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Base de datos CISDOC

ID (ISN) del documento51659
Número CIS 89-853
ISSN - Título de la serie 0007-1072 - British Journal of Industrial Medicine
Año 1989
Número de serie
Autor(es) Borm P.J.A., Bast A., Zuiderveld O.P.
Título In vitro effect of toluene diisocyanate on beta adrenergic and muscarinic receptor function in lung tissue of the rat
Información bibliográfica Jan. 1989, Vol.46, No.1, p.56-59. Illus. 17 ref.
Resumen To investigae the role of pharmacological mechanisms in toluene diisocyanate (TDI) induced occupational asthma, the effects of TDI on rat trachea ring and lung parenchymal strip were studied in vitro. The most prominent effect observed was a stimulation of metacholine (1µM) induced contraction of the tracheal ring by 1µM TDI (added in dimethyl sulfoxide). The results were less pronounced when TDI was added from a stock solution prepared in water, which is possibly due to (co)polymerisation. It is concluded that the pharmacological effect of TDI may result from an autonomic imbalance between cholinergic and B-adrenergic neural control.
Descriptores (primarios) diisocianato de toluileno; sistema nervioso autónomo; polimerización; enfermedades respiratorias
Descriptores (secundarios) reacción del tejido pulmonar; pruebas in vitro; investigaciones en el animal
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
Cyano compounds