ILO Home
Volver a la página de entrada
Site map | Contact us English | Français

Base de datos CISDOC

ID (ISN) del documento45354
Número CIS 86-108
ISSN - Título de la serie 0016-9900 - Gigiena i sanitarija
Año 1984
Número de serie
Autor(es) Karpenko V.N., Hohol'kova G.A., Pokrovskaja T.N., Rjazanova R.A., Gricevskaja I.D.
Título Bases for the hygienic characterisation of the pesticide kroneton
Título original Materialy k gigieničeskoj harakteristike pesticida kronetona [en ruso]
Información bibliográfica Oct. 1984, No.10, p.23-26. 6 ref.
Resumen The carbamate insecticide kroneton (2-(ethylthiomethyl)phenyl N-methylcarbamate) was subjected to a typical battery of toxicological tests. A single intragastric dose is moderately toxic for rats (LD50=400-500mg/kg) and highly toxic for mice and rabbits (LD50=150 and 118mg/kg, respectively). The pesticide has weakly cumulative effects. Its principal mode of action is inhibition of cholinesterase. It penetrates intact skin, producing embryotoxic, gonadotoxic and mutagenic effects. A subthreshold chronic dose is 0.043mg/kg at a concentration of 0.34mg/m3. A MAC for workplace air of 0.05mg/m3 is proposed. Work with the pesticide should be conducted with the same precautions as for highly toxic carbamate and organophosphorus pesticides.
Descriptores (primarios) efectos neurotóxicos; valores umbrales; inhibición enzimática; URSS; absorción cutánea; carbamatos; insecticidas; toxicología; cronetón
Descriptores (secundarios) efectos mutágenos; investigaciones en el animal; efectos embriotóxicos
Tipo de documento D - Artículos periódicos
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Blood diseases
Diseases of the nervous system
Amides
Genetic factors in reaction to exposures
Agricultural chemicals
Occupational exposure limits