| ID (ISN) del documento | 57321 |
| Número CIS |
92-240 |
| Año |
1989 |
| Número de serie |
ECETOC Monograph No.13
|
| Título |
DNA and protein adducts: Evaluation of their use in exposure monitoring and risk assessment |
| Información bibliográfica |
European Chemical Industry Ecology and Toxicology Centre, Avenue Louise 250, Boîte 63, 1050 Bruxelles, Belgium, Oct. 1989. 89p. Illus. ca. 280 ref. |
| Resumen |
Contents of this monograph: principles, fundamental assumptions and ethical considerations; mechanisms (adduct formation, reaction of chemicals with DNA and proteins, DNA adducts and biological effects); methods for detecting adducts, and comparisons of sensitivity, cost and time; DNA and protein adducts in animals and in man; evaluation of DNA and/or protein adducts as measures for exposure and for risk assessment; recommendations for further research; glossary. These techniques are very promising for measurement of low levels of human exposure to genotoxic chemicals, but cannot be used confidently to predict health risk. |
| Descriptores (primarios) |
substancias tóxicas; dosificación en medio biológico; valoración de la exposición; valoración del riesgo |
| Descriptores (secundarios) |
proteínas; hemoglobina; tests de carcinogénesis; valoración del método; glosario; ADN |
| Tipo de documento |
E - Libros, informes, actas |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Cuestiones éticas
Risk evaluation
Exposure evaluation
|
