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Base de datos CISDOC

ID (ISN) del documento59358
Número CIS 93-146
ISSN - Título de la serie 0096-1736 - Journal of Occupational Medicine
Año 1991
Número de serie
Autor(es) Robins T.G., Weinstein R.J., Demers R.Y.
Título Lymphocytopenia, T-lymphocyte subsets, and colorectal polyps in automotive pattern and model makers
Información bibliográfica Apr. 1991, Vol.33, No.4, p.510-515. 26 ref.
Resumen The association of total lymphocyte, CD4 (T-helper cell), CD8 (T-suppressor cell), CD2 (total T-cell), and CD16 (natural killer cell) counts with biopsy-proved colorectal polyp status was investigated in 70 pattern makers. In logistic regression analyses after adjusting for age or trade years, pack-years smoked, and material worked with most frequently, a history of any type of polyp was significantly associated with total lymphocyte count (odds ratio of 2.01 for a 500 cell/cc decrease, p=0.03), and somewhat associated with decreased CD4 and CD2 counts (p values of 0.06 and 0.07, respectively). In linear regression models adjusted for age, pattern and model makers had (regardless of polyp status) significantly lower CD4, CD8, CD2, and CD16 counts than did laboratory reference controls (p value less than 0.01 for each comparison). The findings appear consistent with a sequence of carcinogenesis initiated by workplace exposure of pattern and model makers that depresses immune surveillance and therefore promotes the development of colorectal polyps as a precursor of carcinoma.
Descriptores (primarios) recuento de glóbulos y plaquetas; linfocitos; cáncer de recto; autoinmunización; tumores; modeladores y maquetistas; industria del automóvil; citología sanguínea; cáncer gastrointestinal
Descriptores (secundarios) Estados Unidos; valoración estadística; encuesta por cuestionario; Michigan
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaEstados Unidos
Tema(s) Metalurgia, trabajo de los metales
Broad subject area(s) Medicina del trabajo, epidemiología
Navegación por categoria(s) Motor vehicle manufacturing industry
Gastrointestinal diseases