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Base de datos CISDOC

ID (ISN) del documento53280
Número CIS 90-199
ISSN - Título de la serie 0002-8894 - American Industrial Hygiene Association Journal
Año 1988
Número de serie
Autor(es) Leung H.W., Murray F.J., Paustenbach D.J.
Título A proposed occupational exposure limit for 2,3,7,8-tetrachlorodibenzo-p-dioxin
Información bibliográfica Sep. 1988, Vol.49, No.9, p.466-474. 74 ref.
Resumen Wastes containing 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been detected at many hazardous waste sites which in recent years have been in the processs of remediation. Concerns about worker exposure to TCDD-contaminated soil (dust) during remediation of hazardous waste sites have produced a need for an occupational exposure limit (OEL) for TCDD. The animal toxicology data and human experience with TCDD are reviewed, and an occupational exposure limit for TCDD is proposed. The data indicate than an 8-hr time-weighted average limit of 2ng/m3 is appropriate, and the associated risk would be consistent with other carcinogens at their corresponding OELs. A preliminary OEL of 0.2ng/m3 (200pg/m3) is recommended, however, in light of other sources of exposure because of TCDD's ubiquitousness in the environment, its unclear mechanism of action, and its rather long biological half-life in humans. This limit provides an ample margin of safety to prevent chloracne following repeated, acute exposure, and it addresses those chronic effects of TCDD observed in animal studies as well as those observed after accidental human exposure.
Descriptores (primarios) tetraclorodibenzodioxina; determinación de los límites de la exposición; eliminación de desechos
Descriptores (secundarios) acné clórico; substancias cancerígenas
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Heterocyclic compounds
Waste collection and disposal