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Base de datos CISDOC

ID (ISN) del documento53976
Número CIS 90-922
ISSN - Título de la serie 0007-1072 - British Journal of Industrial Medicine
Año 1990
Número de serie
Autor(es) Yardley-Jones A., Anderson D., Lovell D.P., Jenkinson P.C.
Título Analysis of chromosomal aberrations in workers exposed to low level benzene
Información bibliográfica Jan. 1990, Vol.47, No.1, p.48-51. 7 ref.
Resumen Metaphase chromosome preparations were analysed as part of a larger study from a population occupationally exposed to benzene and compared with a control group. The incidence of chromosomal aberrations in the exposed group was slightly increased compared with the control group. This increase was of borderline significance in parametric statistical tests but was significant using Fisher's exact test. No lifestyle factors had any consistent effect on the incidence of chromosome aberrations, although there was a small reduction in gaps with increasing cigarette smoking. Older individuals had a higher incidence of chromosome exchanges and "other" aberrations. Individuals who reported a recent viral illness had a higher incidence of aberrations, particularly gaps. The increased incidence of aberrations seen in the group exposed to benzene may result from a history of exposure to benzene. Nevertheless, other explanations such as sampling, interindividual variability, and unintentional bias in the selection of the 2 groups cannot be excluded.
Descriptores (primarios) benceno; cambios cromosómicos; efectos genéticos
Descriptores (secundarios) enfermedades víricas; estudio comparado; análisis de las aberraciones cromosómicas; diferencias por la edad
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Antifertility and prenatal effects
Viral diseases (other than aids)
Aromatic hydrocarbons
Genetic factors in reaction to exposures
Bacterial and parasitic diseases