| ID (ISN) del documento | 60741 |
| Número CIS |
93-1631 |
| ISSN - Título de la serie |
Journal of the National Cancer Institute |
| Año |
1992 |
| Número de serie |
|
| Autor(es) |
Garabrant D.H., Held J., Langholz B., Peters J.M., Mack T.M. |
| Título |
DDT and related compounds and risk of pancreatic cancer |
| Información bibliográfica |
20 May 1992, Vol.84, No.10, p.764-771. 44 ref. |
| Resumen |
To identify risk factors for pancreatic cancer, a nested case-control study of chemical manufacturing workers was conducted using 28 verified cases of pancreatic cancer and 112 matched controls. DDT was associated with pancreatic cancer (risk ratio (RR) for ever exposed compared with never exposed = 4.8; 95% confidence interval = 1.3-17.6). Among subjects who had a mean exposure to DDT of 47 months, the risk was 7.4 times that among subjects with no exposure. Two DDT derivatives, Ethylan and DDD, were additionally associated with pancreatic cancer (RR = 5.0 and 4.3, respectively). Smoking was identified as an independent risk factor, but controlling for it (and other potential confounders) in the analyses did not appreciably alter the risks seen for DDT, DDD, or Ethylan. These results may indicate that DDT can cause pancreatic cancer in humans under circumstances of heavy and prolonged exposure. |
| Descriptores (primarios) |
pertano; DDT; exposición de larga duración; tumor de páncreas; p,p'-ddd |
| Descriptores (secundarios) |
factores de riesgo; industria química |
| Tipo de documento |
D - Artículos periódicos |
| País / Estado o Provincia | Estados Unidos |
| Tema(s) |
Química, hidrocarburos,plásticos, caucho
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Endocrine diseases
Halogenated hydrocarbons
|
