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Amides - 479 entries found

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  • Amides

1998

CIS 00-1677 de Vreede J.A.F., Brouwer D.H., Stevenson H., van Hemmen J.J.
Exposure and risk estimation for pesticides in high-volume spraying
During twenty applications with a spray pistol of methomyl to chrysanthemums, inhalation exposure as well as potential and actual dermal exposure were monitored using the "whole-body" method. On the basis of exposure data, the health risk from methomyl and thirteen other pesticides frequently used in flower horticulture was evaluated. From the No-Observed-Adverse-Effect-Level (NOAEL) in animal experiments an Indicative Limit Value (ILV) was derived. The ILV is considered indicative of the limit of daily exposure which probably has no adverse health effects. This value is only a rough approximation, as it is based on limited data. The database for a proper assessment of such a value is generally incomplete. To reduce dermal exposure levels below the ILV, exposure of the hands in particular has to be reduced, for example by using impermeable gloves.
Annals of Occupational Hygiene, Apr. 1998, Vol.42, No.3, p.151-157. Illus. 16 ref.

CIS 00-786 Morales Suárez-Varela M., Andreu Moliner E., Pérez Hernández F., Llopis González A., Sáez Arnall M.J.
Assessment of poisoning risk in workers exposed to organophosphorus and carbamate pesticides
Evaluación del riesgo de intoxicación en personas expuestas a plaguicidas: organofosforados y carbamatos [in Spanish]
The objective of this study was to understand the characteristics of workers who suffer poisoning from organophosphorus and carbamate pesticides, and to provide guidance for preventive measures. 662 workers were included in the study. Levels of erythrocyte cholinesterase in blood were taken as indicators of exposure level. The profile of the workers identified to be at risk was: women, workers less than 30 years old, few years in the job, with alcoholic and/or tobacco habit. Preventive measures proposed are: promotion of information campaigns on the toxic effects of these products; establishment of an educational programme on relevant protection measures; generating awareness of the importance of periodic medical supervision in the detection of an increased risk of pesticide poisoning.
Medicina y seguridad del trabajo, 1998, Vol.XLV, No.178, p.61-73. 20 ref.

CIS 99-1955 Amatimaggio F., Calistri S., Ventura F., Margheri M., Niglio F., Perico A., Perissi S.
Acute dimethylformamide (DMF) intoxication: A case report
Intossicazione acuta da dimetilformamide (DMF): descrizione di un caso [in Italian]
A case of acute occupational poisoning by dimethylformamide in a worker assigned to polyurethane resin preparation in an artificial leather factory is described. The case is distinguished by the association of the classical clinical syndrome of dimethylformamide poisoning (alcohol intolerance, gastroenteric manifestations with liver injury), with coagulation alterations and thrombocytopenia. Measurement of environmental concentrations of solvents and biological monitoring revealed high levels of exposure to dimethylformamide at the workplace. Observations confirm the effects of dimethylformamide on hemostasis reported in previous studies. It may be surmised that the effects of dimethylformamide on coagulation and platelets strictly depend on the amount of solvent accumulated in the body. Topics: acute poisoning; blood coagulation disorders; dimethylformamide; case study; cumulative properties; health hazards; hepatic damage; polyurethanes; thrombocytopenia.
Medicina del lavoro, Nov.-Dec. 1998, Vol.89, No.6, p.533-537. 14 ref.

CIS 99-549 Surgiewicz J., Nazimek T.
Captan
Kaptan [in Polish]
Topics: captan; description of technique; determination in air; gas chromatography; sampling and analysis.
Podstawy i Metody Oceny Środowiska Pracy, 1998, Vol.19, p.105.108. 5 ref.

CIS 99-533 Gawęda E.
Acetanilide
Acetanilid [in Polish]
Topics: acetanilide; description of technique; determination in air; gas chromatography; sampling and analysis.
Podstawy i Metody Oceny Środowiska Pracy, 1998, Vol.19, p.5-8. 5 ref.

