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Base de datos CISDOC

ID (ISN) del documento38061
Número CIS 82-1353
ISSN - Título de la serie 0098-4108 - Journal of Toxicology and Environmental Health
Año 1981
Número de serie
Autor(es) Ellis K.J., Morgan W.D., Zanzi I., Yasumura S., Vartsky D., Cohn S.H.
Título Critical concentrations of cadmium in human renal cortex: dose-effect studies in cadmium smelter workers
Información bibliográfica May 1981, Vol.7, No.5, 691-703p. 23 ref.
Resumen Cadmium (Cd) was measured in vivo (using a neutron activation technique) in the left kidney and liver of 82 industrially exposed workers and 10 control subjects. The range of Cd values for the industrial group was 0.9-57mg for the whole kidney and 0.8-120ppm for the liver, compared to 0.4-11.8mg and 0.6-7.9ppm for the controls. At <40ppm in the liver, the kidney Cd burden increased with increasing liver concentration. At >40ppm, the kidney Cd content decreased as the liver concentration increased. This relation between Cd in the kidney and the liver for all subjects showed a critical level (Cd burden at which adverse effects occurred in the kidney) of 31mg Cd in the kidney. Estimates of the critical level by β2-microglobulin and urinary protein measurements yielded values of 31-42mg Cd for the whole kidney (300-400µg/g for the renal cortex).
Descriptores (primarios) enfermedades del rinon; industrias de metales no ferrosos; cadmio; efectos nefrotóxicos
Descriptores (secundarios) proteinuria; valoración de la exposición; estudio comparado; vigilancia de la orina; escintigrafía; relación dosis-respuesta
Tipo de documento D - Artículos periódicos
Tema(s) Patología profesional
Broad subject area(s)
Navegación por categoria(s) Diseases of the kidney and the urinary system
Smelting and refining operations
Cadmium and compounds
Inorganic substances