ID (ISN) del documento | 59166 |
Número CIS |
92-2010 |
ISSN - Título de la serie |
0339-6517 - Documents pour le médecin du travail |
Año |
1991 |
Número de serie |
DMT 48 TC 39
Fiche médico-technique No.39
|
Autor(es) |
Pillière F., Falcy M. |
Título |
Exposure to genotoxic chemical products: Biological markers used in the monitoring of workers |
Título original |
Exposition aux produits chimiques génotoxiques - Marqueurs biologiques pour la surveillance des salariés [en francés] |
Información bibliográfica |
4th Quarter 1991, No.48, p.329-336. Illus. 40 ref. |
Resumen |
This information note surveys the scientific literature on genotoxic products, i.e. those that are liable to induce cancers or genetic mutations. The advantages and disadvantages of current methods used for the monitoring of workers exposed to such products are discussed. These methods are: 1. Detection of mutagenic activity in biological fluids (the Ames test). 2. Tests that detect cytogenetic changes (chromosomal aberrations, micronuclei, sister-chromatic exchanges) in human cells. 3. Protein and DNA adducts. 4. Unscheduled DNA synthesis (UDS). All these tests are subject to very sensitive interpretation, and there are actually few laboratories able to carry them out. As far as choice is concerned, it makes more sense to use a short-time test (sister-chromatic exchanges, adducts) when monitoring recent exposure, and a long-term test (chromosomal aberrations) when monitoring ancient or cumulative exposure. |
Descriptores (primarios) |
substancias tóxicas; riesgos biológicos; efectos genéticos; valoración de la exposición |
Descriptores (secundarios) |
revisión bibliográfica; ADN; tests de mutagénesis; cambios cromosómicos; efectos biológicos; nota informativa; tests de exposición; pruebas bioquímicas; exámenes citogenéticos; análisis de las aberraciones cromosómicas; descripción del procedimiento; dosificación en medio biológico |
Tipo de documento |
F - Notas informativas, directrices prácticas, normas |
País / Estado o Provincia | Francia |
Tema(s) |
Sustancias tóxicas y peligrosas
|
Broad subject area(s) |
Riesgos químicos
|
Navegación por categoria(s) |
Antifertility and prenatal effects Biological hazards Genetic factors in reaction to exposures Exposure evaluation
|