ID (ISN) del documento | 38070 |
Número CIS |
82-1354 |
ISSN - Título de la serie |
0003-0805 - American Review of Respiratory Disease |
Año |
1981 |
Número de serie |
|
Autor(es) |
Chichester C.O., Palmer K.C., Hayes J.A., Kagan H.M. |
Título |
Lung lysyl oxidase and prolyl hydroxylase: Increases induced by cadmium chloride inhalation and the effect of β-aminopropionitrile in rats |
Información bibliográfica |
Dec. 1981, Vol.124, No.6, p.709-713. Illus. 30 ref. |
Resumen |
Rats were exposed for 2h to 0.1% cadmium chloride aerosol and were killed 2, 4, 7, 10 and 21 days after exposure. At 4 days lung lysyl oxidase (LO) was increased 14.8 times compared with control animals and returned to near normal at 10 days. Total lung prolyl hydroxylase (PH) activity increased 7.4 times by day 4 in exposed versus unexposed animals. A significant increase in total lung hydroxyproline was also observed. Administration of β-aminopropionitrile prevented much of the increase in LO activity and the accumulation of collagen. The altered tissue amounts of LO and PH correlated well with interstitial cell hyperplasia 4-5 days after exposure and indicated that connective tissue protein synthesis is activated soon after cadmium exposure. |
Descriptores (primarios) |
reacción del tejido pulmonar; bioquímica pulmonar; aerosoles; cadmio y sus compuestos |
Descriptores (secundarios) |
hidroxilasas; alteraciones enzimáticas; oxidasas; investigaciones en el animal; cloruro de cadmio; desarrollo del tejido conjuntivo |
Tipo de documento |
D - Artículos periódicos |
Tema(s) |
Patología profesional
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Broad subject area(s) |
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Navegación por categoria(s) |
Cadmium and compounds Inorganic substances
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