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Base de datos CISDOC

ID (ISN) del documento59772
Número CIS 93-605
Año 1992
Número de serie ECETOC Technical Report No.52
Título Styrene toxicology investigations on the potential for carcinogenicity
Información bibliográfica European Centre for Ecotoxicology and Toxicology of Chemicals, 4 Avenue E. Van Nieuwenhuyse, 1160 Bruxelles, Belgium, Nov. 1992. 61p. ca. 180 ref.
Resumen New toxicokinetic data on styrene and the metabolic occurrence of styrene oxide are presented along with information on macromolecular binding in vivo. Based on experimental data, a physiologically-based pharmacokinetic model for styrene and styrene oxide was developed, validated and used to calculate the body burden of these compounds for man in relation to animals. From results of these studies and DNA binding studies, it is concluded that the carcinogenic potential of styrene, if one exists at all, must be so low that occupational or environmental exposure to styrene is unlikely to present any genotoxic or carcinogenic hazard for man.
Descriptores (primarios) efectos mutágenos; estireno; toxicología; tests de carcinogénesis; valoración de la toxicidad; efectos cancerígenos; óxido de estireno
Descriptores (secundarios) revisión bibliográfica; modelos matemáticos; investigaciones en el animal; metabolización
Tipo de documento E - Libros, informes, actas
País / Estado o ProvinciaBélgica
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Antifertility and prenatal effects
Toxicology
Aromatic hydrocarbons
Ethylene oxide
Ethers
Genetic factors in reaction to exposures