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ID (ISN) del documento41924
Número CIS 84-991
ISBN(s) 951-801-352-7
Año 1983
Número de serie
Autor(es) Linnainmaa K.
Título Genotoxicity of phenoxy acid herbicides 2,4-D and MCPA
Información bibliográfica Institute of Occupational Health, University of Helsinki, Haartmaninkatu 1, Helsinki, Finland, 1983. 140p. Illus. Bibl.
Resumen Academic dissertation. There was no correlation between exposure of sprayers to 2,4-D or MCPA and the frequency of sister chromatid exchanges (SCE) in their blood lymphocytes. Exposure of rats to the compounds likewise gave no increase in lymphocyte SCE. MCPA gave a slight increase in SCE in the bone marrow of Chinese hamsters; 2,4-D and the drug clofibrate (a suspected carcinogen structurally related to 2,4-D and MCPA) did not. Both herbicides gave a slight increase in SCE in hamster ovary cells in culture, but there was no dose-effect correlation and no relation between the frequency of SCE and the purity of the compounds administered. Both 2,4-D and MCPA induced proliferation of peroxysomes in the livers of hamsters and rats, and decreased serum lipid levels in rats; both effects are typical of clofibrate. Thus, any genotoxic effect that the herbicides might have would be due to the same indirect mechanism as that postulated for clofibrate.
Descriptores (primarios) herbicidas; ácidos fenoxiacéticos; cambios cromosómicos; protección de los cultivos; toxicología
Descriptores (secundarios) ácido cloro-4 metil-2 fenoxiacético; Finlandia; investigaciones en el animal; tesis; ácido diclorofenoxiacético
Tipo de documento E - Libros, informes, actas
Tema(s) Sustancias tóxicas y peligrosas
Broad subject area(s)
Navegación por categoria(s) Antifertility and prenatal effects
Agricultural chemicals
Genetic factors in reaction to exposures