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Base de datos CISDOC

ID (ISN) del documento50662
Número CIS 88-2005
Año 1987
Número de serie ECETOC Monograph No.9
Título Assessment of mutagenicity of industrial and plant protection chemicals
Información bibliográfica European Chemical Industry Ecology and Toxicology Centre, Avenue Louise 250, Bte 63, 1050 Bruxelles, Belgium, 1987. 28p. Illus. 29 ref.
Resumen Contents of this report prepared by experts on behalf of ECETOC: general considerations; strategy for the detection of germ cell mutagens; selection of assays and interpretation of test results; tests in-vitro, number and types of tests to employ, genetic specificity of mutagenic action, terminology associated with activity in in-vitro assays, handling of isolated positive responses observed in-vitro, metabolism and tissue distribution; tests in-vivo, the difference between experiments in-vitro and in-vivo, the use of in-vivo somatic cell assays as a pre-sceen for potential germ cell mutagens; correspondence between proposed testing strategy and governmental requirements; recommendations. Regulatory requirements, including suggested tests for the detection of anomalies, are summarised for plant protection chemicals (USA, Netherlands, United Kingdom, Italy and Japan) and for general chemicals (EEC, USA, OECD recommendations).
Descriptores (primarios) productos químicos agrarios; substancias peligrosas; tests de mutagénesis; valoración del riesgo; valoración de la toxicidad; mutágenos
Descriptores (secundarios) efectos mutágenos; legislación; anomalías genéticas; Países Bajos; Estados Unidos; Japón; Bélgica; Reino Unido; comunidades europeas; Italia; pesticidas; investigaciones en el animal; pruebas in vitro; efectos genéticos; riesgos para la salud; efectos cancerígenos; substancias cancerígenas
Tipo de documento E - Libros, informes, actas
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Risk evaluation
Agricultural chemicals
Genetic factors in reaction to exposures