| ID (ISN) del documento | 44522 |
| Número CIS |
85-1402 |
| ISSN - Título de la serie |
0016-9900 - Gigiena i sanitarija |
| Año |
1984 |
| Número de serie |
|
| Autor(es) |
Kagan Ju.S., Pan'šina T.N., Vojtenko G.A., Sasinovič L.M., Rodionov G.A., Voronina V.M., Kokšareva N.V., Šuljak V.G., Deši I., Karmoš-Varsegi M., Štromajer A. |
| Título |
Toxicology of the pesticide Hostaquick and establishment of a safe exposure level |
| Título original |
Toksikologija pesticida hostakvika i ustanovlenie bezopasnyh urovnej ego vozdejstvija [en ruso] |
| Información bibliográfica |
Apr. 1984, No.4, p.18-22. Illus. 3 ref. |
| Resumen |
In a battery of toxicological tests with rats, mice and guinea pigs, the systemic insecticide Hostaquick was found to be highly toxic and mildly cumulative. Its basic mechanism of action is inhibition of cholinesterases in the blood, and other tissues. Changes in the functional states of the central nervous system, liver and peripheral blood are sensitive indicators of Hostaquick intoxication. The anticholinesterase activity of the compound is more marked on continuous administration via the respiratory tract than on periodic administration, although the latter protocol produces a greater sensitising effect. Extrapolation of the data to man gives a daily exposure limit of 0.003mg/kg and a recommended MAC under agricultural conditions of 0.5mg/m3. |
| Descriptores (primarios) |
efectos neurotóxicos; valores umbrales; inhibición enzimática; URSS; efectos hematotóxicos; hostaquick; insecticidas; toxicología; efectos hepatotóxicos |
| Descriptores (secundarios) |
investigaciones en el animal; colinesterasa |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Agricultura, pesca, cría de ganado
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Agricultural chemicals
Esters and salts
Toxicology
Diseases of the nervous system
Occupational exposure limits
Blood diseases
|