CIS 99-185 Wrbitzky R., Angerer J.
N,N-Dimethylformamide - Influence of working conditions and skin penetration on the internal exposure of workers in synthetic textile production
Topics: methylformamide; dimethylformamide; cross-sectional study; determination in air; determination in urine; exposure evaluation; job-exposure relation; personal sampling; protective clothing; skin absorption; synthetic fibre industry; urinary metabolites.
International Archives of Occupational and Environmental Health, July 1998, Vol.71, No.5, p.309-316. Illus. 52 ref.

CIS 99-172 Kanerva L., Estlander T., Alanko K., Jolanki R.
Occupational airborne allergic contact dermatitis from dibutylthiourea
Topics: airborne dust; dibutylthiourea; case study; eczema; irritants; paint removal; sensitization dermatitis; skin allergies.
Contact Dermatitis, June 1998, Vol.38, No.6, p.347-348. 11 ref.

CIS 98-1669 de Cock J., Heederik D., Kromhour H., Boleij J.S.M., Hoek F., Wegh H., Ny E.T.
Determinants of exposure to captan in fruit growing
Topics: captan; crop protection; exposure evaluation; inhalation; job-exposure relation; length of exposure; Netherlands; orchards; pesticides; risk factors; skin absorption; survey.
American Industrial Hygiene Association Journal, Mar. 1998, Vol.59, No.3, p.166-172. Illus. 12 ref.

CIS 98-1668 de Cock J., Heederik D., Kromhour H., Boleij J.S.M., Hoek F., Wegh H., Ny E.T.
Exposure to captan in fruit growing
Topics: captan; crop protection; deposited dust; dust measurement; exposure evaluation; inhalation; job-exposure relation; length of exposure; neighbourhood populations; Netherlands; orchards; personal sampling; pesticides; respirable dust; skin absorption; survey.
American Industrial Hygiene Association Journal, Mar. 1998, Vol.59, No.3, p.158-165. 24 ref.

CIS 98-1682
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Thiourea
Topics: carcinogenic effects; thiourea; criteria document; ecotoxicology; eczema; Germany; legislation; literature survey; thyroid disorders; toxic effects; toxicology; translation.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1998. xxi, 171p. Bibl.ref. Price: DEM 97.00.

CIS 98-836
International Programme on Chemical Safety (IPCS)
Chlordimeform
Topics: agricultural chemicals; bladder diseases; bladder tumour; carcinogenic effects; cardiovascular disorders; 4-chloro-o-toluidine; chlordimeform; criteria document; haematuria; ILO; IPCS; literature survey; pesticide poisoning; poisoning; skin absorption; toxic effects; toxic metabolites; toxicology; UNEP; WHO.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1998. 159p. 335 ref. Price: CHF 36.00 (CHF 25.20 in developing countries).

CIS 98-419 Dimethylformamide
Dimetilformamida [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: dimethylformamide; data sheet; dermatitis; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; gastrointestinal diseases; health hazards; hepatic damage; irritation; limitation of exposure; medical supervision; personal protective equipment; respirators; skin absorption; USA; waste disposal.
Noticias de seguridad, Mar. 1998, Vol.60, No.3. 4p. Insert.

1997

CIS 02-351 Lühr H.P., Grunder H.T., Stein D., Körkemeyer K., Borchardt B.
Bundesanstalt für Arbeitsschutz und Arbeitsmedizin
Products and processes for the repair of sewers, with a special emphasis on waterproof mortars based on acrylamide
Produkte und Verfahren zur Sanierung von Abwasserkanälen unter besonderer Berücksichtigung acrylamidhaltiger Andichtungsmörtel [in German]
This study consists of two parts. The first describes nine processes for repairing sewers using different techniques (repair, resin injection, coating, applying a liner). The second part covers six processes in more detail. The exposure hazards linked to each step of the processes and to the various products used are listed, and the preventive measures are discussed. Many processes involve the use of reactive or volatile substances which require protective measures for the workers. A single process used mortars based on acrylamide which is a carcinogen, but its content level is relatively low.
Wirtschaftsverlag NW, Postfach 10 11 10, 27511 Bremerhaven, Germany, 1997. ix, 98p. Illus. 10 ref.

