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Base de datos CISDOC

ID (ISN) del documento63037
Número CIS 94-1763
ISSN - Título de la serie 0096-1736 - Journal of Occupational Medicine
Año 1993
Número de serie
Autor(es) Gottlieb S.J., Garibaldi E., Hutcheson P.S., Slavin R.G.
Título Occupational asthma to the slime mold Dictyostelium discoideum
Información bibliográfica Dec. 1993, Vol.35, No.12, p.1231-1235. Illus. 25 ref.
Resumen Dictyostelium discoideum is a slime mould that exists in a unicellular amoeboid form under certain nutritional conditions. In this form it produces unique lysosomal enzymes that are valuable in studying cell-to-cell signalling systems. A research microbiologist developed rhinoconjunctivitis and asthma after release of the organism from a pressurized canister. Immediate skin-test reactivity to whole and lysed organisms was demonstrated. Enzyme-linked immunosorbent assay results revealed IgE antibody against whole organisms, lysed organisms, and lysosomal enzymes with the strongest response being directed toward lysosomal enzymes. Pulmonary function testing showed a decline in forced expiratory volume in one second and forced expiratory flow after modified laboratory exposure to D. discoideum. This case represents the first report of occupational rhinoconjunctivitis and asthma from slime mould.
Descriptores (primarios) trabajos de laboratorio; riesgos biológicos; asma alérgico; champiñones
Descriptores (secundarios) rinitis; estudio de caso; microrganismos; pruebas funcionales respiratorias; conjuntivitis; volumen espiratorio máximo por segundo; débito espiratorio forzado
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Patología profesional
Broad subject area(s) Riesgos biológicos
Navegación por categoria(s) Diseases of the respiratory system (except for pneumoconiosis & similar)
Biological hazards
Alergias