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ID (ISN) del documento57335
Número CIS 92-192
ISSN - Título de la serie 0829-0369 - Travail et santé
Año 1991
Número de serie
Autor(es) Tat-Ha C.
Título The use of experimental data in teratogenic risk assessment: Standard testing and recent developments
Título original L'utilisation des données expérimentales dans l'évaluation des effets tératogènes des produits industriels. Les acquis et les développements récents [en francés]
Información bibliográfica Summer 1991, Vol.7, No.2, p.S-11 to S-16. Illus. 41 ref.
Resumen Developmental toxicity hazard assessment of industrial chemicals usually involves an evaluation of human studies and animal data. Epidemiological data being generally scarce, adequate assessment of human risk from experimental reproductive studies requires knowledge and familiarity with the performance of conventional teratology testing protocols and understanding of several parameters involved in embryonal or foetal toxicity. This paper examines the influence of time of exposure and route of administration in standard teratology testing with special emphasis on the influence of experimental doses. The use of high dose levels in experiments frequently induces overt maternal toxicity that causes considerable difficulties in the interpretation of concurrent embryo/foetal insult. In response to these problems, most teratologists propose to rank the teratogenic potential of xenobiotics on the basis of the A/D ratio derived from the adult toxic dose (A) and the developmental toxic dose (D). The last part of the discussion focuses on the concepts of threshold, no-observed-effect level and safety factor which form the bases of extrapolation for a safe human exposure.
Descriptores (primarios) substancias teratogénicas; toxicología; efectos teratogénicos; investigaciones en el animal; productos industriales
Descriptores (secundarios) efectos embriotóxicos; valores umbrales; descripción del procedimiento; embarazadas; criterios de riesgo
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaCanadá
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Genetic factors in reaction to exposures
Antifertility and prenatal effects