work with hardening plastics. General requirements cover work with all hardening plastics, especially spraying, work with hot objects and control of hazardous substances in the air. Employers must provide workers with medical examinations before work is initiated, and again if a worker shows respiratory problems. Cleaning and general housekeeping are covered. Special chapters deal with epoxies, polyurethanes, esters, acrylates and amino- and phenoplastics. Comments and rules of application are included.
National Board of Occupational Safety and Health, Publikationsservice, Box 1300, 171 25 Solna, Sweden, 23 Aug. 1993. 78p.

CIS 95-70 Urea
International chemical safety card. Short term exposure effects: eye irritation.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Geneva 27, Switzerland, 1993. 2p.

CIS 94-1857 Thioacetamide
International chemical safety card. Short term exposure effects: irritation of the eyes, skin and respiratory tract. Long term exposure effects: possible human carcinogen.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Geneva 27, Switzerland, 1993. 2p.

CIS 94-1019
International Programme on Chemical Safety (IPCS)
Carbendazim
Given the similar toxicities of benomyl and carbendazim (methyl 2-benzimidazolylcarbamate, the main metabolite of benomyl in mammals), the two fungicides are evaluated together in this monograph. No adverse effects on human health have been reported. Both substances represent a very low risk for acute poisoning in humans; benomyl causes dermal sensitization. Animal data and the limited human data available indicate that it is unlikely that these substances would cause systemic toxicity effects in occupationally exposed subjects. Detailed summaries in French and Spanish.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1993. 132p. Illus. approx. 190 ref. Price: CHF 22.00 (developing countries: CHF 12.60).

CIS 94-1031 Garnier R.
Acrylamide - Acrylonitrile
Acrylamide - Acrylonitrile [in French]
There exist many acrylic monomers, with diverse industrial uses. As far as toxicology is concerned, acrylamide and acrylonitrile are the two most important. Acrylamide is used above all in the production of polymers utilized principally in water treatment. Its main toxicity acts on the nervous system (central and peripheral neuron damage). Acrylonitrile is used mostly in the manufacturing of textile fibres and elastomers. It is a powerful irritant, with high acute toxicity (widespread damage to internal organs). It is also genotoxic and carcinogenic.
Encyclopédie médico-chirurgicale, Intoxications - Pathologie professionnelle, 1993, Vol.64, No.101, 10p. 62+44 ref.

CIS 94-974 Brouwer R., van Maarleveld K., Ravensberg L., Meuling W., de Kort W., van Hemmen J.J.
Skin contamination, airborne concentrations, and urinary metabolite excretion of propoxur during harvesting of flowers in greenhouses
In eight greenhouses used for carnation culture, workers engaged in harvesting (n=16) were monitored for dermal and respiratory exposure and urinary excretion of propoxur. Total estimated dermal and respiratory exposure during harvesting ranged from 0.2 to 46mg and from 3 to 278µg, respectively. To study the relationship between external and internal exposure to propoxur, respiratory and dermal exposure levels were compared with the total amount of 2-isopropoxyphenol (IPP), the major metabolite of propoxur, excreted in urine in 24hrs. The Pearson correlation coefficient between dermal exposure and the total amount of excreted IPP was 0.95. A correlation coefficient of 0.84 was found between respiratory exposure and the amount of IPP excreted. The latter association was probably caused by the covariation of respiratory and dermal exposure levels (r=0.85). Calculations indicated that dermal exposure could account for >80% of the amount of excreted IPP. On the basis of the amount of IPP excreted, there was no reason to suspect increased health risks for workers from exposure to propoxur during harvesting.
American Journal of Industrial Medicine, Nov. 1993, Vol.24, No.5, p.593-603. Illus. 29 ref.

