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Base de datos CISDOC

ID (ISN) del documento56235
Número CIS 91-1201
ISSN - Título de la serie 0355-3140 - Scandinavian Journal of Work, Environment and Health
Año 1990
Número de serie
Autor(es) Wass U., Belin L.
Título An in vitro method for predicting sensitizing properties of inhaled chemicals
Información bibliográfica June 1990, Vol.16, No.3, p.208-214. Illus. 63 ref.
Resumen A method for monitoring chemical reactivity in aqueous solutions, at neutral pH and 37°C, was developed. The chemical was allowed to react with a lysine-containing peptide, and the reaction was monitored with high-performance liquid chromatography. Simple acids, bases, and solvents did not react with the peptide, whereas isocyanates, anhydrides, and chloramine-T, substances well known for their sensitising and asthma-inducing properties, did. Thus a positive test strongly suggested that the chemical had the potential to act as a hapten and cause sensitisation when inhaled. Prepolymers of diphenylmethane diisocyanate were considerably more reactive than prepolymers of toluene diisocyanate or hexamethylene diisocyanate. Isocyanates blocked with caprolactam, butanone oxime, malonic acid diethylester, or isononyl phenol showed no reactivity. This result suggested a significantly reduced risk of respiratory reactions when such blocked isocyanates are handled at room temperature.
Descriptores (primarios) isocianatos; inhalación; sensibilización; patología experimental; productos químicos
Descriptores (secundarios) cromatografía de alta resolución; asma alérgico; reactividad alérgica; pruebas bioquímicas; pruebas in vitro
Tipo de documento D - Artículos periódicos
País / Estado o ProvinciaSuecia
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Isocyanates
Cyano compounds