CIS 01-1763 Baum S.L., Suruda A.J.
Toxic hepatitis from dimethylacetamide
Two cases of toxic hepatitis from dimethylacetamide (DMAC) occurred among 25 employees on a new acrylic-fiber production line at a U.S. manufacturing plant. Interesting features of these cases include: inadequate personal protective equipment for dermal exposures, resulting in skin penetration during maintenance and repair procedures; the subjects of these case reports are female, while all workers at the manufacturer's European parent plant were male, and DMAC related liver dysfunction had not been encountered at that site; the new American production line required more frequent maintenance and repair work than existing production lines at the European parent company, resulting in greater opportunities for DMAC exposure. Hepatotoxicity due to dermal absorption of DMAC and other amide-type solvents deserves special consideration in industrial settings.
International Journal of Occupational and Environmental Health, Jan.-Mar. 1997, Vol.3 No.1, p.1-4. 10 ref.

CIS 01-1607 Pillière F., Protois J.C., Reynier M., de Ceaurriz J.
Aldicarb
Aldicarbe [in French]
Chemical safety information sheet. Update of data sheet already summarized in CIS 80-2018. Synonyms: (2-methyl-2-methylthiopropylidene)amine N-methylcarbamate; 2-methyl-2-(methylthio)propionaldehyde; O-(methylcarbamoyl)oxime. Acute toxicity: cholinesterase inhibition (signs of muscarinic and nicotinic intoxication); respiratory disorders; the symptoms disappear after administration of atropine. Chronic toxicity: skin irritation. EEC number and mandatory labelling codes: No.006-017-00-X; T+, R27/28, S22, S36/37, S45, 204-123-2. Complete datasheet collection on CD-ROM analysed under CIS 01-201.
Institut national de recherche et de sécurité, 30 rue Olivier-Noyer, 75680 Paris Cedex 14, France, Rev.ed., CD-ROM CD 613, 2000. 4p. Illus. 20 ref.

CIS 99-1230 Pontal P.G.
Carbamate insecticides
Insecticides carbamates [in French]
Topics: carbamates; cholinesterase monitoring; encyclopaedia; insecticides; medical treatment; metabolic process; poisoning; toxicology.
Encyclopédie médico-chirurgicale, Toxicologie-Pathologie professionnelle, 4th Quarter 1997, No.117, 4p. Illus. 9 ref.

CIS 98-1302 Sampling and analysis - Application sheet: N-methylformamide
Méthode de prélèvement et d'analyse - Fiche d'application: N-méthylformamide [in French]
Topics: methylformamide; data sheet; description of technique; France; gas chromatography; sampling and analysis; threshold limit values.
Cahiers de notes documentaires - Hygiène et sécurité du travail, 3rd Quarter 1997, No.168, MPA 023, p.477-478. Illus.

CIS 98-748 Paulsen E., Andersen K.E., Skoven I.G.
Concomitant sensitization to Lannate® and Gerbera
Topics: methomyl; Denmark; dermatitis; eczema; flower and perfume-plant growing; pesticides; plants; sensitization dermatitis; skin allergies; skin tests.
Contact Dermatitis, Sep. 1997, Vol.37, No.3, p.128-129. 4 ref.

CIS 98-412 Antu
Antu [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: 1-naphthylthiourea; data sheet; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; hepatic damage; limitation of exposure; lung diseases; medical supervision; personal protective equipment; pulmonary oedema; respirators; rodenticides; USA; waste disposal.
Noticias de seguridad, Dec. 1997, Vol.59, No.12. 3p. Insert.

CIS 98-48 2-Acetylaminofluorene
2-Acetilaminofluoreno [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Topics: 2-acetylaminofluorene; carcinogenic effects; data sheet; dermatitis; determination in air; elimination of spills; explosion hazards; fire fighting; fire hazards; first aid; health hazards; limitation of exposure; medical supervision; personal protective equipment; respirators; skin allergies; USA; waste disposal.
Noticias de seguridad, Oct. 1997, Vol.59, No.10. 4p. Insert.