CIS 94-462 Fenamiphos
International chemical safety card. Short-term exposure effects: skin absorption. Long-term exposure effects: depression of blood cholinesterase. Occupational exposure limits: TLV: 0.1mg/m³ (TWA) (skin) (ACGIH 1990-1991).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 94-322 Canossa E., Angiuli G., Garasto G., Buzzoni A., de Rosa E.
Dose indicators in farm workers exposed to mancozeb
Indicatori di dose in agricoltori esposti a mancozeb [in Italian]
A study was performed on seven farm workers exposed to mancozeb to validate dose indicators. Two indirect methods were employed to monitor air-dispersed mancozeb in the working environment (average concentration 57.2µg/Nm³): carbon disulfide and manganese dosage. The latter proved to be more applicable. To assess skin contamination, the concentration of mancozeb was measured on pads placed on work overalls and in the liquid employed to wash workers' hands. Average concentrations of 0.86µg/cm² and 641µg were obtained respectively. A good correlation was found between mancozeb concentration on pads and in the air. Urinary ethylenethiourea (ETU) and manganese measured before and after a three-day exposure were selected as indicators for internal dose. In all but three cases (2.9-2.3 and 4.4mg/g creat.), ETU was below the sensitivity limit of the method employed. Urinary manganese increased from a mean of 0.32µg/g creat. to a mean of 0.53µg/g creat. after the exposure. The correlation with environmental data was r=0.667.
Medicina del lavoro, Jan.-Feb. 1993, Vol.84, No.1, p.42-50. Illus. 13 ref.

CIS 94-39 N,N-Dimethylformamide
International chemical safety card. Short-term exposure effects: skin absorption; irritation of eyes, skin and respiratory tract; may affect the liver; neurotoxic effects. Long-term exposure effects: dermatitis; may affect the liver. Occupational exposure limits: TLV: 10ppm; 30mg/m³ (skin) (ACGIH 1989-1990). PDK: 10mg/m³ (skin) (USSR 1988).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 93-1889 Mastrangelo G., Serena R., Marzia V.
Mortality from tumours in workers in an acrylic fibre factory
A retrospective epidemiological cohort study of mortality was undertaken in 671 workers with at least 12 months' exposure to acrylonitrile (AN) in an acrylic fibre factory at Porto Marghera, Venezia; 571 subjects had simultaneous exposure to dimethylacetamide (DMA). Observed mortality in the cohort was compared with expected mortality, calculated on the basis of the mortality rates of the general population in the Veneto region. A statistically significant excess was found in the mortality rate from intestinal and colon tumours (SMR=10.5, 4 observed). However, this finding was significant only in subgroups with 1 to 4 years exposure or 1 to 9 years latency. It is therefore concluded that there is no relationship between AN and/or DMA exposure and mortality from tumours of the colon and intestine.
Occupational Medicine, Aug. 1993, Vol.43, No.3. p.155-158. 15 ref.

CIS 93-1797 Chloramine-T
International chemical safety card. Short term exposure effects: irritation of eyes and respiratory tract; asthmatic reactions. Long term exposure effects: skin sensitisation; asthma.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 93-1775 Benomyl
International chemical safety card. Short-term exposure effects: skin irritation; neurotoxic effects (central nervous system). Long-term exposure effects: dermatitis; skin sensitisation; may impair male fertility; may cause birth defects. Occupational exposure limits: TLV: 0.84ppm, 10mg/m³ (as TWA) (ACGIH 1990-1991).
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 93-1974
International Programme on Chemical Safety (IPCS)
Benomyl
Benomyl causes contact dermatitis and dermal sensitisation in humans. No other effects have been reported. It is unlikely that benomyl, or its decomposition product carbendazim, would cause systemic toxicity effects in occupationally exposed subjects. Detailed summaries in French and Spanish.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1993. 135p. Bibl.ref. Price: CHF 18.00 (CHF 12.60 in developing countries).

CIS 93-1866 Bruynzeel D.P., de Boer E.M., Brouwer E.J., de Wolff F.A., de Haan P.
Dermatitis in bulb growers
A damaged skin forms a health hazard in flower-bulb growers as it enables higher permeation rates for pesticides than normal skin. An investigation was performed of the skin condition of 103 bulb growers and 49 controls. Contact dermatitis of the hands was of the same order (11 and 10%) in both groups. However, minor signs of dermatitis were seen more often in bulb growers (30% versus 8%, p<0.05). Most growers had contact with narcissus sap during the investigation. This irritant sap, as well as many other skin contacts with irritants such as hyacinth dust and pesticides, seemed to be responsible for many skin complaints. Contact sensitisation was suspected in 19 growers and 3 controls. Patch tests showed that contact sensitisation existed to pesticides in probably 10, and to flower-bulb extracts in 4 growers. Reactions to propachlor were not regarded as very reliable as the test concentration seemed to be marginally irritant. There were only a few allergic reactions to narcissus (3) and tulip (2) and none to hyacinth. This investigation showed that minor irritant contact dermatitis was frequent in bulb growers, and indicated that contact sensitisation to pesticides and bulbs seemed to be a less frequent but important cause of dermatitis.
Contact Dermatitis, July 1993, Vol.29, No.1, p.11-15. 26 ref.

