ID (ISN) del documento | 47299 |
Número CIS |
86-1996 |
ISSN - Título de la serie |
0096-1736 - Journal of Occupational Medicine |
Año |
1986 |
Número de serie |
|
Autor(es) |
Carrano A.V. |
Título |
Chromosomal alterations as markers of exposure and effect |
Información bibliográfica |
Oct. 1986, Vol.28, No.10, p.1112-1116. Illus. 28 ref. |
Resumen |
Structural changes in chromosomes were one of the first recognised forms of genetic injury resulting from exposure to physical and chemical agents. Depending on the lesions induced in the DNA, and therefore, on the nature of the genotoxic substances, damage to chromosomes falls into 2 categories, structural aberrations and sister chromatid exchange (SCE). Because these 2 end points respond differently to chromatin lesions, they are complementary in any study designed to identify potential exposure. The circulating lymphocyte in the human is an appropriate cell type in which to measure cytogenetic changes because it is readily accessible, carries genotoxic substances and their metabolites throughout the body, is long-lived, and can integrate exposure. In animal and human studies, it has been shown that both SCEs and aberrations can persist in the lymphocyte following acute or chronic exposure. |
Descriptores (primarios) |
diagnostico precoz; vigilancia médica; cambios cromosómicos; valoración de la exposición |
Descriptores (secundarios) |
pruebas biológicas y médicas |
Tipo de documento |
D - Artículos periódicos |
Tema(s) |
Patología profesional
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Broad subject area(s) |
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Navegación por categoria(s) |
Antifertility and prenatal effects Genetic factors in reaction to exposures Exposure evaluation
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