| ID (ISN) del documento | 45911 |
| Número CIS |
86-735 |
| ISSN - Título de la serie |
0007-1072 - British Journal of Industrial Medicine |
| Año |
1985 |
| Número de serie |
|
| Autor(es) |
Salmon A.G., Kerr Muir M., Andersson N. |
| Título |
Acute toxicity of methyl isocyanate: a preliminary study of the dose response for eye and other effects |
| Información bibliográfica |
Dec. 1985, Vol.42, No.12, p.795-798. 8 ref. |
| Resumen |
Acute toxic effects of methyl isocyanate in the rat were determined for 2h exposures to concentrations in the range 11ppm (very slight effect) to 65ppm (death due to pulmonary oedema). Non-respiratory effects included a narcotic or sedative effect producing unconsciousness at concentrations as low as 11ppm, with only minimal changes in the eyes or in the breathing rate. Effects in the eye (mostly epithelial erosions) were most pronounced at intermediate exposure levels. Following sublethal exposures, respiratory problems disappeared completely, but there was some evidence of residual neurological or pulmonary changes. When these observations are connected with those made in exposed people after the Bhopal incident, a clear relationship can be seen between animal and human data. Urinary thiocyanate concentrations in the exposed rats were lower than those in controls, indicating that conversion to cyanide did not take place. |
| Descriptores (primarios) |
efectos tóxicos; toxicidad aguda; edema pulmonar; relación dosis-respuesta; isocianato de metilo |
| Descriptores (secundarios) |
metabolitos urinarios; ojos; efectos narcóticos; investigaciones en el animal |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Patología profesional
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Cyano compounds
Diseases of the respiratory system (except for pneumoconiosis & similar)
Isocyanates
|
