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Base de datos CISDOC

ID (ISN) del documento52977
Número CIS 89-1941
ISSN - Título de la serie 0007-1072 - British Journal of Industrial Medicine
Año 1989
Número de serie
Autor(es) Nise G., Attewell R., Skerfving S., Ørbaek P.
Título Elimination of toluene from venus blood and adipose tissue after occupational exposure
Información bibliográfica June 1989, Vol.46, No.6, p.407-411. 18 ref. Illus.
Resumen In a group of 37 rotogravure printers a close correlation was found between the time weighted toluene exposure during a five day working week (range 8-416mg/m3, median 75) and the concentration of toluene in subcutaneous adipose tissue (range 1.1-20.7mg/kg, median 3.8). After exposure ceased, the elimination of toluene was followed up in 11 subjects. The toluene concentration in venous blood decreased non-linearly and the elimination curves contained at least three exponential components. The first two had median estimated half times of nine minutes and two hours respectively. The third component, with a median half time of 90 hours, reflected the decline in adipose tissue, which had a median half time of 79 hours. The study showed protracted endogenous toluene exposure from adipose tissue depots long after the end of exogenous exposure. The observations also suggest that the blood toluene concentrations on Monday mornings might be used as an index of exposure during the previous week.
Descriptores (primarios) tolueno; duración de la exposición; heliograbado; dosificación en los tejidos; dosificación en la sangre
Descriptores (secundarios) vigilancia de la sangre; tests de exposición
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Aromatic hydrocarbons
Printing, photography and photocopying industry