ID (ISN) del documento | 52139 |
Número CIS |
89-1285 |
ISSN - Título de la serie |
0007-1072 - British Journal of Industrial Medicine |
Año |
1988 |
Número de serie |
|
Autor(es) |
Åesson B., Skerfving S., Mattiasson L. |
Título |
Experimental study on the metabolism of triethylamine in man |
Información bibliográfica |
Apr. 1988, Vol.45, No.4, p.262-268. Illus. 14 ref. |
Resumen |
Five healthy volunteers were exposed by inhalation to triethylamine (TEA; 4 or 8h at about 10, 20, 35, and 50mg/m3), a compound widely used as a curing agent in polyurethane systems. Analysis of plasma and urine showed that an average of 24% of the TEA was biotransformed into triethylamine-N-oxide (TEAO) but with a wide interindividual variation (15-36%). The TEA and TEAO were quantitatively eliminated in the urine. The plasma and urinary concentrations of TEA and TEAO decreased rapidly after the end of exposure (averge half time of TEA was 3.2h). There was excellent association between air levels of TEA and the urinary concentrations in samples obtained within 2h of the end of exposure. Thus the urinary level of TEA taken in this period is useful as a biological monitoring of exposure. An air concentration of 10mg/m3 corresponds to an average urinary concentration of about 40mmol/mol creatinine (at sedentary work). |
Descriptores (primarios) |
trietilamina; pruebas por inhalación; valoración del riesgo |
Descriptores (secundarios) |
condiciones de la exposición; investigaciones sobre el hombre; determinación de la concentración; dosificación en la sangre; dosificación en la orina; duración de la exposición |
Tipo de documento |
D - Artículos periódicos |
Tema(s) |
Patología profesional
|
Broad subject area(s) |
Riesgos químicos
|
Navegación por categoria(s) |
Aliphatic amines Risk evaluation
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