| ID (ISN) del documento | 50630 |
| Número CIS |
88-2019 |
| ISSN - Título de la serie |
0097-6326 - Federal Register |
| Año |
1986 |
| Número de serie |
|
| Autor(es) |
Environmental Protection Agency |
| Título |
Guidelines for carcinogenic risk assessment [USA] |
| Información bibliográfica |
24 Sep. 1986, Vol.51, No.185, p.33992-34003. 29 ref. |
| Resumen |
These guidelines are non-binding policy statements, with no direct effect on the regulated community. It is emphasised that risk assessment is on a case-by-case basis, giving full consideration to all relevant scientific information. Contents: hazard identification (physical and chemical properties, routes and patterns of exposure; structure-activity relationships; metabolic and pharmacokinetic properties; toxicologic effects; short-term, long-term and human tests; weight of the evidence); dose-response assessment, exposure assessment and risk characterisation; the EPA Classification System for categorising weight of evidence for carcinogenicity. Appendices contain responses to comments from outside the Agency on, among other topics: inference guidelines; evaluation of benign tumours; transplacental and multigenerational animal bioassays; maximum tolerated doses; mouse liver tumours; quantitative estimates of risk. |
| Descriptores (primarios) |
substancias cancerígenas; Estados Unidos; toxicología; tests de carcinogénesis; riesgos químicos; valoración de los resultados; valoración del riesgo |
| Descriptores (secundarios) |
tumores benignos; vías de penetración; valoración de la exposición; directiva; exposición de corta duración; exposición de larga duración; relación dosis-respuesta; investigaciones en el animal |
| Tipo de documento |
F - Notas informativas, directrices prácticas, normas |
| Tema(s) |
Sustancias tóxicas y peligrosas
|
| Broad subject area(s) |
Riesgos químicos
|
| Navegación por categoria(s) |
Risk evaluation
|
