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Base de datos CISDOC

ID (ISN) del documento48426
Número CIS 87-1335
ISSN - Título de la serie 0002-8894 - American Industrial Hygiene Association Journal
Año 1987
Número de serie
Autor(es) Saltzman B.E.
Título Lognormal model for health risk assessment of fluctuating concentrations
Información bibliográfica Feb. 1987, Vol.48, No.2, p.140-149. Illus. 27 ref.
Resumen Health risk assessments of exposures to harmful materials increasingly are required because of legal and economic pressures. An important part of the procedure is the mathematical model for the dose-effects relation. If a linear no-threshold relation is assumed, then the mean of fluctuating concentrations may be used for the calculation of health risk. For threshold and nonlinear relations the calculation with the use of the mean concentration is inaccurate because higher concentrations produce disproportionately higher effects. A mathematical model based upon lognormal concentrations and probit effects is proposed. Rather than monitoring concentrations for unlikely high values, the method requires estimation of their geometric mean and geometric standard deviation. A health risk assessment may then be calculated simply and conveniently from the charts and tables provided. The method clarifies some issues and the specifics of utilising and improving the required data.
Descriptores (primarios) substancias tóxicas; modelos matemáticos; valoración del riesgo
Descriptores (secundarios) relación dosis-respuesta
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s) Riesgos químicos
Navegación por categoria(s) Risk evaluation