| ID (ISN) del documento | 53782 |
| Número CIS |
90-898 |
| ISSN - Título de la serie |
0098-4108 - Journal of Toxicology and Environmental Health |
| Año |
1989 |
| Número de serie |
|
| Autor(es) |
Benigni R., Andreoli C., Giuliani A. |
| Título |
Interrelationships among carcinogenicity, mutagenicity, acute toxicity, and chemical structure in a genotoxicity data base |
| Información bibliográfica |
May 1989, Vol.27, No.1, p.1-20. Bibl. |
| Resumen |
Computerised data analysis of the data base generated by the International Program for the Evaluation of Short-Term Tests for Carcinogens (IPESTTC). With the use of statistical regression methods, three main associations were evidenced: (1) the well-known correlation between carcinogenicity and mutagenicity; (2) a correlation between mutagenicity and toxicity (LD50 ip in mice); and (3) a correlation between toxicity and a recently introduced estimator of the free energy due to the binding of molecules to biological receptors. No simple relationship between mutagenicity or carcinogenicity and chemical descriptors was found. To overcome this problem, a new pattern recognition method (REPAD) was used. This approach generated a classification rule able to correctly assign about 80% of carcinogens or mutagens. |
| Descriptores (primarios) |
mutágenos; efectos genéticos; dosis letal 50; substancias cancerígenas |
| Descriptores (secundarios) |
análisis por ordenador; bases de datos automatizadas |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Genetic factors in reaction to exposures
Antifertility and prenatal effects
|