CIS 93-1456 Ethyl carbamate
International chemical safety card. Short-term exposure effects: neurotoxic effects (central nervous system); may affect the liver. Long-term exposure effects: may affect the bone marrow, brain, kidney and eyes; possible human carcinogen; may cause antifertility effects.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 93-1440 Alachlor
International chemical safety card. Synonym: Lasso. Short-term exposure effects: eye irritation. Long-term exposure effects: skin sensitisation; hepatic damage; blood-cell anomalies; possible human carcinogen.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 93-1437 Acetamide
International chemical safety card. Short-term exposure effects: irritation of eyes, skin and respiratory tract. Long-term exposure effects: possible human carcinogen.
Official Publications of the European Communities, 2985 Luxembourg, Grand Duchy of Luxembourg; International Programme on Chemical Safety (IPCS), World Health Organization, 1211 Genève 27, Switzerland, 1993. 2p.

CIS 93-1645
International Programme on Chemical Safety (IPCS)
Propachlor
There is little information on the effects of propachlor (synonym: ramrod) on humans. A few cases of contact and allergic dermatitis in exposed farmers and production workers have been reported. Patch tests revealed a positive patch test reaction, irritation reaction or hypersensitivity. There have been no reports of other symptoms or diseases either among occupationally exposed humans or the general population. Detailed summaries in French and Spanish.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1993. 110p. Bibl.ref. Price: CHF 16.00 (developing countries CHF 11.20).

1992

CIS 07-1404
International Programme on Chemical Safety (IPCS)
Propachlor - Health and safety guide
This document provides practical guidance on the application of exposure limitation guidelines contained in Environmental Health Criteria 147 (see CIS 93-1645). Contents: identity and uses of propachlor (Ramrod); human health hazards; health surveillance and first aid; safety in storage and use; environmental hazards; current regulations and guidelines. Propachlor is irritating to the skin and may cause sensitization; it is irritating to the eyes and may cause corneal damage; dust and mist are irritating to the respiratory system.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1992. 26p. Illus. 20 ref.
http://www.inchem.org/documents/hsg/hsg/hsg77_e.htm [in English]

CIS 94-1645 Yasugi T., Kawai T., Mizunuma K., Horiguchi S., Iguchi H., Ikeda M., Watanabe T., Cai S.X., Huang M.Y., Xi L.Q., Qu J.B., Yao B.Z., Li Y.L.
Occupational dimethylformamide exposure
A series of three articles: 1. A diffusive sampling method with water as absorbent was successfully used to measure the time-weighted average concentration of dimethylformamide (DMF) vapour in air; the method was compared with three conventional methods. 2. A study of monomethylformamide (MMF) excretion in urine after occupational exposure to DMF indicated a linear correlation between the time-weighted average intensity of vapour exposure to DMF and the subsequent excretion level of MMF at the end of a workshift. 3. An examination of workers exposed to DMF and other solvents, showed an increased prevalence of some subjective symptoms, especially those related to the digestive system, although there was essentially no change in liver function indicators or in kidney damage indicators.
International Archives of Occupational and Environmental Health, 1992, Vol.63, No.7, p.449-468. Illus. 99 ref.

CIS 94-891 French Society of Occupational Medicine and Hygiene - Meetings of 14 Jan., 11 Feb., 10 Mar. and 14 Apr. 1992
Société de médecine et d'hygiène du travail - Séances du 14 janvier, 11 février, 10 mars et 14 avril 1992 [in French]
Topics of papers presented at the meetings of the French Society of Occupational Medicine and Hygiene (France, 14 Jan., 11 Feb., 10 Mar., 14 Apr. 1992): ligament hyperlaxity and work aptitude; respiratory diseases among jewellers; the industrial physician and the employment of handicapped workers in France (preliminary results of a survey); rhinitis and asthma due to latex are compensable occupational diseases in France; assistance provided to the industrial physician in France to promote the employment of handicapped workers; two cases of occupational asthma due to Chloramine T; an accident due to carelessness and caused by the crushing of a worker between two trucks in a garage; alertness in relation to work among interns on call; risk assessment of a new activity: the removal of graffiti; feasibility study of an olfactometry test in occupational medicine.
Archives des maladies professionnelles, 1992, Vol.53, No.7, p.645-664.

