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Base de datos CISDOC

ID (ISN) del documento62555
Número CIS 94-1309
ISSN - Título de la serie 0022-443X - Journal of Science of Labour - Rōdō Kagaku
Año 1993
Número de serie
Autor(es) Hanaoka T., Ishizu S., Yamano Y.
Título Effects of cigarette smoking on lymphocyte subsets in office workers
Información bibliográfica Oct. 1993, Vol.69, No.10, p.15-20. Illus. 19 ref.
Resumen Some immunotoxicological studies have applied the analysis of lymphocyte subsets to the detection of biological effects of chemical exposures. The purpose of this research was to examine the effects of cigarette smoking and alcohol drinking on lymphocyte subsets. Some lymphocyte subsets in healthy office workers (n=36) with no industrial exposure to chemicals were determined. A significant increase of the total peripheral white blood cell counts, the total lymphocyte counts, the percentages of CD4+CD45RA-cells and CD25 positive cells was found in smokers (n=16) compared to non-smokers (n=20). A positive correlation was also observed between the percentage of CD4+CD45RA-cells and the Brinkman index (p<0.05) and between the percentage of CD20 positive cells and the Brinkman index (p<0.1). Furthermore, a negative correlation was seen between the percentage of CD8+CD11b-cells and Brinkman index (p<0.05). On the other hand, no effects of alcohol drinking and age were observed on the percentages of lymphocyte subsets. Thus, it is necessary to take into account smoking habits in industrial toxicological studies using the analysis of lymphocyte subsets.
Descriptores (primarios) linfocitos; efectos hematológicos; fumadores
Descriptores (secundarios) trabajo de oficina; Japón
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaJapón
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Tabaquismo
Blood diseases