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Base de datos CISDOC

ID (ISN) del documento61612
Número CIS 94-293
ISSN - Título de la serie 0748-2337 - Toxicology and Industrial Health
Año 1992
Número de serie
Autor(es) Dourson M.L., Knauf L.A., Swartout J.C.
Título On reference dose (RfD) and its underlying toxicity data base
Información bibliográfica May-June 1992, Vol.8, No.3, p.171-189. Illus. 18 ref.
Resumen Toxicity data on pesticides were summarized and compared amongst different animal species and types of bioassays. These comparisons showed the expected variability. After quantitative and statistical analysis, it was concluded that, on the average, a two-year dog bioassay detected toxic responses at similar doses as a two-year rat study, and that both of these bioassays detected toxic responses at lower doses than either a rat two-generation bioassay, a rat developmental toxicity study, or a two-year mouse bioassay. Although these chronic dog and rat bioassays were found to detect toxic responses at lower doses than the other studies listed, this analysis does not reflect the seriousness of the effects that were compared. Within the confines of this analysis, then, it appears that a two-year dog and rat study, reproductive and developmental bioassays are a sufficient data base on which to estimate high confidence Reference Doses (RfDs), and furthermore, that an additional uncertainty factor is needed to estimate RfDs to account for this variability when fewer than this number of bioassays are available.
Descriptores (primarios) efectos tóxicos; pesticidas; substancias tóxicas; documentación de seguridad y salud; valoración de la toxicidad; investigaciones en el animal; relación dosis-respuesta; patología experimental
Descriptores (secundarios) revisión bibliográfica; perros; estudio comparado; extrapolación del animal al hombre; roedores
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Agricultural chemicals
Safety and health information