1996

CIS 98-827
International Programme on Chemical Safety (IPCS)
Methomyl
Topics: agricultural chemicals; methomyl; cholinesterase; criteria document; ILO; IPCS; literature survey; pesticide poisoning; poisoning; toxic effects; toxicology; UNEP; WHO.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1996. 150p. 264 ref. Price: CHF 23.00 (CHF 16.10 in developing countries).

CIS 98-234
International Programme on Chemical Safety (IPCS)
Diflubenzuron
Topics: criteria document; ILO; insecticides; IPCS; literature survey; methaemoglobinaemia; toxic effects; toxicology; UNEP; WHO.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1996. 164p. 352 ref.

CIS 97-1102 Dimethylformamide
Data sheet. May enter the body when breathed in and through the skin. It is a carcinogen and should be handled with extreme caution. May damage the developing foetus. May irritate the eyes, skin and respiratory tract. May cause stomach pain, loss of appetite and nausea. May damage the liver and kidneys.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-763 Thioacetamide
Data sheet. May enter the body when breathed in and through the skin. It is a carcinogen and should be handled with extreme caution. May irritate the eyes and respiratory tract. May seriously damage the liver.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-411 Ammonium carbamate
Data sheet. May enter the body when breathed in. May irritate the skin, eyes and respiratory tract. May release ammonia.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-68, USA, 1996. 6p.

CIS 97-404 Thiourea
Data sheet. May enter the body when breathed in. It is a carcinogen and should be handled with extreme caution. May damage the bone marrow, reducing the numbers of red blood cells, white blood cells and platelets. May cause skin allergy.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1996. 6p.

CIS 97-570 Mulloy K.B.
Two case reports of neurological disease in coal mine preparation plant workers
Cases of neurotoxicity related to occupational exposures at plants producing acrylamide monomers have been reported in medical literature. However, cases involving neurotoxicity related to jobs using polymers with acrylamide monomer contamination have not been widely reported. In 1992, two patients who had worked in different coal preparation plants in southern West Virginia for over 10 years and had exposure to an acrylamide polymer flocculent contaminated with acrylamide monomer were evaluated. Neither patient had any instruction in the proper use or dangers of acrylamide or was given adequate safety equipment. One of the patients developed parkinsonism and the other, peripheral neuropathies with a neurogenic bladder. Many chemicals are being introduced into mining operations and awareness of potentially toxic exposures and new diseases not previously reported in the mining industry must become part of the surveillance system. Further research on the extent of acrylamide neurotoxicity in the mining industry is encouraged.
American Journal of Industrial Medicine, July 1996, Vol.30, No.1, p.56-61. 9 ref.

CIS 96-2205 Hoekstra E.J., Kiefer M., Tepper A.
Monitoring of exposure to benomyl in nursery workers
Urinary levels of the metabolite methyl-5-hydroxy-2-benzimidazole carbamate (5-HBC) were measured in 10 workers exposed to the fungicide benomyl at 5 nurseries. Environmental exposures were evaluated from gloves, body patches, and air samples were collected with area and personal monitors. The median concentration of 5-HBC for the exposed workers was 23.8µmol per mole of creatinine; no 5-HBC was detected in 9 unexposed controls. Weighing, mixing and application activities involved the highest exposures. Dermal contact appeared to be the primary route of exposure.
Journal of Occupational and Environmental Medicine, Aug. 1996, Vol.38, No.8, p.775-781. 18 ref.

CIS 96-2177 Koch P.
Occupational allergic contact dermatitis and airborne contact dermatitis from 5 fungicides in a vineyard worker - Cross-reactions between fungicides of the dithiocarbamate group?
In February 1995, a case of a vineyard worker with occupational contact dermatitis due to sensitization to mancozeb and perhaps metiram was reported. Patch testing showed strong allergic reactions to two of the commercially available preparations used. Further patch tests showed allergic reactions to mancozeb (0.5 and 1% pet.), a weak reaction to metiram (1% pet.), as well as to four other fungicides of the dithiocarbamate group (maneb, nabam, propineb and zineb), which had never been used in the vineyard.
Contact Dermatitis, May 1996, Vol.34, No.5, p.324-329. 36 ref.

