| ID (ISN) del documento | 54505 |
| Número CIS |
90-1613 |
| ISSN - Título de la serie |
Gigiena truda i professional'nye zabolevanija |
| Año |
1988 |
| Número de serie |
|
| Autor(es) |
Vasilenko N.M., Kogan I.M., Zvezdaj V.I., Jašina L.N., Hipko S.E., Sventickij V.V. |
| Título |
N-cyanoethylaniline (CEA) toxicity |
| Título original |
K voprosu o toksičnosti N-cianėtilanilina (CĖA) [en ruso] |
| Información bibliográfica |
Sep. 1988, No.9, p.53-54. |
| Resumen |
Physical and chemical properties. Toxicity: 30-fold intragastric administration of N-cyanoethylaniline (CEA) at 1/10 of the LD50 (0.47g/kg) to rats resulted in anaemia (reduction of oxyhaemoglobin levels and erythrocyte number) accompanied by reticulocytosis (up to 157.7%), an increase of met- and sulfhaemoglobinlevels, appearance of Heinz bodies (36.9%), a reduction of blood sulfhydryl groups, leucocytosis and a reduction in the relative weight of the spleen. CEA exposure may cause signs of liver functional disturbances. The threshold of acute toxicity for CEA is 9mg/m3 (criterion of methaemoglobin formation). A MAC of 0.1mg/m3 for CEA (aerosol) in workplace air (with the notation "skin", hazard class 2) is recommended. Precautions: protection of respiratory tract, gastrointestinal tract and skin from contact with CEA. |
| Descriptores (primarios) |
valores umbrales; valoración de la toxicidad; n-cianoetilanilina |
| Descriptores (secundarios) |
efectos tóxicos; aminas aromáticas; dosis letal 50; investigaciones en el animal; límites admisibles |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Occupational exposure limits
Cyano compounds
|