CIS 94-289 Cone J.E., Sult T.A.
Acquired intolerance to solvents following pesticide/solvent exposure in a building - A new group of workers at risk for multiple chemical sensitivities?
This study describes an incident involving resort hotel workers who reported various symptoms most likely associated with pesticide applications to control cockroach infestation. Many of these workers subsequently developed acquired intolerance to pesticides, solvents, or other agents, suggesting multiple chemical sensitivities (MCS). The accepted hypothesis for the outbreak is that it represents acute and chronic poisoning with a cholinesterase-inhibiting pesticide, probably the carbamate pesticide Baygon, mixed with organic solvent carriers. It is noted that in two previous building-associated pesticide poisoning cases there were far fewer MCS-like symptoms reported. It is suggested that the difference in the outbreak under review may be the ongoing nature of the exposure, namely that the repeated applications of pesticides and carriers in the same environment contrast with the evacuation and clean-up that occurred in the other two building outbreaks.
Toxicology and Industrial Health, July-Aug. 1992, Vol.8, No.4, p.29-39. Illus. 8 ref.

CIS 94-280 Hryhorczuk D.O., Aks S.E., Turk J.W.
Unusual occupational toxins
Twelve of the most unusual industrial toxins are reviewed and their clinical manifestations and treatments explored: acetonitrile (laboratory reagent, solvent; primary toxicity due to its delayed metabolism to cyanide); acrylonitrile (commonly used; interesting toxicology); boron hydrides (rocket fuels; toxic); dimethylaminopropionitrile (DMAPN, used as a catalyst in the chemical industry); dimethylformamide (widely used solvent; hepatotoxic); hydrazines (rocket and jet fuels, corrosion inhibitors etc; serious toxic effects); methyl isocyanate (intermediate in insecticide manufacturing; extremely toxic); 2-nitropropane (solvent, many other uses; hepatotoxic); phosphine (pesticide; toxic); stalinon and other organotin compounds (mostly of historical interest); tellurium (metal used as an alloy component, other uses; toxic); vanadium (trace metal used in alloys, other uses; toxic).
Occupational Medicine: State of the Art Reviews, July-Sep. 1992. Vol.7, No.3, p.567-586. 145 ref.

CIS 93-1988 FINNIDA's manual. Risk management of toxic chemicals
Part 1 of this loose-leaf manual contains 30 project manager's guides providing practical information on the safety management of a specific toxic chemical or group of chemicals. Part 2 comprises a collection of 31 chemical data sheets on the impacts of a particular chemical on the environment and human health along with guidelines for safe use. These are arranged in eight chemical groups (organochlorinated pesticides and other chlorinated hydrocarbons, organophosphorus pesticides, carbamate pesticides, natural and synthetic pyrethrins, aromatic hydrocarbons, dithiocarbamates, quaternary nitrogen compounds, triazine derivatives). An alphabetical index is provided and a separate A3-size display-type warning card is included for each of the chemicals listed.
Ministry of Foreign Affairs of Finland, Finnish International Development Agency, Mannerheimintie 15, 00260 Helsinki, Finland, Apr. 1992. 762p. loose-leaf. Index.

CIS 93-2007 Lundberg P.
Scientific basis for Swedish occupational standards - XIII
Vetenskapligt underlag för hygienska gränsvärden. 13 [in Swedish]
Consensus reports of the Criteria Group of the Swedish National Institute of Occupational Health on diethanolamine, ethanolamine, catechol, resorcinol, acetamide, dimethyl sulfoxide, ethyl chloride, dioxane, chloromethane, methylhydrazine, hydrazine, cadmium and pyridine. An appendix lists consensus reports appearing in previous volumes of Arbete och Hälsa.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1992. 85p. (Eng.); 152p. (Swe.). 496 ref.