CIS 96-1383 Kanerva L., Estlander T., Jolanki R.
Allergic patch test reactions caused by the rubber chemical cyclohexyl thiophthalimide
In a survey of 310 subjects patch tested with 30 rubber chemicals, 11 (3.5%) showed an allergic reaction to N-(cyclohexylthio)phthalimide (CTP), a chemical used as a vulcanization retarder; a further 30 showed doubtful or irritant reactions. 4 subjects reacted only to CTP and not to other rubber chemicals; the other 7 reacted concomitantly to other rubber chemicals. Since the subjects had no conspicuous occupational exposure to rubber chemicals, the origin of the sensitivity is unknown.
Contact Dermatitis, Jan. 1996, Vol.34, No.1, p.23-26. Illus. 18 ref.

CIS 96-488 Carbaryl (Sevin (R))
Carbaril (Sevin (R)) [in Spanish]
Chemical safety card published by the Consejo Interamericano de Seguridad, 33 Park Place, Englewood, NJ 07631, USA. Health hazards: skin absorption; irritation of the skin; blood cholinesterase inhibition: may cause convulsions; may cause birth malformations.
Noticias de seguridad, Feb. 1996, Vol.58, No.2. 4p. Insert.

1995

CIS 02-1551 Zinc ethylphenyl dithiocarbamate
Zinkethylphenyldithiocarbamat [in German]
Zinc ethylphenyl dithiocarbamate may cause hypersensitivity reactions to alcohol similar to those caused by disulfiram; skin sensitization is relatively rare. Animal experiments show no toxicity upon acute oral exposure. A mutagenic as well as an embryotoxic effect at maternal toxic doses have been observed.
Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, June 1995. 19p. 26 ref.

CIS 02-583 Dimethylol dihydroxyethylene urea
Dimethyloldihydroxyethylenharnstoff [in German]
Patients suffering from contact dermatitis or eczema had positive results to dimethylol dihydroxyethylene urea in patch tests. Aqueous solutions can induce sensitization. Animal experiments show a low acute toxicity upon oral administration. After inhalation, dyspnoea and irritation of the mucous membranes are observed which increase with exposure to higher temperatures. However the substance begins to decompose at 40°C, and it is assumed that the symptoms are attribuable to decomposition products of dimethylol dihydroxyethylene urea. A slight mutagencic effect has been found. It is not possible to assess conclusively whether the observed mutagenic and sensitizing effetcts are due to dimethylol dihydroxyethylene urea and/or to formaldehyde contamination or liberation.
Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, June 1995. 19p. 25 ref.

CIS 02-581 Ethylenethiourea
Ethylenthioharnstoff [in German]
A few cases of dermal sensitization to ethylenethiourea have been described. Studies on five workers employed in the processing of ethylenethiourea showed lower serum T4 levels than controls, indicating a possibility of a disturbance of the thyroid function. The are no indications of thyroid tumour development in workers in the rubber industry and no indication of an increased incidence of congenital malformations in the children of occupationally exposed women. Animal experiments show that ethylenethiourea is concentrated in the thyroid. Thiourea is carcinogenic (dose-dependent thyroid carcinomas) and teratogenic.
Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, June 1995. 94p. 147 ref.

CIS 02-580 Thiourea
Thioharnstoff [in German]
Thiourea has no clear mutagenic activity in bacterial systems. Genotoxic tests have given contradictory results and the tumorigenic effect of thiourea on the thyroid gland may represent an epigenetic effect. Research is currently underway on the question as to whether thiourea is metabolically activated in the rat thyroid gland to give a genotoxic metabolite.
Berufsgenossenschaft der chemischen Industrie, Postfach 10 14 80, 69004 Heidelberg, Germany, June 1995. 15p. 23 ref.

