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ID (ISN) del documento40589
Número CIS 83-1739
Año 1982
Número de serie
Título Genotoxic hazards in the rubber industry
Título original Genotoxiska risker i gummiindustrin [en sueco]
Información bibliográfica Arbetarskyddsfonden, Box 1122, 11181 Stockholm, Sweden, 1982. 202p. Illus. 25 ref.
Resumen Final report of a major study of the genotoxic and teratogenic hazards of exposure to rubber chemicals. The 80 chemicals whose effects were examined belonged to these groups: vulcanisers, vulcanisation accelerators, antioxidants, retarding agents, vulcanisation gases. To measure genotoxicity, the Ames test for mutagens in Salmonella was used, and strong mutagenic effects were found with thiurams, dithiocarbamates (both vulcanisation accelerators) and with almost all the vulcanisation gases. Other genotoxic tests confirmed the results of the Ames test. For embryotoxic and teratogenic effects, the chemicals were tested with chicken embryos, and the effective dose 50 (ED50) level was tabulated, together with the maximum percentage of malformed embryos. Urinary mutagenicity in rubber workers was measured and correlated with type of work and smoking. The biochemistry of the genotoxic process after exposure to thiurams and dithiocarbamates is described. Cancer and miscarriage epidemiology in rubber workers are discussed. Protective measures in the rubber industry are suggested.
Descriptores (primarios) mutágenos; efectos genéticos; substancias teratogénicas; industria del caucho
Descriptores (secundarios) efectos embriotóxicos; monosulfuro de tetrametiltiuramo; aceleradores de la vulcanización; disulfiramo; disulfuro de tetrametiltiuramo; ditiocarbamatos; fumadores; autoclaves de vulcanización; aborto; encuesta epidemiológica; pruebas in vitro; tests de mutagénesis; efectos cancerígenos; dosificación en la orina; antioxidantes; agentes vulcanizantes; dosis eficaz 50
Tipo de documento E - Libros, informes, actas
Tema(s) Química, hidrocarburos,plásticos, caucho
Broad subject area(s)
Navegación por categoria(s) Antifertility and prenatal effects
Rubber industry
Genetic factors in reaction to exposures