| ID (ISN) del documento | 59335 |
| Número CIS |
93-145 |
| ISSN - Título de la serie |
0096-1736 - Journal of Occupational Medicine |
| Año |
1992 |
| Número de serie |
|
| Autor(es) |
McConnell R., Cedillo L., Keifer M., Palomo M.R. |
| Título |
Monitoring organophosphate insecticide-exposed workers for cholinesterase depression - New technology for office or field use |
| Información bibliográfica |
Jan. 1992, Vol.34, No.1, p.34-37. 9 ref. |
| Resumen |
A limitation to the diagnosis of mild organophosphate poisoning and to the preventive screening of organophosphate-exposed workers has been the large interindividual variability in erythrocyte cholinesterase, thus necessitating a pre-exposure baseline measurement of enzyme activity as a basis for evaluating subsequent declines. A new colorimetric erythrocyte cholinesterase kit was tested on 23 pesticide plant workers. All workers had normal cholinesterase, and exposed and unexposed workers had similar mean cholinesterase levels. Although erythrocyte cholinesterase was found to have a coefficient of variation of 12%, haemoglobin-adjusted erythrocyte cholinesterase had a markedly reduced coefficient of variation (7.4%). The 90% confidence interval (24.9-31.7IU/g haemoglobin) resulted in a lower normal limit, i.e. 78% of the upper limit. Even if a pre-exposure baseline was high normal but unknown at the time of examination, the clinician can be confident that any person with a normal result will have cholinesterase levels not less than 78% of baseline. |
| Descriptores (primarios) |
compuestos organofosforados; pesticidas; tests de exposición; diagnostico; insecticidas |
| Descriptores (secundarios) |
vigilancia de la colinesterasa; envenenamiento; pruebas enzimológicas; pruebas en el puesto de trabajo; variables individuales |
| Tipo de documento |
D - Artículos periódicos |
| País / Estado o Provincia | México; Nicaragua; Estados Unidos |
| Tema(s) |
Agricultura, pesca, cría de ganado
|
| Broad subject area(s) |
Medicina del trabajo, epidemiología
|
| Navegación por categoria(s) |
Biological monitoring
Agricultural chemicals
|
