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Base de datos CISDOC

ID (ISN) del documento57740
Número CIS 92-533
ISSN - Título de la serie 0300-5771 - International Journal of Epidemiology
Año 1991
Número de serie
Autor(es) Graves A.B., Van Duijn C.M., Chandra V., Fratiglioni L., Heyman A., Jorm A.F., Kokmen E., Kondo K., Mortimer J.A., Rocca W.A., Shalat S.L., Soininen H., Hofman A.
Título Occupational exposures to solvents and lead as risk factors for Alzheimer's disease: A collaborative re-analysis of case-control studies
Información bibliográfica 1991, Vol.20, no.2 (suppl.2), p.S58-S61. 20 ref.
Resumen A meta-analysis, involving the secondary analysis of original data from 11 case-control studies of Alzheimer's disease, is presented for occupational exposures to solvents and lead. Three studies included data on occupational exposure to solvents. The meta-analysis was particularly useful in validating negative results from individual studies and in increasing the statistical power for the analysis of lead exposure, where stratum-specific cell sizes were frequently smaller than 5 in individual studies. However, since exposure in the various studies was ascertained in a rather broad manner, prospective studies are recommended which focus on high-risk occupational populations and which determine the incidence of Alzheimer's disease in these and comparable unexposed populations.
Descriptores (primarios) plomo; disolvente; enfermedades del sistema nervioso central
Descriptores (secundarios) encuesta epidemiológica; valoración estadística; factores de riesgo
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaPaíses Bajos; Estados Unidos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Diseases of the nervous system
Lead and compounds
Inorganic substances