CIS 99-251
International Programme on Chemical Safety (IPCS)
Diflubenzuron health and safety guide
This document provides practical guidance on the application of exposure limitation guidelines contained in Environmental Health Criteria 184 (CIS 98-234). Includes a summary of chemical safety information for workplace display. Topics: diflubenzuron; containment of spills; disposal of harmful waste; fire protection; first aid; health engineering; health hazards; IPCS; legislation; methaemoglobinaemia; permissible levels; storage; toxic effects.
World Health Organization (WHO), Distribution and Sales Service, 1211 Genève 27, Switzerland, 1995. 28p. 27 ref. Price: CHF 5.00 (CHF 3.50 in developing countries).

CIS 98-1413
International Programme on Chemical Safety (IPCS)
Methomyl - Health and safety guide
Topics: agricultural chemicals; methomyl; containment of spills; disposal of harmful waste; fire protection; first aid; health engineering; health hazards; IPCS; legislation; neurological effects; permissible levels; storage; toxic effects.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1995. 28p. Illus. 19 ref. Price: CHF 5.00 (CHF 3.50 in developing countries).

CIS 97-584 Frentzel-Beyme R., Domizlaff I.
Epidemiologic study on solvent-induced diseases
Studie über die Epidemiologie lösemittelbedingter Erkrankungen [in German]
The present knowledge of the toxic and carcinogenic effects caused by exposure to solvents in the varnish industry from published case studies and epidemiologic studies is reviewed. The following solvents are covered: butyl alcohol, butyl acetate, carbon disulfide, chloromethane, dichloromethane, dimethylformamide, ethyl acetate, glycol ethers, methoxyethanol, cellosolve, hexane, isopropyl alcohol, methanol, 2-hexanone, butanone, styrene, toluene, 1,1,1-trichloroethane, trichloroethylene and xylene.
Umweltbundesamt, Postfach 33 00 22, 14191 Berlin, Germany, 1995. 235p. 436 ref.

CIS 96-859 de Cock J., Heederik D., Hoek F., Boleij J., Kromhout H.
Urinary excretion of tetrahydropht[h]alimide in fruit growers with dermal exposure to captan
Uptake of captan by pesticide applicators was measured by urinary monitoring of its metabolite, tetrahydrophthalimide (THPI). Respiratory and dermal exposures were estimated by personal air sampling and skin patches. Dermal exposure showed a clear relation to THPI in urine when exposure was estimated from skin pads on the ankles and neck. No relation was found for total dermal exposure or for respiratory exposure. Protection of the skin by using a cabin on the tractor and wearing rubber boots resulted in a lower uptake of captan. Results indicate that the skin is the major route of absorption and that there is an apparent contribution of specific body areas.
American Journal of Industrial Medicine, Aug. 1995, Vol.28, No.2, p.245-256. Illus. 29 ref.

CIS 96-892
Dutch Expert Committee on Occupational Standards (Werkgroep van Deskundigen ter Vaststelling van MAC-waarden)
Formamide and dimethylformamide: Health based recommended occupational exposure limits
In this report the Dutch Committee on Occupational Standards discusses the consequences of occupational exposure to formamide and dimethylformamide (DMF) and recommends health-based occupational exposure limits for these substances. Attention is given to: identity, physical and chemical properties, monitoring; sources of exposure; environmental levels and human exposure; toxicokinetics; effects in animals and man (acute toxicity, short-term toxicity, long-term toxicity/carcinogenicity, mutagenicity, reproduction toxicity); previous evaluations by national and international bodies; evaluation of human health risk. Based on the data available the committee recommends a health-based occupational exposure limit for formamide of 16mg/m3 (9ppm) as an 8h TWA concentration. For dimethylformamide the committee recommends a health-based occupational exposure limit of 15mg/m3 (5ppm) as a 8h TWA concentration. Since skin absorption can contribute substantially to total body burden, a skin notation is recommended. Summary in Dutch.
Gezondheidsraad, Postbus 90517, 2509 LM Den Haag, Netherlands, 1995. 128p. Illus. 84 ref.

