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Base de datos CISDOC

ID (ISN) del documento52139
Número CIS 89-1285
ISSN - Título de la serie 0007-1072 - British Journal of Industrial Medicine
Año 1988
Número de serie
Autor(es) Åesson B., Skerfving S., Mattiasson L.
Título Experimental study on the metabolism of triethylamine in man
Información bibliográfica Apr. 1988, Vol.45, No.4, p.262-268. Illus. 14 ref.
Resumen Five healthy volunteers were exposed by inhalation to triethylamine (TEA; 4 or 8h at about 10, 20, 35, and 50mg/m3), a compound widely used as a curing agent in polyurethane systems. Analysis of plasma and urine showed that an average of 24% of the TEA was biotransformed into triethylamine-N-oxide (TEAO) but with a wide interindividual variation (15-36%). The TEA and TEAO were quantitatively eliminated in the urine. The plasma and urinary concentrations of TEA and TEAO decreased rapidly after the end of exposure (averge half time of TEA was 3.2h). There was excellent association between air levels of TEA and the urinary concentrations in samples obtained within 2h of the end of exposure. Thus the urinary level of TEA taken in this period is useful as a biological monitoring of exposure. An air concentration of 10mg/m3 corresponds to an average urinary concentration of about 40mmol/mol creatinine (at sedentary work).
Descriptores (primarios) trietilamina; pruebas por inhalación; valoración del riesgo
Descriptores (secundarios) condiciones de la exposición; investigaciones sobre el hombre; determinación de la concentración; dosificación en la sangre; dosificación en la orina; duración de la exposición
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Aliphatic amines
Risk evaluation