| ID (ISN) del documento | 38404 |
| Número CIS |
82-1665 |
| ISSN - Título de la serie |
0098-4108 - Journal of Toxicology and Environmental Health |
| Año |
1982 |
| Número de serie |
|
| Autor(es) |
York R.G., Sowry B.M., Hastings L., Manson J.M. |
| Título |
Evaluation of teratogenicity and neurotoxicity with maternal inhalation exposure to methyl chloroform |
| Información bibliográfica |
Feb. 1982, Vol.9, No.2, p.251-266. Illus. 19 ref. |
| Resumen |
In 4 groups of female rats, 1 was exposed to 2100±200ppm methyl chloroform (MC) for 2 weeks before mating and through day 20 of gestation, a second group was exposed only before mating, a third only during pregnancy and a fourth was exposed to filtered air as a control. At term, half of each group were sacrified and assessed for maternal toxicity, embryotoxicity and teratogenicity. No significant differences were found in measurements of maternal toxicity or embryotoxicity except for a decrease in foetal body weight when rats were exposed during pregnancy alone. Increased incidences of skeletal and soft tissue variations were found in foetuses from the group exposed before mating and during pregnancy. In a post-natal evaluation of offspring from half the sample no significant effects of exposure were noted in body weight or neuro-behavioral tests of open-field activity. |
| Descriptores (primarios) |
efectos neurotóxicos; tricloroetano; embarazadas; efectos teratogénicos; toxicología |
| Descriptores (secundarios) |
efectos embriotóxicos; tricloro-1,1,1 etano; toxicidad por inhalación; investigaciones en el animal; valoración de la exposición |
| Tipo de documento |
D - Artículos periódicos |
| Tema(s) |
Patología profesional
|
| Broad subject area(s) |
|
| Navegación por categoria(s) |
Halogenated hydrocarbons
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Diseases of the nervous system
|
