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Base de datos CISDOC

ID (ISN) del documento42181
Número CIS 84-1086
Año 1982
Número de serie ECETOC Monograph No.4
Título Hepatocarcinogenesis in laboratory rodents: relevance for man
Información bibliográfica European Chemical Industry, Ecology and Toxicology Centre, Avenue Louise 250, Boîte 63, 1050 Bruxelles, Belgium, Oct. 1982. 77p. Illus. 253 ref.
Resumen 2 broad mechanisms are considered: in the genotoxic model, chemicals are thought to act by altering the structure of the genetic material of the cell, thus converting it to a cancerous cell; in the non-genotoxic model, the cancer develops from a non-cancerous lesion - involving necrosis, at the subcellular level, or involving hyperplasia. A recommended sequence of steps is given for establishing the hepatocarcinogenic potential of a chemical to laboratory animals and man.
Descriptores (primarios) substancias cancerígenas; productos químicos; extrapolación del animal al hombre; investigaciones en el animal; cáncer de hígado
Descriptores (secundarios) efectos mutágenos; metabolización; enzimas; aflatoxinas; efectos genéticos; esteroides; hepatitis vírica; cirrosis; ADN
Tipo de documento E - Libros, informes, actas
Tema(s) Patología profesional
Broad subject area(s)
Navegación por categoria(s) Viral diseases (other than aids)
Genetic factors in reaction to exposures
Bacterial and parasitic diseases