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Base de datos CISDOC

ID (ISN) del documento38070
Número CIS 82-1354
ISSN - Título de la serie 0003-0805 - American Review of Respiratory Disease
Año 1981
Número de serie
Autor(es) Chichester C.O., Palmer K.C., Hayes J.A., Kagan H.M.
Título Lung lysyl oxidase and prolyl hydroxylase: Increases induced by cadmium chloride inhalation and the effect of β-aminopropionitrile in rats
Información bibliográfica Dec. 1981, Vol.124, No.6, p.709-713. Illus. 30 ref.
Resumen Rats were exposed for 2h to 0.1% cadmium chloride aerosol and were killed 2, 4, 7, 10 and 21 days after exposure. At 4 days lung lysyl oxidase (LO) was increased 14.8 times compared with control animals and returned to near normal at 10 days. Total lung prolyl hydroxylase (PH) activity increased 7.4 times by day 4 in exposed versus unexposed animals. A significant increase in total lung hydroxyproline was also observed. Administration of β-aminopropionitrile prevented much of the increase in LO activity and the accumulation of collagen. The altered tissue amounts of LO and PH correlated well with interstitial cell hyperplasia 4-5 days after exposure and indicated that connective tissue protein synthesis is activated soon after cadmium exposure.
Descriptores (primarios) reacción del tejido pulmonar; bioquímica pulmonar; aerosoles; cadmio y sus compuestos
Descriptores (secundarios) hidroxilasas; alteraciones enzimáticas; oxidasas; investigaciones en el animal; cloruro de cadmio; desarrollo del tejido conjuntivo
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s)
Navegación por categoria(s) Cadmium and compounds
Inorganic substances