CIS 95-2185
Gesellschaft Deutscher Chemiker (GDCh) - Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Butoxyethoxyethyl acetate. 1,4-Dimethoxybenzene. Acetoacetyl-m-xylidide. Pigment red 53:1
Conclusions of these criteria documents, translation of reports finalized in Aug. 1992 - Aug. 1993: animal studies indicate that butoxyethoxyethyl acetate (butyl carbitol acetate) has a low toxicity; contact dermatitis was observed in one case of occupational exposure, but only on affected skin which had been previously damaged. No data are available on the effects of 1,4-dimethoxybenzene or acetoacetyl-m-xylidide (N-(2,4-dimethylphenyl)-3-oxobutanoamide) or pigment red 53:1 (D&C red no.9) in man; animal studies indicate a low acute toxicity.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1995. x, 141p. Bibl.ref. Price: DEM 88.00.

CIS 95-1751 Streicher R.P., Arnold J.E., Cooper C.V., Fischbach T.J.
Investigation of the ability of MDHS Method 25 to determine urethane-bound isocyanate groups
Method 25 for the Determination of Hazardous Substances (MDHS 25, see CIS 88-955) was developed by the Health and Safety Executive of the United Kingdom for the identification and quantification of all isocyanates in an air sample. This investigation sought to determine if this Method was capable of the identification and quantification of intermediates possessing free isocyanate groups created during polyurethane formation. Model compounds derived from 2,4-toluene diisocyanate (2,4-TDI) and ethylene glycol were prepared. These urethanes contained two ("dimer") and three ("trimer") TDI units and terminal MOPP-derivatized isocyanate groups. Neither the ultraviolet nor the electrochemical response of the Method is proportional to the number of isocyanate groups present in the model compounds. Therefore MDHS 25 is neither capable of correctly identifying TDI-urethane intermediates possessing MOPP-derivatized isocyanate groups nor is it capable of accurately identifying these isocyanate groups. The proposed way to overcome this problem is to use a derivatizing reagent yielding derivatized isocyanates whose detector responses come more exclusively from the derivatized isocyanate moiety and therefore are more proportional to the number of derivatized isocyanate groups.
American Industrial Hygiene Association Journal, May 1995, Vol.56, No.5, p.437-442. Illus. 13 ref.

CIS 95-1812 Simonsen L., Midtgård U., Lund S.P., Hass U.
Nordic Council of Ministers
Occupational neurotoxicity: Evaluation of neurotoxicity data for selected chemicals
Previously determined criteria for evaluating published data on the neurotoxicity of chemicals (see CIS 95-000) were applied to the literature on 79 common industrial chemicals. Data were too sparse to permit classification of 28. Of the rest, eight were classified as probably and 16 as possibly neurotoxic, and the following 27 as definitely neurotoxic: acrylamide, acrylonitrile, aluminium, arsenic, sodium azide, borax, boric acid, carbon monoxide, carbon disulfide, potassium cyanide, ethanol, ethylene oxide, hexachlorophene, manganese, mercury, methanol, methyl bromide, methyl butyl ketone (2-hexanone), methyl chloride, methyl methacrylate, n-hexane, nitrous oxide, styrene, thallium, toluene, trichloroethylene, triorthocresyl phosphate.
National Institute of Occupational Health, Lersø Parkallé 105, 2100 København Ø, Denmark, 1995. 119p. Bibl.ref.

CIS 95-1799
Gesellschaft Deutscher Chemiker (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Acrylamide
Translation of a document finalized in Aug. 1992. Irritation of the skin and mucous membranes has been observed in humans following contact with acrylamide. Repeated exposure has been reported to cause neurotoxic effects in the form of ataxia, tremor, reflex disturbances and peripheral neuropathy; in most cases, the effects were reversible. Acrylamide produces carcinogenic effects in laboratory animals.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1995. xvii, 150p. approx. 330 ref. Price: DEM 88.00.

CIS 95-1796
Gesellschaft Deutscher Chemiker (GDCh) Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Urea. Isobutylidene diurea. Potassium amylxanthate. Potassium isobutylxanthate
Translation of reports finalized in Oct.-Dec. 1991. Toxicological data provide no indication of a hazard potential associated with exposure to urea or isobutylidene diurea; irritation dermatitis and conjunctivitis have been reported following occupational exposure to urea. On the basis of acute toxicity data in animals, potassium amylxanthate and potassium isobutylxanthate are classified as harmful; direct contact with the skin causes burns. These latter two substances are no longer produced or used in Germany.
S. Hirzel Verlag, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 1995. ix, 122p. 82 + 9 + 28 + 18 ref. Price: DEM 72.00.

