ID (ISN) del documento | 41924 |
Número CIS |
84-991 |
ISBN(s) |
951-801-352-7 |
Año |
1983 |
Número de serie |
|
Autor(es) |
Linnainmaa K. |
Título |
Genotoxicity of phenoxy acid herbicides 2,4-D and MCPA |
Información bibliográfica |
Institute of Occupational Health, University of Helsinki, Haartmaninkatu 1, Helsinki, Finland, 1983. 140p. Illus. Bibl. |
Resumen |
Academic dissertation. There was no correlation between exposure of sprayers to 2,4-D or MCPA and the frequency of sister chromatid exchanges (SCE) in their blood lymphocytes. Exposure of rats to the compounds likewise gave no increase in lymphocyte SCE. MCPA gave a slight increase in SCE in the bone marrow of Chinese hamsters; 2,4-D and the drug clofibrate (a suspected carcinogen structurally related to 2,4-D and MCPA) did not. Both herbicides gave a slight increase in SCE in hamster ovary cells in culture, but there was no dose-effect correlation and no relation between the frequency of SCE and the purity of the compounds administered. Both 2,4-D and MCPA induced proliferation of peroxysomes in the livers of hamsters and rats, and decreased serum lipid levels in rats; both effects are typical of clofibrate. Thus, any genotoxic effect that the herbicides might have would be due to the same indirect mechanism as that postulated for clofibrate. |
Descriptores (primarios) |
herbicidas; ácidos fenoxiacéticos; cambios cromosómicos; protección de los cultivos; toxicología |
Descriptores (secundarios) |
ácido cloro-4 metil-2 fenoxiacético; Finlandia; investigaciones en el animal; tesis; ácido diclorofenoxiacético |
Tipo de documento |
E - Libros, informes, actas |
Tema(s) |
Sustancias tóxicas y peligrosas
|
Broad subject area(s) |
|
Navegación por categoria(s) |
Antifertility and prenatal effects Agricultural chemicals Genetic factors in reaction to exposures
|