| ID (ISN) del documento | 62598 |
| Número CIS |
94-1288 |
| ISSN - Título de la serie |
0091-6765 - Environmental Health Perspectives |
| Año |
1993 |
| Número de serie |
|
| Autor(es) |
Melnick R.L., Shackelford C.C., Huff J. |
| Título |
Carcinogenicity of 1,3-butadiene |
| Información bibliográfica |
Apr. 1993, Vol.100, p.227-236. Illus. 50 ref. |
| Resumen |
1,3-Butadiene, a high-production-volume chemical used widely in the manufacture of synthetic rubber, is a multiple organ carcinogen in rats and mice. Human exposures by workers employed at facilities that produce this chemical and at facilities that produce styrene-butadiene rubber have been measured at levels higher than those that cause cancer in animals. Furthermore, epidemiological studies have consistently revealed associations between occupational exposure to 1,3-butadiene and excess mortality due to lymphatic and haematopoietic cancers. In response to the carcinogenicity findings for 1,3-butadiene in animals and in humans, the US Occupational Safety and Health Administration has proposed lowering the occupational exposure standard for this chemical from 1,000ppm to 2ppm. Future work is needed to understand the mechanisms of tumour induction by 1,3-butadiene; however, the pursuit of this research should not delay the reduction of human exposure to this chemical. |
| Descriptores (primarios) |
substancias cancerígenas; efectos cancerígenos; cáncer; butadieno-1,3 |
| Descriptores (secundarios) |
revisión bibliográfica; valores umbrales; aspectos epidemiológicos; roedores; linfoma; industria del caucho sintético; inhalación; límites admisibles; investigaciones en el animal; relación dosis-respuesta; mortalidad |
| Tipo de documento |
D - Artículos periódicos |
| País / Estado o Provincia | Estados Unidos |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Aliphatic and alicyclic hydrocarbons
Butadiene
|