CIS 93-1102 Benomyl
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Effects of short-term exposure: irritation; erythema; reproductive effects; muscular incoordination; angina pectoris; neurotoxic effects (central nervous system); cholinesterase inhibition. Effects of long-term exposure: skin sensitisation; cholinesterase inhibition; mutagenic in human in vitro test systems; animal teratogen.
US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, 1992. 6p. 20 ref.

CIS 93-1095 Acrylamide
Acrylamide [in French]
Chemical safety information sheet. Acute toxicity: neurotoxic effects (central nervous system); convulsions. Chronic toxicity: skin absorption; neurotoxic effects (peripheral nervous system); nystagmus; disturbances of co-ordination; sensitisation; contact dermatitis; eczema.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, 1992. 5p. 31 ref.

CIS 93-1278 Garnier R., Chataigner D., Perez-Trigalou B., Efthymiou M.L.
Dimethylformamide poisoning after occupational exposure. Report of 30 cases
Intoxications professionnelles par le diméthylformamide. 30 cas [in French]
Thirty cases of dimethylformamide (D.M.F.) poisoning after occupational exposure are reported and compared with published clinical and experimental data. The observed effects included chemical burns of the skin and the eyes, central nervous system depression, abdominal pain and gastric symptoms, alcohol intolerance and hepatic damage. Alcohol intolerance, abdominal pain and increased levels of gamma-glutamyltranspeptidase could be observed for airborne concentrations of D.M.F. under the occupational exposure limit in France (30mg/m³), even when skin contamination was avoided. However, most cases of occupational poisoning with D.M.F. are the consequences of prolonged and/or repeated skin contamination. Failure to recognise the risk or to use adequate skin protection are the main causes of such dangerous poisonings. Present French regulation does not allow the compensation of most cases of D.M.F. poisoning.
Archives des maladies professionnelles, 1992, Vol.53, No.2, p.111-120. Illus. 59 ref.

CIS 93-1290 Fairhurst S., Gregg N., Cocker J., Brown R., South D., Garrod A.
Health and Safety Executive
N,N-dimethylacetamide: Criteria document for an occupational exposure limit
Current knowledge on exposure to and measurement, toxicokinetics and toxic effects of n,n-dimethylacetamide is reviewed. No acute toxicity information is available. Mild skin irritation following application of the liquid to the skin was reported in one of four subjects. No data are available on eye irritation, skin or respiratory sensitisation or on effects arising from inhalation or dermal exposures. There are no useful studies on carcinogenic or reproductive effects. On the basis of animal data, an occupational exposure standard (OES) is proposed at 10ppm (8-hour TWA), and a short-term OES at 20ppm (10-minute ref. period). In view of the high potential for skin absorption, a 'skin' notation is proposed.
HMSO Books, P.O. Box 276, London SW8 5DT, United Kingdom, 1992. vi, 30p. 61 ref. Price: GBP 10.00.

CIS 93-749 ANTU
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Synonym: 1-naphthylthiourea. Effects of short-term exposure: skin absorption; pulmonary oedema; pneumonitis; irritation of the skin and eyes. Effects of long-term exposure: symptoms of bladder cancer; hypothyroidism; eczema.
US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health (NIOSH), Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, 1992. 7p. 15 ref.

CIS 93-739 Acrylamide
Chemical safety information sheet taken from the newly revised edition of the NIOSH publication "Occupational Safety and Health Guidelines for Chemical Hazards". Effects of short-term exposure: skin absorption; irritation; neurotoxic effects (central nervous system). Effects of long-term exposure: irritation; neurotoxic effects (central nervous system); possible human carcinogen.
US Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Standards Development and Technology Transfer, 4676 Columbia Parkway, Cincinnati, OH 45226, USA, 1992. 7p. 17 ref.

CIS 93-925 Brouwer R., Brouwer D.H., Tijssen S.C.H.A., Van Hemmen J.J.
Pesticides in the cultivation of carnations in greenhouses - Part II. Relationship between foliar residues and exposures
The relationship between the levels of dermal and respiratory exposure to four pesticides and the amount of pesticide on the leaves of the plants has been studied during the cutting of carnations in 18 farms. Dermal exposure is strongly related to the amount of dislodgeable foliar residue (DFR). A transfer factor from leaves to hands of approximately 4500cm²/h has been calculated. Dermal exposure of hands and forearms can be predicted from measurements of DFR. The DFR was mainly determined by the amount of the pesticide remaining from previous applications and the last application rate, not by the application technique (spraying or dusting). The concentrations in the breathing zone after dusting of zineb (dustable powder) and chlorothalonil (wettable powder) were significantly correlated with DFR. The concentrations of thiram did not correlate with DFR. Respiratory exposure results from dispersion of foliar dust containing pesticides.
American Industrial Hygiene Association Journal, Sep. 1992, Vol.53, No.9, p.582-587. Illus. 30 ref.

