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Base de datos CISDOC

ID (ISN) del documento56736
Número CIS 91-1598
ISSN - Título de la serie 0003-9896 - Archives of Environmental Health
Año 1990
Número de serie
Autor(es) Sakai T., Araki T., Ushio K.
Título Accumulation of erythrocyte nucleotides and their pattern in lead workers
Información bibliográfica Sep.-Oct. 1990, Vol.45, No.5, p.273-277. Illus. 12 ref.
Resumen Nucleotides in erythrocytes of lead-exposed subjects were analysed by high-performance liquid chromatography (HPLC). Most of the pyrimidine levels correlated well with blood lead concentrations (Pb-B) and pyrimidine 5'-nucleotidase (P5N) activity. Highly significant correlations were found between Pb-B and uridine 5'-diphosphate-glucose (UDPG), cytidine 5'-triphosphate (CTP), or CDP-choline (CDPC). The levels of these compounds were sharply elevated when P5N activity was reduced to levels less than 7µmole/h.g haemoglobin (Hb), which corresponded to a Pb-B of 60µg/100g. Therefore, concentration of these nucleotides may provide a useful index of lead poisoning. Adenosine 5'-triphosphate (ATP) concentrations were correlated negatively with Pb-B, whereas adenosine 5'-monophosphate (AMP) concentrations were correlated positively with Pb-B. These results suggest that lead affects not only pyrimidine nucleotide metabolism but also purine nucleotide metabolism (the energy production system).
Descriptores (primarios) nucleótidos; imprenta; plomo; eritrocitos; fabricas metalúrgicas; industria del plomo; tests de exposición
Descriptores (secundarios) primidina-nucleotidasa; vigilancia de la hemoglobina; intoxicaciones crónicas
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaJapón
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Biological monitoring
Inorganic substances
Printing, photography and photocopying industry
Smelting and refining operations
Lead and compounds