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Base de datos CISDOC

ID (ISN) del documento56913
Número CIS 91-1871
ISSN - Título de la serie 0096-1736 - Journal of Occupational Medicine
Año 1991
Número de serie
Autor(es) Moscato G., Dellabianca A., Vinci G., Candura S.M., Bossi M.C.
Título Toluene diisocyanate-induced asthma: Clinical findings and bronchial responsiveness studies in 113 exposed subjects with work-related respiratory symptoms
Información bibliográfica June 1991, Vol.33, No.6, p.720-725. Illus. 39 ref.
Resumen We report the clinical findings and the results of inhalation challenge with toluene diisocyanate (TDI) and methacholine in 113 subjects with a history of exposure to TDI and work-related respiratory symptoms. Only some of the subjects (40.7%) had isocyanate asthma, diagnosed by a positive TDI inhalation challenge. Most reactors had a dual (30.4%) or a late (41.3%) response. The interval between the last occupational exposure and the specific challenge was significantly shorter in reactors, and among this group the number of immediate reactions to TDI decreased progressively with an increasing interval. The reactors had a significantly higher proportion of positive responses to methacholine and a significantly lower mean PD15 FEV1 (provocative dose of methacholine which provoked a 15% decrease in forced expiratory volume in 1 second): reactors 557µg, SEM 92.3; non-reactors 1346µg, SEM 128, P < .01. Methacholine challenge could not identify subjects with isocyanate asthma.
Descriptores (primarios) isocianatos; diisocianato de toluileno; broncopatias; exposición; enfermedades respiratorias; pruebas funcionales respiratorias; relación dosis-respuesta; asma alérgico
Descriptores (secundarios) sensibilidad individual; fumadores
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaItalia
Tema(s) Patología profesional
Broad subject area(s) Medicina del trabajo, epidemiología
Navegación por categoria(s) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds
Alergias