ID (ISN) del documento | 59417 |
Número CIS |
93-218 |
ISSN - Título de la serie |
0271-3586 - American Journal of Industrial Medicine |
Año |
1991 |
Número de serie |
|
Autor(es) |
Hu H., Pepper L., Goldman R. |
Título |
Effect of repeated occupational exposure to lead, cessation of exposure, and chelation on levels of lead in bone |
Información bibliográfica |
Dec. 1991, Vol.20, No.6, p.723-735. Illus. 33 ref. |
Resumen |
A sensitive K-X-ray fluorescence (K-XRF) instrument was used to measure lead levels in the tibia and patella on 12 subjects who had relatively well-documented histories of lead exposure and blood lead levels. For some subjects, K-XRF measurements were taken before and after chelation with EDTA (ethylenediamine tetraacetic acid). Results confirm that K-XRF measured bone lead levels correspond to cumulative blood lead indices and not to current blood lead levels. Moreover, the data suggest that bone lead levels: (1) correspond to urinary lead following the EDTA mobilisation test unless previous chelation has occurred; (2) rise initially after lead exposure ceases and blood lead levels decrease, and then fall; (3) do not decrease with a 3 to 5-day course of therapeutic EDTA chelation. Lead levels in the patella were noted to decrease more rapidly than levels in the tibia after cessation of lead exposure, a finding that probably reflects the greater turnover of lead in trabecular bone than in cortical bone. |
Descriptores (primarios) |
plomo; dosificación en los huesos; relación dosis-respuesta |
Descriptores (secundarios) |
fluorescencia de rayos x |
Tipo de documento |
D - Artículos periódicos |
País / Estado o Provincia | Estados Unidos |
Tema(s) |
Sustancias tóxicas y peligrosas
|
Broad subject area(s) |
Riesgos químicos
|
Navegación por categoria(s) |
Lead and compounds Inorganic substances
|