CIS 93-924 Brouwer D.H., Brouwer R., De Mik G., Maas C.L., Van Hemmen J.J.
Pesticides in the cultivation of carnations in greenhouses - Part I. Exposure and concomitant health risk
Respiratory exposure and dermal exposure of the hands and forearms to four pesticides have been measured in 18 farms for carnation culture. For 94 workers, the geometric mean dermal exposure rate during flower cutting was 10.1mg/h and during sorting/bundling by 35 workers the dermal exposure rate was 7.3mg/h. The average concentration in air as measured by personal air sampling during cutting after a pesticide had been dusted was 0.7mg/m³. For the same area, pesticide spraying exposed the applicator to a dermal exposure seven times higher than dusting. However, during dusting respiratory exposure was higher. Generally, overall exposure is higher during manual activities in treated crops than during application. Risk to health occurs after application of pesticides that are relatively toxic and show relatively good skin-penetrating properties at relatively high application rates. The respiratory exposure to dusted pesticides may in some situations also result in health risks.
American Industrial Hygiene Association Journal, Sep. 1992, Vol.53, No.9, p.575-581. Illus. 36 ref.

CIS 93-918 Moody R.P., Nadeau B.
Effect of the mosquito repellent DEET and long-wave ultraviolet radiation on permeation of the herbicide 2,4-D and the insecticide DDT in natural rubber gloves
Studies were conducted to determine the effect of a commonly used insect repellant, DEET (N,N-diethyl-m-toluamide), on the permeability of rubber gloves used for protection by pesticide applicators. The glove percentage permeation data obtained with 2,4-D (dichlorophenoxyacetic acid) and DDT showed no significant difference between the chemicals in glove permeability caused by the presence of DEET. Scanning electron microscopy of the natural rubber glove material, however, demonstrated disruption of the surface structure following a 24-hour treatment with DEET. Glove permeation analysis also suggested that exposure of the glove material to long-wave ultraviolet (UVA) radiation enhanced the glove permeability to 2,4-D but had no effect on the permeation of DDT. Because the gloves of pesticide applicators are commonly exposed to solar UVA, this finding may raise safety concerns.
American Industrial Hygiene Association Journal, July 1992, Vol.53, No.7, p.436-441. Illus. 12 ref.

1991

CIS 07-1419
International Programme on Chemical Safety (IPCS)
Acrylamide - Health and safety guide
This document provides practical guidance on the application of exposure limitation guidelines contained in Environmental Health Criteria 49 (see CIS 86-123). Contents: identity and uses of acrylamide; human health hazards; health surveillance and first aid; safety in storage and use; environmental hazards; summary of chemical safety information for use in the workplace; current regulations and guidelines. Acrylamide is considered to be a possible human carcinogen. The vapour and solutions are skin irritants and the substance is readily absorbed through the skin. It causes eye irritation and lacrimation. Possibility of liver and kidney damage.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1991. 33p. 11 ref.
http://www.inchem.org/documents/hsg/hsg/hsg045.htm [in English]

CIS 07-1399
International Programme on Chemical Safety (IPCS)
Aldicarb - Health and safety guide
This document provides practical guidance on the application of exposure limitation guidelines contained in Environmental Health Criteria 121 (see CIS 91-1955). Contents: identity and uses of aldicarb; human health hazards; health surveillance and first aid; safety in storage and use; environmental hazards; summary of chemical safety information for use in the workplace; current regulations and guidelines. Aldicarb induces toxicity by cholinesterase inhibition. Poisoning may affect the respiratory and central nervous systems and may cause death. Nonfatal poisoning in humans is rapidly reversible and recovery is aided by the administration of atropine.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1991. 29p. Illus. 8 ref.
http://www.inchem.org/documents/hsg/hsg/hsg064.htm [in English]

< previous | 1, 2, 3, 4, 5, 6, 7, 8 ...10 | next >