| ID (ISN) del documento | 59772 |
| Número CIS |
93-605 |
| Año |
1992 |
| Número de serie |
ECETOC Technical Report No.52
|
| Título |
Styrene toxicology investigations on the potential for carcinogenicity |
| Información bibliográfica |
European Centre for Ecotoxicology and Toxicology of Chemicals, 4 Avenue E. Van Nieuwenhuyse, 1160 Bruxelles, Belgium, Nov. 1992. 61p. ca. 180 ref. |
| Resumen |
New toxicokinetic data on styrene and the metabolic occurrence of styrene oxide are presented along with information on macromolecular binding in vivo. Based on experimental data, a physiologically-based pharmacokinetic model for styrene and styrene oxide was developed, validated and used to calculate the body burden of these compounds for man in relation to animals. From results of these studies and DNA binding studies, it is concluded that the carcinogenic potential of styrene, if one exists at all, must be so low that occupational or environmental exposure to styrene is unlikely to present any genotoxic or carcinogenic hazard for man. |
| Descriptores (primarios) |
efectos mutágenos; estireno; toxicología; tests de carcinogénesis; valoración de la toxicidad; efectos cancerígenos; óxido de estireno |
| Descriptores (secundarios) |
revisión bibliográfica; modelos matemáticos; investigaciones en el animal; metabolización |
| Tipo de documento |
E - Libros, informes, actas |
| País / Estado o Provincia | Bélgica |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Ethylene oxide
Ethers
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Toxicology
Aromatic hydrocarbons
|
