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Base de datos CISDOC

ID (ISN) del documento42963
Número CIS 84-1973
ISSN - Título de la serie 0355-9831 - Työterveyslaitoksen tutkimuksia
Año 1983
Número de serie
Autor(es) Sorsa M., Donner M., Falck K., Heinonen T., Hemminki K., Husgafvel-Pursiainen K., Lindbohm M.L., Mäki-Paakkanen J., Norppa H., Vainio H.
Título Genotoxic effects of occupational chemical exposure
Título original Työperäisen kemiallisen altistumisen genotoksiset vaikutukset [en finlandés]
Información bibliográfica 1983, No.3, p.170-191. Illus. 102 ref.
Resumen A study of groups of workers in the reinforced plastics, rotogravure printing and rubber industries. The reactivity, metabolism and mutagenicity of some potential problem chemicals were studied in the laboratory. Worker exposure to genotoxic agents was then assessed by determining the mutagenicity of urine samples, with bacteria as the indicator organisms. Examination of lymphocytes from the workers showed a marked elevation in chromosomal aberrations in reinforced plastics workers, who are exposed to styrene; rubber workers, who are exposed to several agents, showed frequencies of chromosomal aberration only slightly higher than control values, and printing industry workers, exposed to toluene, showed no increase at all. Smoking was associated with chromosome defects. There was no elevated frequency of spontaneous abortion among women in the rubber industry as a whole, and no teratogenic effect was observed. A subset of the women in the rubber industry was at risk of spontaneous abortion, but no cause was identified.
Descriptores (primarios) mutágenos; industria del caucho; transformación de materias plásticas; substancias teratogénicas; efectos genéticos; imprenta
Descriptores (secundarios) fumadores; aborto; tests de exposición; cambios cromosómicos; efectos teratogénicos; encuesta epidemiológica
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s)
Navegación por categoria(s) Antifertility and prenatal effects
Printing, photography and photocopying industry
Rubber industry
Genetic factors in reaction to exposures