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Base de datos CISDOC

ID (ISN) del documento59417
Número CIS 93-218
ISSN - Título de la serie 0271-3586 - American Journal of Industrial Medicine
Año 1991
Número de serie
Autor(es) Hu H., Pepper L., Goldman R.
Título Effect of repeated occupational exposure to lead, cessation of exposure, and chelation on levels of lead in bone
Información bibliográfica Dec. 1991, Vol.20, No.6, p.723-735. Illus. 33 ref.
Resumen A sensitive K-X-ray fluorescence (K-XRF) instrument was used to measure lead levels in the tibia and patella on 12 subjects who had relatively well-documented histories of lead exposure and blood lead levels. For some subjects, K-XRF measurements were taken before and after chelation with EDTA (ethylenediamine tetraacetic acid). Results confirm that K-XRF measured bone lead levels correspond to cumulative blood lead indices and not to current blood lead levels. Moreover, the data suggest that bone lead levels: (1) correspond to urinary lead following the EDTA mobilisation test unless previous chelation has occurred; (2) rise initially after lead exposure ceases and blood lead levels decrease, and then fall; (3) do not decrease with a 3 to 5-day course of therapeutic EDTA chelation. Lead levels in the patella were noted to decrease more rapidly than levels in the tibia after cessation of lead exposure, a finding that probably reflects the greater turnover of lead in trabecular bone than in cortical bone.
Descriptores (primarios) plomo; dosificación en los huesos; relación dosis-respuesta
Descriptores (secundarios) fluorescencia de rayos x
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Lead and compounds
Inorganic substances