1994

CIS 07-1428
International Programme on Chemical Safety (IPCS)
Tri-allate - Health and safety guide
This document provides a hazard evaluation of tri-allate based on critical national reviews along with practical guidance on exposure limitation. Contents: identity and uses; human health hazards; health surveillance and first aid; safety in storage and use; environmental hazards; current regulations and guidelines. The acute oral toxicity of technical tri-allate for humans is thought to be moderate; most formulations are likely to be only slightly toxic. It is irritating to the eyes and skin.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1994. 20p. 6 ref.
http://www.inchem.org/documents/hsg/hsg/hsg89.htm [in English]

CIS 98-1401
International Programme on Chemical Safety (IPCS)
Carbaryl
Summaries in French and Spanish. Topics: agricultural chemicals; carbaryl; central nervous system; cholinesterase monitoring; criteria document; IPCS; literature survey; neurotoxic effects; skin absorption; toxic effects; toxicology; urinary metabolites.
World Health Organization, Distribution and Sales Service, 1211 Genève 27, Switzerland, 1994. 358p. Illus. Approx. 700 ref. Price: CHF 51.00 (CHF 35.70 in developing countries).

CIS 97-939 Lundberg P.
Criteria Group for Occupational Standards
Scientific basis for Swedish occupational standards XV
Vetenskapligt underlag för hygieniska gränsvärden. 15 - Criteria Group for Occupational Standards XV [in Swedish]
Critical evaluation of those scientific data which are relevant as background for discussion of Swedish occupational exposure limits. This volume consists of the consensus reports submitted by the Criteria Group at the Swedish National Institute of Occupational Health between July 1993 and June 1994. They cover: ethylene glycol monopropylether (propoxyethanol) and its acetate (2-propoxyethanol acetate), hexachloroethane, some metal stearates, some stearates, hexylene glycol, barium and barium compounds, strontium and strontium compounds, dicyclopentadiene, N,N-dimethylacetamide, indium and inorganic indium compounds, o-chlorobenzylidene malononitrile and thioglycolic (mercaptoacetic) acid.
Arbetsmiljöinstitutet, Förlagstjänst, 171 84 Solna, Sweden, 1994. 72p. (Eng.); 79p. (Swe.). 298 ref.

CIS 96-1960 Acrylamide
Data sheet. Can be absorbed by inhalation and through the skin. Should be handled as a carcinogen, with extreme caution. May affect the nervous system. Irritates the skin, eyes and respiratory tract.
New Jersey Department of Health, Right to Know Program, CN 368, Trenton, NJ 08625-0368, USA, 1994. 6p.

CIS 95-1405 Passarelli M.M.
Occupational exposure to dimethylformamide: Toxicological aspects
Exposição ocupacional a dimetilformamida: aspectos toxicológicos [in Portuguese]
Revista brasileira de saúde ocupacional, Apr.-June 1994, Vol.22, No.82, p.59-65. Illus. 34 ref. ###

CIS 95-1016 Kanerva L., Estlander T., Jolanki R.
Occupational allergic contact dermatitis caused by thiourea compounds
Case reports are presented of five patients with allergic patch test reactions caused by thiourea compounds. Sources of thiourea included diphenylthiourea in neoprene gloves and pesticides, and diethylthiourea in a knee brace. Since allergic contact dermatitis by thiourea compounds can be verified only by patch testing, patients with contact dermatitis who have been exposed to thiourea compounds (such as rubber, PVC plastic or adhesive, diazo paper, paints or glue remover, anticorrosive agents, fungicides or pesticides) should be patch tested with a series of thiourea compounds.
Contact Dermatitis, Oct. 1994, Vol.31, No.4, p.242-248. 48 ref.

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